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宋瑞日,田在耕 동아대학교 공과대학 부설 한국자원개발연구소 1985 硏究報告 Vol.9 No.1
This thesis deals with the problem of determining a minimum cost sampling inspection plan for double destructive testing by attribute. Using Hald's Bayesian approach in a single nondestructive testing, procedures for finding the minimum cost double destructive sampling inspection plan by attribute are given. The linear cost model is constructed under the assumption that unit cost, destructive testing cost, and salvage cost are given. Assuming the uniform distribution as a prior distribution and being presentation theoretical approach, sampling inspection plan and a minimum cost is obtained. However, when the lot size is large, the global plan is very difficult to obtain even with the aids of an electronic computer. Therefore a method of finding suboptimal plan will be studied.
SOM을 이용한 온라인 게임 제공업체의 고객이탈방지 방법론
김재경,채경희,송희석 한국경영과학회 2004 經營 科學 Vol.21 No.3
The retention of customer is an increasingly pressing issue in today's competitive environment. The proposes of this paper is a personalized defection detection and the procedure of prevention based on economic analysis of customer defection possibility, and behaviour state transition cost. This procedure is based on the observation that potential defectors have a tendency to take a couple of months or weeks to gradually change their behaviour before their eventual withdrawal. In this procedure, the SOM(Self-Organizing Map) is used to determine the possible states of customer behaviour from past behaviour data, and to prevent the defection of potential defectors, the proposed procedure recommends the desirable behaviour state for the next period based on the analysis of transition cost, and likelihood of defection. The case study has been conducted for a Korean on-line game provider to evaluate of this procedure.
B_(2)O_(3)를 첨가한 Ni-Cu-Zn Ferrite의 자성에 대한 소결온도 효과
김민경,이명호,고재귀,송승기 명지대학교 자연과학연구소 2005 자연과학논문집 Vol.24 No.-
B_(2)O_(3)가 첨가된 Ni-Cu-Zn 페라이트의 소결온도 변화에 따른 자기적 성질을 연구하였다. 실험에 사용한 시료는 0.1 wt%의 B_(2)O_(3)를 (Ni_(0.204)Cu_(0.204)Zn_(0.612))Fe_(1.198)O_(2.98)에 첨가하여 각각 1000℃, 1100℃ 그리고 1200℃으로 4시간 동안 소결시켜 제작했다. 시료의 자기적 성질은 X-ray 회절 패턴, 자기이력 곡선, 초투자율, 손실계수 그리고 비저항을 측정하여 연구하였다. 자기이력 곡선과 초투자율 측정 결과로부터 세 시료 모두 우수한 연자성체가 되었음을 확인하였고, 소결온도가 높을수록 coercive force(H_(c))의 감소와 초투자율의 증가가 관찰되었다. 특히 가장 높은 온도(1200℃)로 소결한 시료의 Hc는 0.217Oe이었고, 초투자율은 전 영역의 주파수에 걸쳐 가장 큰 값을 유지하였다. 전력손실은 1 ㎑~10 ㎒ 주파수 영역의 교류에 대해 시료 모두 안정된 값을 갖고, 1200℃로 소결된 시료의 전력손실과 비저항은 시료 중 가장 적은 값을 가졌다. We have studied the dependence of B-doped Ni-Cu-Zn ferrite on sintering temperature. The samples were prepared from 0.1 wt% B_(2)O_(3)-doped (Ni_(0.204)Cu_(0.204)Zn_(0.612))Fe_(1.198)O_(2.98) ferrites and sintered at 1000℃, 1100℃ and 1200℃ for 4 hours respectively. The crystal structures of the samples were identified by X-ray diffraction pattern, and the magnetic properties of those were investigated by measuring X-ray diffraction pattern, hysteresis curve, initial permeability and resistivity. The results showed that all of the three samples were good soft magnetic materials, and initial permeability increased with the decreasing of Hc as the sintering temperature became higher. Especially, the sample sintered at 1200℃ showed Hc of 0.217Oe and maintained the highest value of initial permeability through the whole frequency range. The loss factors of the samples showed good frequency stability from 1 ㎑ to 10 ㎒ and both the loss factor and resistivity of the ssample sintered at 1200℃ was the least.
첨가제가 Mn-Zn 페라이트의 자기적 성질에 미치는 효과
이명호,김민경,고재귀,송승기 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-
우리 연구는 첨가제가 페라이트에 미치는 효과를 연구하기 위해 두 종류의 서로 다른 금속이온을 첨가제로 한 Mn-Zn 페라이트 시료를 제작하여 이들의 자기적 성질을 비교 분석하였다. 시료 제작에 사용된 Mn-Zn 페라이트의 주 원료 조성비는 31 mol% MnO, 16 mol% ZnO 그리고 53 mol% Fe_(2)O_(3)이다. 볼밀 작업을 통해 주 원료를 잘 혼합한 후 950℃에서 3시간 동안 하소하였다. 하소된 재료에 실험에 필요한 첨가물을 혼합한 뒤 성형과정을 거쳐 1300℃에서 3시간 동안 소결하였다. 첨가물은 0.1 wt% Na_(2)SiO_(3)만을 사용한 경우 (Sample 1)와 0.05 wt% Na_(2)SiO_(3), 0.1 wt% CaO와 0.05 wt% Al_(2)O_(3)를 첨가한 (Sample 2) 두 종류의 첨가제를 이용하였다. 두 시료에 대한 자성 특성을 측정한 결과 Sample 2 시료가 Sample 1에 비해 포화자속밀도(saturation flux density) B_(8)는 더 커진 반면 잔류자속밀도(residual flux density) B_(1)과 보자력(coercive force) H_(6)는 더 적어졌음을 확인하였다. 또한 고주파 측정에서도 0.05 wt% Na_(2)SiO_(3), 0.1 wt% CaO와 0.05 wt% Al_(2)O_(3)가 첨가된 시료에서 주파수 증가에 따르는 자기손실이, 다른 시료에 비해, 매우 완만하게 증가하는 것을 관찰하였다. 이들 자기 측정으로부터 0.05 wt% Na_(2)SiO_(3), 0.1 wt% CaO와 0.05 wt% Al_(2)O_(3)의 첨가제가 Mn-Zn 페라이트의 연자성 특성을 향상시켯음을 확인하였고, 이 결과는 이들 첨가물이 소결(sintering)과정에 관하여 Mn-Zn 페라이트 미세구조의 치밀화와 입자성장을 촉진시키는 효과가 있음을 보인다. We prepared two kinds of Mn-Zn ferrites composed of 31 mol% MnO, 16 mol% ZnO and 53 mol% Fe_(2)O_(3) as a main material. These were well mixed in a ball-milling machine and calcinated at 950℃ for 3 hours. After being mixed with two kinds of additives of 0.1 wt% Na_(2)SiO_(3) (Sample 1) and 0.05 wt% Na_(2)SiO_(3), 0.1 wt% CaO and 0.05 wt% Al_(2)O_(3) (Sample 2) respectively, the materials were molded and sintered at 1300℃ for 3 hours. The sample 2 was found to have more saturation flux density, and less residual flux density and coercive force than the other one, which means that the sample 2 is more suitable for soft-magnetic material. When the samples were applied by AC magnetic field in the frequency range of 10 kMz~1 MHz, both have shown relatively stable initial permeabilities up to 1 MHz. On the other hand, the loss factof of sample 2 became less than that of sample 1 in the high frequency range above 100 kHz although there was no much difference in the resistivity of both samples through the frequency change, which suggests the additives in the sample 2 has suppressed the viscosity loss in the high frequency range. We conclude that the 0.05 wt% Na_(2)SiO_(3), 0.1 wt% CaO and 0.05 wt% Al_(2)O_(3) additives has promoted coarsening and densification of the microstructure of the Mn-Zn ferrite and resulted in the better quality of the Mn-Zn ferrite
황해익,임재택,김정신,송연숙,이경화,김남희 부산대학교 영유아보육연구소 1998 영유아보육연구 Vol.4 No.-
This study aimed to develop Materials for (The Infant Educare Program) (Dept. of Health & Welfare, 1996). Infant educare Materials were developed through following procedures: 1) analysis of reference and other educare materials 2) content analysis of (The Infant Educare Program) 3) developing materials and 4)testing and revising materials by professionals. Infant educare Materials that developed in this study were constituted of 12 kinds in 5 areas - Materials for management of daycare center, the nursery stories for infants, musical materials for infants, play things for infants, and educational materials for parents. First, materials for management of daycare center were considered various conditions whithin daycare centers and were compased of 2 kinds - diary for educare plan and diskettes for documents. Second, the nursery stories for infants were compased of materials for 3 stages-the weaning stage, the toddling stage, and the independent stage. Similarly, musical materials for infants were composed of 3 stages. And play things for infants were composed of 2 kinds - play things to be easily founded and easily making play things. Finally, educational materials for parents were composed of 2 kinds - guide book for parents education and diskettes for communication with parents. It is needed that persistent attention from professionals in developing and testing materials for infant educare. Also, further educational implications were discussed
강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.
HL-60 세포주를 이용한 결핵균항원의 세포성면역반응의 분석
박정규,강윤중,김운옥,임재현,송창화,조은경,김화중 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2
Most persons who become infected with M. tuberculosis mount a protective immune response and remain clinically well, the only evidence of infection being development of a positive tuberculin skin test. Five to 10% develop tuberculosis disease within the first 2 years after infection (primary tuberculosis) or thereafter (reactivation tuberculosis). Acquired resistance against tuberculosis paradigmatically rests on cell-mediated immunity, with the major factors being mononuclear phagocytes and T Lymphocytes. While the former cells act as the principal effectors, the latter ones serve as the predominant inducers of protection. The usefulness of the single dose of BCG routinely given in childhood in many developing countries in preventing far more commonly occurring tuberculosis in adults is in doubt. An effective and safe vaccine against tuberculosis is sorely needed. A subunit vaccine are capable of inducing protective immunity and could have substantial advantages over BCG or other whole-bacterium vaccines. The human promyelocytic cell line HL-60 adopted characteristic macrophage-like properties, including adherence and CD14 expression after a period of continuous culture at high ambient CO_(2) concentration. When HL-60 cells were cultured with 1,25-dihydroxyvitamin D_(3) for 4 days, the cells acquired the activity to potentiate T cell proliferation by the 30 kDa or 38 kDa antigen of Mycobacterium tuberculosis H37Rv Therefore, vitamin D-treated HL-60 cells showed the function of the antigen presenting cells.
김복수,김영훈,강재필,백아영,차유정,김민경,서용문,송승기 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-
K_(2)SnCl_(6)는 antifluoride계에 속하는 결정으로서 K_(2)SnCl_(6)에 Li^(+)를 첨가하여 ^(7)Li 핵자기공명(NMR)을 측정하여 동형(isomorphic) 혼합결정(K_(1-x)Rb_(x))_(2)SnCl_(6)와 비동형(nonisomorphic) 혼합결정 K_(2)SnCl_(6):Al^(3+)에서의 핵자기공명(NMR), ^(87)Rb NMR과 ^(27)Al NMR의 측정값과 비교하였다. Rb^(+) 이온은 K_(2)SnCl_(6)의 K^(+)이온을 대신해 동형 결정을 이루며, Al^(3+)이온은 Sn^(4+)이온을 대치하면서 비동형 결정을 이루는데 Li^(+)이온 또한 K^(+)이온을 대신하는 동형 혼합결정과 유사한 결과 값을 얻을 수 있었다. 이 연구 결과는 종래의 Cl-NQR 연구 결과와 비교함으로서 K_(2)SnCl_(6)의 동력학적 특성과 구조 상전이 근처에서의 임계현상을 새로운 관점에서 볼 수 있는 가능성을 보여주었다. ^(7)Li, ^(87)Rb and ^(27)Al NMR have been investigated in the isomorphic and nonisomorphic impurity doped crystals (K_(1-x)Li_(x))_(2)SnCl_(6), (K_(1-x)Rb_(x))_(2)SnCl_(6) and K_(2)SnCl_(6):Al^(3+) as a supplementary to the previous Cl NQR studies in these crystals. The results yielded that the features of NMR spectra for both types of crystals are roughly in line with the systematic trends shown in the Cl NQR in these crystals, though the outstanding characteristics exhibited in the Cl NQR become in the case of the NMR of the doped impurities in crystals somewhat weakend. This is due to the degradation of the role of the local field from the main hamiltonian in NQR to the subsidiary in NMR. Each NMR result of the iso/nonisomorphic crystals has been analyzed in terms of the 'impurity induced dynamic lattice defects' for K_(2)SnCl_(6):Al^(3+) and the 'static primary impurity effects' for (K_(1-x)Rb_(x))_(2)SnCl_(6) and (K_(1-x)Li_(x))_(2)SnCl_(6) respectlvely.
결핵균 30 kDa 항원과 Triton X-100 Solubilized Protein 항원에 의한 대장암 주변 림프절 단핵구의 활성화
박정규,김광호,조은경,임재현,민들레,송영자,김화중,백태현 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1
Tumor-draining lymph node mononuclear (TDLMN) cells are specifically sensitized to the growing tumor but such cells are deficient for mediating an antitumor response. In this study, we examined the feasibility of using mycobacterial 30 kDa or Triton X-100 solubilized protein (TSP) antigen to stimulate mononuclear cells of colon cancer-draining lymph node for the generation of cell mediated immune effector cells. The proliferative response of TDLMN cells stimulated with mycobacterial 30 kDa or TSP antigen was determined by ^(3)H-thymidine incorporation assay. The proliferation of TDLMN cells to mycobacterial 30 kDa or TSP antigen was significantly increased in PPD (+) patients, but a poor response to the 30 kDa or TSP antigen was observed in PPD (-). The expression on γδ T cells to mycobacterial 30 kDa or TSP antigen was assessed by flow cytometry. The γδ T cells from PPD ( + ) patient responded only to 30 kDa antigen but to TSP antigen. An investigation of cytokine mRNA expression was undertaken using reverse transcription-polymerase chain reaction (RT-PCR) to follow TDLMN cells stimulated with the 30 kDa or TSP antigens for 5 days. The IFN-γ and TNF-α mRNA expression was only induced in TDLMN cells of PPD ( + ) patient in response to the 30 kDa or TSP antigen. The IL-2 mRNA expression was induced in both PPD (+) and PPD (-) in response to the 30 kDa or TSP antigen. But the IL-4 mRNA expression was not induced in response to the 30 kDa or TSP antigen. These results suggest that the 30 kDa and TSP antigens may serve as biologic response modifier for the generation of cell mediated immune effector cells.
김화중,김홍성,임재현,조은경,송창화,박정규 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Identification and characterization of mycobacterial antigens are critical for evaluation of their role in diagnosis, vaccination, and pathogenesis of mycobacterial diseases. An attempt has been made to immunologic characterize the 55 kDa protein antigen of Mycobacterium tuberculosis H37Rv which attracted our interest because it is present in high concentration in 50-80% ammonium sulfate fraction of the culture filtrate. Two monoclonal antibodies (MAbs) directed to 55 kDa antigen were produced. MAbs MT55-1 and MT55-2 reacted with a single 55 kDa protein band. On examination of degree for cross-reactivity with other mycobacterial species by enzymelinked immunosorbent assay (ELISA) and immunoblotting, these antibodies reacted strongly with M. tuberculosis and M. bovis BCG, and reacted weakly with M. marinum and M. smegmatis. To investigated the subcellular distribution of MAbs defined epitopes in the 55 kDa antigen within the mycobacterium, we isolated three major subcellular factions of M. tuberculosis, namely, cell wall, cytoplasmic membrane, and cytosol, by a simple fractionation procedure. MAb MT55-1 reactive cpitope was found in the cytosol when tested by immunoblotting. A sandwich ELISA was initially developed for detecting 55 kDa antigen using MT55-1 MAb in mycobacterial culture filtrate before detecting it in clincal specimens. The minimal detectable concentration was 1.0 ㎍/m1 for M. tuberculosis culture filtrate and 100 ㎍/ml for sonic extracts of M. bovis BCG and M. marinum, respectively. But the 55 kDa antigen was not detected in sonic extracts of other mycobacterial species examined. Although further evaluations are required, this study suggests that the 55 kDa antigen may be of interest as potential diagnostic reagent.