데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과

양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.

자발성 뇌실내출혈 환자에서 임상적 -전산화단층촬영상소견의 상관관계

황선철,김범태,장재칠,주교성,신원한,최순관,변박장 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.6

복직근 및 박근 근피판술을 이용한 골반 및 서혜부 연부조직 결손의 재건

이재화,정윤규,김주봉,유대현,황성관,이훈범,김석원 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.6

Many operations for the reconstruction of the pelvic area have been studied until now. The local muscle flap is often used for the closure of these complex wound. But, these local muscle flaps may not be available for reconstruction due to the factors of infection, radiation, and surgical trauma. Since rectus abdominis muscle and gracilis muscle were introduced, their use has been steadily increased for the reconstruction of soft tissue defect of the pelvic area. Inferiorly based rectus abdominis muscle flap and the gracilis muscle flap have been adopted for well-vascularized soft tissue coverage of the defect of pelvis and groin area. These techniques were utilized in seven patients. Of these patients, rectus abdominis muscle flap was used on four patients and three patients were treated with gracilis muscle flap. Among these, chronic osteomyelitis of pelvic bone has been managed with inferiorly based rectus abdominis muscle flap in three patients. No complication has been found. The mean postoperative follow-up period was 26 months, with a range of 12 to 39 months. In conclusion, these muscles are functionally expandable , and provide adequate tissue volume with sufficient blood supply away from the zone of injury, and readily transposed into the pelvis and groin area through subcutaneous tunnel, and serve as an antibiotic delivery system that aids in the eradication of infection. These findings suggest a reconstructive option for the defect of pelvis and groin, and/or bone infection in this area.

高濃度에타놀投與가 흰쥐 數種臟器의 酸素消費量과 肺容壓率에 미치는 影響

朴東盛,黃樹寬,朴載植,朱永恩 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

Ethanol 投與로 因한 흰쥐 數種臟器의 酸素消費量(QO_2)과 血中乳酸濃度 및 肺容壓率의 變化를 살펴보기 위해서, 흰쥐를 材料로하여 50% ethanol을 體重 100gm 當 1.5㎖ 씩 經口적으로 單回投與하여 1時間에서 24時間까지 經時的으로 肝, 腎, 脾 및 腦組織의 QO_2를 測定하고, 血中乳酸濃度 및 肺容壓率를 測定하여 對照群과 比較하여 다음과 같은 結果를 얻었다. QO_2는 肝組織에서 對照의 2.11±0.10㎕O_2/hr/㎎D. W. 에 比해 ethanol 投與後 1∼6 時間에는 有意하게 높았으며, 特히 1 및 3時間에는 各各 2.81±0.15 및 2.82±0.07㎕O_2/hr/㎎D. W. 로서 最高値를 나타내었다. 腎組織은 對照의 5.33±0.26㎕O_2/hr/㎎D. W. 에 比해 ethanol投與後 1∼12時間에는 有意하게 높았으며, 그 中 3時間에는 7.47±0.32㎕O_2/hr/㎎D. W. 로서 最高値를 나타내었다. 腦組織은 對照의 4.20±0.14㎕O_2/hr/㎎D. W.에 比해 ethanol 投與後 1∼6時間에는 有意하게 높았으며, 特히 3時間에는 5.53±0.29㎕O_2/hr/㎎D. W로서 最高値를 나타내었다. 脾組織은 對照의 3.55±0.13㎕O_2/hr/㎎D. W.에 比해 ethanol 投與後 1∼6 時間에는 有意하게 높았으며, 이 中 3時間에는 5.81±0.23㎕O_2/hr/㎎D. W로서 最高値를 나타내었다. 卽 肝, 腎, 脾 및 腦組織 모두의 QO_2는 對照値에 比해서 ethanol 投與後 1, 3 및 6時間에 有意하게 높았으며, 이 中 3時間에 最高値를 나타낸 後 漸次 減少하여 12 및 24時間에는 別差異가 없었다. 腎은 12時間까지 有意하게 높았다. 그리고 各 組織의 QO_2의 比較에서 腎이 가장 높고, 다음이 腦, 그리고 脾, 肝의 順으로 나타났다. 血中乳酸濃度는 對照의 12.57±0.47㎎/㎗ 에 比해 ethanol 投與後 1 및 3時間에 各各 24.36±2.70㎎/㎗ 및 22.48±3.21㎎/㎗로서 有意하게 높았으며, 6∼24時間에는 別 差異가 없었다. 血中乳酸濃度 對 QO_2의 比는 對照에 比해 1 및 3時間에는 有意하게 높았고, 6 및 12時間에는 有意하게 낮았다. 組織의 QO_2 對 血中乳酸濃度의 比는 對照에 比해 ethanol 投與後 1時間에 有意하게 높다가 3時間에는 有意하게 낮으며, 다시 6 및 12時間에는 有意하게 높은 후 漸次 낮아져 24時間에는 特히 腎과 脾가 有意하게 낮았다. 組織의 QO_2×血中乳酸濃度에서 對照에 比해 ethanol 投與後 1 및 3時間에는 有意하게 높다가 漸次 減少하여 脾는 12時間에 有意하게 낮았다. 肺容積은 ethanol投與後 1∼2時間에서 낮은 壓力下에서는 대체로 正常보다 낮았고, 높은 壓力下에서는 對照値와 비슷했으며, 24時間에는 모든 壓力下에서 對照와 거의 같은 값을 나타내었다. 肺容壓率은 ethanol投與後 3時間까지 對照보다 增加된 후 그 後 次次 減少하였다. 以上을 綜合해 보면 血中 ethanol 濃度가 0.72gm/㎗ 가 될 程度의 高濃度 ethanol을 投與해서도 QO_2가 增加되며, ethanol投與 1∼3時間에 最高値를 나타낸 事實과 ethanol 投與로 因한 血中乳酸濃度의 增加에서 1時間에 最高値에 達한 점, 그리고 肺容壓率이 ethanol 投與 初期에 增加를 보이고 肺容積이 ethanol 投與後 24時間에 거의 對照値로 되돌아온다는 事實等은 意義있는 結果인 것으로 思料되는 바이다. In order to elucidate the effect of ethanol (EOH) administration on the oxygen consumption rate (QO_2) of some vital organs and lung compliance, ??a single dose of 1.5㎖ of 50% EOH per 100gm of body weight was administered orally to rats, and QO_2 of the liver, kidney, brain and spleen, and blood lactate level and lung compliance were measured from 1 hr to 24 hrs after EOH ingestion. The results were compared with the control group and summarized as follows: QO_2 of the liver was significantly elevated from 1 through 6 hrs after EOH ingestion compared with the control value of 2.11 0.10㎕O_2/hr/㎎ dry weight (D.W. ). The values at 1 and 3 hrs were 2.81±0.15 and 2.81±0.07㎕O_2/hr/㎎D. W. both being the peak levels, respectively. QO_2 of the kidney was significantly elevated from 1 through 12 hrs compared with the control value of 5.33±0.26㎕O_2/hr/㎎D. W. The value at 3 hrs showed the heighest value of 7.47±0.32㎕O_2/hr/㎎ D. W. QO_2 of the brain was significantly elevated from 1 through 6 hrs compared with the control value of 4.20±0.14㎕O_2/hr/㎎D. W. The value at 3 hrs showed the peak level of 5.53±0.29㎕O_2/hr/㎎D. W. QO_2 of the spleen was significantly elevated from 1 through 6 hrs compared with the control value of 3.55±0.13㎕O_2/hr/㎎D. W. The peak level was 5.81 0.23㎕O_2/hr/㎎D. W. at 3 hrs. Thus, QO_2 of the liver, kidney, brain and spleen were uniformly elevated after EOH ingestion showing the peak level at 3 hrs and returning to the control level by 12 or 24 hrs. Also, among the studied organs, the kidney showed the highest QO_2 value, followed by the brain, spleen and liver in the order named. The blood lactate was also elevated significantly at 1 and 3 hrs after EOH ingestion, the figures being 24.36 2.70 and 22.48 3.21 ㎎/㎗, respectively, compared with the value of 12.57±0.47 ㎎/㎗. The blood lactate vs. QO_2 ratio was significantly elevated at 1 and 3 hrs after EOH ingestion and was significantly lowered at 6 and 12 hrs aompared with control. The QO_2 vs. blood lactate ratio was significantly elevated at 1 hr after EOH ingestion, significantly lowered at 3 hrs, significantly elevated at 6 and 12 hrs, again significantly in the kidney and spleen, lowered at 24 hrs compared with the control value. The product of QO_2 times the blood lactate was significantly elevated at 1 and 3 hrs after EOH ingestion and gradually lowered subsequently, and significantly lowered in the spleen at 12 hrs compared with the control value. The dynamic lung volume from 1 to 2 hrs after EOH ingestion compared with the control was smaller under lower pressures but similar under higher pressures. At 24 hrs after EOH ingestion it was almost the same as the control under all pressures. The lung compliance was increased until 3 hrs after EOH ingestion but was decreased gradually thereafter. From the above, we should note that the QO_2 is increased by ingestion of EOH as concentrated as 0.72gm/㎗ showing its peak value from 1 to 3 hrs after ingestion, that the blood lactate is increased by EOH ingestion with the peak at 1 hr, and that the lung compliance is increased during the initial period with the dynamic lung volume returning almost to the control value in 24 hrs after EOH ingestion.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

體育特技者의 肺機能과 運動後 恢復期의 血液가스의 變化

崔圭澤,朴載植,黃樹寬,朱永恩 慶北大學校 1985 論文集 Vol.39 No.-

The pulmonary function and changes of blood gas tensions and pH in the athletes have been reported but are fragmentary as to require more complete studies including all the pulmonary parameters and blood gas tensions especially at the early part of 20 years of age. This study was aimed to elucidate the pulmonary function at the rest and the changes of venous blood gas tension and pH after the exercise in the athletes of physical education students. The subjects chosen for this study were 15 athletes of physical education students (special group) of 21-25 years of age. The athletes had at least four years of exercise careers, and were compared with 12 non-athletes of physical education students (general group) who had not been subjected to any form of rigorous training program. All the subject were directed to perform running on the treadmill for three minutes under the condition of 15% grade and 5 MPH. The venous blood samples were taken at the rest as well as at 0, 5, 10 and 20 minutes after the exercise to check the changes of Pco_2, Po_2 and pH during the recovery period. The venous blood Pco_2, Po_2 and pH were determined using the Model 175 Automatic Blood Gas Analyzer by Corning Co., and the pulmonary function using the computerized spirometer. The results obtained were compared with the general group and summarized as follows: The special group exhibited higher values of the pulmonary function except FVC compared with the general group, and particularly FEV_0·5% and FEV_1% were significantly different. The venous Po_2 was decreased immediately after the exercise, but increased during the recovery period. The special group generally showed higher oxygen partial pressure than the general group. The venous Pco_2 in contrast to the oxygen increased immediately after the exercise, but decreased during the recovery period. The special group showed lower carbon dioxide partial pressure. Blood pH was significantly decreased from the resting value after the exercise and returned to the resting value at 20 minutes. In the special group, however, the change of pH was less than in the general group.

관상동맥경화증 환자에서 전곡섭취가 지질과산화 및 혈중 인슐린과 호모씨스테인 농도에 미치는 영향

장양수,이종호,엄영람,조은영,바현영,황재관,여익현 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

Industrial Potential of Phytochemicals in Functional Foods and Natural Products

Jae-Kwan Hwang 한국식품과학회 2008 심포지엄 Vol.2008 No.1

Structure and Function of Sidechains of Pectins

Jae Kwan Hwang 한국응용생명화학회 1992 한국응용생명화학회 학술발표회 Vol.1992 No.-

The occurrence of sidechains of pectins in the plant cell walls is discussed in conjuction with their structural features with respect to chemical constituents and distribution. In the plant cell walls the arabinogalactan sidechains of pectins function to connect the rhamnogalacturoran backbone of pectins to other cell wall materials such as hemicelluloses and cellulose. The degree of sidechains of pectins varies among plant sources, extraction procedures and their site in the plant cell walls. It has been well documented that the presence of sidechains in carbohydrate polymers significantly affects their functional properties such as solubility, gelatinization, gelling, retrogradation, freeze-thaw stability, film formation, interaction properties and rheology. In this presentation, the effects of sidechains on the functional properties of pectins in food systems are reviewed with particular emphasis on gelling and rheological properties. In addition, the enzymatic extraction of pectins in discussed on the basis of topology in situ of sidechains in the plant cell walls.

Solubilization of Cereals by Extrusion

Jae Kwan Hwang,Hae Hun Shin,Moon Jung Choi,Chang Ho Park,Sun Hee Lee 한국식품과학회 1999 한국식품과학회 학술대회 Vol.1999 No.1