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Son, Cheol-Hun,Bae, Jae-Ho,Shin, Dong Yeok,Lee, Hong-Rae,Choi, Yung Hyun,Yang, Kwangmo,Park, You-Soo Informa Healthcare 2013 Immunological investigations Vol.42 No.4
<P>Dendritic cells (DCs) are potent antigen-presenting cells that can be matured <I>in vitro</I> from immature dendritic cells (iDCs) in the presence of several biological agents such as cytokine cocktail, CD40L, TNF-a and antigen loading, which are necessary and achieved using various protocols, such as lipofection, passive pulse or electroporation. However, these DCs maturation protocols may cause with a significant loss of cells because of cellular attachment and spreading during culturing. Some biomaterials that influence adhesion and development of cells have been used in cell culture techniques, and it was thought that they might be applied on the culture of DCs. In this study, we used polyHEMA, which is a hydrogel coating biomaterial that prevents DCs from adherence, and investigated whether hydrogel coating affects the maturation of iDCs. The efficiency in the generation of mDCs was improved through hydrogel coating procedure and a dendritic cell maturation marker, CD83, was significantly increased in hydrogel-coated culture condition. The antigen-loaded mDCs from electroporation were further expressed the CD83. The mDCs generated in the hydrogel-coated culture condition showed more, longer and thicker dendrites, and produced more amounts of cytokines such as IL-12 and IFN-γ. Therefore, it was suggested that the hydrogel-coated culture condition could improve function of mDCs.<fn><P>Cheol-Hun Son and Jae-Ho Bae contributed equally to this work.</P></fn></P>
Si의 변형퍼텐셜 폴라론계에 대한 싸이클로트론 흡수곡선
최상돈,이재훈,남인호 경북대학교 산업기술연구소 1987 産業技術硏究誌 Vol.15 No.-
Choi-Chung's cyclotron resonance lineshape formula is applied to a deformation potential polaron system in Si. The result is in qualitative agreement with the experimental result of Kido et al.
(Sr.Ca)TiO_(3)세라믹스의 C-V특성과 Ca의 역할
최운식,강재훈 대불대학교 2002 大佛大學校大學院 硏究論文集 Vol.- No.1
It this study, the capacitance-voltage properties of (Sr_(1-x)·Ca_(x))TiO_(3)(0.05≤x≤0.20)-based grain boundary layer ceramics were investigated. The ceramics were fabricated by the conventional oxide-mixed method. The sintering temperature and time were 1480∼1500℃ and 4hour, respectively. The 2nd phase formed by the thermal diffusion of CuO from the surface leads to very excellent dielectric properties, that is, ε_(γ)>50000, tanδ<0.05, ΔC<±10%. The capacitance is almost unchanged below about 20[V] but it decreases slowly over 20[V]. The results of the capacitance-voltage properties indicated that the grain boundary was composed of the continuous insulating layers. The voltage-current characteristics was due to space charge condensed to interface between grain and grain boundary. The specimens treated thermal diffusion in 1150℃ for 2hrs appeared nonlinearity characteristic of α>7.
최동훈,이중림,민승기,박종환,김해영,조재선 慶熙大學校 1998 論文集 Vol.27 No.-
Strain type of lactic acid bacteria was analysed by PCR and SDS-PAGE. PCR allows the rapid and specific detection of lactic acid bacteria using primers based on 16S rRNA gene-sequences. The analysis of protein pattern on SDS-PAGE can be used to determine the differences among the same or similar species of lactic acid bacteria. Therefore, the complementary use of PCR and SDS-PAGE method is one of simple way to classify the lactic acid bacteria and to compare with genetic analysis.
Ciprofloxacin 제제의 생물학적 동등성에 관한 연구
최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1
국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.
최승주,이재현,이찬규,김근수,이종훈 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-
Hot corrosion behavior of the CMSX-2, CMSX-4, Rene 77, Rene 80 Ni-base superalloys was investigated at 900℃ by two different corrosion methods, immersing the samples in Na2SO4-NaCl mixture(immersion test)and coating the salt mixture on the surface of the samples(modified coating test). The effects of corrosion times and salt compositions from 0 to 100 percent in Na2SO4-NaCl mixtures were examined. Experimental results showed that the corrosion depths in the alloys increased with increasing time, and the depths of the modified coating test were shotter than those of the immersion test in the mixed salt. It was found that the depths of CMSX series alloys increasing NaCl contents in the mixtures up to 50% NaCl. Corrosion products of the alloys were composed of Cr, Al, Ti oxides. The oxide scale, such as Cr₂O₃, Al₂O₃, TiO₂, were shown to improve hot corrosion resistance in the fused Na₂SO₄-NaCl mixtures.
최재혁,윤두호,윤석훈 한국해양대학교 산업기술연구소 2002 연구논문집 Vol.19 No.-
Heat transfer characteristics of self-oscillating heat pipe were experimentally investigated for the effect of fill charge ratios and heat loads. The heat pipe used for this study is made of copper capillary, has 0.002m internal diameter, a 0.34m length in one turn and consists of 19 turns. Heating and cooling section each have a length of 70mm. Water was used as working fluid inside the heat pipe. As the experimental results, the self oscillating heat pipe was operated b self-exited oscillation and circulation of working fluid and the oscillation within the self-oscillating heat pipe assumed chaotic behavior.