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李金泳,吳永南,馬在濚,曺徵 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1
한국인의 정상 남자 112명, 여자 118명 총 230명의 460足蹠에 나타난 皮紋을 분석하여 다음과 같은 결과를 얻었다. 1) 족척의 중간부의 降線 方向은 橫行(76.5%), 輕度의 비골측 近位傾斜(11.5%), 輕度의 비골측 遠位傾斜(11.1%), 뚜렷한 비골측 遠位傾斜(0.9%)의 순으로 나타났으며 중간부의 융선 배열에 대한 대칭 빈도는 63.9%로 나타났다. 2) 무지구부 紋形은 원위측 제상문(64.8%), 와상문(20.2%), 개방문(5.9%)의 순으로 나타났으며 무지구에 나타난 대칭 빈도는 83.2%이었다. 3) 趾間部 紋形은 Ⅱ지간부에서는 개방문(73.7%), 원위측 제상문(22.2%), 근위측 제상문(3.3%), 와상문(0.9%)의 순으로, Ⅲ지간부에서는 개방문(54.8%), 원위측 제상문(41.7%), 와상문(2.4%), 근위측 제상문(1.1%)의 순으로, Ⅳ지간부에서는 개방문(81.7%), 원위측 제상문(17.4%), 와상문(0.9%)의 순으로 나타났다. 4) 趾間部 降線數는 a-b 57.76, b-c 70.74, c-d 75.09이며 남녀 사이, 또는 양족 사이에는 통계적으로 유의한 차이가 없었다(P>0.01). The dermatoglyphic patterns of the hands and feet form during early fetal life and thereafter remain essentially unchanged. These traits are useful to study genetics and environmental factors that influence prenatal life and used in practice for personal identification and diagnosis of some diseases. The students of 112 male and 118 female were tested for the patterns of plantar regions. The most common patterns were open fields in the four interdigital areas and the frequency of the mirror pattern on them was 57.2%. For a-b, b-c and c-d ridge counts of the plantar interdigital areas sampled from 105 male and 109 female students, the nonsignificances were found between both sexes and between both feet.
조재금,이재연,정성목,김명철 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1
Seven-year old, castrated male pekingese was presented with sudden onset of pain and tetraparesis. He was diagnosed with multiple intervertebral disc disease (lesion: C6-7 [mild], T12-13 [mild], L2-3 [moderate] via MRI in 2006. After undergoing conservative therapy at local hospital, he had more severe symptom in December 2009 than before. In order to identify exact site, he had been taken second MRI and transferred to CNU VMTH. Definitive diagnosis is also multiple intervertebral disc disease (IVDD) with the same lesion except C3-4 (+++). The spinal cord between C3 and C4 is ventrally compressed by intervertebral disc and the compression is much more severe than other lesions. Since the symptoms were severe and took place rapidly and didn't respond to medical treatment, surgical treatment, ventral slot for new lesion(C3-4) was planned. After the ventral compression of spinal cord between C3 and C4 was achieved, he showed enhancement which is gradual return to normal neurologic response, sternal recumbency, and occasional standing. After postoperative treatment at local hospital, he fully recovered to the normal. It was considered that accurate diagnosis timely adequate treatment are essential for the cure of IVDD.
성인간호학회지 논문(1989-2000)의 내용과 경향 분석
서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4
"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.
Lee, Jae-Chul,Cho, Jeong-Hwi,Lee, Tae-Kyeong,Kim, In Hye,Won, Moo-Ho,Cho, Geum-Sil,Shin, Bich-Na,Hwang, In Koo,Park, Joon Ha,Ahn, Ji Hyeon,Kang, Il Jun,Lee, Young Joo,Kim, Yang Hee Medknow PublicationsMedia Pvt Ltd 2017 Neural regeneration research Vol.12 No.9
<P>Calbindin D-28K (CB), a Ca<SUP>2+</SUP>-binding protein, maintains Ca<SUP>2+</SUP> homeostasis and protects neurons against various insults. Hyperthermia can exacerbate brain damage produced by ischemic insults. However, little is reported about the role of CB in the brain under hyperthermic condition during ischemic insults. We investigated the effects of transient global cerebral ischemia on CB immunoreactivity as well as neuronal damage in the hippocampal formation under hyperthermic condition using immunohistochemistry for neuronal nuclei (NeuN) and CB, and Fluoro-Jade B histofluorescence staining in gerbils. Hyperthermia (39.5 ± 0.2°C) was induced for 30 minutes before and during transient ischemia. Hyperthermic ischemia resulted in neuronal damage/death in the pyramidal layer of CA1–3 area and in the polymorphic layer of the dentate gyrus at 1, 2, 5 days after ischemia. In addition, hyperthermic ischemia significantly decreaced CB immunoreactivity in damaged or dying neurons at 1, 2, 5 days after ischemia. In brief, hyperthermic condition produced more extensive and severer neuronal damage/death, and reduced CB immunoreactivity in the hippocampus following transient global cerebral ischemia. Present findings indicate that the degree of reduced CB immunoreactivity might be related with various neuronal damage/death overtime and corresponding areas after ischemic insults.</P>
Lee, Jae-Chul,Tae, Hyun-Jin,Kim, In Hye,Cho, Jeong Hwi,Lee, Tae-Kyeong,Park, Joon Ha,Ahn, Ji Hyeon,Choi, Soo Young,Bai, Hui Chen,Shin, Bich-Na,Cho, Geum-Sil,Kim, Dae Won,Kang, Il Jun,Kwon, Young-Guen Humana Press 2017 Molecular Neurobiology Vol. No.
<P>Ischemic preconditioning (IPC) provides neuroprotection against subsequent severe ischemic insults by specific mechanisms. We tested the hypothesis that IPC attenuates post-ischemic neuronal death in the gerbil hippocampal CA1 region (CA1) throughout hypoxia inducible factor-1 alpha (HIF-1 alpha) and its associated factors such as vascular endothelial growth factor (VEGF) and nuclear factor-kappa B (NF-kappa B). Lethal ischemia (LI) without IPC increased expressions of HIF-1 alpha, VEGF, and p-I kappa B-alpha (/and translocation of NF-kappa B p65 into nucleus) in CA1 pyramidal neurons at 12 h and/or 1-day post-LI; thereafter, their expressions were decreased in the CA1 pyramidal neurons with time and newly expressed in non-pyramidal cells (pericytes), and the CA1 pyramidal neurons were dead at 5-day post-LI, and, at this point in time, their immunoreactivities were newly expressed in pericytes. In animals with IPC subjected to LI (IPC/LI)-group), CA1 pyramidal neurons were well protected, and expressions of HIF-1 alpha, VEGF, and p-I kappa B-alpha (/and translocation of NF-kappa B p65 into nucleus) were significantly increased compared to the sham-group and maintained after LI. Whereas, treatment with 2ME2 (a HIF-1 alpha inhibitor) into the IPC/LI-group did not preserve the IPC-mediated increases of HIF-1 alpha, VEGF, and p-I kappa B-alpha (/and translocation of NF-kappa B p65 into nucleus) expressions and did not show IPC-mediated neuroprotection. In brief, IPC protected CA1 pyramidal neurons from LI by upregulation of HIF-1 alpha, VEGF, and p-I kappa B-alpha expressions. This study suggests that IPC increases HIF-1 alpha expression in CA1 pyramidal neurons, which enhances VEGF expression and NF-kappa B activation and that IPC may be a strategy for a therapeutic intervention of cerebral ischemic injury.</P>
Lee, Jae-Chul,Kim, Yang Hee,Lee, Tae-Kyeong,Kim, In Hye,Cho, Jeong Hwi,Cho, Geum-Sil,Shin, Bich-Na,Park, Joon Ha,Ahn, Ji Hyeon,Shin, Myoung Cheol,Cho, Jun Hwi,Kang, Il Jun,Won, Moo-Ho,Seo, Jeong Yeol SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol.16 No.2
<P>Ischemic preconditioning (IPC) is induced by exposure to brief durations of transient ischemia, which results in ischemic tolerance to a subsequent longer or lethal period of ischemia. In the present study, the effects of IPC (2 min of transient cerebral ischemia) were examined on immunoreactivity of platelet-derived growth factor (PDGF)-BB and on neuroprotection in the gerbil hippocampal CA1 region following lethal transient cerebral ischemia (LTCI; 5 min of transient cerebral ischemia). IPC was subjected to a 2-min sublethal ischemia and a LTCI was given 5-min transient ischemia. The animals in all of the groups were given recovery times of 1, 2 and 5 days and change in PDGF-BB immunoreactivity was examined as was the neuronal damage/death in the hippocampus induced by LTCI. LTCI induced a significant loss of pyramidal neurons in the hippocampal CA1 region 5 days after LTCI, and significantly decreased PDGF-BB immunoreactivity in the CA1 pyramidal neurons from day 1 after LTCI. Conversely, IPC effectively protected the CA1 pyramidal neurons from LTCI and increased PDGF-BB immunoreactivity in the CA1 pyramidal neurons post-LTCI. In conclusion, the results demonstrated that LTCI significantly altered PDGF-BB immunoreactivity in pyramidal neurons in the hippocampal CA1 region, whereas IPC increased the immunoreactivity. These findings indicated that PDGF-BB may be associated with IPC-mediated neuroprotection.</P>
UPLC-QqQ/MS-Based Lipidomics Approach To Characterize Lipid Alterations in Inflammatory Macrophages
Lee, Jae Won,Mok, Hyuck Jun,Lee, Dae Young,Park, Seung Cheol,Kim, Geum-Soog,Lee, Seung-Eun,Lee, Young-Seob,Kim, Kwang Pyo,Kim, Hyung Don American Chemical Society 2017 JOURNAL OF PROTEOME RESEARCH Vol.16 No.4
<P>In this study, UPLC-QqQ/MS-based lipidomics was applied to profile various lipids from RAW264.7 macrophages treated with different concentrations of lipopolysaccharide (LPS). The degree of inflammation increased with the LPS concentration. To elucidate the altered lipid metabolism of inflammatory macrophages, we targeted to analyze 25 lipid classes from LPS-treated RAW264.7 cells. As a result, 523 lipid species were successfully profiled by using the optimal UPLC and MRM. Statistical data analyses such as PCA, PLS-DA, and HCA differentiated five RAW264.7 cells treated with different concentrations of LPS. VIP plot, heat map, and bar plot also provided lists of up-or down-regulated lipids according to the LPS concentration. From the results, 11 classes of lipids, TG, DG, ChE, PE, PS, PI, PA, LyPC, LyPE, Cer, and dCer, were increased, and three classes, cholesterol, PC, and LyPA, were decreased in an LPS concentration-dependent manner. Furthermore, the treatment of an anti-inflammatory compound recovered the levels of PC, PE, PI, PA, LyPE, LyPA, and Cer from the activated macrophages. Finally, these results demonstrate the correlation between inflammation and lipid metabolism in macrophages. The differentially regulated lipids also have the potential to be used as biomarkers for inflammation.</P>
Optical design of ZnO-based antireflective layers for enhanced GaAs solar cell performance
Lee, Hye Jin,Lee, Jae Won,Kim, Hee Jun,Jung, Dae-Han,Lee, Ki-Suk,Kim, Sang Hyeon,Geum, Dae-myeong,Kim, Chang Zoo,Choi, Won Jun,Baik, Jeong Min The Royal Society of Chemistry 2016 Physical chemistry chemical physics Vol.18 No.4
<P>A series of hierarchical ZnO-based antireflection coatings with different nanostructures (nanowires and nanosheets) is prepared hydrothermally, followed by means of RF sputtering of MgF2 layers for coaxial nanostructures. Structural analysis showed that both ZnO had a highly preferred orientation along the < 0001 > direction with a highly crystalline MgF2 shell coated uniformly. However, a small amount of Al was present in nanosheets, originating from Al diffusion from the Al seed layer, resulting in an increase of the optical bandgap. Compared with the nanosheet-based antireflection coatings, the nanowire-based ones exhibited a significantly lower reflectance (similar to 2%) in ultraviolet and visible light wavelength regions. In particular, they showed perfect light absorption at wavelength less than approximately 400 nm. However, a GaAs single junction solar cell with nanosheet-based antireflection coatings showed the largest enhancement (43.9%) in power conversion efficiency. These results show that the increase of the optical bandgap of the nanosheets by the incorporation of Al atoms allows more photons enter the active region of the solar cell, improving the performance.</P>