1,4-나프토퀴논 유도체의 항균 및 항진균 작용

유충규,류재천,정세영,김동현 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2

In order to evaluate the antimicrobial effect of 2,3-substituted-1.4-naphthoquinone derivatives, we newly synthesized several 2-chloro, 2-bromo and 2-hydroxy-1, 4-naphthoquinones and subjected to antibacterial and antifungal activites, in vitro, against Escherichia coli NIHJ, Staphylococcus aureus ATCC6538p, Candida albicans 10231, Aspergillus niger 1231 and Tricophyton mentagrophytes 6085. Among these derivatives 3, 9, 18 and 23 showed the potent antibacterial activities. 18, 23 and 28 have the antifungal activities. However, these compounds have no significant hemolytic activity at concentrations higher than that required for showing the antibacterial and antifungal activities.

환경 오염물질의 진보된 독성 평가 기법

류재천,최윤정,김연정,김형태,방형애,송윤선 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.1

Recently, several new methods for the detection of genetic damages in vitro and in vivo based on molecular biological techniques were introduced according to the rapid progress in toxicology combined with cellular and molecular biology. Among these methods, mouse lymphoma thymidine kanase (tk) gene forward mutation assay, single cell gel electrophoresis (comet assay) and transgenic animal and cell line model as a target gene of lac I (Big Blue) and lac Z (Muta Mouse) gene mutation are newly introduced based on molecular toxicological approaches. The mouse lymphoma tk^(+/-) gene assay (MOLY) using L5178Y tk+i- mouse lymphoma cell line is one of the mammalian forward mutation assays, and has many advantages and more sensitive than hprt assay. The target gene of MOLY is a heterozygous tk^(+/-) gene located in 11 chromosome, so it is able to detect the wide range of genetic changes like point mutation, deletion, rearrangement, and mitotic recombination within tk gene or deletion of entire chromosome 11. The comet assay is a rapid, simple, visual and sensitive technique for measuring and analysing DNA breakages in mammalian cells. Also, transgenic animal and cell line models, which have exogenous DNA incorporated into their genome, carry recoverable shuttle vector containing reporter genes to assess endogenous effects or alteration in specific genes related to disease process, are powerful tools to study the mechanism of mutation in vivo and in vitro, respectively. Also in vivo acridine orange supravital staining micronucleus assay by using mouse peripheral reticulocytes was introduced as an alternative of bone marrow micronucleus assay. In this respect, there was an International workshop on genotoxicity procedure (IWGTP) supported by OECD and EMS (Environmental Mutagen Society) at Washington D, C, in March 25-26, 1999. The objective of IWGTP is to harmonize the testing procedures internationally, and to extend to finalization of OECD guideline, and to the agreement of new guidelines under the International Conference of Harmonization (ICH) for these methods mentioned above. Therefore, we introduce and review the principle, detailed procedure, and application of MOLY, comet assay, transgenic mutagenesis assay and supravital staining micronucleus assay.

임신과 동반된 난소섬유난포막종 1례

류은석,김윤숙,전섭,김종수,최승도,선우재근,배동한,양승화 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Fibrothecoma are mesenchymal tumors deriving from the ovarian stroma and consisting of theca-like elements and fibrous tissues. The reported incidence is between 0.4 and 8.0% of all ovarian tumors and this side variability can be attributed to the difficulty in differentiation fibrothecoma from ovarian fibroma or hyperplastic stroma nodules. We experienced a rare case of ovarian fibrothecoma in woman at 38 weeks gestation with previous repeat cesarean section diagnosed after tertiary cesarean delivery and bilateral tubal ligation with a brief review of literature.

Telemetering을 이용한 자동 원격기상정보 측정 시스템에 관한 연구

류재춘,이천우,박종국 慶熙大學校 材料科學技術硏究所 1991 材料科學技術硏究論集 Vol.4 No.-

In this paper, The configuration of the AWS system, telemetering using public telephone line, data compressing, and data transmission were studied. Also, the new and more observatory(radius 8 Km) position were proposed for minute weather forcasting and bad climate phenomia. And, the experimental result was successful, and telephone pair and data transmission time were decresed by the success of AWS-public telephone line connection using Telemetering.

암모니아성 질소(NH_4^+-N)제거를 위한 제올라이트성 물질의 제조

류태공,류재춘,한명식,김철규,김영호,양현수 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.2

The objectives of this study were to synthesize high ion-exchangeable zeolitic materials prepared from coal fly ash and to determine the adsorption capacities for the removal of NH_4^+4-N in wastewater For comparison. NH_4^+-N adsorption capacities of commercial, natural, and synthetic(4A type, Si0_2/Al_2O_3=1.98. Na_2O/SiO_2=1.54. H_2O/Na_2O=46.95) zeolites were investigated at the same condition. Zeolitic materials were prepared from coal fly ash by hydrothermal reaction with various NaOH concentrations at the reaction time of 4h and the reaction temperature of 100℃. It showed that the zeolitic material prepared at a 4M-NaOH concentration had the most NH_4^+-N adsorption capacity. Theremoval efficiency of NH_4^+-N on the zeolitic material was little difference compared with those on natural and commercial zeolites, though it was lower than that on a synthetic zeolite(4A type). As a result, it is expected that the prepared zeolitic material could be applicable to adsorbent for the NH_4^+-N removal in wastewater.

林相別 夏期 流出量 調査硏究

柳澤圭,李天龍,金載水 圓光大學校 1986 論文集 Vol.20 No.2

우리나라의 水資源을 論함에 있어서 全 國土의 66%를 차지하고 있는 山地의 물 收支문제는 河川의 流量을 決定하게 되는 매우 重要한 要因이라고 생각된다. 이리하여 京畿道 光陵의 優良한 闊葉樹와 고거 甚한 山地荒廢로 砂防事業을 實施한 바 있는 京畿道 楊洲郡 檜泉面 栗亭里 불량 소나무 ?樹林地를 選定하여 降水量 및 流水量調査 施設을 設置하여 調査하고 山林狀態가 降水에 따른 流出이 어떻게 나타나고 있는가를 綿密하게 分析하였다. Natural water resource of our country depends on o forest area because of it is occupied about 66% of country area. The yield of water in the forest is very important factor to decide of stream flow for use. Two area of good forest land and a poor forest land near the Euijeong-bu city for this study. The good forest is consisted of natural old aged broad-leaf trees and the poor forest is consisted of natural pine sapling. The permanant gauge station which installed with a self-recording raingague and a stage recorder in a stilling well was established in each experimental plot. It was carried out during 1978-1982 about the characterize of rainfall and runoff. We are clear up the effect of forest in the control of water discharge. In monthly distribution of annual rainfall, more than 60% of the total annual rainfall were recorded for 2 months from July to August. Annual run-off rate was analysed as 35.4% from the good forest, while 39.8% from the poor forest. Good forest has increased larger storage water in the soil than a poor forest.

자궁근종의 양성 폐전이 치료 1례

유애리,문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2S

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요하지통 환자에서 두 개의 캐눌라를 이용한 박동성 고주파 신경근 응고술의 임상 연구

김천숙,배재영,배덕구,강규식,안기량,권진형,김지은,유시현 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Dorsal root ganglion(DRG) block by the local anesthetics and steroids which has done classically in low back pain(LBP) patients with radiculopathy has high incidence of recurrence rate and side effects of steroids. Recently a new technique of pulsed radiofrequency thermocoagulation(P-RFTC) was introduced and substituted for it because of the benefits such as relatively low recurrence rate, low risk of nerve injury and comfort during the procedure. We experienced 15 patients who had LBP with radiculopathy and no or little response to epidural steroid injection. When we performed DR ganglionotomy by P- RFTC under the C-arm guide in these patients, we tried to approach the exact DR ganglion using tow cannulas - the one for obtaining patient's subjective symptoms and injection of contrast dye, the other for making a RF lesioning after identifying the impedance of sensory and motor stimulation. In conclusion, DR ganglionotomy by P- RFTC using two cannulas in LBP patients is an easy and safe procedure with satisfactory results.

軟弱地盤 壓密特性과 沈下豫測

이재식,류제천,김송만,박춘수 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

Recently, developed countries have brought about a considerable increase in the study of soft ground for the reasons of policy on farming protection, key industry and sightseeing development since the middle of the nineteenth century, particularly 1950s. In spite of the long and copious experience associated with these types of construction, the constructions of soft ground still have many delicate problems. In general, problems of soft ground related to stability are probably to meet settlements on the various circumstances. In order to accelerate the rate of consolidation settlement and gain a required shear strength for a given soft ground, the preloading technique combined with a vertical drainage system has been widely applied. In this paper, laboratory tests have analyzed to change the soil parameters that executed the plan of stage construction. The void ratio and water content of the clay decreases and the strength of soft ground rises during consolidation period. In order to predict of magnitude, rate of settlement and pore pressure dissipation under embankment of loading on drainage-installed soft ground, consolidation settlement prediction methods such as Asaoka method, curve fitting method, TAN method and Hyperbolic method applied to gain final consolidation settlement from the field settlement data. The Reliability analysis of consolidation settlement prediction methods made use of additional settlement data. Sequentially, it has been found that Hyperbolic method can appropriately predict the consolidation behavior of drainage-installed soft ground of Yangsan Mulgum.

급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.