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( Young Kul Jung ),( Kwang Seok Kim ),( Ji Kyoung Lee ),( Sang Yoon Chung ),( Chang Bum Bae ),( Joo Hee Park ),( Sang Jun Suh ),( Seung Young Kim ),( Jong Jin Hyun ),( Ja Seoul Koo ),( Hyung Joon Yim 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The aim of this study is to compared with transient elastography and other invasive fi brosis marker, and to investigate several factors infl uencing the liver stiffness measurement (LSM) in chronic hepatitis B patients. Methods: Two hundred twenty eight patients with chronic hepatitis B who underwent liver biopsy and TE in the same time were recruited from January 2008 to December2013. Results: 159 (69.7%) of them were Male, and mean age was 41.9 years old. Mean of AST and ALT were 114.9 IU/L and 165.1 IU/L, respectively. Platelet count was 1.75 x 103 cell/uL.. 102 (44.7%) patients had HBeAg positivity. In liver Biopsy, 39 patients (17.1%) had F0-1, 57 (25.0%) had F2, 76 (33.3%) had F3, and 56 (24.6%) had F4, respectively. In view of the signifi cant fi brosis (F4), TE showed signifi cantly good estimate of liver fi brosis, and corresponding area under the ROC curves of LSM was 0.733 that showed slightly good estimate value compared with APRI (0.468) and fiB-4 (0.641). Among the lower ALT patients (ALT under 100 IU/L) corresponding area under the ROC curves of LSM was 0.804, and among HBeAg negative patients corresponding area under the ROC curves of LSM was 0.755. The cutoff LSM values for >F2, >F3, and F4 were 6.9, 8.5, and 10.1 kPa, respectively, whereas they were 6.2, 7.5, and 9.6 kPa, respectively, in those with ALT <X2 UNL. Conclusions: TE has good estimate performance for liver stiffness and fi brosis compared with AFRI and fiB-4 in chronic hepatitis B patients. However, ALT and HBeAg could influence liver stiffness. So, different cutoff LSM values may be applied in chronic hepatitis B patients.