DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase

Won, Kyung Jong,Jung, Seung Hyo,Jung, Soo Hyun,Lee, Kang Pa,Lee, Hwan Myung,Lee, Dong-Youb,Park, Eun-Seok,Kim, Junghwan,Kim, Bokyung Oxford University Press 2014 Cardiovascular research Vol.101 No.3

<P><B>Aims</B></P><P>DJ-1/park7, a multifunctional protein, may play essential roles in the vascular system. However, the function of DJ-1/park7 in vascular contractility has remained unclear. The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP).</P><P><B>Methods and results</B></P><P>Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7<SUP>−/−</SUP>) mice than in wild-type (DJ-1/park7<SUP>+/+</SUP>) mice. Acetylcholine inhibited NE-evoked contraction in endothelium-intact vessels, and this was markedly impaired in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP>. Nitric oxide (NO) production (82.1 ± 2.8% of control) and endothelial NO synthase (eNOS) expression (61.7 ± 8.9%) were lower, but H<SUB>2</SUB>O<SUB>2</SUB> production (126.4 ± 8.6%) was higher, in endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice than in those from DJ-1/park7<SUP>+/+</SUP> controls; these effects were reversed by DJ-1/park7-overexpressing endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice. Histone deacetylase (HDAC)-1 recruitment and H3 histone acetylation at the eNOS promoter were elevated and diminished, respectively, in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls. Moreover, SBP was significantly elevated in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls, but this elevation was inhibited in mice treated with valproic acid, an inhibitor of Class I HDACs including HDAC-1.</P><P><B>Conclusion</B></P><P>These results demonstrate that DJ-1/park7 protein may be implicated in the regulation of vascular contractility and blood pressure, probably by the impairment of NO production through H<SUB>2</SUB>O<SUB>2</SUB>-mediated epigenetic inhibition of eNOS expression.</P>

근린공원에 대한 환경지각이 이용자의 건강증진인식에 미치는 영향 - 창원시의 8개 근린공원을 대상으로 -

박영은,이우성,정성관,박경훈,Park, Young-Eun,Lee, Woo-Sung,Jung, Sung-Gwan,Park, Kyung-Hun 한국조경학회 2015 韓國造景學會誌 Vol.43 No.1

본 연구는 근린공원에 대한 이용자의 공원지각환경이 건강증진인식에 미치는 영향을 분석하기 위해 경상남도 창원시의 8개 근린공원을 대상으로 공원별 현장조사 및 설문조사를 실시하였다. 연구결과에 따르면, 먼저 공원별 공원지각환경에서는 대부분의 공원이 집에서 공원까지의 거리와 집에서 공원까지의 길 환경이 높게 평가된 반면, 수공간과 공원 내 다양한 볼거리는 충분하지 못한 것으로 분석되었다. 다음으로 23개의 지각환경 변수들을 요인분석한 결과, 경관성, 안락성, 접근성, 활동성, 편의성, 쾌적성의 6개 요인으로 분류되었다. 이를 토대로 건강증진인식과 지각환경요인과의 관련성을 분석한 결과, 8개 공원 중 4개 공원에서 지각환경요인이 신체적 건강증진인식에 유의한 영향을 주는 것으로 나타났다. 특히, 접근성과 활동성이 3개의 공원에서 영향력이 있는 변수로 분석되었다. 또한, 심리적 건강증진인식의 경우, 8개 공원 중 5개 공원에서 유의한 영향을 주는 것으로 나타났으며, 접근성이 4개의 공원에서 영향력이 있는 변수로 평가되었다. 이상과 같은 결과들은 기존의 공원 환경을 개선하고, 새로운 공원을 조성하고자 할 때 효율적인 기초자료로 활용될 수 있을 것으로 판단된다. The purpose of this study was to analyze the effect of environmental perception in neighborhood parks on user's recognition of health improvement. This study used objective field survey data and subjective user survey data at 8 neighborhood parks in Changwon City. According to the results, the perceptions of distance and street environment from home to park were evaluated highly but the perception of water spaces and various attractions within the parks were rated lowly in most of parks. As a result of factor analysis, 23 environmental perception variables were classified into 6 factors such as scenery, comfort, accessibility, activity, convenience and amenity. For the result of regression analysis between environmental perceptions and user's recognition of health improvement based on 6 factors, the recognition of physical health improvement was significantly influenced from environmental perception factors in 4 parks among 8 parks. 'Accessibility' and 'activity' were analyzed as the meaningful factors in 3 parks. Also, recognition of mental health improvement was significantly influenced from environmental perception factors in 5 parks among 8 parks and especially 'accessibility' was showed as the significant factor in 4 parks. The findings from this study can contribute to improve the physical environments of the present parks and can be a basic data for new park development.

근린공원 환경의 만족도가 신체활동과 건강에 미치는 영향 - 창원시 성산구와 의창구를 대상으로 -

박경훈,이우성,김태환,김은정,Park, Kyung-Hun,Lee, Woo-Sung,Kim, Tae-Hwan,Kim, Eun-Jung 한국조경학회 2014 韓國造景學會誌 Vol.42 No.3

본 연구의 목적은 경상남도 창원시를 대상으로 근린공원 환경에 대한 만족도가 신체활동과 건강증진 목적의 공원이용횟수와 체질량지수(BMI)에 의한 건강수준에 미치는 영향을 분석하는 것이다. 설문조사는 창원시 성산구와 의창구 도심지역에 분포하는 8개 근린공원의 이용자와 그 주변에 거주하는 429명의 주민들을 대상으로 실시하였고, 설문분석은 근린공원 환경에 대한 만족도가 신체활동과 건강에 미치는 영향을 분석하기 위해 일대일대응 선형회귀분석을 활용하였다. 연구결과를 요약하면, 공원을 이용하지 않는 주된 이유는 시간적 여유의 부족, 공원까지의 이동거리와 소요시간, 공원 내 이용시설의 부족 등이고, 공원을 이용하는 주된 이유는 공원까지의 접근성, 걷기 또는 산책, 휴식시설, 수목이나 그늘, 운동공간의 다양성 등으로 나타났다. 공원 이용자의 경우, 공원에서 걷기나 산책을 가장 많이 하고, 주 2회 이상 평균 10분 정도 걸어가서 1시간 정도 운동을 하는 것으로 나타났다. 공원과 그 주변의 물리적 환경 중에서 집에서 공원까지의 거리와 이동하는 가로 환경에 대한 만족도가 높았고, 공원 내 수공간이나 볼거리 등에 대한 만족도가 낮게 나타났다. 다음으로, 운동목적의 공원이용 여부, 공원이용시간, 공원이용의 만족도와 건강증진 효과, 공원까지의 거리, 따른 건강증진 효과만이 유의수준 10% 이내에서 상호관련성이 있는 것으로 나타났다. 향후에도 공원의 신체활동과 건강 증진 효과에 대한 실증적 사례노약자들의 공원이용 편이성 등이 유의수준 5% 이내에서 신체활동과 건강증진 목적의 공원이용횟수에 긍정적인 영향을 보였고, 체질량지수와는 공원이용에 를 지속적으로 축적해 나갈 필요가 있으며, 이를 통해서 각종 개발용도로 전환되거나 그 면적이 축소되고 있는 도시지역의 공원 및 녹지공간을 보전 확대시켜 나가고, 신체활동 및 건강증진 장소로서의 기능을 제고하기 위한 공원계획 설계 요소를 도출하는데 근거 자료를 제공하는 것이 가능할 것으로 판단된다. The purpose of this study is to analyze the effects of satisfaction in neighborhood park environments located in the Changwon-si of Gyeongsangnam-do, South Korea, on physical activity, the number of parks used for health improvement, and health levels based on Body Mass Index(BMI). Accordingly, a survey was conducted of 429 nearby residents and users of eight neighborhood parks located in urban areas of Seongsan-gu and Uichang-gu in the Changwon-si. The correlation between the environmental perception of neighborhood parks and physical activity and health, which was observed in the survey results, was analyzed using one-by-one linear regression analysis. By summarizing the study results, it was found that the primary reasons for avoiding park use were lack of time, time and effort required to reach the park(i.e., distance from the park), and lack of facilities within the park. Conversely, the primary reasons for using the park included accessibility, walking or strolling, leisure facilities, trees or shade, and diversity in exercise areas. In the case of park users, walking or strolling was the most common activity in the park. On average, park users walked to the parks for 10 minutes and exercised for an hour at least twice per week. With respect to the physical environment of the parks and surrounding areas, park users showed a high level of satisfaction with the distance between their houses and parks and the street environment. On the contrary, they exhibited low levels of satisfaction with water spaces and sightseeing within the parks. Subsequently, it was shown that the number of people using the parks for physical activities and health improvement was positively influenced(within a 5% significance level) by the intent to use the park for exercise, time spent in the park, satisfaction with park use and health improvement, distance to the park, and the convenience of using the park for the elderly. However, only the health improvement gained from park use was found to exhibit a correlation with BMI at the 10% significance level. Continuous accumulation of practical case studies on physical activities in parks and their health improvement effects is required. Through this, park spaces that are under the threat of reduction or elimination owing to various development plans can be conserved and expanded. Furthermore, such case studies can be used to provide data as the basis for deriving park plans and designs that improve parks' functions as sites of physical activity and health improvement.

도시소공원의 사회체육시설 환경색채 연구

박혜경(Park, Hey Kyung),오지영(Oh, Ji Young) 한국전시산업융합연구원 2016 한국과학예술융합학회 Vol.26 No.-

본 연구는 도시소공원 색채환경에 관한 연구로서 사회체육시설 영역을 중심으로 서울과 동경사례를 비교, 분석하여 색채환경 차이를 이해하고 시민건강증진을 위한 도시소공원 사회체육시설 색채계획을 수립하기 위한 자료로 활용하고자 한다. 서울과 동경에 위치한 순환선인 2호선과 야마노테선을 중심으로 인근 지하철역에 위치한 도시소공원을 선정, 분광측색기로 환경색채를 측정하였다. 서울 도시소공원 4곳, 동경의 도시소공원 4곳 총 8곳을 직접 방문하여 현장조사를 실시하였으며 도시소공원의 사회체육시설물, 공원시설물, 바닥 포장면으로 구분하여 조사하였다. 연구결과는 다음과 같다. 첫 번째 서울과 동경의 도시소공원의 사회체육시설 영역의 환경색채는 전반적으로 Y계열(Y, YR, GY)의 색채의 분포가 높게 나타났다. Y계열 다음으로 서울의 경우 B계열(B, BG, PB), 동경은 R, P계열로 나타나 색상분포가 차이가 있는 것으로 나타났다. 두 번째, 사회체육시설물의 경우, 서울보다 동경이 다양한 색상분포를 보였고, 서울이 명도가 다소 높게 나타나 밝은 색채가 시설물에 적용되었고 동경의 경우 원색에 가까운 고채도의 색채가 적용되고 있었다. 세 번째, 공원시설물 색채는 서울과 동경이 비슷한 명도, 채도값을 나타냈고, 색상분포에서 서울은 Y계열-B계열 순으로 높게 나타나며, 동경은 Y계열-R계열 순으로 높게 나타나고 있다. 바닥포장면의 명도와 채도도 서울과 동경이 비슷하게 나타나지만 색상분포에서 차이를 보였다. 향후, 색채의 생리적, 심리적 반응에 대한 연구결과를 사회체육시설 색채에 적용하는 것이 바람직하다고 사료된다. The purpose of this study is to analyze the color environment of urban small parks. We selected the urban small parks located in the subway stations around the line 2 and the Yamanote line in Seoul and Tokyo, and measured the environmental color with a spectroscopic colorimeter. Four urban parks, four urban parks, four urban parks, four urban parks, and four urban parks in Tokyo, and conducted field surveys. The study was divided into social sports facilities, park facilities and floor paved areas. The results of the study are as follows. The color of Y, YR, and GY colors were high in the environmental color of the first sports facilities in Seoul and Tokyo. In the case of Seoul, B, BG, PB, and Tokyo are R and P series, respectively. econd, in the case of social sports facilities, Tokyo has a different color distribution than Seoul, and Seoul has a somewhat higher brightness, so bright colors have been applied to the facilities. Third, the colors of park facilities showed similar brightness and saturation values in Seoul and Tokyo. In color distribution, Seoul is higher in Y-series and B-series, and Tokyo is higher in Y-series and R-series. The brightness and the saturation of the bottom pavement are similar to those of Seoul and Tokyo. However, the difference in color distribution shows that the color difference of the social facilities of urban small parks in Seoul and Tokyo varies depending on the color distribution rather than brightness and saturation.

공원의 CPTED 실행전략에 관한 연구

강용길(Kang Yong Gil),박경래(Park Kyung Rae) 경찰대학 경찰학연구편집위원회 2011 경찰학연구 Vol.11 No.4

The purpose of this study is to develop Crime Prevention Implementation Strategy in the park, to make the park a safe space as increased use of residents. This study searches the development of CPTED Implementation Strategy through examination of literatures and studies in the past. And for seeking the needs of crime prevention and the direction of implementation strategy, This study collects and analyzes data about the korean parks situations and criminal statistics on the quantitative - methods. Finally, based on the park crime analysis and the natural, organizational, and mechanical strategies presented by Crowe(2000), this study suggests CPTED strategies for park crime prevention, as follows. First, the Surveillance Strategy selects the park site taking into account the surrounding environment of the park, secures the visibility through planting of the landscape with night lighting, and secures an open spaces in the park. In addition, It installs and operates CCTVs around the vulnerable places and times. CCTV monitoring is desirable to be included into the existing integrated center model. Second, the Access Control places that park's walkways and public areas with high frequency apart from the vulnerable places, and makes fences in the Control Area by planting trees or using the rope, artificial structures such as wood. And also, It establishes the rules for access control and installs the guide board. Attaching sensors on the fences can increase the control effects. Third, the Territorial Strengthen sets boundaries around the contolled areas of the park and the shelter, separates spaces into compartments according to the each spaces' using purposes. Fourth, the Promoting Activities considers the improvements of the design of the park facilities and various facilities installation, and work-study programs and cultural programs developments and operation for increasing users' participation and emotional stability. In particular, developing Music-Broadcasting applying the effects of music therapy is expected to suppress criminal psychologies and opportunities. Fifth, the Maintenance and Management estimates for the support activities of crime prevention, the operation of park management department, and the effectiveness of crime prevention, objectively and periodically.

포스트 코로나 시대 도시주거지 근린공원의 행태지원성 변화가능성에 관한 연구

박인경(Park, In-Kyung),유다은(Yoo, Da-Un) 대한건축학회 2021 대한건축학회 학술발표대회 논문집 Vol.41 No.2

Neighborhood park in urban residential area provides easier access to everyday life and works as important leisure space. However, due to spatial limitations, it is not enough to satisfy the behavioral needs of various users. The purpose of this study is to analyze the affordances that can be expected in neighborhood parks that are readily accessible on a daily basis. This study derives the framework of analysis on various usage behavior and affordance of urban parks. Usage behavior was classified as static, dynamic and social exchange behaviors. Finally, this study can be used as an initial data in the planning and design research for neighborhood parks that might reflect the behavior and needs of park users.

ESSD 개념을 도입한 대구시 녹지보전등급 설정에 관한 연구

박경훈(Kyung Hun Park),정성관(Sung Kwan Jung) 한국환경영향평가학회 1999 환경영향평가 Vol.8 No.3

The purpose of this research is to establish a green space conservation grade for sustainable urban development of Taegu metropolitan city using GIS and RS methods, together with the valuation items of green spaces centered around ecological, useful, and socio-cultural factors. The results of this study are as follows: 1. According to the ecological factor, the first grade is 81.4km² and then Kachag-myun, Dong-gu in order, have needs of sustaining conservation policy of urban environment improvement and protection of the wild habitats. 2. According to the usefulness of urban parks, the first and second grade which is over 150 persons/km² in population density of the catchment areas, were Talsung park, Sinam park, Yongsan park and etc., the areas of those parks consists of 0.7% of the whole urban parks. 3. According to the socio-cultural factor, the first grade is located in urban natural parks, and the second grade is which are composed of Green Belt and agriculture in Talsung-gun. 4. Analyzing these results synthetically, the first grade conservation is 18%, as the forest in the upper zone of Mt. Palgongsan, Mt. Bisul, and Mt. Daeduck, these regions needed to preserve absolutely. This research is a basic step to show the methodology for all-round evaluation of green space using GIS and RS. Hereafter, it is necessary to consider general evaluation index of green spaces, and to consider the quantitative and qualitative aspect.

박춘무의 패션 디자인에 나타난 미적 특성 - 2010 FW ~ 2017 SS 컬렉션을 중심으로 -

박은경 ( Eun Kyung Park ) 한국디자인트렌드학회 2018 한국디자인포럼 Vol.23 No.4

연구배경 최근 세계적으로 한국 패션에 대한 관심이 높아지면서 한국 패션의 역사 기록과 특성에 대한 연구가 중요해지고 있다. 본 연구는 국제와 국내 무대에서 활발히 활동하고 있는 한국 중견 패션 디자이너 박춘무의 작품을 분석하고 디자인의 미적 특성을 밝혀 한국 현대 패션 역사의 일부를 기록하고 한국 패션의 정체성을 논의할 수 있는 자료를 제공하고자 하였다. 연구방법 본 연구는 인터넷 검색 사이트를 이용하여 박춘무 디자이너와 그의 컬렉션, 디자인에 대한 기사와 리뷰를 수집하였고, 그가 뉴욕패션위크에 참가한 2010 FW~ 2017 SS까지의 컬렉션 사진자료를 수집하여 디자인 특성을 실증적으로 분석하였다. 사진 자료는 여러 패션전문 매체 인터넷 사이트를 이용하여 수집하였고 컬렉션 주제와 영감, 조형 특성, 이미지를 분석하였다. 그리고 이를 기반으로 디자이너 작품세계의 미적 특성을 총체적으로 논의하였다. 연구결과 박춘무 관련 기사와 컬렉션 작품을 분석한 결과 그의 디자인에서 반복적으로 나타나는 대표 디자인 특성은 무채색과 모노톤, 구조적 라인과 비정형적 라인의 조화, 소재 대비와 혼합에 의한 조형 표현, 미니멀리즘, 모호한 성의 표현, 스포티즘, 그리고 한국적인 미학의 이미지 표현으로 나타났다. 결론 30년의 역사를 지닌 브랜드 디자이너 박춘무는 비교적 일찍부터 해외 진출을 시도하여 성과를 거두었고, 상업성과 디자이너 감성의 조율을 통해 성장하였다. 그는 아방가르드와 모던한 디자인 감성을 기본으로, 최근에는 한국적 감성의 도입을 시도하고 있다. 본 연구결과 박춘무의 컬렉션에 나타난 디자인의 미적특성은 ‘컨템포러리 아방가르드’,‘한국적 미학의 아방가르드’로 결론내릴 수 있었다. Background Recently, the record and research on the characteristics of Korean fashion is becoming important. The purpose of this study is to analyze the works of Korean fashion designer Park Choonmoo, who is actively engaged in international and domestic stage, to reveal her design aesthetic features. Methods This study collected articles and reviews on Park Choonmoo and her fashion collection, using an internet search site. And study analyzed the design of collection from 2010 FW to 2017 SS in New York Fashion Week. Collection photographs were collected from various fashion media web sites and brand facebook. The collection theme, inspiration, formative characteristics, and images were analyzed. Result The characteristics of Park’s design appeared as achromatic and monotone, harmony of structural line and irregular line, formative expression by mixture of material and material. Also images of minimalism, ambiguous sex expression, sportism, and expression of Korean aesthetics was appeared. Conclusion Park Choonmoo has been based on avant-garde and modern design sensibility, and recently she is trying to introduce Korean sensibility. As a result of this study, the aesthetic characteristics of the design shown in Park's collection appeared as ‘contemporary avant-garde' and ‘Korean aesthetic avant-garde’.

素問·調經論에 대한 연구(Ⅱ)

鄭憲瑩,琴坰樹,朴炅 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2

'Joe'(調) implies the harmony or the regulation, and 'Kyung'(經) indicates a meridian on that is translating meridian blood and Meridian-Qi. The Meridian channel is opened to the Five viscera(五藏) and the Six bowels(六腑) internally and that is connected with three hundred and sixty five joints externally. The body never occurs disease until Qi-hyul(氣血) is harmonied and Yin-Yang(陰陽) is balanced. If the disease occurs by means of the internal cause-the eating and drinking, the living of dwelling space, the importance of the emotion etc, I or by means of the external cause- the wind and rain, and the cold and dampness, it has influence on the Qi-hyul(氣血) of the body. Therefore with disharmony of the body has Qi-hyul, each kind of the Hei-shil disease brake(&實病燮) occur. From this chapter, Joe kyung(調經) implies the regulation that each kind of Hei-shil disease brake with ocwrance of the disorder of the body Yin-Yang-Qi-hyul(陰陽氣血), the shortage(&) is supplied, and the surplus(R) is decreased. Summerizing the contents of the "Joe Kyung Ron(調經陰)" in reference to the contents of successive generation note, the contents were as follows; In chapter 1, it was made clear that the revelation of the body normal physiological function had an action that connected human being's inside with it's outside, and that play the part of a passage in Qi-hyul(氣血) risvolving. In chapter 2, it was made clear about the plentiful disease, and it's administration of the Shen-Qi-Hyul-Hyung-Zhi(神·氣·血·形·志) with kept in the five viscera. In chapter 3, it was made clear about the Hei-shil(虛實) of the cause of the disease(病機), Qi-Hyul(氣血) union malim(雅氣), that by Qi-Hyul(氣血) itself union how Hei syndrome(虛證) and Shil syndrome(#%) are? In chapter 4, it was made clear that cause of a disease about Hei-Shil(虛實) has an attack of disease by pung(風)·woo(雨)·han(寒)·seo(署), and by the eating and drinking, the living of dwelling space and it explained the cause of a disease. In chapter 5, it explained the cause of a disease about Yin-Yang-Han-Yul(陰陽寒熱). In chapter 6, it explained an acupuncture technique about Hei syndrome(虛證) and Shil syndrome(l實證). chapter 7, it explained the method of Joe Kyung(調經) through the region of the body. The above contents had significient influence on the assortment and demonstration of the method of the acupuncture and moxibustion and disease in the future.

경희대학교 수원캠퍼스 노천극장 주변 공원 기본계획

김동찬,이윤수,권오원,민창기,김태현,박경모 경희대학교 디자인연구원 2004 예술· 디자인학연구 Vol.7 No.1

We, Kyung-hee University in Suwon has planned to build an open-air theater behind the building of natural science, and feel the need of creating places for cultural life and recreation. As the origin aim of this construction and landscape, university students can use this facilities and place for their daily relaxation and cultivation of emotion, and they also can utilize them for places of their meetings and events. Concerning the following completion of the UN Peace Park, our theater and the surrounding places will expectingly play important roles for the park because the open-air No-cheon theater is included in the full site of the UN Peace park. The focused elements of this basic plan are maintaining the basic plan of the UN Peace Park, forming the visually creative background, of the open-air theater cultural and recreational places, balancing and integrating human, nature, and the useful facilities.