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위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성
이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1
Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)
CHOI, SUN-IL,JUNG, TAE-DONG,CHO, BONG-YEON,CHOI, SEUNG-HYUN,SIM, WAN-SUP,HAN, XIONGGAO,LEE, SANG JONG,KIM, YOUNG-CHEUL,LEE, OK-HWAN UNKNOWN 2019 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.44 No.2
<P> Processed products from agricultural produce generate a large number of agricultural by-products that contain a number of functional substances. These are often discarded owing to the lack of suitable processing methods. The present study investigated the anti-photoaging properties of fermented rice bran (FRB), soybean cake (FSB) and sesame seed cake (FSC) on ultraviolet B (UVB)-irradiated hairless mouse skin. Results indicated that the oral administration of FRB, FSB and FSC effectively inhibited the UVB irradiation-induced expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-3 and MMP-13. Reverse transcription-quantitative polymerase chain reaction results also demonstrated that FRB, FSB and FSC significantly inhibited the UVB-induced expression of the genes encoding tumor necrosis factor-α, inducible nitric oxide synthase, interleukin (IL)-6 and IL-1β when compared with the UVB-vehicle group (P<0.05). Additionally, collagen degradation and mast cell infiltration were reduced in hairless mouse skin. Furthermore, UVB-induced wrinkle formation was also significantly reduced in mouse skin compared with the UVB-vehicle group (P<0.05). These results reveal that fermented agricultural by-products may serve as potential functional materials with anti-photoaging activities. </P>
조현일,노일환 公州大學校스포츠科學硏究所 1999 스포츠科學硏究所論文集 Vol.- No.13
To accomplish the pupose of this study, l have compared two groups : Superior group of 30 players and less-superior proup of 30 platers to examone the effect of competition anxiety for western style acheries tournament records and training records. The superior group contains the players who have won the prize for national tournament and less-superior group does not but same record in training stage. The differences of tournament records, training records and SCAT score between these two groups have been verified by using t-verification. In addition, pearson's correlationship of these two groups and SCAT score. The results of this study has shown : Frist, SCAT score shows statistical differences between two groups (P〈001) Second. No statistical differences in single and frand training records, but in tournament records(P〈001) Third, the meaninful differences of SCAT score has shown between male and female superior group and less-superior group Fourth, No difference of training records of single and grand but in tournament records of these two groups. Fifth, the SCAT score, has a reliable relation between two groups. Finally, the SCAT score, single and grand training records shows no difference statistically but in tournament records has high correlation between these superior group and less-superior group. According to this study, the competition anxiety has a negative effect for Western-Style acheries in tournament records. The level of this negative effect is greater among less-superior players compared to superior group.
조규갑,김갑환,문일경,김기영 한국경영과학회 1993 經營 科學 Vol.10 No.2
A production control information system developed for multi-product, small-lot-sized production is presented. The system is composed of interrelated modules for production planning, shop floor control, and inventory / material management. The architecture of the system, functions of each module, and information processing procedures of each function are discussed.
曺日煥 東義大學校地域社會開發硏究所 1985 공공정책연구 Vol.1 No.-
The infringement of right, one of the legal factors for the causation of responsibility which is regarded as an illegal activity, is an infraction of upholding the law benefit according to the private opinion. The illegal activity of infringement of right of life cannot be made unless there is an occurrence in consequence of the victim's death. The provision 750, virtually one of the general stipulations for the illegal activity in the civil law, imposes the indemnity obligation upon a person who inflicts the damages on other person, by intention or lapse. Any infringement of right of life couldn't possibly exist without the termination of the victim's life in accordance with the national stipulation against the infringement of right of life. In order for us to define and assert the infringement of right of life, there accordingly should be ensued a victim's death. Mostly both the constituent of causation of responsibility in the illegal activity and the damages incurred by the infraction of right could be strictly distinguished. The intention or the lapse is involved only in the infringement of right of body. When the victim's death results from both the infringement of right of body and the corresponding causation when the infringement of right of body precipitates a considerable loss, the illegal doer shall be liable to assume the indemnity against the death. Nobody can doubt about a theory of law of illegal activity, and the infringement of that illegal activity is not an infringement of right of life but that of right of body. It should be remembered that the extent of indemnity against the claims which bases on the illegal activity in consequence of the infringement of right of body exerts only the loss incurred by the death.