Glutaraldehyde의 농도 및 pH에 따른 항균효과 및 결체조직에 미치는 자극에 관한 비교연구

윤형석,김용기 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

The purpose of this study was to compare the antmicrobial and irritational effects of various glutaraldehyde groups under defferent concentrations along with pH levels on two species of microorganisma,S.aureus and S. sanguis, and dorsal connective tissue of 16 Sprague Dawley rats. The results can be summarized as follows: 1.The intensity of antimicrobial effects on two tested species increased as the concentration of glutaraldehyed got higher. 2.Buffered groups demonstrated stronger antimicrobial effects over unbufferde groups under all tested concentrations and showed statistically significant differences(<0.05) except 10% S. sanguis group. 3.The results of connective tissue reaction study showed the general increased in severity of tissue irritation and in the diffusion of fixed tissue layer. 4.No apparent histological differences could be found in the degree of tissue irritation between buffered and unbuffered glutaraldehyde groups. 5.The overall picture of histological ovservation demonstrated the decrease of inflammatory response with time and no notably different findings bwtween experimental groups were indicated after 4 weeks of test periods.

HPLC-MS/MS를 이용하여 혈장 중 레보티인정의 정량분석

채석,오형근,이상선,김형기,손동렬,염윤기,맹주양,권준택 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2

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부분적 무치증을 동반한 법랑질 형성부전 환자의 치험례

윤형석,김용기 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.2

Enamel hypoplasia may be defined as an incomplete formation of the organic enamel matrix of teeth can be derived from a variety of local and systemic factors. A 9-year-old female patient with a chief complaint of abnormal crown shape with partial anodontia came to the clinic for complete rehabilitation. Family history revealed the presence of notched central incisors in her brother and VDRL was performed to rule out congenital syphilis which responded positively in this case. Functional orthodontic appliance were delivered to increase vertical dimension and hypoplastic teeth were restored either stainless steel crown or composite resin restoration. Congenital missing and extracted areas were recovered by delivering upper and lower removable acrylic partial dentures.

Midazolam의 백서 기관평활근 이완효과와 Flumazenil의 길항작용

윤석화,신용섭,손수창,이원형,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Midazolam have been used widely as adjuvants in both regional and general anesthesia and in high risk patients in the intensive care unit. In the present study we evaluated the effect of midazolam and antagonistic effect of flumazenil on isolated rat tracheal preparations mounted for recording isometric contractile force. Trachea smooth muscle were contracted with acetylcholine (10^-5M, Ach) and potassium chloride (40mM KC1). Midazolam 5x10 exp (-6)M and 5x10 exp (-5)M produced dose-dependent relaxation and flumazenil (3.2 x 10 exp (-7)M), central antagonist of benzodiazepine, pretreatment had no significant change midazolaminduced relaxation. Midazolam probably did not relax airway smooth muscle by activatong central benzodiazepine receptors, as flumazenil did not block the concentration-related relaxation of midazolam. Our study suggests that flumazenil may be used satety for asthmatic patients who have been with midazolam, as flumazenil did not antagonize airway relaxation elicited by midazolam.

정맥내 통증자가조절법을 이용한 Nalbuphine-Ketorolac과 Butorphanol-Ketorolac의 술후 진통효과 비교

윤석화,이원형,손수창,신용섭,김윤희,양신영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study aimed to compare analgegic efficacy, satisfaction score and side effect of nalbuphine-ketorolac and butorphanol-ketorolac by using intravenous patient controlled analgesia(IV-PCA) for postoperative anlgesia following a gastrectomy for stomach cancer. Ninety patients who had undergone gastrectomy for stomach cancer under general anesthesia were randomly divided into two groups. Each group recieived nalbuphine 50mg with ketorolac 150mg(Group 1, n=45) and butorphanol 5mg with ketorolac 150mg(Group 2, n=45) by using IV-PCA during postoperative 48hrs. Assessments for pain with numerical rating scale(NRS), and side effects were evaluated at 2hr, 6hr, 12hr, 24hr, 36hr and 48hr after the operation. There were no significant difference in NRS for pain during rest, but Group 2 requested significantly greater amount of supplementary diclofenac during first 24 hours. Side effects were higher Group 1 in pruritus, nausea and vomiting and Group 2 in sedation, nausea and vomiting. This study suggests that adding ketorolac with intravenous nalbuphine or butrophanol in using an intravenous PCA can decrease analgesics requirement and improve analgesic property without the major morbidity like respiratory depression, but needs for the careful observation and treatment on the side effects like nausea. vomiting, pruritis and sedation...

한국인에서의 CYP2C19 돌연변이 유전자형의 다형성에 관한 연구

채석,채상우,양동규,김형기,권준택,염윤기 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

The S-mephenytoin 4'-hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). Recent studies have found a third (CYP2C19*4) and forth (CYP2C19*5) mutations in Caucasians. In the present study, we genotyped 536 healthy unrelated Koreans for functionally defective alleles, CYP2C19*2, CYP2C19*3, CYP2C19*4, and CYP2C19*5. Detection of the normal (CYP2C19*1) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19*1) and CYP2C19*2 were 72.6% and 27.4%, and the wild-type (CYP2C19*1) and CYP2C19*3 were 85.1% and 14.9%, respectively. For each CYP2C19*2 and CYP2C19*3 the observed number of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19*2, CYP2C19*3 and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). The mutated CYP2C19*4 and CYP2C19*5 alleles were not detected in this study. These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians, and we founded the racial variability of the frequencies of the CYP2C19*4 and CYP2C19*5 alleles in the Orientals.

6상 여자방식을 이용한 7상 BLDC 전동기 구동시스템

전윤석,이용균,목형수 건국대학교 산업기술연구원 2003 건국기술연구논문지 Vol.28 No.-

3-Phase BLDC Motor, which is generally used, has limited usage in high speed, due to pulsation torque occurring commutation and variable speed. To solve this problem, it is necessary to increase invariable, pole number or the number of slots. Currently, due to rapid growth of semiconductor technology and trend toward smaller and cheaper production of switching device, Multi-Phase BLDC Motor for high speed and high output power is being actively pursued to produce. In this paper 7-Phase BLDC Motor drive system and controller are designed and 7-Phase modulation method with 6-Phase conduction is studied for ideal operation of controller.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

장루 보유자의 생활 만족도 조사

서현석,이석환,고영관,오수명,윤충,주흥재,이기형 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

T1b 병기의 신세포암에서 수술 후 예후를 예측할 수 있는 임상 및 병리학적 인자에 대한 연구

오승용, 김영원, 윤형윤, 서성필, 이상근, 김원태, 윤석중, 이상철, 김원재, 김용준 충북대학교 의과대학 충북대학교 의학연구소 2014 忠北醫大學術誌 Vol.24 No.1

연구목적: T1병기의 국소신세포암(localized clear-cell renal cell carcinoma)은 근치적신적출술이 나 부분신절제술이 표준치료이며 수술 후 타 병기에 비해 양호한 예후를 보인다. 하지만, 많은 수의 환 자에서 추적관찰 중 재발 및 사망이 발생하는데, 이는 T1b 병기에서 더 높게 보고되고 있다. 본 연구 에서는 국소신세포암 중 T1b 병기의 신세포암에서 표준적 치료 후 환자의 예후에 영향을 주는 임상 및 병리학적 인자에 대하여 알아보고자 하였다. 대상 및 방법: 1999년부터 2011년 까지 5개 기관에서 근치적신적출술이나 부분신제술을 시행 받은 3567명의 국소신세포암 환자들 중 병리학적 병기가 T1b로 확진 된 702명을 대상으로 하였다. 이들 환자가 가지는 임상 및 병리학적 특성 [연령, 성별, 고혈압, 당뇨, 비만도, European Cooperative Oncology Group(ECOG) 수행도, 증상유무, 수술방법, 종양크기, 분화도, 조직학적 형태 등]을 이용 하여 환자의 예후 [무재발생존율(relapse-free survival), 암특이생존율(cancer-specific survival) 및 전체생존율(overall survival)]에 영향을 미치는 인자에 대하여 다양한 방법으로 비교분석 하였다. 결과: 추적 관찰 기간은 34.0개월 (중앙값, 0-152개월)이었으며, 이 기간 중 재발, 사망 및 암특이사 망은 각각 72례 (10.3%), 57례 (8.1%) 및 24례 (3.4%)에서 발생하였다. 단변량 및 다변량 Cox 비례위험회귀분석에서 다양한 인자들이 무재발생존율(당뇨 유무, 종양크기 및 Fuhrman등급), 암특이 생존율(나이, 체질량지수, 당뇨 유무, 종양크기) 및 전체생존율(나이, 체질량지수, ECOG 수행도, 종 양크기)에 영향을 줄 수 있는 독립적 예후인자였다. 결론: 본 연구결과 국소신세포암의 예후를 예측할 수 있는 다양한 임상 및 병리학적 인자를 확인 할 수 있었다. 이러한 위험인자를 가지고 있는 환자는 보다 적극적인 추적관찰을 통하여 재발을 조기에 발 견한다면 이들의 생존율 향상에 많은 기여를 할 수 있을 것으로 생각한다.