물질남용 치료프로그램 후 재범여부에 대한 예비적 추적조사 연구

김현수,조선미,오은영,임기영,정영기,윤웅장,이영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구는 물질사범에게 시행되는 수강명령 프로그램의 효과를 재범률을 중심으로 살펴보고자 한 것이다. 방 법: 이 연구의 대상집단은 보호관찰소에서 의뢰받은 물질남용자집단이다. 이들은 법원으로부터 보호관찰, 수강명령, 치료명령, 사회봉사 등을 부과받았다. 총 104명의 대상자집단을 치료프로그램을 이수한 수강군과 비수강군으로 나누었으며 이들에 대한 재범률을 조사하였다. 결 과: 프로그램을 이수한 수강군이 비수강군에 비해 재범률이 낮았다(p<.05). 또한 단기 수강군과 장기수강군의 재범률의 차이를 조사하였는데 대상자 집단의 수가 적기 때문에 장기 수강군의 효과가 통계적으로 입증되지는 않았다. 결 론: 우리는 물질남용자에 대한 정책이 보다 교육적으로 변화할 것을 본 논문을 통하여 제시하려 하였으며 정부 및 법무부는 물질남용자에게 교육과 치료를 제공해주어야만 한다. Objectives: Using recidivism rate, we investigated the outcome after our substance abuse treatment program had been implemented. Methods: Our target population was substance abuse criminals referred by probational office. They either received the parole and probation order, treatment order or social service order from the court. We divided 104 substance abuse criminals into treatment group and non-treatment group. We examined their recidivism rate. Results: We reached a conclusion that treatment group had lower recidivism rate than non-treatment group(p<.0.5). We examined the effectiveness of short-term and long-term programs. However, no effectivess of long-term program was found because the sabject number was too small. Conclusion: We suggest that the strategies for substance abuse should be changed to more educative ones. The Government and Ministry of Justice must provide education and treatment to the substance abuse criminals.

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis B (초)

( Hyun Woong Lee ),( Heon Ju Lee ),( Jae Seok Hwang ),( Joo Hyun Sohn ),( Jae Young Jang ),( Ki Jun Han ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Yong Han Paik ),( Chun Kyon Lee ),( Kwa 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3(S)

Development and application of a technique for detecting beach litter using a Micro-Unmanned Aerial Vehicle

Jang, Seon Woong,Kim, Dae Hyun,Chung, Yong Hyun,Seong, Ki Taek,Yoon, Hong-Joo The Korean Society of Remote Sensing 2014 大韓遠隔探査學會誌 Vol.30 No.3

The aim of this study was to develop software for beach litter detection that includes a Graphical User Interface (GUI) and uses images taken by a micro-unmanned aerial vehicle. Videos were taken over Doomo pebble beach, Sogye pebble beach, and Heungnam sand beach on the northeast coast of Geojedo (Geoje Island), Korea. Still images of actual beach litter were obtained from the videos. The image processing involved preprocessing, morphological image processing, and image recognition. Comparison with still images showing beach litter demonstrated that the software could generally detect litter larger than 50 cm in size such as Styrofoam buoys and circular fish traps (excluding small pixel-size ropes). Combining the proposed method with the conventional surveying approach is expected to enhance the accuracy of beach litter detection. The new technique will also aid in predicting the amount of beach litter generated along coastlines, which is currently difficult to monitor.

Disorders of Liver : Entecavir Provides Inferior Viral Load Reduction In Lamivudine Resistant Patients To In Naive patients-Preliminary Report

( Hyun Woong Lee ),( Hyung Joon Kim ),( Seuk Hyun Lee ),( Kyung Ah Kim ),( June Sung Lee ),( Hong Ju Moon ),( Jang Sik Mun ),( Sang Jung Kim ),( Chang Hwan Choi ),( Jung Uk Kim ),( Jae Hyuk Do ),( Jae 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: A lot of trials involving nucleoside- naive, lamivudine-resistant patients are needed to determine entecavir`s optimal treatment duration, long-term safety, and durability of response, including rate of resistance. The aim of our study is to compare the efficacy of entecavir (ETV) between chronic hepatitis B (CHB) patients who had not received a mucleoside analogue and who had failed in lamivudine (LMV) therapy. Methods: From July 2006 to April 2007, 77 patients with CHB were treated with ETV from 2 medical institutions in Korea. 77 patients were divided into two groups. 49 patients who had not received a nucleoside analogue were treated with ETV 0.5 mg/d. 28 patients who were resistant to LMV therapy (persistent viremia and documented YMDD mutations while receiving LMV) were switched to ETV 1.0 mg/d. The duration of treatment was 3-9 (median, 7) months. All patients were assessed for HBV DNA, alanine aminotransferase (ALT) normalization, HBeAg sero-conversion, and safety. Results: The rates of virologic response and normalization of ALT levels were significantly higher naive patients than in LMV resistant patients at week 12 and 24, respectively (p=0.015, p=0.003). Mean change from baseline in serum HBV DNA was -4.1, and -5.5 log10 copies/mL for naive patients and -2.5, and -2.6 log10 copies/mL for LMV resistant patients at 12 and 24 weeks, respectively (p<0.001, p<0.001). Although there was no virologic breakthrough, only one LMV resistant patient did not show the decline in baseline serum HBV DNA. There were no serious adverse events on-treatment. Conclusions: In patients with LMV resistant CHB, entecavir provides inferior viral loud reduction and ALT normalization compared with naive patients.

Ethanol extract of Curcuma phaeocaulis rhizomes inhibits the activation of LPS-mediated tolllike receptor 4(TLR4)

JANG Hyun-Jae,KIM Min Seok,LEE Seung Woong,OH Hyun-Mee,JO Jin-ha,PARK Chan Sun,RHO Mun-Chual 한국특수교육학회 2014 한국특수교육학회 학술대회 Vol.2014 No.-

내용 정보를 이용한 이미지 자동 태깅

장현웅 ( Hyun-woong Jang ),조수선 ( Soosun Cho ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1

이미지 인식과 내용분석은 이미지 검색과 멀티미디어 데이터 활용 분야에서 핵심기술이라 할 수 있다. 특히 최근 스마트폰, 디지털 카메라, 블랙박스 등에서 수집되는 영상 데이터 양이 급격히 증가하고 있다. 이에 따라 이미지를 인식하고 내용을 분석하여 활용할 수 있는 기술에 대한 요구가 점차 증대되고 있다. 본 논문에서는 이미지 내용정보를 이용하여 자동으로 이미지로부터 태그정보를 추출하는 방법을 제안한다. 이 방법은 기계학습 기법인 CNN(Convolutional Neural Network)에 ImageNet 의 이미지 데이터와 라벨을 학습시킨 후, 새로운 이미지로부터 라벨정보를 추출하는 것이다. 추출된 라벨을 태그로 간주하고 검색에 활용한다면 기존 검색시스템의 정확도를 향상시킬 수 있다는 것을 실험을 통하여 확인하였다.

<i>SlPMEI</i>, a pollen-specific gene in tomato

Kim, Woong Bom,Lim, Chan Ju,Jang, Hyun A.,Yi, So Young,Oh, Sang-Keun,Lee, Ha Yeon,Kim, Hyun A.,Park, Youn-Il,Kwon, Suk-Yoon Canadian Science Publishing 2014 Canadian journal of plant science. Revue canadienn Vol.94 No.1

<P> Kim, W. B., Lim, C. J., Jang, H. A., Yi, S. Y., Oh, S.-K., Lee, H. Y., Kim, H. A., Park, Y.-I. and Kwon, S.-Y. 2014. SlPMEI, a pollen-specific gene in tomato. Can. J. Plant Sci. 94: 73-83. Pectin is one of the main components of plant cell walls, and its biosynthesis is controlled by pectin methylesterase (PME). Pectin methylesterase inhibitors (PMEIs) are key regulators of PME. We report here the cloning and characterization of a novel Solanum lycopersicum L. PMEI gene, SlPMEI. RT-PCR studies of leaf, seed, fruit, flower, and flower organs confirmed that SlPMEI is expressed specifically in pollen. Promoter analysis of SlPMEI revealed pollen-specific cis-acting elements (pollen lat52 and g10). In addition, SlPMEI is expressed independently of abiotic stress, pathogen exposure, and growth stage in tomato, and a histochemical analysis of promoter activity revealed pollen-specific expression in both Arabidopsis and tomato. Under the microscope, we observed pollen-specific GUS expression in the stamen of transgenic tomato plant. These results indicate that the promoter of SlPMEI has strong pollen-specific activity, and could therefore be useful for development of industrially and agronomically important transgenic plants. </P>

Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg‐positive chronic hepatitis B

Lee, Hyun Woong,Lee, Heon Ju,Hwang, Jae Seok,Sohn, Joo Hyun,Jang, Jae Young,Han, Ki Jun,Park, Jun Yong,Kim, Do Young,Ahn, Sang Hoon,Paik, Yong Han,Lee, Chun Kyon,Lee, Kwan Sik,Chon, Chae Yoon,Han, Kwa Wiley Subscription Services, Inc., A Wiley Company 2010 Hepatology Vol.51 No.2

<P><B>Abstract</B></P><P>The reported durability of virologic response after successful lamivudine monotherapy is variable, and the question remains as to whether virologic responses can be maintained over an extended follow‐up period. The aim of this study was to investigate posttreatment durability, the optimal duration of additional treatment after HBeAg clearance or seroconversion, and determinants for sustained virologic response (SVR) following lamivudine monotherapy in patients with HBeAg‐positive chronic hepatitis B (CHB). From January 1999 to August 2004, 178 Korean patients with HBeAg‐positive CHB were treated with lamivudine and achieved complete responses, defined as a loss of serum HBeAg and hepatitis B virus DNA, and alanine aminotransferase normalization. The mean duration of lamivudine monotherapy was 26 months (range, 12‐77). SVR was maintained in 138 patients (77.5%). Host and viral factors were compared between 138 patients with SVR and 40 patients whose response was not sustained. The cumulative relapse rates increased from 15.9% at 1 year to 30.2% at 5 years, with a mean time to relapse after cessation of lamivudine of 12 months (range, 7‐42). Most relapses occurred within 2 years after discontinuation of lamivudine (33/40, 82.5%). On multivariate analysis, age ≤40 years and additional treatment for more than 12 months after HBeAg clearance or seroconversion were independent factors for SVR. <I>Conclusion:</I> The lamivudine‐induced virologic response was durable in patients under 40 years old and those receiving lamivudine for more than 12 months after HBeAg clearance or seroconversion. Age and additional treatment were major predictive factors for SVR. (H<SMALL>EPATOLOGY</SMALL> 2010.)</P>