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D-Amino Acid Aminotransferase 활성보유 고온성미생물의 탐색 및 분류학적 특성 연구
곽미선,이승구,정상철,서승현,이재흥,전영중,김영호,성문희 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
To acquire an industrially useful biocatalyst for the enzymatic synthesis and production of various D-amino acids, 1,300 thermophiles isolated from the soil of Korea were analyzed for D-amino acid aminotransferase (D-AAT) activity. The enzyme activity was found from 110 strains of isolated thermophiles revealing its wide occurrence in thermophiles. Enzyme activity and thermal stability of the D-AAT producers were compared. Finally we have selected four thermophiles as producers of potent biocatalysts for the D-amino acid production; two therrnophiles, Bacillus sp. LK-I and LK-2, having higher specific activity and two thermophiles, B. stearothermophilus KL-01 and Bacillus sp. KLS-0l, having higher thermal stability than the D-AAT producers. Taxonomic and physiological characteristics of the four isolated thermophiles were described herein.
임영희,김미원,곽현옥,박상현 대전대학교 생활과학연구소 2002 생활과학연구 Vol.8 No.-
This study aimed at examining the foodservice satisfaction on dormitory restaurant by gender, age, college. The subjects of the study were 236 students living in the dormitory of Daejeon University. The survey was conducted between June 4 to June 12, 2002. The data was collected by survey and- was analyzed by SPSS package. The evaluation of the foodservice satisfaction by gender, showed that answers of the most students were below average. Generally, male students were more satisfied than females. The evaluation of the foodservice satisfaction by age, showed that younger students were more disatisfied than older students. The results suggest that food preference of subjects should be considered in meal planning and various cooking method should be utilized to enhance taste of foods for better foodservice. The management of the foodservice will be made efforts to improve the quality of foodservice on the basis of these results.
Distribution of Dog Ticks in the Republic of Korea, 2017
Hyun-Ji Seo(Hyun-Ji Seo),Mi-Sun Yoo(Mi-Sun Yoo),Keun-Ho Kim(Keun-Ho Kim),Kyu-Won Kwak(Kyu-Won Kwak),Hyunkyoung Lee(Hyunkyoung Lee),Jung-Won Park(Jung-Won Park),Seunghee Lee(Seunghee Lee),Soon-Seek Yoo 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Kwak, Hyun-Jeong,Park, Kyoung Mi,Choi, Hye-Eun,Park, Hyun-Young Harwood Academic ; Distributed by STBS Ltd 2009 Free radical research Vol.43 No.8
<P>Cardiomyocyte apoptosis is involved in several cardiovascular diseases, including ischemia, hypertrophy and heart failure. Nitric oxide (NO) signalling is crucial in the regulation of cardiomyocyte apoptosis, capable of both inducing and preventing apoptosis depending upon the level of NO production. Growing evidence suggests that NO preconditioning has cardioprotective effects, but the mechanism remains unclear. The purpose of this study was to elucidate how NO preconditioning inhibits subsequent NO-induced apoptosis in H9c2 cells. According to the data, preconditioning with a low concentration of sodium nitroprusside (SNP, 0.3 mM) inhibited subsequent high-concentration-SNP (1.5 mM)-induced apoptosis and this effect was reversed by the protein kinase C (PKC) inhibitor chelerythrine and the cyclooxygenase-2 (COX-2) inhibitor rofecoxib. Low-concentration-SNP-mediated protection involved extracellular signal regulated kinase 1/2 (ERK1/2), a signal transducers and activators of transcription 1/3 (STAT1/3) activation and increased COX-2 expression. Activation of ERK1/2 and STAT1/3 was abolished by chelerythrine. However, COX-2 expression was not inhibited, implying that the COX-2-mediated protective effect occurred via a PKC-independent pathway. The results showed that low-concentration-SNP preconditioning suppresses subsequent high-concentration-SNP-induced apoptosis by ERK1/2-STAT 1/3 activation via PKC-dependent mechanisms in H9c2 cells. COX-2 also plays a role in NO-induced preconditioning, but is independent of PKC.</P>
난치성 원발성 막성신염 및 초점분절성사구체경화증 환자에서 mycophenolate mofetil의 치료효과
김현철 ( Hyun Chul Kim ),장미현 ( Mi Hyun Jang ),황은아 ( Eun Ah Hwang ),여상목 ( Sang Mok Yeou ),곽충환 ( Choong Hwan Kwak ),한승엽 ( Seung Yeup Han ),박성배 ( Sung Bae Park ),최미선 ( Mi Sun Choe ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6
Purpose: This study was planned to determine the efficacy and safety of mycophenolate mofetil (MMF) as a rescue treatment in patients with membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS) who were not responsive to standard therapy with steroid and immunosuppressive regimen. Methods: We planned a prospective, non-randomized study from Oct. 2002 to Aug. 2009, including biopsy-proven MN or FSGS patients in Keimyung university Dongsan hospital. MMF was initiated at 0.5-0.75 g twice daily, and advanced as appropriate or as tolerated to 0.75-1 g twice daily. Results: 14 cases with MN and 5 cases with FSGS was enrolled. The mean age of patients was 51.7±12.3 years, and mean treatment duration was 14.4±6.5 months. Five patients (26.4%) went into complete remission and the seven (36.8%) into partial remission. The mean value of 24hr total urine protein over the follow-up 6 months` period declined significantly from 7.6±6.2 g in pre-treatment, to 4.1±3.2 g in 3 months, and 3.1±2.1 g in 6 months (p=0.011). The mean 24hr total urine protein decreased from 7.5±6.3 g in pre-MMF to 1.9±1.8 g in post-MMF (p=0.001). The mean serum albumin rose from 3.2±0.8 g/dL in pre-MMF to 3.9±0.5 g/dL in post-MMF (p=0.001). There were no significant changes in mean value for WBC, hemoglobin, serum creatinine, and total cholesterol. Side effects of MMF were infrequent and generally mild. Conclusion: MMF appears effective in 63% of patients with MN and FSGS who are resistant to other forms of treatment. Studies with more cases and multicenter controlled trials are required to establish the role and standards of MMF in these disorders.
The Influence of Flip-flops Gait on the Muscle Activity of Tibilalis anterior and Gastrocnemius
Jung Hyun Choi,Mi Ri Song,Joong Hyun Lee,Hong Rae Kim,Si Eun Park,Ji Sung Kim,Dae Young Kwak,Sang Bin Lee,Nyeon Jun Kim,Ja Pung Koo,Soon Hee Kim 국제물리치료학회 2013 Journal of International Academy of Physical Ther Vol.4 No.2
The fact that flip-flops, one of many different types of unstable shoes, are light and relatively easy to put on, accounts for their popularity among people. But because flip-flops rely heavily on the support of a single thong between your first and second toes, they impose a huge amount of pressure onto lower leg. Thus in the following experiment we tried to examine the different effects of flip-flops and running shoes in terms of their effect on muscle activity and fatigue of tibialis anterior and gastrocnemius during walking. In order to measure an electromyogram we used Free EMG system. 10 men and 10 women in running shoes ran on treadmills for 15 minutes at 4.8km/h, 2 days later the same experiment was carried out, but this time, in flip-flops. p value turned out to be greater than .05 and thus there was no considerable difference between the effects of flip-flops and running shoes on muscle activity and fatigue during walking. Therefore we conclude that despite the fact that flip-flops are considered unstable, their effects on muscle activity and fatigue of tibialis anterior and gastrocnemius are negligible.
우리춤체조가 사상체질에 따른 복부비만 고령여성의 대사증후군 위험인자, 뇌 성장인자에 미치는 영향
곽현미 ( Kwak Hyun-mi ),이한준 ( Lee Han-joon ) 한국무용과학회 2016 한국무용과학회지 Vol.33 No.4
본 연구는 우리춤체조가 사상체질에 따른 복부비만 고령여성의 대사증후군 위험인자, 뇌 성장인자에 미치는 영향을 알 아보는 것이 목적이다. 이를 위해 65세 이상의 복부비만 고령여성의 사상체질을 판별하고, 이 중 소수인 태양인과 비만 율이 낮은 소음인을 제외한 태음인과 소양인을 대상으로 연구를 진행하였다. 집단은 태음인 운동군(13명), 소양인 운동군(16명), 태음인 통제군(11명), 소양인 통제군(8명) 등 4집단 총 48명으로 구성하였다. 우리춤체조는 60분으로 구성되어 있으며, 12주간 주3회를 실시하였으며 강도는 HRR 40~60%로 구성하였다. 측정된 자료는 사전값을 공변인으로 한 공분 산분석(ANCOVA)을 실시하였다. 사후 검사는 최소유의차 검증(LSD)을 실시하였고 유의수준 α=.05로 설정하였다. 본 연구의 결과에서는 대사증후군 위험인자인 허리둘레와 혈당, 그리고 HDL에서 태음인과 소양인 모두 비운동집단보다 운동집단에서 긍정적인 효과가 있었고, 뇌성장인자 BDNF도 태음인과 소양인 모두에서 운동집단이 비운동집단보다 긍정적인 효과가 있었다. 결론적으로, 규칙적인 우리춤체조의 참여는 비만 고령여성의 대사증후군 위험인자와 뇌성장인자에 긍정적인 영향을 미쳤다. 그러나 사상체질에 따른 차이는 나타나지 않았다. This purpose of this study was to investigate the effects of the Woorichum exercise on metabolic syndrome risk factors, brain growth factor in obese elderly women according to Sasang Constitution. 48 elderly women were recruited and tested. Subjects were assigned to Taeeumin exercise group(G1; n=13), Taeeumin control group(G2; n=11), Soyangin exercise group(G3, n=16), Soyangin control group(G4; n=8). Woorochum exercise was done for 12 weeks, 3 times per week, 60 minutes per day. Exercise intensity was 40~60%HRR. Data was analyzed using the Analysis of Covariance (ANCOVA). Post-hoc of LSD was conducted when there was a significantly difference. The level of significance was decided at α=0.05. Woorichum exercise has given a positive effects in waist circumference, glucose, HDL, and BDNF in exercise group of Taeeumin and Soyanggin. In conclusion, Woorichum exercise had a positive effect on metabolic syndrome risk factors, and brain growth factor in obese elderly women. But difference in Sasang Contitution was not observed.
곽미애 ( Mi Aie Kwak ),차현주 ( Hyun Ju Cha ),김성현 ( Sung Hyun Kim ),정관용 ( Kwan Yong Jung ) 한국시스템다이내믹스학회 2015 한국시스템다이내믹스 연구 Vol.16 No.1
The purpose of this paper is to simulate public trust on nuclear regulation policy. The first of all, public trust variables and the model were developed and analysed by system dynamic method. The model are consisted of the operator safety culture level, regulatory competence levels, the public satisfaction and public trust level. The scenario is made up three type which base scenario, the system operator``s safety culture level and accident event level. First. the simulation results of standard scenario shows that rapidly declining public satisfaction and trust level of the national safety after Japan``s nuclear accident in November 2011. Second, operator safety culture level and simulated divided into three levels. The results showed that a greater impact on the public satisfaction if bad than good case. Finally, the size of the accident was simulated divided into three levels levels(no accident, medium, serious accidents). the results showed a weak effect against the regulatory capacity and safety performance levels but showed a significant impact on public satisfaction and confidence level.