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안현경 ( Hyun Kyong Ahn ) 대한주산의학회 2011 Perinatology Vol.22 No.2
Preeclampsia(PE) remains a leading cause of maternal and fetal morbidity and mortality. Despite decades of intense research on the problem, there is no early pregnancy screening test to recognize those at risk. Recently, altered immune responses have been suspected to be involved in preeclampsia pathogenesis, which may concern the inflammatory context in which an immune response is mounted. In this review, the innate immunologic pathogenesis of the preeclampsia is reviewed.
Influence of conditions of first preterm birth on subsequent pregnancy
박수현 ( Su Hyun Park ),( Jae Hyug Yang ),( Hyun Mee Ryu ),( Moon Young Kim ),( Jung Yeol Han ),( Hyun Kyong Ahn ),( Joo Oh Kim ),( Joong Sik Shin ),( June Seek Choi ),( Jin Hoon Chung ),( Ha Jung Lim ) 대한산부인과학회 2004 대한산부인과학회 학술대회 Vol.90 No.-
Ahn, Sun Hee,Song, Ji-Eun,Kim, Suhee,Cho, Sung-Hyun,Lim, Yun Kyong,Kook, Joong-Ki,Kook, Min-Suk,Lee, Tae-Hoon Springer-Verlag 2016 Archives of microbiology Vol.198 No.6
<P>Periodontal diseases are infectious polymicrobial inflammatory diseases that lead to destruction of the periodontal ligament, gingiva, and alveolar bone. Sequential colonization of a broad range of bacteria, including Fusobacterium nucleatum and Porphyromonas gingivalis, is an important phenomenon in this disease model. F. nucleatum is a facultative anaerobic species thought to be a key mediator of dental plaque maturation due to its extensive coaggregation with other oral bacteria, while P. gingivalis is an obligate anaerobic species that induces gingival inflammation by secreting various virulence factors. The formation of a bacterial complex by these two species is central to the pathogenesis of periodontal disease. Reactive oxygen species (ROS) are produced during bacterial infections and are involved in intracellular signaling. However, the impact of oral bacteria-induced ROS on the ecology of F. nucleatum and P. gingivalis has yet to be clarified. In the present study, we investigated ROS production induced in primary human oral cells by F. nucleatum and P. gingivalis and its effect on the formation of their bacterial complexes and further host cell apoptosis. We found that in primary human gingival fibroblasts (GFs), two NADPH oxidase isoforms, NOX1 and NOX2, were activated in response to F. nucleatum infection but not P. gingivalis infection. Accordingly, increased NADPH oxidase activity and production of superoxide anion were observed in GFs after F. nucleatum infection, but not after P. gingivalis infection. Interestingly, in NOX1, NOX2, or NOX1/NOX2 knockdown cells, the number of P. gingivalis decreased when the cells were coinfected with F. nucleatum. A similar pattern of host cell apoptosis was observed. This implies that F. nucleatum contributes to attachment of P. gingivalis by triggering activation of NADPH oxidase in host cells, which may provide an environment more favorable to strict anaerobic bacteria and have a subsequent effect on apoptosis of host cells.</P>
Ahn, Hyun-A,Hong, Seong-Kwan,Kwon, Oh-Kyong Institute of Electrical and Electronics Engineers 2018 IEEE transactions on power electronics Vol.33 No.10
<P>This paper presents an average current control method for a light-emitting diode (LED) lamp driver that achieves a highly accurate current and removes low-frequency light flicker. The proposed LED lamp driver accurately maintains an average LED forward current by precisely adjusting the duration of the on- and off-times of the LED lamp driver. It also removes the low-frequency flicker by regulating the LED forward current without being affected by the low-frequency component of the ac line voltage. In addition, it reduces power consumption by eliminating the necessity of a high-voltage sensor or a high-side resistor, which causes conduction loss. The proposed average current controller was fabricated using a 0.18 μm bipolar, complementary metal-oxide-semiconductor, and double diffused metal-oxide-semiconductor process technology. The measurement results of the proposed LED lamp driver show that the variation in the average LED forward current is less than 0.6%, and the light flicker below 120 Hz is completely removed. In addition, the measured maximum power efficiency and power factor of the proposed LED lamp driver are 89.22% and 0.93, respectively.</P>
( Hyun Lim ),( Do Hoon Kim ),( Hwoon Yong Jung ),( Eun Jeong Gong ),( Hee Kyong Na ),( Ji Yong Ahn ),( Mi Young Kim ),( Jeong Hoon Lee ),( Kwi Sook Choi ),( Kee Don Choi ),( Ho June Song ),( Gin Hyug The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.2
Background/Aims: The efficacy of surveillance for esophageal squamous cell neoplasia (ESCN) in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Our study aimed to provide clinical data concerning the necessity of surveillance for detecting early ESCN in patients with HNSCC. Methods: We retrospectively reviewed the data from 714 patients who were pathologically confirmed as having HNSCC (n=236 oral cavity cancers, 137 oropharyngeal cancers, 87 hypopharyngeal cancers, and 254 laryngeal cancers). Results: Of 714 patients, during a median follow-up of 31 months, 48 ESCNs (37 synchronous and 11 metachronous) were detected in 36 patients (5%). Fifteen synchronous lesions (40.3%) were early ESCN, whereas nine metachronous lesions (81.8%) were early ESCN. The 3-year survival rates of HNSCC only and HNSCC combined with ESCN were 71.2% and 48.2%, respectively (p<0.001). Among 36 patients with ESCN, the 3-year survival rates for early and advanced ESCN were 77.7% and 21.7%, respectively (p=0.01). In the multivariate analysis, alcohol consumption and hypopharyngeal cancer were significant factors associated with the development of ESCN. Conclusions: HNSCC patients with early ESCN were similar in prognosis with patients without ESCN, in contrast to patients with advanced ESCN. Therefore, surveillance for the early detection of ESCN in patients with HNSCC, especially in alcohol drinkers and those with hypopharyngeal cancer, is warranted. (Gut Liver, 2015;9:159-166)