손상정도계수와 외상치를 이용한 외상환자의 분석

송근정,장문준,김성중,조광현,김인병,최성욱,이한식 대한응급의학회 1993 대한응급의학회지 Vol.4 No.2

Trauma is one of the most common causes of death. Recently, injury severity score(ISS) is widely used to evaluate and classify the patients with multiple injury. Trauma score(TS) was developed as a means of providing rapid accurate assessment of the injured patient. Authors conducted a review of trauma patients who visited the emergency department of YongDong Severance Hospital from September 1992 to August 1993. ISS and TS were collected from comprehensive initial evaluation. The results were as follows : 1) The subjects were 10.2%(2,666 patients) of total 26,202 emergency patients. 2) Male to female ratio was 2.1 : 1. The age distribution was highest under 10 year(24.9%). The mean ISS was 3.5, and the mean ISS increased with ago. 3. Analysis of injury mechanism showed high incidence of traffic accident(35.3%), blunt trauma 25.7%, fall 24.2%, stabbing 10.7%, and others 4.3% in order. 4. The 8.0% of patients were admitted after initial management and their mean Iss was 12.6 mean TS was 15.5. 5. Among admitted traffic accident patients, the mean ISS of passenger T.A., pedestrian T.A. and driver T.A. were 19.0 ±9.9, 14.4 ±10.6, and 11.3 ±7.7 respectively. 6. Among 42 mortality cases, 25 patients were D.O.A. and 17 were expired. The mean ISS of D.O.A. Patients was 30.0; the mean Iss and mean Iss and mean TS of expired patients were 28.3 and 11.8 respectively. 7. The most common cause of death was head trauma(66.7%). 8. By comparing the ISS and TS of admitted and expired patients, mortality occurred above 16 point of ISS. The mortality increased with increasing ISS, but it was influenced by the trauma site and the severity of the particular injury site. Mortality also occurred below 15 point of TS, the mortality increased inversely with TS, and the mortality with TS, and the mortality was high below 13 point (above 40%).

유방암에서 종양의 크기와 액와림프절 전이의 상관성을 근거로 한 액와림프절 절제술의 생략

송근영,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Purpose: The aim of this study is evaluation of the relations between axillary lymph node status and tumor size, and then applied the omission criteria of axillary lymph node dissection in early breast cancer. Materials and Methods: We reviewed 110 patients underwent radical mastectomy and axillary lymph node dissection in breast cancer at Chosun university Hospital between Feb. 1996 and Mar. 2003. We evaluated the correlations between clinicopathologic factors, axillary lymph node status, and presence of metastasis. Results: Correlations between clinicopathologic factors and axillary lymph node status were statistically significant (p=0.01). Correlation between locoregional metastasis and distant metastasis and axillary lymph node status was significant (p=0.03). Results from the number of histologically-positive lymph nodes were significant (p=0.02) as that of lymph node status. Conclusions: The rate of axillary lymph node metastasis in Tla breast cancer is minute. And, preoperative evaluations and postoperative routine radiation therapy can control the axillary lymph node metastasis in Tla breast cancer. So, omission of the axillary lymph node dissection in Tla breast cancer may be considerable.

안면부, 유방 및 상완부에 발생한 홍반성 루푸스 지방층염 1예

송유근,손두식,명형준,이현정,임중규,김순호,김윤아 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Lupus erythematous panniculitis is a chronic inflammatory disease of subcutaneous fat that occurs in 2-3% of patients with systemic lupus erythematosus. Lupus erythematous panniculitis typically presents with firm, indurated subcutaneous nodules or plaques commonly developed in proximal extremities, trunks, head and neck. Face, breast and upper extremities involvement with lupus erythematous panniculitis has been infrequently reported. We report a case of lupus erythematous panniculitis developed in a 27-year-old female confirmed by histologic features and laboratory findings.

The Effects of Green Juice of Angelica Keiskei Koidz on the Toxicity of Several Selected Elements

Song,Sook Ja,Eom,Hyun Sook,Lee,Jin Hee,Choi,Soon Nam,Chung,Keun Hee 韓國營養學會 1997 Journal of Nutrition and Health Vol.30 No.9

대형 충격해머를 이용한 구조물 동특성 실험

송민석,정현호,전종균 선문대학교 2001 공학계열 논총 Vol.4 No.-

본 논문에서는 대형 구조물 내의 진동원인 공조기, 펌프 등을 설치, 가동시 구조물의 동적 응답을 예측하고 건물 구조개선 방안을 제시하는데 목적을 두고 있다. 구조물에 대한 동특성 해석은 해석적인 방법과 실험적인 방법으로 이루어지고 있다. 두 가지 방법 중 본 논문에서는 실험적인 방법을 통해서 구조물 동특성 해석을 시도해 보았다. 자체 제작한 대형 충격 해머(Large Impact Hammer)를 이용해서 구조물 바닥부분에 충격을 가진하여 물체에 작용하는 힘과 이로 인하여 발생되는 진동을 각각의 센서에 의해 측정, 분석하여 구조물의 모드형상을 확인하고 고유주파수를 측정하였다. 해석결과에서는 대형 충격 해머를 이용하여 대형 구조물의 동특성 테스트가 가능할 것이라는 것도 예상할 수 있었고, 임의의 진동원 설비가 설치되어 있는 구역에서 구조물의 동특성을 알고 진동원 가동시 발생하는 진동레벨을 측정하여 실험적으로 구하면 임의의 진동원 설비에서 발생하는 동하중이 산출 가능함을 알 수 있었다. 역으로 구조물의 동특성과 진동원의 동하중을 알면 구조물에 발생하는 진동레벨을 예측할 수 있음을 확인하였다. This paper predicted dynamic responses of structures and presented the solution of structural improvements when vibration sources(pump, motor etc.) were activated in structures. The analyses for the dynamic characteristics are the experimental method and theoretical analysis. This study used the experimental method. The mode shapes and natural frequencies are obtained by large impact hammer. It is possible to test the dynamic characteristics of structures using impact hammer. If it is possible to measure the vibration level when vibration sources were operated, it would be possible to compute dynamic weight. On the other hand, the vibration level could be calculated if dynamic weight can be measured.

AGT 시스템의 동적 증가계수 시뮬레이션

송재필,김기봉,정인근,김현호 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.2

무인궤도운전열차(Automated Guide-way Transit, AGT) 시스템의 접지력 및 교량-차량의 동적 응답을 구하기 위해 노면조도가 있는 주행로를 운행하는 AGT 시스템에 대한 동적 운동방정식을 유도하였다. AGT 시스템의 차량은 3차원 11 자유도 모델로 이상화하였고, 교량은 3차원 프레임 모델로 단순화하였다. 동적 운동방정식의 해를 구하기 위하여 컴퓨터 프로그램을 개발하였고, 해석된 결과는 실험자료의 결과치와 비교 분석하였다. 본 연구에서 개발된 프로그램의 해석결과 AGT 교량, 차량 그리고 노면요철의 상호 작용에 의한 교량과 차량의 동적 응답을 구하여 정밀한 교량의 동적증가계수를 산정할 수 있었다. The equations of motion for an automated guide-way transit(AGT) system running on a path with roughness have been derived to investigate dynamic responses and wheel loads of moving vehicles of the AGT system. A vehicle of the AGT system is idealized as three-dimensional model with 11 degree-of-freedom, and a bridge is modelized with three F.E. method. The computer program is developed to solve the dynamic equations, and analytical results are verified by comparing the results with experimental ones. As a result, the computer program which developed in this study can be used for estimate the dynamic responses of bridge and vehicle due to dynamic interaction of bridge, vehicle and surface roughness, and with these results the dynamic increment factor of bridge can be obtained.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

응급실의 약물중독 환자

송근정,조광현,이한식 大韓應急醫學會 1992 대한응급의학회지 Vol.3 No.1

Any short of medical drug, insecticide or foods sometimes makes harmful situation whether it is beneficial or not. Nowadays, the treatment for drug intoxication started mostly in emergency department. The initial treatment must start as soon as possible. The prognosis is depend upon a kind of drug, exposure time and time of initial treatment. Authors conducted a review of acute poisoned patients seen from April 1983 to July 1992, who visited emergency department of Yong Dong Severance Hospital. The results were as follows, 1. The patients of Drug intoxication account for 0.68% of total emergency department patients. 2. Male to female ratio was 1:1.9 and the age distribution revealed a high incidence in second decade(35.7%) 3. From all the cases of drug intoxication and 67.2% was done on purpose. 4. The drug used were sedatives, CO intoxication, pharmaceuticals, pesticide, in order. 5. Admission rate was 23.8% and mean hospital day 6.0 days. 6. ICU admission rate was 30.0% and mean staying time was 4.7 days.

Graves 병과 혈청 면역글로불린-E의 연관성

김현영,박기룡,김성훈,김지연,송수근,최영식,박요한 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: Graves 병은 미만성 갑상선종, 갑상선기능한진, 안구침법 등을 특징으로 하는 자가면역성 질환으로, 갑상선자극호르몬 수용체에 대한 자가항체(TRAb)가 갑상선을 자극하여 발생된다. TRAb는 Graves병 환자의 약 85%이상에서 검출되며 활성화된 TRAb는 대부분 IgE로 알려져 있다. 그러나 최근 Graves병 환자의 갑상선조직과 안구조직에 IgE의 침착과 꽃가루 등에 의한 알레르기성 비염으로 인해 Graves병이 발생하거나 재발된 견우가 보고되어 Graves병의 병인에 IgE의 연관성이 제기 되고 있으나, 국내에서는 이에 대한 연구가 드물다. 본 연구에서는 Graves병에서의 혈청 IgE농도와 Graves병의 병기와의 관계 및 TRAb와 IgE 농도와의 연관성을 살펴보고자 하였다. 대상 및 방법 : 2000년 4월 1일부터 7월 1일까지 고신의료원 내분비내과를 방문한 환자 중 Graves병 46예, 만성갑상선염 6예 및 고신의료원 건강증진센터를 방문한 환자 중 갑상선질환의 병력이나 가족력 및 알레르기성 비염의 병력이 없는 35예의 정상대조군을 대상으로 연구를 시행하였다. TRAb는 갑상선자극호르몬 결합 억제 면역글로불린(TBII)으로 측정하였으며, IgE는 효소면역분석법으로 측정하였다. 결과: IgG인 TBII는 Graves병에서 만성갑상선염과 대조군에 비해 높았으며, IgE 평균농도는 Graves병에서 598.1±1112.9U/mL로 만성갑상선염 환자의 98350±79.7U/mL, 대조군 161.72±194.4U/mL에 비해 높았다(p<0.05). Graves병에서 알레르기성 비염의 발병율은 10.9%(5/46)였으며, Graves 병에서의 혈청 IgE 농도는 알레르기성 비염의 병력이 있는 경우 903.1±1152.2U/mL로 없는 경우 560.8±1117.0U/mL보다 높은 경향을 보였다. Graves병의 병기에 따른 TBII와 IgE 농도의 변화를 항갑상선제로 치료하지 않은 군(비치료군)과 치료한 군(치료군) 및 재발군으로 나누어 비교하였을 때, TBII는 치료군(7.4±18.6%)에 비해 비치료군(49.9±23.9%)과 재발군(21.1±3.1%)에서 높았으며(p<0.05), 혈청 IgE치도 치료군(233.8±432.7U/mL)에 비해 비치료군(758.6±1250.0U/mL)과 재발군(1198.5±1952.1U/mL)에서 높은 경향을 보였다. 항갑상선제로 치료한 치료기간에 따른 TBII와 IgE 농도 변화에서, TBII는 비치료군(49.9±23.9%)과 1년 미만 치료군(24.8±3.8%)에서 1년 이상 치료군(2.22±1.97%)에 비해 높았으며(p<0.05), 혈청 IgE 농도는 비치료군(758.6±1250.2U/mL)에서 1년 미만 치료한 군(158.3±91.5U/mL)과 1년 이상 치료군(252.7±483.4U/mL)에 비해 높았으나 유의하지는 않았다. 결론: Graves 병에서 IgE 농도는 증가되어 있었으며, Graves 병의 각각 다른 병기에서의 혈청 IgE 농도의 변화는 Graves qudd의 경과에 영향을 미치는 IgG인 TBII치의 변화와 유사한 경향을 보였다. 그러나 혈청 IgE와 Graves 병과의 연관성을 알아보기 위해서 IgE와 더불어 CD23항원 등의 다른 검사도 병행하는 전향적 연구가 필요할 것으로 생각된다. Background: It is widely believed that Graves' disease is and autoimmune disorder characterized by the presence of the circulation TSH receptor antibody (TRAb). The majority of the activity of TRAb is of the immunoglobulin G(IgG) class. However, other immunoglobulin such as immunoglobulin E(IgE), may play a rloe in the activity. IgE accumulation has been reported to occur in the thyroid gland and ocular muscles of subjects with Graves' disease. Furthermore, it has been noted that recurrence of Graves' disease can be induced by and allergy to pollen. Because an allergy to pollen is commonly associated with IgE, IgE might play a role in the induction of Graves' disease. Therefore, investigated whether IgE was elevated in Graves' disease, and evaluated the potential relationship between the levels of TRAb and IgE Graves' disease. Methods: Forty-six patients with Graves' disease, and 6 with chronic thyroiditis, diagnosed at the Kosin Medical Center between April, 2000 and July, 2000 were included in this study. Thirty-five persons without thyroid disease or a history of allergic rhinitis were used as normal controls. The level or TRAb was measured using thyrotropin binding inhibitory immunoglobulin (TBII). Serum total IgE was measured using as enzymeimmunoassay method. Test for thyroid function, TBII and total IgE were performed in all cases, and the results statistically analyzed. Results: TBII, as IgG, and the serum IgE level were higher in the patients with Graves' disease, and the levels of the latter were 598.1±1112.9U/mL, 98.5±79.7U/mL and controls 161.7±194.4U/mL in the Graves' patients, those with thyroiditis and the controls, respectively (p<0.05). The prevalence of allergic rhinitis in Graves' disease was 10.9%. The serum IgE level in Graves' disease with, and without, allergic rhinitis were 903.1±1152.2U/mL and 560.8±1117.0U/mL, respectively, although there was no significancant difference between the two groups. According to the clinical stage, the serum TBII level was higher in the untreated Graves', and relapsed patients 49.9±23.9% and 21.1±3.1%, respectively, than in the treated group, 7.4±18.6% (p<0.05). The serum IgE level was higher in the untreated Graves' and relapsed patients 758.6±1250.2U/mL and 1198.5±1952.1U/mL, respectively, than in the treated group 233.8±432.7U/mL, although this was not significant. According to the duration of treatment, the serum TBII levels were higher in the untreated Graves' patients, and those treated for less than 1 year, than in those treated for more than 1 year, with values of 49.9±23.9, 24.8±3.8 and 2.22±1.97%, respectively (p<.05). The serum IgE level was higher in the untreated Graves' disease (758.6±1250.2U/mL) than in the groups treated for less than 12 months (158.3±91.5U/mL) and more than 12 months (252.7±483.4U/mL), but the differences were not significant. Conclusions: The concentration of IgE was high in Graves' patients, and although not statistically significant, the serum igE level in Graves' patients with allergic rhinitis was higher than those without. With regard to the clinical stage of Grave's disease, the change in the IgE level tended to follow that of the TBII. Further study will be required to define the possible role of IgE in the pathogenesis in Graves' disease (J Kor Soc Endocrinol 17:640∼648, 2002).

Air-coupled 트랜스듀서를 이용한 발전설비 배관에서의 유도초음파 모드 규명

박익근,김현묵,김용권,송원준,조용상,장경영,조윤호 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

발전설비의 중요한 요소인 배관의 효율적인 비파괴검사를 위해, 배관내에 유도초음파를 comb 트랜스듀서를 이용하여 발생시켰으며, 유도초음파를 비접촉 방식으로 수신하기 위해 ACT(air-coupled transducer)를 적용하였다. comb 트랜스듀서의 요소간격과 이론적인 분산선도로부터 발생가능 한 유도초음파 모드가 예측되었다. 또한 예측된 모드를 수신하기 위해 각 모드의 이론적인 위상속도를 이용하여 ACT의 수신 각도를 결정하였다. 수신모드의 특성을 규명하기 위해 웨이블릿 변환과 2D-FFT를 이용한 시간-주파수해석을 수행하여 이론적인 분산선도와 비교한 결과, 수신된 모드는 이론적으로 예측된 모드와 일치하는 것으로 나타났다. In order to inspect the piping effectively, one of the important components in the facility of power plants, the ultrasonic guided wave was generated by a comb transducer and was received in a non-contact fashion by using an air-coupled transducer. The guided wave modes that can be generated by the comb transducer in piping are predicted from the theoretical dispersion curves and the element spacing of a comb transducer. Moreover, to receive the specific modes, the receiving angle of the air-coupled transducer is calculated from Snell's law between the phase velocities of guided waves and the sound velocity of air. The guided wave modes obtained in experiments are identified from the result of time-frequency analysis such as wavelet transform and two-dimensional fast Fourier transform.