청소년의 진로의식성숙과 일의 가치에 관한 연구

권소희,안현주,정혜원 경주대학교 창의력개발연구소 2000 創意力開發硏究 Vol.- No.4

The purpose of this study was to examine the relationship between the career maturity level of adolescent students and work values and to provide basic materials that can be some help to the career guidance and counseling. To achieve this purpose, research problems were as follows; First, this study was to analyze the relationship between the career maturity level and the work values. Second, this study was to investigate the most important predictive variables which influence on the career maturity. The samples consisted of 600 students (300 boys and 300 girls) from 7th grade, 9th grade and 11th grade students in Taegu, Korea. Students were administered the Career Maturity Inventory (CMI) by Crites(1973), and Work Value Inventory (WVI) by Super(1975). The CMI and WVI are self-report written instruments. For the statistical analysis, Pearson's coefficient correlation and stepwise multiple regression by SAS program have been applied. The results of this study were as follows; First, the correlation between the career maturity and intrinsic work values such as altruism, intellectual stimulation showed statistically significant positive correlation at P<.05 level. 7th graders have positive correlation at P<.01 level in achievement, altruism, intellectual stimulation and independence, and 11th graders in activity, esthetics, intellectual stimulation and independence. 9th graders have negative correlation in intrinsic and extrinsic values. Second, there were no influencing predictive variables of work values, grade and gender on the career maturity level, but there were statistically significant relationships at P<.05 level. Variables affecting career maturity were showed as the following order: intrinsic work values, extrinsic work values, gender and grade.

OMR 답안지 판독을 위한 영상의 전처리 방법

권갑현,서정상 동양대학교 2000 동양대학교 논문집 Vol.6 No.1

Recently, in every class of schools and evaluation institutes they are checking the OMR exam sheets through a card reader for exclusive use. Not only because it is very expensive but also because there is few domestic made card reader, it's true that we usually depend on imported products. On the other hand, as the image processing techniques have been improved largely, a digital camera which is image-inputting device is spreading widely. This study suggests a preprocessing method that can put OMR exam sheet in by using a digital camera and read it by using a PC. After we emphasize the contrast of the image that was put into a PC, make it binary, and clear the isolated noises in the binarized image, and then we can make marts on the card be interpreted exactly.

전치태반의 임상적 고찰

정갑인,이해혁,이효환,유정완,남계현,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Objective : Our purpose was to make preparations of what for proper emergency care and delivery in order to improve maternal and fetal well-being. Methods : The study was undertaken for the clinical evaluation and statistical analysis on the patients with placenta previa who had been admitted and delivered at Soonchunhyang University Hospital from January, 1994 to May, 1998, retrospectively. Results : The incidence of placenta previa was 2.0%. Placenta previa has occurred more often in multigravida(92%) than primigravida(8%). Vaginal bleeding was most frequent(37.3%) presentation. The mean gestational age at the first bleeding episode was 31~35 weeks(46.4%). The type of placenta previa was totalis (31.3%), Partialis(18%), marginalis(32.7%), low lying(18%). Conclusion . This study indicates that the obstetrician and the pediatrician should be prepared for emergency care and delivery of the placenta previa patients, with the improvement of delivery room and neonatal intensive care unit.

무대미술의 관례성 : 맨션(Mansion)에서 '임의의 궁전'에 이르기까지 des mansions au palais a` volonte´

권현정 한국 프랑스어문교육학회 2003 프랑스어문교육 Vol.15 No.-

Comme tout art, le the´a^tre a un mode de fonctionnement spe´cifique et ne peut se contenter de copier la re´alite´, me^me s'il exploite des donne´es (personnages, fiction, espace, temps, langage) qui appartiennent au monde de l'expe´rience. Mais ce monde de l'expe´rience ne peut se transporter tel quel sur la sce`ne; l'espace sce´nique, du fait me^me de ses dimensions, ne peut donner qu'un aperc¸u, qu'un concentre´ des lieux e´voque´s par les fictions. De la` naissent des conventions qui sont des modes de fonctionnement fonde´s sur l'accord du spectateur. La de´coration-type est une des conventions essentielles qui couvre la longue pe´riode qui va du Moyen a^ge au the´a^tre classique du 17e`me sie`cle. Que ce soit sur la sce`ne simultane´e ou sur la sce`ne unique, cette convention repose sur l'espace neutre qui fait nai^tre une autre convention, celle du jeu de l'acteur qui demande a` son tour une grande complicite´/re´ceptivite´ de la part du spectateur. Les acteurs du Moyen Age utilisent l'espace sce´nique place´ devant les mansions de fac¸on tout a` fait arbitraire, comme une sorte de lieu de´veloppe´ en prolongement des diffe´rentes mansions. Ne´anmoins ces conventions-la` sont admises sans difficulte´s par le public. Mais au 17e`me sie`cle, les conventions vont devenir progressivement a` la fois plus pre´cises et plus codifie´es du fait de l'intervention des doctes. Ces conventions provoquent des discussions, du moins des remaniements de la part des cre´ateurs car elles entrent en conflit avec un autre grand principe, celui de la vraisemblance. D'autre part, les conventions sont changeantes et de´termine´es par la mentalite´ des spectateurs. De la sce`ne simultane´e a` la sce`ne unique, des mansions au palais a` volonte´ en passant par la pluralite´ des lieux ou le lieu composite des tragi-come´dies ou des pastorales on n'assiste pas seulement a` l'e´volution de l'esthe´tique de la sce´nographie conventionnelle. Il s'agit aussi d'une forme de mentalite´ : pour les gens du Moyen Age, tout signe exte´rieur vaut une re´alite´ palpable auquel on croit sans mettre en doute sa perception imme´diate. On pourrait parler alors d'une convention spontane´e. Pour les Franc¸ais des anne´es 1630-50, la sce´nographie simultane´e est une manifestation de l'esprit baroque, fait de fantaisie, de liberte´ et d'imagination : le spectateur se prome`ne en imagination en divers lieux situe´s pourtant, de fac¸on totalement invraisemblable, co^te a` co^te sur la sce`ne exigue¨ de l'Ho^tel de Bourgogne. Sans doute a` la sortie de la pe´riode trouble´e de la Fronde, dans les anne´es 1660, il n'est pas e´tonnant qu'on e´volue d'un gou^t anarchique vers l' n'est pas e´tonnant qu'on e´volue d'un gou^t anarchique vers l'unite´ de lieu qui n'est d'autre qu'une maifestation du de´sir de rationaliser, d'organiser aussi bien l'espace fictif du plateau que le monde lui-me^me. Pourtant, ce de´sir de se rationaliser a commence´ a` se faire sentir me^me en ces temps de liberte´. Un signe caracte´ristique de ce changement de mentalite´ est donne´ par l'usage des tapisseries : ces rideaux de tissu descendus des cintres masquent les compartiments dont on ne se sert pas a` tel ou tel moment de l'action sce´nique ; on tend au vraisemblance par l'utilisation de tapisseries qui ont pour but de re´duire l'arbitraire. On imagine par la` le combat, qui va durer plusieurs ge´ne´rations, entre des conventions de moins en moins bien accepte´es et un besoin de vraisemblance qui finira par s'imposer a` la sce´nographie du 19e`me sie`cle sous le nom de re´alisme sce´nique puis de naturalisme. Pourtant, au moment ou` la sce`ne d'illusion se perfectionne jusqu'au de´tail avec le naturalisme, la convention renai^t et se renouvelle : 'la convention consciente' veut de´voiler le fonctionnement propre du the´a^tre ; elle devient le signe de reconnaissance de la the´a^tralite´. Par tous ces e´le´ments de´libe´re´ment propose´s comme arbitraires, la sce´nographie fait comprendre au spectateur qu'il est au the´a^tre, qu'il assiste a` un jeu dont on ne cherche plus a` masquer le me´canisme. Ainsi nai^t une nouvelle vision du monde et du the´a^tre : plus c'est faux, plus c'est vrai ; en multipliant les signes visibles de l'artifice du the´a^tre, on essaye de s'approcher de la ve´rite´ des choses...

영상 처리 기법을 이용한 OMR 답안지 판독

권갑현,서정상 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

In this paper, a method for scoring OMR exam sheets using image processing techniques is suggested. In many schools, the special-purpose OMR card reader is used to score OMR exam sheets, but it is very expensive and foreign-made as well. Jn this method, a PC and a digital camera are used, so it is relatively low-priced. In addition, the intermediate images produced in this procedure can be stored easily in the computer storage media. Therefore, the necessary store space can be significantly reduced, and the specific card image can be easily retrieved.

국내 혈액질환 환자에서 침습성 아스페르길루스증의 구제치료로서 Voriconazole의 효과와 안전성

권재철,김시현,최수미,최재기,이동건,박선희,최정현,유진홍,신완식 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Invasive aspergillosis (IA) is associated with significant morbidity and mortality in patients with hematologic malignancies. We investigated the efficacy and safety of voriconazole (VCZ) when used as salvage therapy for IA in Korean adults with hematologic malignancies who had not responded to prior antifungal therapy. Materials and Methods: We retrospectively reviewed data, collected from January 2007 to October 2008, from patients with proven or probable cases of IA. All were probable IA cases, except for one proven case. All cases were refractory or intolerant to antifungal therapy prior to administration of VCZ. Efficacy and safety were assessed in patients treated with VCZ for more than 3 days and for more than one dose, respectively. A favorable response [complete (CR) or partial (PR)] was defined by significant improvement of all clinical symptoms, signs, and radiologic abnormalities. Results: Fifty patients who met the inclusion criteria were enrolled. There were 27 male and 23 female patients with mean age of 44.4 years (range, 15-65 years). Underlying diseases were acute leukemia (35 cases), chronic myelogenous leukemia (4 cases), myelodysplastic syndrome (3 cases), lymphoma (3 cases) and other hematologic diseases (5 cases). Twenty-two patients had received chemotherapy and 13 patients had undergone hematopoietic stem cell transplantation. The lung was the main infection site (94%) followed by the sinus (6%). Amphotericin B deoxycholate alone was the most frequent previous antifungal therapy. The mean duration of antifungal therapy prior to VCZ therapy was 13.9±8.8 days (2-44 days). The median duration of VCZ therapy was 19 days (interquartile range, 49 days). Sixteen patients (32.0%) showed favorable responses (CR:PR=8:8) at the end of VCZ therapy. The numbers of patients with stable disease, progression and death were, 6 (12%), 6 (12%) and 22 (44%) respectively. Most of those with unfavorable responses had relapsed underlying malignancies or refractory graft versus host diseases. Twelve patients developed drug-related adverse events but only one patient stopped VCZ treatment prematurely. Conclusions: VCZ demonstrated an acceptable level of toxicity in patients with hematologic malignancies but further studies are required to prove its efficacy as salvage therapy.

정상교합자의 치열궁 형태

권용철,성정옥,권오원,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.1

This study was designed to investigate dental arch shapes buccally and lingually at Bracket Level of Koreans. This involved studying 63 inviduals (37 males, 26 females) with normal occlusion ranging in age from 17 to 24 yesrs old. The landmarks were digitized and measurements and statistical analysis were performed by NEC 9801 V-M computer. The Results were as Follows: Bicanine width, Bipremolar width and Bimolar width were larger in males than in females. Buccal and lingual arch form and coordination form were obtained by NEC 9801 V-M computer. The parabolic equations which represents buccal and lingual arch form were obtained.

개에 있어서 耳根部의 Lidocaine 水針에 의한 全身 無痛覺의 誘發

권현주,유건주,이상은,이정연,송근호,김명철,정성목,박성준,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Twelve clinically healthy mongrel dogs were used to clarify the possibility of general analgesia induction by lidocaine aquapuncture to auricular root area in the present study. The experimental animals were devided into control (6 heads) and experimental groups (6 heads), respectively. Physiological salines (3 ml/kg) were injected into both auricular root areas in control group. Lidocaine hydrochlorides (3 ml/kg) were injected into both auricular root areas in experimental group. Superficial pain, the changes of vital signs and blood leukocytes, and PCV were examined on pre, 5 min., 15 min., 30 min, and 60 min. after injection in control and experimental groups, respectively. Analgesia was not detected at all in control group, however, all experimental animals were recumbent and analgesia was generally detected in the auricles, noses, dorsal parts, ventral areas, limbs and tails from 5 to 30 minutes after injection with lidocaine hydrochloride into auricular root areas in experimental group. As for the change of vital signs, body temperature showed decreasing tendency from 5 minutes after lidocaine injection in experimental group. Heart rates and respiration rates were increased on 5 minutes after lidocaine injection and then they showed decreasing tendency in experimental group. No significant difference were found among groups. As for the changes of hematological findings, the numbers of blood leukocytes were increased till 15 minutes after lidocaine injection and then they showed decreasing tendency. PCV values were increased on 5 minutes after lidocaine injection, and then they showed decreasing tendency. However, no significant differences were observed among groups. Considering the above findings, it was thought that general analgesia was possible by aquapuncture with lidocaine hydrochloride into auricular root areas and lidocaine aquapuncture didn’t affect so much to the changes of vital signs and blood.

몇 가지 항진균제가 Aspergillus fumigatus에 의한 대식세포의 Cytokine 생산에 미치는 영향

권은영,박철민,박선희,최수미,이동건,유진홍,신완식,최정현 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

배경 : 현재 임상에서 사용되는 서로 다른 계열의 항진균제가 면역세포인 폐 대식세포(alveolar macrophage)에서의 cytokine 생산과 nuclear factor- κB (NF- κB)활성에 미치는 영향을 시험관내에서 파악하고 그 의미를 추론해 보고자 하였다. 재료 및 방법 : AmB, MF, ITZ 등 세 가지 항진균제가 쥐의 폐 대식세포인 RAW264.7 세포의 생존에 미치는 영향과, 이들 항진균제의 전처치가 Aspergillus fumigatus conidia 자극에 의한 RAW264.7 세포에서의 TNF-α, IL-10 생산, NF-κB 활성에 미치는 영향, 그리고 GMCSF와의 상승 작용 등을 WST-1, ELISA, western blot assay를 이용해 통해 측정하였다. 결과 : AmB, MF, ITZ 모두 농도 의존적으로 RAW264.7 세포의 생존을 감소시켰다. A. fumigatus conidia 자극으로 RAW264.7 세포에서 TNF-α 생산이 증가하였으며, 세포 생존에 영향을 미치지 않는 농도의 AmB를 전처치하고 conidia로 자극한 경우 TNP-α 생산에는 차이를 보이지 않았으나, MF와 ITZ을 전처치한 경우에는 TNF-α 생산이 감소하였다. GM-CSF는 AmB 전처치 및 A. fumigatus conidia 자극에 의한 TNF-α 생산에 상승 효과를 보였으나, MF, ITZ은 GM-CSF에 의한 상승 효과를 보이지 않았다. IL-10은 AmB에 의해 생산량이 증가하였으며 GM-CSF와 동시 투여시 IL-10 생산이 유의하게 상승하였다. MF와 ITZ 역시 RAW264.7 세포에서 IL-10 생산을 유도하였으나 AmB에 비해 상승폭이 적었으며 GM-CSF와의 상승 효과는 관찰되지 않았다. A. fumigatus conidia는 NF- κB를 활성화하였으며 항진균제와 GM-CSF 등 약제 처치에 따른 NF-κB의 활성 정도는 분비된TNF-α와 IL-10의 생산 정도와 상관관계를 보였다. 결론 : AmB, MF, ITZ 등 본 연구에 사용된 항진균제는 시험관내에서 A. fumigatus conida로 자극하는 RAW264.7 세포에 전처치함으로써 염증성 cytokine인 TNF-α의 생산을 감소시키고 항염증성 cytokine인 IL-10의 생산을 증가시키는 면역 조절 효과를 나타낼 수 있음이 관찰되었다. 추후 약제간의 면역조절 기능 차이가 항진균효과에 미치는 영향 및 약제에 따른 면역 조절 경로 등에 대한 연구가 필요할 것으로 사료된다. Background : We wanted to evaluate the immunomodulatory effect of three antifungal agents, amphotericin B (AmB), micafungin (MF), itraconazole (ITZ), in the aspect of cytokine production and expression of nuclear factor-κB (NF-κB) in the Aspergillus fumigatus conidia treated-RAW264.7 cells, a murine alveolar macrophage cell line. Materials and Methods : We evaluated cytotoxic effect of antifungal agents using commercial cell proliferation assay. Tumor necrosis factor (TNF)-α and interleukin (IL)-10 production according to stimulation (control, A. fumigatus conidia only, conidia + antifungal drug, conidia + antifungal drug + GM-CSF) was evaluated and compared each using commercial ELISA method. NF-κB activation was evaluated by western blot analysis. Results : AmB, MF, ITZ showed dose-dependent cytotoxic effect on the tested cells. Stimulation of cells by A. fumigatus conidia induced TNF-α production. Pretreatment of AmB at concentration not affecting cellular survival did not change the production of TNF-α compared to conidia treated cells, but pretreament of MF or ITZ showed reduced amount of TNF-α production compared to conidia treated cells. AmB also showed synergistic effect on TNF-α production when simultaneously treated with GM-CSF. IL-10 production was markedly increased when the cells were treated with AmB with conidia. MF and ITZ induced less increase of IL-10 production than AmB. AmB also showed synergistic effect on the production of IL-10 when treated with GM-CSF simultaneously. A. fumigatus conidia enhanced expression of NF-κB. The degree of NF-κB expression was associated with the amount of TNF-α and IL-10 produced. Conclusion : The antifungal agents we used in this experiment showed that decreased TNF-α production and increased IL-10 production from the RAW264.7 cells stimulated by A. fumigatus conidia after pretreatment of antifungal agents. But more studies, such as the association between immunomodulatory effect, antifungal activity and difference of signal pathway of cellular activation according to drugs should be performed.

A Study on DNA Sequences and Mutation of Integrase Region of Korean-type Bovine Leukemia Virus (BLV) pol Gene

권오식,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Bovine leukemia virus (BLV) is a causative agent for lymphoma disease in cattle including cows worldwide. BLV shares similar virion structure and characteristics with other retroviruses. The pol gene of the BLV genome produced reverse transcriptase (RT) and integrase (IN) for important roles for BLV genome integration into host cell chromosomes that is known to be coded in the 3' side of the BLV pol gene (one third portion). In this study, we have sequenced 978 bp in the 3'side of the BLV pol gene from BLV 10C3 in order to determine the BLV IN region of it. And we compared it to the nucleotide sequences of an Australian BLV isolate. As a result, nucleotide sequences of the IN region of the Korean-type BLV pol gene were mutated at a rate of 3.7%. We can confirm that the typical mutations are such as Arg (AGG) → Lys(AAG), Thr (ACG) → Met (ATG), Ile (ATT) → Val (GTT), Asn (ACC) → His (CAC), Phe (TTT) → Leu (TTG) and Asn (ACC) → Asp (GAC). From the analysis of the sequencing data, we were able to determine the zinc-finger-like "HHCC" motif in the amino terminus of BLV IN, that was H-X_(3)-H-X_(25)-C-X_(2)-C. It was also found the DD35E motif in the IN catalytic domain as D-X_(56)-D-X_(35)-E. It fits very well to the consensus sequences of retroviral IN as well as HHCC motif.