진행성 위암환자에서 Capecitabine/Cisplatin 치료군과 Fluorouracil/Cisplatin 치료군 간의 삶의 질 비교

유희원,신은정,이광자,한현주,손인자 韓國病院藥師會 2004 병원약사회지 Vol.21 No.1

The improvement of medical treatment and anticancer drug has led a complete recovery and prolonged survival time of cancer patients. And recent study of cancer has included evaluation of quality of life. This study was performed to evaluate quality of life between Capecitabine/Cisplatin arm and Fluorouracil/Cisplatin arm. This study was performed in the Seoul National University Hospital from August to October 2003. A total of 8 AGC patients on adjuvant chemotherapy successfully completed this study. Method of study is questionnairing by EORTC QLQ-C30, cancer specific questionnaire. The questionnaire consists of Functional, Symptom, Global health quality of life scale. Patients eligible for this study had histologically confirmed stage III or IV AGC. Patients were to be between 18 and 60 years old, and have performance status of 1. Patients were ineligible if they had a history of 6 months prior or concomitant chemotherapy, radiotherapy. Statistically significant differences favoring the Fluorouracil/Cisplatin arm was noted in the physical scale. In addition, patients in the Fluorouracil/Cisplatin arm reported an improvement in physical functioning after one cycle chemotherapy.

PZN-BT-PT계 복합 세라믹스의 유전특성

류주현,이용우 世明大學校 1998 世明論叢 Vol.7 No.-

(1-X)LTC-XHTC composites were manufactured with the variation of X in the range of 0.3<X<0.6 and its dielectric properties were investigated. Here, LTC and HTC are PZN-BT-PT-based ceramics with qurie temperature(Tc) of 100℃, -30℃,respectively. 0.6HTC-0.4LTC composite ceramics show excellent values of △εγ/ε[%] which were -7.1% at -20℃ and -12% at 50℃, respectively. It is thought that composite ceramics with above result can be applied to electrostrictive actuator, high voltage ceramic capacitor etc.

7차 수학과교육과정에 따른 도형 영역 지도의 목표와 강조점

유현주 전주교육대학교 과학교육연구소 2001 科學 敎育 硏究 論文集 Vol.23 No.1

The purpose of this study is to investigate the direction and characteristic of geometry learning -instruction in 7th mathematics curriculum. The results of this study are followings. First, geometry in this new curriculum emphasizes to develop spatial sense. Second, it concentrates on learning-instruction applying to mathematical reasoning, mathematical communication, problem solving. As a result, It emphasize o develop the mathematical power which will be the most important basic ability in the coming society. Third, it Introduce geometrical concept and ideas as symmetry from informal setting to formal one. Finally, geometry in this new curriculum emphasizes mathematical connection.

PLZT 세라믹의 상변이 특성에 관한 연구

유주현,홍순석,박창엽 연세대학교 산업기술연구소 1986 논문집 Vol.18 No.2

PLZT electrooptic ceramics of compositions in the range X/65/35 with 5?? X ??9, where X is the mol % La substixuted for lead in a ceramic with a Zr/Ti ratio of 65/35, were fabricated by the two stage sintering technique. For the ceramics, dielectric properties and phase transition were investigated. X-ray diffraction analysis was performed to analize α-β phase transition. For X=5,6, its crystal structure was Rhombohedral in the thermally depoled state as well as the poled state. For 6〈X〈9, phase transition was occured by poling and the intermediate region existed between the paraelectric and ferroelectric states. For X=9, its crystal structure was the same cubic phase in the thermally depoled state and the poled state.

DTD 정보를 갖는 XML 문서의 효율적 관리를 위한 데이터 모델링

유은경,박현주 한밭대학교 산업과학기술연구소 2001 논문집 Vol.5 No.-

As XML is emerging standard for data representation and exchange on the World-Wide-Web. XML Storage System, which can store and manage a large quantity of XML documents, became one of the major components of present internet application development. In this paper, we propose a data modeling for the efficient management of XML document and to support the versioning of DTD document. This modeling can apply to existing DBMS and support a various user query. Also our paper includes a Repository Interface Module for parsing and extracting XML/DTD's structure. Extracted data from this module is stored in database by Structure Info Manager.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

2006년 경상북도 일부 지역에서 발생한 쯔쯔가무시병의 역학적 특성

임현술,유석주 동국대학교 의학연구소 2008 東國醫學 Vol.15 No.1

쯔쯔가무시병은 국내에서 최근 그 발생이 증가추세에 있다. 이 연구는 쯔쯔가무시병 사례군의 발생 원인을 추적하여 보다 효과적인 예방대책을 마련하기 위하여 수행하였다. 2006년 10월 1일부터 12월 31일까지 경상북도 경주시, 영천시, 청도군 보건소에서 확진된 쯔쯔가무시병 사례를 직접 방문하여 연령, 성별, 직업, 작업행태, 가피위치, 방문 및 진단기관 등에 대해 설문조사를 실시하였다. 이 결과를 토대로 성별, 연령별로 환자를 분류하고 작업행태별로 가피의 위치를 분류해 보았고, 발생일별 분포와 진단기관, 방문기관별 입원 여부 등을 분석하였다. 성별 분포는 남자 28명(45.2%), 여자 34명(54.8%)이었고, 연령별 분포는 60대 19명(30.6%), 70대 17명(27.4%), 50대 13명(21.0%) 등의 순이었다. 사례군의 발생일은 10월과 11월에 집중되어 있었다. 작업행태별로 분류해 보면, 농사관련 작업이 41명(66.1%), 과수재배 작업이 13명(21.0%), 성묘 작업이 3명(6.5%), 실내에 쥐가 있던 경우가 3명(6.5%), 등산과 기타 외부활동이 각각 1명이었다. 농사관련 작업은 다시 세부적으로 다양한 농사활동 17명(41.5%), 논농사 11명(26.8%), 텃밭농사 8명(19.5%), 밭농사 5명(12.2%)이었다. 사례들의 첫 번째 방문기관은 의원이 40명, 병원 6명, 보건소 4명, 보건지소 3명, 한의원 1명, 약국 8명이었으며, 첫 방문기관에서 3명이 입원하였고, 그 후 둘째, 셋째, 넷째 방문기관을 거치면서 최종적으로 47명(75.8%)이 입원하였다. 가피는 52명(83.9%)에서 55건 관찰되었고, 그 위치는 겨드랑이가 15건(27.3%)으로 가장 많았고, 옆구리와 서혜부가 각각 6건, 배꼽근처와 흥부가 각각 5건 등의 순이었다. 일부에서 작업행태를 재연해 본 결과, 가피의 위치와 위험작업 간 관련성을 관찰할 수 있었다. 이 연구는 쯔쯔가무시병 사례군을 대상으로 작업행태를 재연하여 위험작업을 추정할 수 있었던 점에서 의의를 찾을 수 있다. Currently, the incidence of scrub typhus is increasing in Korea. The objective of this study was to enhance the efficiency of management and prevention of scrub typhus. The authors reviewed 62 cases reported by the local public health centers. The cases had the newly developed scrub typhus patients in Gyeongju-si, Yeongcheon-si and Cheongdo-gun from October 1 to December 31, 2006. We conducted a questionnaire survey and reviewed the characteristics of the reported cases. Determination of the cause of disease was evaluated. The occurrence of disease varied with gender, age, working attitude and the date of onset. Twenty-eight patients (45.2%) were male, and 34 patients (54.8%) were female. The most of cases occurred between October and November. The probable causes were fruit harvesting (13 cases), mowing around grave yard (3 cases), indoor activity near mice (3 cases), climbing (1 case), other outdoor activity (1 case), and farming activities (41 cases) such as various farm works (17 cases), rice field farming (11 cases), house garden farming (8 cases), and dry-field farming (5 cases). Total 47 cases (75.8%) were admitted to hospitals at last. The sites of eschar were axilla (15 spells), flank (6 spells), groin (6 spells), and around umbilicus (5 spells). Some of cases reacted to their working, indicating that the site of the eschar had some correlation with the cause of infection. The results of this report provide meaningful information on scrub typhus about etiology and high-risk behavior that can be used for establishing effective prevention programs.

단백질 상호작용 추출을 위한 텍스트 마이닝 기법

이현철,여은주,조완섭,김학용,유재수 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1

단백질 간의 상호작용에 대한 연구는 생물학적 프로세스를 이해하기 위해 중요한 부분이다. 이 논문의 목적은 생물학적 내용을 담고 있는 연구논문으로부터 단백질간의 상호작용을 추출하는 확장성을 가진 텍스트 마이닝 기법을 제안하는데 있다. 단백질 간의 상호작용에 대한 정보는 주로 생명과학 관련 연구논문에 존재하지만 컴퓨터로 자동으로 처리하여 상호작용에 관한 정보를 추출할 수 있기 위해서는 텍스트 마이닝 기술이 적용되어야 한다. 바이오 텍스트 마이닝에서 대두되고 있는 중요한 쟁점은 대용량의 연구논문에서 필요한 정보를 어떻게 효율적으로 정확하게 추출할 것인가에 대한 내용이다. 또한, 관심이 있는 단백질의 종류나 상호작용에 대한 관련성을 나타내는 문장내 패턴의 다양성을 수용하기 위하여 시스템의 확장성을 높이는 것도 소프트웨어 공학적인 측면에서 중요한 이슈이다. The research for protein-protein interactions remains an important part to understand the biological process. This paper suggests a text mining technique with extensibility, which extracts the protein-protein interaction from the biological research papers. There is much information related to the protein-protein interactions in plentiful biological research papers, we need the text-mining technique to extract the protein-protein interaction information automatically and rapidly. The main issue in bio-textming lays how to extract the necessary information efficiently and correctly. In addition, it is a significant issue to accommodate the concerned kinds of proteins and the diversity patterns in sentences with the relevance about protein-protein interactions in order to increase system extendibility in aspect of software engineering.

중학생의 가정과 교육에 대한 인식 연구

임현주,유가효 啓明大學校 生活科學硏究所 2002 科學論集 Vol.28 No.-

The purpose of this study is to investigate the perception and need on home economics education curriculum by middle school students and to supply the basic data for progress of home economics education program. The major result of this study can be summarized as follows. 1. Students have the perception that home economics education is to prepare them for their future family life than to regard job education. 2. In students' need on contents of home economics curriculum, food and nutrition is mostly preffered, and the next is human development and family relationships, clothing and housing are leastly preffered. 3. Students' major complaint of home economics education is the lack of practice programs of curriculum and they want to learn the subject by the more and various practise than the knowledge and theory.

Systemic Lupus Erythematosus를 동반한 Multiple sclerosis

이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.