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      • 혈액 종양환자에서 Tobramycin의 임상약동학

        신재국,신완균,장인진,신상구,김성민,배현주,최강원,김진규 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.1

        항암화학요법을 받고 있던 중 감염으로 tobramycin을 투여받은 36명의 혈액종양 환자에서 tobramycin의 약동학적 특성을 비종양환자군에서의 population 값과 비교 검토하였다. 이들은 모두 정상 신기능을 가진 16세 이상의 성인남녀(21:15)백혈병 환자들이었다. 36명의 혈액종양 환자에서 산출된 tobramycin의 청소율 및 체내분포용적은 각각 120.3± 27.2ml/lg/hr 및 0.386± 0.11 L/㎏로 population 추정 치보다 유의하게 큰 값을 보였다.(P. <0.05).청소율과 체내분포용적을 해당 population 추정치로 나눈 비율치(ratio)의 평균값은 각각 1.47± 0.34 및 1.20± 0.34였다. 연령, hematocrit치, 혈청albumin치, 발열 및 항암화학요법기간과 tobramycin의 청소율 및 체내분포용적 사이에 유의한 상관관계는 발견할 수 없었다. 본 연구결과 혈액종양 환자에서 tobramycin 투여시는 적정혈장농도를 유지하기 위해 일반 환자군에 비해 용량의 증가 및 투여간격의 조정이 필요하며 지속적인 혈장농도 monitoring을 통하여 용법의 재적정화가 필요할 것으로 사료된다. The pharmacokinetics of tobramycin were evaluated in 36 hematologic malignancy patients undergoing anticancer chemotherapy and compared to the expected values from the population parameters. Total body clearance(mean : 12.3±27.2㎖/㎏/hr) and volume of distribution (mean : 0.386±0.11 L/㎏) in hematologic malignancy patients with normal renal function were significantly greater than those of estimated from population parameter distribution(P<0.05). The ratios of total body clearance and volume of distribution to the population estimates were 1.44±0.37 and 1.20±.034, respectively. No relationships were found between age, hematocrit, serum albumin, fever or duration of anticancer chemotherapy and pharmacokinetic parameters. It is suggested that the increment of tobramycin dose regimen wold be considered in patients with hematologic malignancy, and dose readjustment followed by close monitoring of plasma drug concentration would be required.

      • 트레드밀 운동시 흡기근 테이핑이 폐활량에 미치는 영향

        김민지,신수영,송월섭,조수진,최동락,황미진,황진규,박진현,김경,Dennis W. Fell 대구대학교 특수교육재활과학연구소 2011 再活科學硏究 Vol.29 No.1

        이 연구는 트레드밀 운동과 키네시오 테이핑의 효과에 따른 폐활량의 변화를 알아보기 위해 26명의 비흡연자가 참가하였으며 키네시오 테이핑을 적용하지 않은 그룹과 키네시오 테이핑을 적용한 두 그룹으로 무작위로 배정하고 각 군들을 주 3회 6주간의 트레드밀 훈련을 실시하였다. 실험 전과 후, 스파이로미터를 사용하여 키네시오 테이핑의 적용 따른 폐활량 변화 효과를 측정하였다. 이 연구의 결과를 종합해보면 키네시오 테이핑을 적용 그룹에서 적용하지 않은 그룹에 비해 FVC, FEV1에서 유의한 증가를 보였다. 이러한 결과는 건강한 성인에서 키네시오 테이핑을 적용한 경우 키네시오 테이핑을 적용하지 않고 트레드밀 운동을 한 경우보다 폐활량의 향상에 효과적이라고 생각되어진다. The purpose of this study was to investigate the variation of vital capacity(VC) according to the effects of kinesio taping with treadmill exercise. Twenty-six non-smokers were participated in this research and these subjects were randomly assigned into two groups. To measure the VC variation effects of kinesio taping, spirometer was used. The collected data were analyzed statistically by using a paired Mauchly test and repeated measure ANOVA. The results of this study were as follows; A group: treadmill with kinesio taping B group: treadmill without kinesio taping. Between A and B, there were significant differences. In the case of A group, there was 11.66% increase of VC, during 3 weeks experiment(p<.01). In the case of B group, there were significant differences, 3.35% increase of VC, during 3 weeks taping intervention(p<.01). After 6 weeks experiment, the improvement of VC shown a significant difference with intergroup (p<.05). From this result, it was revealed that treadmill exercise with kinesio taping was effective to improve VC to healthy adult than treadmill exercise without kinesio taping.

      • KCI등재

        예비 영유아교사를 위한 자아탄력성 증진 프로그램이 자아탄력성과 공감능력에 미치는 영향

        박진성 ( Park Jin-sung ),신현정 ( Shin Hyun-jung ) 미래유아교육학회 2017 미래유아교육학회지 Vol.24 No.2

        본 연구의 목적은 예비 영유아교사를 위한 자아탄력성 증진 프로그램이 자아탄력성과 공감능력에 미치는 효과를 살펴보는 것이다. 본 연구에서 개발된 예비 영유아교사를 위한 자아탄력성 프로그램은 자신감 및 유능감, 긍정적 사고, 문제해결능력, 감정조절 및 관리, 친밀한 태도와 행동, 대인관계능력을 통하여 자아탄력성 향상을 세부목표로 하였다. 본 연구의 대상은 4년제 대학의 예비 영유아교사 99명이며, 실험집단에 12회에 걸쳐 자아탄력성 증진 프로그램을 실시하였다. 프로그램의 평가를 위하여 Klohnen(1996)이 개발한 자기보고식 자아탄력성 도구를 박현진(1997)에 번역한 자아탄력성도구와 Mehrabian & Epstein(1972), Davis(1980), Bryant(1982) 도구를 전병성(2003)이 수정한 공감능력 검사 도구를 통하여 검사를 실시하였으며, 수집된 자료는 t-검증을 실시하였다. 본 연구 결과, 예비 영유아교사를 위한 자아탄력성 증진 프로그램은 예비 영유아교사의 자아탄력성에서 낙관적 태도와 분노조절, 자아탄력성 전체에 효과가 있었으며, 정서공감과 인지공감 등 공감능력 모두에 효과를 나타냈다. The purpose of this study was to investigate the effects of the ego-resiliency enhancing program on ego-resiliency and empathy of pre-service early childhood teachers. The contents of ego-resilience enhancing program for pre-service early childhood teachers included self-confidence, positive thinking, problem solving, emotion regulation, intimate attitude and behavior, and interpersonal relationship. The subjects of this study were 99 pre-service early childhood teachers. The experimental group had 12 sessions with the ego-resiliency enhancing program. The rating scale was used with a rating scale of ego-resiliency by Hyun-Jin Park(1997) and a rating scale of empathy by Byung-Suk Jun(2003). The data were analyzed by t-test. The result of this study was that the ego-resiliency enhancing program was effective for improving ego-resiliency and empathy for especially positive behavior, anger adjustment, cognitive empathy and emotional empathy of pre-service early childhood teachers.

      • KCI등재후보

        조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

        최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

        Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

      • 고성능 표면탄성파 필터의 최적 설계에 관한 연구

        신양호,김귀현,이진복,엄현석,이중근,박진석 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1

        본 논문에서는 고성능 표면탄성파 필터의 최적 설계를 위하여 다양한 IDT(interdigital transducer) 구조의 필터를 제작하고 각각의 주파수 응답특성을 비교 분석하였다. 기본 구조외에 MSC(micro strip-coupler), double split, reflector, ground line 등의 구조를 일반적으로 널리 사용되고 있는 Y-Z cut l-N(LiNbO3) 기판 위에 형성시켰다. 제작된 소자의 중심주파수, 통과 대역, 삽입손실등을 측정하였으며, 주파수 응답에 기초한 기존 모델의 효용성을 논의하였다. Effects of IDT structures on frequency responses of SAW filters are investigated to achieve a high performance SAW filter, Various types of IDTS, such as MSC(multistrip-coupler), double split, reflector, and ground line, are designed and patterned on a widely used Y-Z cut LN(LiNbO3) substrate. Center frequencies, band widths, and insertion losses are measured and compared. Invalidity of the conventional model based on the impulse response model is also discussed.

      • 중학생들의 식물들에 대한 인지도 연구

        신현철,이진희,황현주,심재민 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

        To investigate the understanding of middle-school students about the plants described in the middle-school textbooks, a questionnaire concerning the observation and understanding of the plants and the usefulness or kind of materials used in the lecture was developed, and distributed to a sample of middle-school students with diverse grades and locations. Although the middle-school student know plants from the textbook, and observe the plants directly or indirectly, they do not exactly know the reality of plants. Among the many reasons about this problem, the most serious aspect is the absence of the materials about the plants described in textbooks, except the textbook or references. They want to observe the plant speceimens at first, and to see the plant photos, video tape, or CD in computers.

      • KCI등재

        Effects of Pilger Rolling and Heat Treatment on Microstructure and Corrosion Resistance of Ag-electroplated 304 Stainless Steel Tubes

        Hyun Park,Woo‑Jin Lee,Jae‑Han Son,Han‑Kyun Shin,Sung‑Kyu Hong,Hyo‑Jong Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8

        We introduce a cost-effective method that combines electroplating with metal cold working processes to manufacture compositetubes with robust corrosion resistance. First, a 3-step electroplating process was developed to form an adhesive anduniform Ag coating on the outer wall of a 304 stainless steel tube. The process consisted of a Ni-strike step for removing thepassivation layer of the initial 304 tube, Cu deposition for smoothing the surface by adding a buffer layer, and Ag deposition. To reinforce the interfacial adhesion between the electroplated layers and the 304 tube and increase the area of the Ag coating,a pilger rolling or pilger rolling + heat-treatment process was performed after the Ag electroplating process. Scanningelectron microscopy of the composite tubes after each process indicated that the as-deposited Ag coating changed fromhaving a rough to smooth surface after only pilger rolling and with additional heat treatment. Electron backscatter diffractionanalysis of the microstructures and textures of the tubes revealed that dynamic recrystallization occurred extensively duringpilger rolling, resulting in the formation of a relatively defect-free grain structure without heat treatment. Furthermore,electrochemical polarization curves determined that the Ag-coated composite tubes are superior to the uncoated 304 tubein terms of corrosion resistance under Cl−atmosphere, owing to the formation of a AgCl passivation layer during testing. Surface analysis of the composite tubes suggests that the properties of the AgCl passivation layer are related to the grainsize of the Ag coating and the density of plastic-deformation-induced defects.

      • SCIESCOPUSKCI등재

        Effect of Platelet-Rich Fibrin on Repair of Defect in the Articular Disc in Rabbit Temporomandibular Joint by Platelet-Rich Fibrin

        ( Hyun Su Baek ),( Hye Sung Lee ),( Bok Joo Kim ),( In Kyo Chung ),( Chul Hoon Kim ),( Sun Mi Jin ),( Hie Sung Hwang ),( Sang Hun Shin2 ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6

        The objective of this study was to evaluate platelet-rich fibrin (PRF)’s effectiveness in repairing articular disc defect in the temporomandibular joint (TMJ) of rabbits. Eight rabbits were divided into four groups of two rabbits each, corresponding to groups A, B, C, and D. Both TMJs of all of the rabbits were used in the experiments: the right joints comprised the experimental groups, and the left ones, the control groups. The disc defect was circular and 2 mm in diameter. In the experimental groups, the PRF was compressed into the defect, whereas the control group defects were left untreated. A, B, C, and D groups were sacrificed at the 1st, 2nd, 4th and 6th weeks, respectively. The defects of each control group exhibited no specific changes. Contrastingly, in each experimental group, there was an increased number of chondroblasts at the margins of the defects, along with accelerated cell differentiation and a columnar cell arrangement observable at the time of cell differentiation. The experimental groups showed inflammatory cell infiltrations and fibrosis by the 1st week, maturation of chondrocytes by the 2nd week, and proliferation by the 4th week, after which the defects began to be filled with chondrocytes, a process that was complete after the 6th week. In the histological evaluation (H-E), the experimental groups showed significant increases of chondroblasts after the 2nd and 4th weeks, as well as regular columns of chondrocyte arrays observable during cell division. After 6 weeks, the defects were filled with chondrocytes.

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