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Kim, Ji-Hyun,Sim, Youn,Shin, Seung-Won 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1
The combination effects of essential oils from Thymus quinquecostatus and T. magnus with norfloxacin were evaluated against three strains of Streptococcus pneumoniae. The checkerboard titer test results demonstrated significant combined effects of norfloxacin and the two Thymus oils or thymol, the main component of this oil, against the susceptible and resistant strains of S. pneumoniae, with FICIs ranging from 0.14 to 1.00. Additionally, the anti-Streptococcus effects of the oils were dose-dependent on Tryptic soy agar plates containing 5% defibrinated sheep blood.
유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성
신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1
Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.
광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교
신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6
연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.
층상구조 산화물 Na_(x)Ni_(x/2)Ti_(1-x/2)O₂의 합성과 구조적 특성
신유주,곽지현 가톨릭대학교 자연과학연구소 1998 자연과학논문집 Vol.19 No.-
층상구조 산화물 Na_(x)Ni_(x/2)Ti_(l-x/2)0₂(0.60≤X≤1.0)이 고상합성법에 의해 Ar 분위기하에서 950℃-1100℃로 가열하여 합성되었다. 단일상 영역은 0.75≤x≤1.0에서 rhombohedral(O3), 0.60≤x≤0.75에서는 primitive hexagonal 상(P2)으로 결정되었고, x<0.60은 층상구조와 함께 pruderite 구조상이 공존하는 혼합상 영역이었다. 격자상수 a는 x가 감소함에 따라 단순감소 하였고 c는 반대로 증가하는 것이 관측되었는데 이는 Ni^(2+)와 Ti^(4+) 이온 반경의 차, (Ni/Ti)O₂ 층간의 정전기적 반발력, (Ni/Ti)O_(6) 정팔면체의 trigonal distortion 정도와 관련지어 논의되었다. O3에서 P2로의 구조전이 과정은 (Ni/Ti)-O와 Na-O간 경쟁적인 공유-이온 결합성의 변화에 기인하는 것으로 이해되었다. Na_(0.67)Ni_(0.33)Ti_(0.67)O₂의 경우 Rietvelt 분석법을 이용하여 그 결정구조를 결정하였다. Layer-type oxides Na_(x)Ni_(x/2)Ti_(l-x/2)0₂(0.60≤x≤1) have been prepared for the first time by solid-state reaction by heating the appropriate mixtures of starting materials at 950℃-1100℃ under Ar ambience. Two consecutive single phases were observed, rhombohedral(03) phase for 0.75≤x≤1.0 and hexagonal one(p2) for 0.60≤x<0.75, and a mixed-phase appeared including pruderite phase with x<0.60. Lattice parameter a decrease with x, while c increases as x diminishes. Such behaviors have been discussed on the basis of the difference of ionie radii between Ni^(2+) and Ti^(4+), the electrostatic repulsion of (Ni/Ti)0₂ slabs and the evolution of trigonal distortion of (Ni/Ti)0_(6) octahedra. Structural transition from 03 to P2 has been understood due to the competitive iono-covalency between (Ni/Ti)-0 and Na-0 bonds. As for Na_(0.67)Ni_(0.33)Ti_(0.67)O, the crystal structure has been determined by the Rietveld profile-analysis method.
申鉉澤,申智容 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-
The effects of the addition of silicone resin with water-repellent properties on the autoclaved lightweight concrete were studied by varing the compositions of silicone resin. ALC samples were cured at 180℃-7hrs under saturated steam pressures. The major experimental results are as follow. 1. The water absorption (7day) of water-repellent ALC specimen with 2.0% of alkyl polysiloxane was smaller than that of experimental standard ALC specimen by 93.1%. 2. The compressive strength after freezing and thawing for 16 days of control ALC specimen was 16.8 ??, but in case of water-repellent ALC specimen with 2.0% alkyi polysiloxane was 41.8 ??. Therefore the performance for freezing and thawing of water-repellent ALC specimen was increased to 149%. 3. The final hydrate materials are 11Å tobermorite, alkyi polysiloxane and unreacted Quartz as results of X-ray diffraction and SEM examination.
층상구조 산화물 Na_(x)Co_(x/2)Ti_(1-x/2)O₂(0.66≤x≤1)의 합성 및 결정화학 연구
신유주,곽지현 가톨릭대학교 자연과학연구소 1997 자연과학논문집 Vol.18 No.-
층상구조 산화물 Na_(x)Co_(x/2)Ti_(1-x/2)O₂(0.66≤x≤1)이 고상합성법에 의해 Ar 분위기, 950℃에서 합성되었다. 단일상 영역은 0.75≤x≤1에서 rhombohedral, x=0.66에서는 primitive hexagnonal 상으로 결정되었고, 0.66<x<0.75에서는 두 개의 상이 공존하는 상 경계가 존재하였다. 두 구조의 결정 화학적 논의가 조성과 연관되어 공유-이온 결합성을 중심으로 이루어졌다. 또한 온도에 따른 자화율 거동을 분석한 결과, 두 구조 내에서 Co^(2+) 이온은 high-spin(S=3/2; ⁴T) 상태임을 알 수 있었고, 자기적 상호 작용에 대해서도 논의되었다. Layer-type oxides Na_(x)Co_(x/2)Ti_(1-x/2)O₂(0.66≤x≤1) have been prepared for the first time by solid-state reaction by heating the appropriate mixtures of starting materials at 950℃ under Ar ambience. They exhibit two kinds of structure according to x, respectively rhombohedral one for 0.75≤x≤1, and primitive hexagonal for x=0.66. Discussion of crystal chemistry of both structure has been made mainly focused to the iono-covalency of Na-O, and correlated to the chemical composition. Magnetic susceptibility measurements confirmed the high-spin state(S=3/2; ⁴T) of Co^(2+) ions in both structures and their magnetic interactions has been also discussed.
저항전분 처리 조건과 냉각시간이 RS 3 전분의 수율과 팽윤력에 미치는 영향
신말식, 이지현, 문세훈 전남대학교 가정과학연구소 2001 生活科學硏究 Vol.11 No.-
Effects of acid hydrolysis, storage period and homogenization with surfactant(SE 1170) on RS 3 formation and properties of RS 3 type starches were investigated. Wheat and corn starches were repeated up to 2 times autoclaving-cooling cycles after treatment with 0.1N HCl for 0, 2, 6 and 12hr at room temperature and autoclaving-cooling cycled starches were stored at 4℃ for 0, 3, 6, 9 and 24hr. Before drying of autoclaving-cooling cycled starch gels, starch gels were homogenized with 0.5% SE 1170 or distilled water by homogenizer. The RS levels and swelling powers of RS at 100℃ were not affected by acid treatment up to 12hr. RS levels of samples which stored at 4℃ for different periods were ranged from 18.62% to 22.54% and increase of storage period at 4℃ was not also helpful to raise RS field. Homogenization with surfactant before drying not only increased RS, but also made starch to be powder easily.
가막사리(Bidens tripartita L.)와 미국가막사리(Bidens frondosa L.) 종자의 발아에 미치는 몇가지 요인
신혜정,신종섭,김지훈,김학윤,이인중,신동현,김길웅 경북대학교 농업과학기술연구소 1999 慶北大農學誌 Vol.17 No.-
The experiments were conducted to determine the factors such as light and darkness, phytohormone and seed coat, influencing on seed germination of Bidens tripartita L. and B. frondosa. The seeds of both species were germinated when seed coat was damaged and weakened GA3 and BA stimulated germination of both species but ABA and IAA had no effect on germination of them, which ranged 50.0% to 80.0%. In B. forndosa, when inner layer of seed coat was removed, germination was highly promoted up to 96.7% compared with 10.0% germination rate in another treatments.