그룹 기여법에 의한 삼성분계의 액-액 평형 예측에 관한 연구

鄭詳勳,申鉉心,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2

The experimemtal binodal curve and tie line data were determined for ternary systems of 2-propanol-water with benzene, toluene and n-butyl acetate as solvents at 25℃. These experimental data were compared with values predicted from UNIFAC model, using group contribution method. From these results the deviation between experimental and calculated equilibrium composition were very small, so it was proved that UNIFAC is good model to predect multicomponent equilibria.

Developmental Characteristics of SCNT Pig Embryos Knocked-out of Alpha-1,3-Galactosyltransferase Gene

Joo-Hyun Shim1,Mi-Rung Park,Byoung-Chul Yang,Yeoung-Gyu Ko,Keon Bong Oh,Jeong-Woong Lee,Jae-Seok Woo,Eung-Woo Park,Soo-Bong Park,Seongsoo Hwang 한국동물번식학회 2009 Reproductive & developmental biology Vol.33 No.3

용매추출에 의한 2-propanol회수에 관한 연구

신현심,정상훈,박동원 東亞大學校 海洋資源硏究所 1994 硏究論文集 Vol.7 No.2

The experimental binodal curve and tie line data were determined for ternary systems of 2-propanol-water with isoamylacetate and 1-butanol as solvents at 25℃. Consistency of the experimental data for several correlations was investigated, the experimental tie line data were correlated with NRTL model and the parameters in NRTL model were estimated and the calculated values of tie lines were predicted.

남성의 신체 크기 인식에 따른 디자인 선호도

이정임,조장현,김종서,이연심,노영미 배재대학교 자연과학연구소 2006 自然科學論文集 Vol.17 No.1

The purpose of this study is to analyze the design preference according to the body consciousness for 20∼26 years old male. The consciousness of body size and the satisfaction with body proportion were investigated. And the relationship between the body consciousness and the design preference was analyzed. Most subjects thought their body size was proper generally and their body proportion was proper or a little unsatisfied. The subjects preferred 'Round neckline', 'loose sleeve', and 'loose and long tops'. They didn't like the style that tops are under pants on the waist. They also preferred 'loose and long pants'. When the subjects chose clothing design, especially 'V-neckline tops' and 'short pants', they considered their height. They also considered their girth size and it meant they thought much of looseness. There was not any preference in clothing design according to the consciousness of height. The most significant relationships between the size consciousness and the preference in design was found in tops more than pants. The higher satisfaction with their body proportion was connected with the higher preference in some design. From all these results, it was found that the preference of clothing design could vary according to the consciousness of body size. The results from this study could give the important tips to improve the satisfaction with the clothing for each person.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

정신재활 치료가 정신분열병 환자의 재발율, 입원횟수, 입원일수 그리고 치료 경비에 미치는 효과 : 2년 추적조사 연구

조진석,공지현,김진원,심경순,하준선,김철권,강동호,장정희,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 사회기술훈련, 환자교육, 가족교육, 집단치료, 예술치료, 작업치료와 같은 포괄적인 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 정신분열병 환자의 재발율, 입원횟수, 입원일수, 직접 치료경비 등에 어떤 효과가 있는 지를 알아보기 위함이다. 연구방법 : 1993년 9월부터 1995년 2월까지 양산 신경정신병원의 폐쇄병동에서 퇴원한 20∼35세 사이의 정신분열병 환자 173명을 대상으로 46명에게는 6개월동안 정신재활 치료를 시행하였고 127명에게는 통상적인 외래치료만 시행한 후 연구시작 시점을 포함하여 2년동안 양군에 속한 환자들을 대상으로 재발율, 입원횟수, 입원일수, 직접 치료경비 등을 1년 단위로 추적 조사하였으며, 연구시작 시점을 기준으로 전과 후의 매년 평균 입원횟수, 입원일수, 직접 치료경비도 서로 비교하였다. 결 과 : 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 재발율, 입원횟수, 입원일수, 직접 치료비용이 현저히 감소되었다. 그리고 정신재활 치료를 받은 군에서는 치료 전에 비해 치료 후에 재발율, 입원횟수, 입원일수, 직접 치료비용이 유의하게 감소하였지만 통상적인 외래치료만 받은 군에서는 치료 전과 후간에 유의한 변화를 보이지 않았다. 결 론 : 정신분열병 환자들에게 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 환자의 임상적 경과를 호전시킬 뿐 아니라 가족의 경제적 부담도 줄일 수 있다. Objective : We evaluated the clinical efficacy of a comprehensive psychiatric rehabilitation of schizophrenia, including family psychoeducation, patient education, social skills training, group psychotherapy, art therapy, and occupational therapy. Method : From September 1993 to February 1995, 173 chronic schizophrenics who met DSM-IV criteria and were discharged from a locked ward were assigned into the psychiatric rehabilitation service group(psychiatric rehabilitation group, n=46) or the customary out-patient service group(out-patient group, n=127) prospectively, but not randomly. Assignment was based on preferences of patients and their relatives, Each subject included in the psychiatric rehabilitation group received twice weekly patient education, social skills training, family psychoeducation, group psychotherapy, art therapy, occupational therapy and maintenance chemotherapy during a 6-month period. Those in the out-patient group received individual supportive psychotherapy and maintenance chemotherapy according to their clinical needs for 10-20 minutes once per week. After entry into the study, all subjects were assessed for the number of readmission, days of hospitalization, and the direct treatment costs through the first and second year of follow-ups. These outcome variables were also compared pre-and post-2 years at the time point of entry into the study. Aftercare chemotherapy on a weekly to monthly basis continued for the remainder of the two year follow-up period. Results : With regard to the mean number of hospital admissions per year, the mean days of hospitalization per year, and the direct treatment costs per year, the psychiatric rehabilitation group had significantly decreased all clinical outcomes 2 years after compared with before receiving psychiatric rehabilitation. But there were no significant differences in the all clinical outcomes between before and after study intake in the out-patient group. For the number of relapse regardless of drug compliance, 4 patients(9%) during first year and 14 patients(30%) during second year were relapsed in the 46 subjects of the psychiatric rehabilitation group. In contrast, 75 patients(59%) during first year and 90 patients (71%) during second year relapsed in the out-patient group. When considering the effect of drug noncompliance to relapse, 4(9%) and 14 patients(30%) were relapsed while on medication respectively during the first and second year in the 46 of the psychiatric rehabilitation group, vs. 27(34%) of 79 patients on medication during the first year and 31(46%) of 68 patients on medication during the second year were relapsed in the out-patient group. Conclusions : These results indicate that the comprehensive psychiatric rehabilitation can be useful therapeutic intervention both to improve the clinical outcomes of schizophrenic patients and to reduce the economical burden of their relatives.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

Effect of Seaweed Calcium and Cockle Shell Calcium Addition on the Quality of Kimchi during Fermentation

Hyun-Jeong Shim,Seung-Ran Yoo,Sung-Hee Park 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Proton spin-echo magnetometer: a novel approach for magnetic field measurement in residual field gradient

Shim, Jeong Hyun,Lee, Seong-Joo,Hwang, Seong-min,Yu, Kwon Kyu,Kim, Kiwoong BUREAU INTERNATIONAL DES POIDS ET MESURES 2015 METROLOGIA -BERLIN- Vol.52 No.4

<P>We demonstrate a proton spin echo magnetometer, in which the interrogation time is not limited by <img SRC='http://ej.iop.org/images/0026-1394/52/4/496/met513248ieqn001.gif' ALIGN='MIDDLE' ALT='$T_{2}^{*}$ '/> and can be prolonged to <I>T</I><SUB>2</SUB>. Therefore, even under a severe field gradient, the precision of the measurement does not degrade. We devised a phase linearization method that enables accurate estimation of the precession frequency from a spin-echo train. With proton spins in deoxygenated tetramethylsilane and a superconducting quantum interference device-detected NMR system at KRISS, an average field of around 5 μT was measured with an uncertainty of 0.42 nT in the presence of a field gradient of 12.8 μT m<SUP>−1</SUP>. This implies that our system tolerated a 25% variation in magnetic field over the sample area. The proton spin-echo magnetometer will be useful in measuring magnetic fields without compensating for residual field gradients.</P>

Korean Medication Algorithm for Depressive Disorder 2021, Fourth Revision: An Executive Summary

Jeong Seok Seo,박원명,Young Sup Woo,Young-Min Park,Won Kim,Jong Hyun Jeong,Se-Hoon Shim,Jung Goo Lee,Seung-Ho Jang,Chan-Mo Yang,Sheng Min Wang,Myung Hun Jung,Hyung Mo Sung,IL Han Choo,Bo-Hyun Yoon,이상열,전덕 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.4

Objective: In the 19 years since the Korean College of Neuropsychopharmacology and the Korean Society for Affective Disorders developed the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2002, four revisions have been conducted. Methods: To increase survey efficiency in this revision, to cover the general clinical practice, and to compare the results with previous KMAP-DD series, the overall structure of the questionnaire was maintained. The six sections of the questionnaire were as follows: 1) pharmacological treatment strategies for major depressive disorder (MDD) with/without psychotic features; 2) pharmacological treatment strategies for persistent depressive disorder and other depressive disorder subtypes; 3) consensus for treatment-resistant depression; 4) the choice of an antidepressant in the context of safety, adverse effects, and comorbid physical illnesses; 5) treatment strategies for special populations (children/adolescents, elderly, and women); and 6) non-pharmacological biological therapies. Recommended first-, second-, and third-line strategies were derived statistically. Results: There has been little change in the four years since KMAP-DD 2017 due to the lack of newly introduced drug or treatment strategies. However, shortened waiting time between the initial and subsequent treatments, increased preference for atypical antipsychotics (AAPs), especially aripiprazole, and combination strategies with AAPs yield an active and somewhat aggressive treatment trend in Korea. Conclusion: We expect KMAP-DD to provide clinicians with useful information about the specific strategies and medications appropriate for treating patients with MDD by bridging the gap between clinical real practice and the evidence- based world.