골수이식 후 사이토카인과 골교체 생화학적표지자의 변화 및 상관관계

민우성,강무일,한제호,강성구,오기원,이원영,김혜수,문성대,손현식,신완식,김춘추,윤건호,차봉연,이광우,손호영 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.1

Background : Loss of bone mass is usually detected after BMT. The causes of bone loss are related with gonadal dysfunction and immunosuppressants. Cytokines, especially IL-6, play an important role in the pathogenesis of postmenopausal osteoporosis. However, the pathogenetic role of cytokines in post-BMT bone loss is unknown and data on the changes of cytokines in accordance with bone turnover markers are scarce. The aim of this study is to assess the relationship of bone turnover markers and cytokines of peripheral blood and bone marrow before and after allogeneic BMT. Methods : This prospective study included two analyses. The first was a study of 46 BMT recipients, examining the relationship between bone turnover markers and cytokines of serum which were measured before and 1, 2, 3, 4 week and 3 months after BMT. The second was a study of 14 BMT patients, measuring bone marrow plasma cytokines such as IL-6 and TNF-? at post-BMT 3 week and bone turnover marker at the same time to assess the relationship beween two parameters. Results : Serum ICTP, bone resorption marker, increased progressively until 4 weeks (peak) after BMT and then decreased thereafter. Serum osteocalcin, bone formation marker, decreased progressively until 3 weeks after BMT and then increased thereafter. There was positive correlation between serum ICTP and bone marrow IL-6 levels at the post-BMT 3 week with a statistical significance, but the correlation between bone turnover markers and bone marrow TNF-? or peripheral blood cytokines was not found. Conclusion : Our data suggest that the progressive increase of bone resorption after BMT is related with the increase of bone marrow IL-6, which is a potent stimulator of bone resorption in vivo(J Kor Soc Endocrinol 15:85-96, 2000).

자전거타기가 60대 노인의 체력 개선에 미치는 효과

김일곤,정문현 忠南大學校體育科學硏究所 1996 體育科學硏究誌 Vol.14 No.1

The Purpose of this study was anlyze relationship between ride a bicycle and physical fitness of an old perosn. so we worked out a way to improvement of the physical fitnees as a ride a bicycle. Following conclusion were obtained. 1. The ride a bicycle of 12 weeks has reduced of the body fat % more experimental group than conparative group. 2. The ride a bicycle of 12 weeks has improved of the muscular strength more experimental group than conparative group. 3. The ride a bicycle of 12 weeks has improved of the flexibility more experimental group than conparative group. 4. The ride a bicycle of 12 weeks has improved of the cardiovascular endurance more experimental group than conparative group.

Platelet-Rich Plasma (PRP)가 토끼 척골의 분절 결손의 치료로 이식된 동종 장관골의 골유합에 미치는 효과

송주현,정진영,강용구,이한용,손문익,서상일 대한골절학회 2003 대한골절학회지 Vol.16 No.3

목적: 골종양 환자나 외상, 골수염, 인공관절 치환술 등의 환자 등의 환자 치료에 많이 사용하는 장관골의 동종 이식에 대한 PRP (Platelet-Rich Plasma)의 효과를 토끼를 이용한 실험으로 알아보고자 하였다. 대상 및 방법: 20마리의 토끼를 대상으로 각각에 일련번호를 붙이고, 각 토끼의 양측 척골에 약 2㎝ 길이의 골편을 얻어 장관골 결손을 만들고 동시에 동종 장관골을 얻어, 홀수 토끼의 척골 골편을 짝수 토끼의 골결손 분위에 이식하고, 반대로 짝수 토끼의 척골 골편을 홀수 토끼의 골결손 분위에 이식하였다. 그 후 각 토끼의 좌측 척골 이식 부위에는 아무런 처치를 하지 않고 대조군으로 삼고, 우측 척골 이식부에는 PRP 0.7cc를 처치하여 실험군으로 삼았다. 술 후 0, 4, 8, 12주에 골이식부에 대한 방사선 촬영을 통하여 골유합 성적을 평가 비교하였다. 결과: 실험군의 척골 분절 결손부에서는 대조군에서보다 동종 분절골 이식부의 골유합이 방사선학적으로 향상된 것을 관찰 할 수 있었다. 결론: 동종 장관골 분절 이식시 PRP를 병용하여 사용할 경우 더욱 효과적인 신생조직 형성을 유도할 수 있으며, 임상에도 유용하게 적용할 수 있으리라 사료된다. Purpose: The purpose of this study was to evaluate the effect of Platelet-Rich Plasma(PRP) on the healing of the allograft for the treatment of the segmental bone defect of the ulna in Rabbits. Materials and Methods: About 2 ㎝-sized segmental bone defects were created on both ulna of twenty rabbits. The rabbits were divided into two groups, even and odd number groups after numbering them from 1 to 20. The segmental bone from the odd numbered animal was transplanted to the even numbered animal, and the even numbered to the odd numbered. The left side of the ulna was grafted with a segmental allograft only. The right side of the ulna was grafted with a segmental allograft and 0.7cc of PRP. Radiographs obtained at 0, 4, 8, and 12 weeks postoperatively were graded for radiologic union. Result: The use of the combination of PRP and segmental allograft demonstrated improved healing on radiographic study compared with that demonstrated after use of allograft alone. Conclusion: The results of the study suggests that the use of the combination of PRP and segmental allograft can be considered as an alternative method to manage the segmental defect of the long bone.

삶의 질 향상을 위한 가정체육 실태조사

진윤수,김일곤,정문현 忠南大學校體育科學硏究所 1997 體育科學硏究誌 Vol.15 No.1

The research on the condition of family's health and physical exercise was made by three thousand families in Thaejon and in Chungnam. In the questionnaire, there were questions about health condition, existing physical exercises at home, quality of life, and a developmental plan for domestic exercises. And the report runs as follows. 1. In most of families, they feel happy. They believe that the most important thing to decide their happiness is their job. So they consider working more importantly than leisure for family happiness. 2. The health conditions of families are good. The bad factors that injure their health were fatness, irregular habit, ill balanced nutrition, and lack of exercise. They are taking exercise for health of family. 3. They keep on exercise to promote health. And they think that new programs of family physical education should be made continuously. As a usual, every husband in the families decides what kind of exercise to do. They spend about thirty or sixty minutes per one exercise. 4. It is necessary for husbands and wives to exercise together. They can not exercise because they don't have enough time. The couples prefer public sports facilities in the park because they are convenient to use anytime. 5. It is necessary for family to exercise together. Most of them exercise once a week at most. They prefer public sports facilities in the park because of their convenience. 6. They think that it is necessary to exercise with their neighbors. They have participated in exercise with neighbors once and less. When they exercised with neighbors, most of them used to do so in the nearest park. 7. When they exercise, most of couples play tennis. They usually go mountain climbing for family exercise. Badminton is prefered for an exercise with neighbors. 8. They want lots of family physical education programs to be developed and supplied by the support of government, And it is necessary to inspire people with new consciousness about family physical education to develop family exercise. And the financial problems should be supported by national treasury and a loc al tax.

Stored pest management in response to the climate change in Korea: Problems and task

Mun Il Ryoo,Ki Jeong Hong,Ja Hyun Na 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10

Basic : A case of acute hepatitis E in a foreign worker from India (초)

( Hyun Il Mun ),( Yong Kook Lee ),( Kang Kim ),( Jeong Bae Park ),( Jeong Ill Suh ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)

Ni 박막 위치에 따른 GZO 투명전도막의 전기광학적 물성 변화

문현주 ( Hyun Joo Mun ),전재현 ( Jae Hyun Jeon ),공태경 ( Tae Kyung Gong ),서기웅 ( Ki Woong Seo ),오정현 ( Jeong Hyun Oh ),김선경 ( Sun Kyung Kim ),최동혁 ( Dong Hyuk Choi ),손동일 ( Dong Il Son ),김대일 ( Daeil Kim ) 한국열처리공학회 2015 熱處理工學會誌 Vol.28 No.3

GZO single layer, Ni buffered GZO(GZO/Ni), Ni intermediated GZO (GZO/Ni/GZO) and Ni capped GZO (Ni/GZO) films were prepared on poly-carbonate (PC) substrates by RF and DC magnetron sputtering without intentional substrate heating and then the influence of the Ni (2 nm thick) thin film on the optical, electrical and structural properties of GZO films were investigated. As deposited GZO single layer films show the optical transmittance of 81.3% in the visible wavelength region and a resistivity of 1.0 × 10(-2) Ωcm, while GZO/Ni/GZO trilayer films show a lower resistivity of 6.4 × 10(-4) Ωcm and an optical transmittance of 74.5% in this study. Based on the figure of merit, it can be concluded that the intermediated Ni thin film effectively enhances the opto-electrical performance of GZO films for use as transparent conducting oxides in flexible display applications.(Received April 2, 2015; Revised April 13, 2015; Accepted April 17, 2015)

Changes in Bone Mineral Density in Renal Transplant Recipients : a Cross - Sectional and Longitudinal Study

남재현(Jae Hyun Nam),임승길(Sung Kil Lim),문장일(Jang Il Mun),김선일(Soon Il Kim),박기일(Ki Il Park),이현철(Hyun Chul Lee),허갑범(Kab Bum Huh) 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-

Genetic Diversity of Porcine Circovirus Type 2 in Korean Pigs with Postweaning Multisystemic Wasting Syndrome during 2005-2007

KIM, Ha-Hyun,PARK, Sang-Ik,HYUN, Bang-Hun,PARK, Su-Jin,JEONG, Young-Ju,SHIN, Dong-Jun,CHUN, Young-Hyun,HOSMILLO, Myra,LEE, Bong-Joo,KANG, Mun-Il,CHO, Kyoung-Oh Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.3

<P>The comparison of nucleotide and deduced amino acid sequence was conducted with 9 porcine circovirus type 2 (PCV2) strains isolated from PCV2-infected pigs with postweaning multisystemic wasting syndrome (PMWS) and 50 tissue samples obtained from PCV2-infected 50 pigs with PMWS during 2005-2007. At amino acid positions 88-89 of the ORF2 gene, 50 Korean PCV2 had amino acids PR/L consistent with group 1 PCV2, whereas 9 Korean PCV2 contained amino acids KI, characteristic of group 2 PCV2. Phylogenetically, 47, 3, 2 and 7 Korean PCV2 belonged to subgroups 1A/B (79.7%), 1C (5.1%), 2D (3.4%) and 2E (11.9%), respectively. Although the predominant Korean PCV2 was subgroup 1A/B, subgroups 1C and 2E were still circulating and subgroup 2D PCV2 were found to be newly emerged in Korea.</P>

신이식후 당뇨병의 발병원인에 있어서 인슐린 분비능과 저항성의 역할

남재현,이현철,안철우,문장일,김순일,박기일,송영득,임승길,김경래,허갑범 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

연구배경 : 신이식후 발생하는 당뇨병의 유병률은 정상 인구에서의 당뇨병 유병률보다 훨씬 높다. 이에 대한 원인적 요소로 면역억제제, 유전적 영향, 스트레스 및 이뇨제의 사용 등이 제시되고 있으나 아직까지 그 기전은 정확히 알려져 있지 않으며 특히 인슐린저항성과 인슐린결핍 중 어느 것이 더 중요한 요인인지에 대해서도 아직 밝혀지고 있지 않다. 본 연구는 신이식후 당뇨병의 병리기전과 가능한 위험요인에 대해 알아보기 위해서 연구를 수행하였다. 방법 : 본 연구는 114명의 환자(평균 연령 39세, 23∼55세 사이)를 대상으로 이식 전 1주일과 이식 후 9개월에서 12개월 사이에, 인슐린(0.1U/㎏)을 정맥 투여한 후 혈당감소 속도를 통하여 인슐린저항성을 측정하였으며, 75g 경구당부하 검사를 통하여 인슐린분비능을 각각 측정하였다. 이식 후에 시행한 경구당부하검사의 결과를 통하여 WHO 기준에 따라 이식환자들을, 정상(normal glucose tolerance, NGT), 내당능장애(impaired glucose tolerance, IGT), 그리고 당뇨병(posr-renal transplantation diabetes mellitus, PTDM)군으로 나누었다. 방사능면역분석법으로 인슐린과 프로인슐린을 측정하였다. 결과 : 세 군 사이에 스테로이드와 cyclosporin A의 복용량에는 차이가 없었다. 공복 및 경구당부하 2시간 혈당, 프로인슐린/인슐린 비 등은 세 군 간에 의미있는 차이를 보였다. 인슐린저항성은 이식 후에 모든 군에서 개선되었으나, 이식 후 IGT 및 PTDM군에서는 저항성이 NGT군에 비해 의미있게 있었으며 이는 체중 증가군에서 더욱 의미가 있었다. 또한 인슐린분비능은 이식 전에 IGT및 PTDM군에서 감소되어 있었으며 이식 후에도 인슐린분비능은 더욱 감소되었으며 역시 IGT및 PTDM군에서 의미있게 감소되었다. 이식 후 프로인슐린/인슐린 비는 NGT군에 비해 PTDM구에서 의미있게 높았다. 허리-둔부 둘레비는 이식 후 IGT와 PTDM 군에서 의미있게 높았으며 이는 체중증가군에서 더욱 현저하였다. 결론 : 이상의 결과를 요약하면 이식 전에 인슐린분비능이 감소되어 있는 환자가 이식 후에 신 이식 후 당뇨병이 의미있게 높았으며 이는 이식 후에 인슐린저항성이 개선되었음에도 불구하고 면역억제제에 의한 인슐린 분비능이 더욱 나빠졌을 것으로 사료되며 이식 전과 후 모두 PTDM군 당뇨병 환자는 체중 증가군과 비체중 증가 군에서 NGT군보다 인슐린 분비능력은 의미있게 저하되어 있었으나 체중 증가군에서는 인슐린저항성에 의해 당뇨병의 유병률이 높았다. 따라서 이식 전에 베타세포의 기능 이상을 나타내는 공복 및 식후 2시간 혈당과 프로인슐린 수치는 이식 후 당뇨병의 발병 여부에 대한 예측인자가 될 수도 있을 것으로 사료되며 인슐린 분비장애가 신 이식후 당뇨병의 발병에 주요한 인자로 사료된다. Background : Our study was undertaken to investigate the pathogenesis and possible risk factors for post-renal transplantation diabetes mellitus (PTDM). Methods : We recruited 114 patients with normal glucose tolerance, and performed the 75g oral glucose to lerance tests (OGTT) and the short insulin to lerance tests 1 week before and 9 ~ 12 months after transplantation, respectively. Results : The subjects were classified into three groups on the basis of OGTT after transplantation by WHO criteria : 1) 36 (31.6%) subjects with normal glucose tolerance ; 2) 51 (45.7%) subjects with impaired glucose tolerance ; and 3) 27 (23.7%) subjects with post-renal transplantation diabetes mellitus. Dosages of steroid and cyclosporin-A (CsA) were equivalent among the 3 groups. Before transplantation, the fasting and 2-h plasma glucose, and proinsulin/ insulin (PI/I) ratios were significantly higher in the IGT and PTDM groups than in the NGT group, but insulin sensitivity index (ISI) was not different among 3 groups. In addition, the area under the curve (AUC)-insulin on OGTT was significantly lower in the PTDM group than in the NGT group. After transplantation, however, ISI was increased in all groups. Furthermore, the ISI and PI/I ratios revealed significantly higher values in the PTDM group than in the NGT group after transplantation. Conclusion : These results revealed that fasting and 2-h plasma glucose levels, as wellas proinsulin/insulin ratio before transplantation, which may all be indicators of cell dysfunction, could be the predictors for the development of PTDM and β-cell dysfunction rather than insulin resistance was proved to be the main factor for the pathogenesis of PTDM (J Kor Diabetes Asso 485~496, 2000).