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A Study on the obesity of middle-aged women
Cho, Hyun,Jin, Eun-Hee 仁濟大學校 2005 仁濟論叢 Vol.20 No.1
The goal of this study is to help promote the health of middle-aged women whose health is often not taken care of , by controlling weight to prevent obesity and various adult-related diseases. This research covered basic data related to obesity as well as exercise and food ingestion patterns of middle-aged women in the Gimhae and Jinju area. Research was conducted through a survey of 400 parents with children in elementary school on basic information as well as exercise and dietary habits. The survey composed of 11 exercise-related questions with a reliability factor of chronbach's a=.880, and 19 dietary habit related questions with a reliability factor of chronbach's a= .825. The data was analyzed using SAS 8.1, through frequency analysis, X^(2), and ANOVA. Math results of this study were as follows ; 1. Among general characteristics, subjects exhibited high instances of the followings: 70% of them are age 30-49, 75% have two chidren, 59.4% have 12years of education, 36.9% have a monthly income of 2,000-2,990thousand won, 57.3% are unemployed, and 51.9% are Buddhists. 2. On characteristics related to obesity, 64.6% are BMI 18.5 - 23, within normal range, 48.1% are trying to control weight, and 81.5% are exercising to control weight. 62.0% sited childbirth as the cause of weight increase. Average height of test subjects was 160.06cm, average weight 56.26kg, and BMI 21.96. The average pre-marital weight was 49.61kg and BMI 19.34. 3. On dietary habit related questions (max 5 points), the mean score was 4.00 among underweight subjects and 3.58 among overweight subjects, suggesting better dietary habits for the underweight group. Dietary habits and BMI have a significant statistical difference. 4. On exercise related questions (maximum 5 points), the mean score was 3.38 among overweight subjects and 2.66 for underweight subjects, suggesting that the overweight subjects exercised more. Exercise and BMI have a significant statistical difference.
조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성
김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.
측뇌실내 수막종 : 임상분석 및 수술접근법 Clinical Analysis and Surgical Approach
양희진,김동규,정희원,이현구,김현집,조병규,최길수,한대희 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10
The authors present six cases of lateral ventricle meningiomas treated at Seoul National University Hospital between 1979 and 1991. These six cases of lateral ventricular meningiomas constitute 1.8 percent of all intracranial meningiomas and 16.7 percent of mass lesions of the lateral ventricle. The mean age was 29 years ranging from 11 to 50 years, younger than that or intracranial meningiomas with a statistical significance(p<0.01). Four of the patients were women and two were men. All cases were located in the trigonal area. The most common clinical symptoms and signs were related to increased intracranial pressure such as headache, nausea and vomiting. Based on the clinical presentation and radiological features(CT. MRI and angiography), correct preoperative diagnosis was possible in five cases. Gross total removal of the tumor was achieved in all cases. There was no operative mortality. A temporal gyrus approach was used in five cases with good surgical results. The benefits and drawbacks of each surgical approach for meningiomas of the lateral ventricle is discussed with review of pertinent literatures.
간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구
서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1
As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions
조인숙,김태의,김정식,이해혁,이권해,김희경,남계현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
A case of omental mass during Pregnancy Omental cyst is a rare lesion and occur primarily during childhood and young adulthood. When encountered, most of them are benign and intraabdominal masses. It shows a large mass but not palpable and often asymptomatic. The precise diagnosis is made by most commonly at surgery or during pathologic examination. So, we report this case with brief review of literatures.
리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성
조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2
The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.
스프렌딜 지속정(펠로디핀 5㎎)에 대한 스타핀 지속정의 생물학적동등성
조혜영,강현아,이석,백승희,박은자,최후균,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4
Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by means of a direct, selective action on smooth muscle in arterial resistance vessels. Furthermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). THe felodipine release from the two felodipine formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method at pH 6.5 buffer solution. Twenty six healthy male subjects, 22.73±1.78 years in age and 66.66±7.28 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 5 ㎎ as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as AUG_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for AUC_(t), C_(max) and T_(mzx), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.86)∼log(1.20) and long(0.89)∼long(1.23) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.
장기간 댄스스포츠가 혈중 지질 및 효소 활성도에 미치는 영향
조현철,김준희,한주희 龍仁大學校 體育科學硏究所 1999 體育科學硏究論叢 Vol.9 No.1
The purpose of this study was to assay effect on blood lipid and ezyme activity during 20 weeks of dance sport and acute exercise. Ten females participated in dance sport program(90min./day. 2day/week) for 20 weeks. The results were obtained as follow : 1. CHOL and TG were decreased during dance sport program but no significant, also no significant between before exercise and after. 2. Amylase, Lipase, GGT and LDH were slightly increased during dance sport program but no significant, however, GOT was significantly(p<.05) increased between after 10 weeks and after 20 weeks. Also, LDH was significantly(p<.05) increased before exercise and after 10 weeks only in acute exercise variance. Conclusively, it is showed that CHOL and TG were decreased and enzyme activity was increased induced 20 weeks of dance sport program and acute exercise. It is suggested that dance could be serviceable effectively not only leisure but also good for health.
장기간 댄스스포츠가 호흡순환 기능 및 심폐지구력에 미치는 효과
조현철,김준희,한주희 龍仁大學校 體育科學硏究所 1998 體育科學硏究論叢 Vol.8 No.1
The purpose of this study was to evaluate the effects in respire-circulatory function and cadio-pulmonary endurance capacity. Twelve females(trained 6, untrained 6) participated in dancesport program that is 90min/day, 2day/week for 20weeks. The results were obtained as follow : 1. No significant difference was found in heart rate, ventilation and respiration rate among pretest, after 10 weeks and 20 weeks of dance program and between trained and untrained group. 2. Significant differenced was found in VCO₂between pretest and 20Weeks later in untrained group. 3. There was significantly increased VO₂max in 20 weeks dance program later compared with pretest and significant difference between groups. 4. There was no significant difference in ventilatory threshold and exercise time was not significant difference among trials and between groups. Conclusively, respiro-circulatory function and cardio-pulmonary endurance capacity were not changed at submaximal stage of excise test but those were significantly increased at maximal of exercise test during 20 weeks. Therefore, it is suggested that long term dancesport exercise program is expected more effective on the repiro-circulation function and cardio-pulmonary endurance capacity.