S-580 : Vitamin D and carotid subclinical atherosclerosis in SLE

( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.

병원 위탁급식 품질관리를 위한 품질평가도구 개발

양일선,김현아,이영은,박문경,박수연 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

The purposes of this study were: a) to develop the a quality measurement tool for the contract-managed hospital foodservice, and b) to evaluate their performance with the developed quality measurement tool, and c) to verify the reliability and validity of the quality measurement tool. The developed quality measurement tool comprised two parts, which were foodservice management and medical nutrition care service. The foodservice management part was classified into six functional categories which were Menu, Procurement and Storage, Production and Distribution, Facility and Utility, Sanitation and Safety, and Management and Evaluation. The medical nutrition care service part indicated the medical nutrition care provided. Quality measurement tool had 91 standards and 324 indicators. The quality measurement tools were distributed to the hospital foodservice manager employed by the foodservice company. The 324 indicators were measured by foodservice manager on the 5-Likert-type scales, and then adapted to a 100 point scale. The SPSS Ver. 11.0 was used for statistical analysis. The categories whose scores were evaluated as being high were Procurement', General Sanitation', Personal sanitation' and Waste' and the categories whose scores were evaluated as being low were Diet Order Manual', Standard Recipe', Appropriateness (Facility and Utility)', Check (Facility and Utility)' and Information Management'. All the categories of medical nutrition service were evaluated as having seriously low scores. Therefore, it was necessary for the contract-managed hospital foodservice to improve its performance in the area of medical nutrition care service. For the verification of the developed quality measurement tool, the reliability obtained by calculating Cronbach's α was 0.8747, and the content validity was also proved by scrutiny of the modification of the professional group's techniques.

서울시내 고등학교 위탁급식의 급식비와 투자비의 실태 및 위탁업체의 기대수준 비교 분석

양일선,배환미,김현아,신서영,조미나,박수연,차진아,이보숙 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.5

The purposes of this study were to a) find out the operational characteristics of the contract-managed highschool foodservice in Seoul, b) investigate the expected level of meal-price and facilities investment cost perceived by contract-managed highschool foodservice managers c) compare the present level and expected level of meal-price and facilities investment cost. From October 12 to November 13 in 2001, the questionnaires were mailed to 249 high schools which was managed by contract foodservice company with respondent rate 40.2%. Data were analyzed using SPSS Win(10.0) for descriptive analysis and one group paired t-test. The results of this study were as follows ; 1. The student enrollment of highschools run by contract-managed foodservice was 1,243 with 72.6% participation rate of school lunch program. The average meal-price was 2,138 won. The average annual period of school foodservice operation was 156.78 days per year. The average contracting period was about 3 years. 2. The average cost concerned in the facilities investment amounts 169,578,180 won at the initial investment and 25,204,092 won at the repairs and maintenance cost in the course of operation. 3. The present level of meal-price and facilities investment cost were respectively 2,136won/meal and 171,157,336.72 won. And expected level.of meal-price and amount of facilities investment cost were 2,418.75 won and 121,353,215.19 won. Comparing the present level with expected level of the meal-price and facilities investment cost, expected level of meal-price was significantly higher than the present level of meal-price(p<.001) and expected level of facilities investment cost was significantly lower than present level of facilities investment cost(p<.001).

위탁급식업체 선정에 영향을 미치는 요인에 대한 개발영업사원의 인식도 조사

김현아,양일선,이보숙,박진영 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The purpose of this study was to investigate the importance level on factors affecting the foodservice management contract perceived by the salespersons in the foodservice company. To get the data on the perceived importance level on the affecting the foodservice management contract, the questionnaires were developed by the delphi technique and modified by the pilot test. The questionnaires consisted of 4 categories and 19 items on the factors affecting the foodservice management contract and the importance level on the factors were measured by 5-likert scale. From March 12 to April 13 in 2003, the self-administrative questionnaires were mailed to the 60 salespersons. The questionnaires were responded from the 48 salespersons(respondent rate : 77%). As a result, the salesperson' perceived importance level of 「the sales ability」 was higher than those of the other categories in the private contract and the salesperson' perceived importance level of 「the evaluation of the foodservice company」 was higher than those of the other categories in the competitive bid. The importance of the 「the evaluation of the foodservice company」 between the private contract and the competitive bid was significantly different(p<.05), and the importance of 「the sales ability」 of the competitive bid was significantly higher than that of the private contract(p<.001).

광중합형 글래스아이오노머 시멘트의 전단결합강도에 대한 연구

김현양,태기출,국윤아,김상철 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.5

법랑질의 표면처리에 따른 광중합형 글래스아이오노머 시멘트의 전단결합강도를 알아보고자 사람 소구치 80개를 선택하여 8개군으로 나누어 전단 결합 강도를 측정하고, 접착 파절의 양상을 평가하여 다음과 같은 결과를 얻었다. 1. 37% 인산용액으로 부식한 후 건조상태에서 글래스아이오노머 시멘트, 광중합형 레진, 화학중합형 레진으로 각각 부착한 실험군에서 글래스아이오노머 시멘트 실험군의 전단결합강도는 두 군과 유의한 차가 없었으나 화학중합형 레진군의 그것은 광중합형 레진군에 비해 유의성있게 낮았다 (P<0.05). 2. 37% 인산 실험군, 10% 폴리아크릴산 실험군, 1.23% APF 실험군, 산처리하지 않은 실험군의 습한 상태에서 부착한 글래스아이오노머 시멘트의 전단결합강도에서 산처리하지않은 실험군의 그것이 유의성 있게 낮았으며, 그 외 군간에는 유의성 있는 차이가 없었다 (P<0.05). 3. 글래스아이오노머 실험군에서 습기의 존재가 전단결합강도에 유의성 있는 영향을 미치지 않았다 (P<0.05). 4. 산부식처리를 하지않은 군의 접착제 잔류지수가 가장 낮았으며 37% 인산용액으로 처리한 군의 접착제 잔류지수가 가장 높았다. The purpose of this study was to evaluate the shear bond strength of light cured glass ionomer cement to enamel surface which treated with 37% phosphoric acid, 10% polyacrylic acid, 1.23% acidulated phosphate fluoride gel and no etching agent. To compare the shear bond strength of glass ionomer cement, light-cured composite resin and chemically-cured composite resin were empoloyed as controls. Eight experiments groups were composed. 10 specimens of each group were bonded by metal bracket by tested in universal testing machine for shear bond strength, in stereoscope for adhesive remnants index. The data were evaluated statistically by SPSS/PC+. The results were as follows. 1. Among the groups of 37% phosphoric acid treated and dry and bonded with light cured glass ionomer, light cured composite resin, and chemically cured composite resin, the shear bond strength of glass ionomer group showed no significant difference to the others, but the shear bond strength of chemically cured resin showed statistically lower than that of light cured resin (P<0.05). 2. The shear bond strengths of glass ionomer cement to enamel treated group with 1.23% acidulated phosphate fluoride gel and 10% polyacrylic acid and 37% phosphoric acid showed statistically higher than that of no etched enamel group(P<0.05). 3. In the glass ionomer cement, the presence of moisture was not significantly effect to the shear bond strength (P<0.05). 4. After debonding, no etched enamel group showed less residual materials on the enamel surface than the group of enamel etched with 37% phosphoric acid.

몇몇 플라보노이드의 항상화활성의 비교 연구

정현균,정민아,송동업,안봉환,양성렬 全南大醫大 2000 전남의대학술지 Vol.36 No.2

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

위탁급식계약 개발전략수립을 위한 업체선정 요인분석

이보숙,양일선,박진영,김현아 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.5

The purposes of this study were to compare, through a factor analysis, the perceived level of importance of 4 categories of features relating to food service management between salespeople and clients, to establish an effective marketing strategy for successful contracting. To obtain data on the perceived level of importance level of the factors affecting foodservice management contracts, questionnaires were developed using the Delphi technique, which were modified by apilot test. The questionnaires consisted of 4 categories and 19 items on the factors affecting foodservice management contracts, with the importance level of these factors measured on a 5 point-Liken type scale. Between March 12 and April 13 2003, the self-administrative questionnaires were mailed to the 60 salespeople and 280 clients. A total of 50 clients (25%) and 48 stlespeople(77%) responded to the questionnaires. As a result, forprivate contracts and in competitive hiding, the differences of the perceived importance level between the salespeople and clients of the 3 categories the appropriateness of foodservice operation plan, sales ability, the conditions and costs of the contract) were sis_naificant. For the 5 items relating to private contracts, Field trip, Menu Management Plan. Sanitation and Safety Management, Cost per meal and Food Cost per meal, both the salespeople and clients perceived high levels of importance for all these items. For competitive biding, both the salespeople and clients perceived high levels of importance for the 6 item the Fooxiservice operation supportive system, Field trip, Menu Management Plan, Renewal plans for interior and environment, Cost per meal and Food Cost per meal.

병원급식 위탁관리의 운영 실태조사

김진수,양일선,김현아,박문경,박수연 대한영양사협회 2003 대한영양사협회 학술지 Vol.9 No.2

The purposes of this study were to investigate the current status of contracted hospital food services and to find out the difference in accordance with the number of beds in hospitals. Thirty six hospitals having more than 100 beds in Seoul, Inchon and Kyungkido were the subjects of this study. Data was collected through surveys. The survey was conducted during March and April in 2002. The Questionnaires were mailed to the 36 directors of dietetic departments of the hospitals and 36 managers of contracting patient food services. Statistical analysis was completed using SPSS Win(11.0) for descriptive analysis and t-test. The results of the study are summerized as follows; Ⅰ. Hospital perspective : The range covered by contract food service was 63.3% and 36.7% in hospital food services, and medical nutrition services. The patient and employee food services were in 83.3% and patient food services were in 6.7%. The methods selecting contractors were general, limited, selected and competitive biddings, and private contracts. The responsibility for supervision of contract food services was the dietetic department(51.7%) in most cases. Hospitals having personnel responsible for contracting affairs were in 75.9% of the cases and 24.1% did not have personnel. The biggest reason for contracting was facilitation of personnel management. The most important criteria on selecting food services contractors was the professionality of the contractor. Ⅱ. Contractor's perspective : The cost per meal in the year 2001 was composed of 1,905 won for food cost, 1,081 won for labor cost, 222 won for expenses, 114 won for VAT, 14 won for rent and 146 won for miscellaneous or controllable expense, representing 109 won loss per meal. The profit-and-loss contract cost was higher than the fee-contract cost. The ratios of food cost, labor cost and expenses were higher and the ratios of miscellaneous or controllable expense, VAT, rent and profit were lower in hospitals with more than 400 beds compared with those less than 400 beds. However, no significant differences are present between these two groups of hospitals. The actual contract period was 2.2 years upon initial contract and 1.2 years upon renewal. The initial investment cost was 53 million won and the cost of renovation and repair was 8.5 million won. Significant differences were present between two groups of hospitals. The conditions of employment and number of personnel hired by contractors for contract patient food services were significantly different according to the number of beds.

하고초의 지질과산화 및 간독성에 미치는 영향

김태희,양기숙,이현아 숙명여자대학교 1995 약학논문집-숙명여자대학교 Vol.11 No.-

Prunella vulgaris L. var. lilachina(Labiatae) is used as herbal remedies for infectious hepatities, cancer, human tuberculosis, bacilliary dysentery. In order to investigate the efficacy of the plant in vitro and in vivo, its fractions were examined antilipid peroxidative activity and therapeutic effect of carbon tetrachloride induced hepatotoxicity in rats. In liver lipid, the lipid peroxidative activity was inhibited significantly by ether and butanol fractions in vitro, also in butanol fraction in vivo (p>0.001). In serum, the antilipid peroxidative activity was increased significantly in chloroform fraction in vivo. Butanol fraction had significantly reduced the elevated level of S-GOT and S-GPT(p<0.001). The liver and lipid weights of CCl_4 administration group tend to increase compared with those of normal group. The administration of each fraction P.O. after CCl_4, S.C., lipid weight tend to reduce, but not significant.