유제놀에 의한 즉시형 알레르기 반응의 억제

김상현,신태용,김형룡,이영미,이은희,신보경,김윤철,안년형,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1 M/kg. i.p.) at 60 min before and 5.10 min after the compound 48/80 treatment (8 mg/kg.i.p.) were shown the mortality rates as 0.44.4. and 77.8%. respectively. A 60 min before administered group revealed a singificant inhibition of serum his-tamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

토착형 P. vivax에 의한 Malaria 4례

박형렬,이성원,이경미,김태겸,한진영,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.2

형광검출 역상 액체크로마토그래피에 의한 Histamine의 정량

유희춘,김형룡,김상현,김대기,이영미,김형민,안년형,신태용 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

Histamine을 정확하고 신속하게 정량하기 위해 9.Fiuorenylmethyl chloroformate를 형광유도체화제로 하여 역상 HPLC법으로 정량하였다. 히스타민을 형광유도체화할 때 반응액의 pH, 반응시간, 형광유도체화제의 농도 등 최적 반응 조건을 검토하였다. 이 방법으로 히스타민을 분석한 결과 0.1~0.5ug/ml의 농도범위에서 상관계수가 0.922인 양호한 직선성을 나타내었으며 검출한계는 0.01??/ml였다. A rapid and simple method for the determination of histamine by reverse-phase high performance liquid chromatography with fluorescence detection was established. 9-Fluorenylmethyl chloroformate(FMOC) was used as fluorescent derivative reagent. The optimum conditions for the derivatiation such as pH, reaction time and he concentration of FMOC were investigated. Linearity of calibration curve was obtained between 0.1ug/ml/and 0.5ug/ml(r=0.922) and the limit of detection was 0.01ug/ml.

비내시경을 이용한 안와 내벽 골절 정복 2예

김진국,남태욱,임채형,김재영,김정석 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Traditional surgical approaches to orbital medial wall fractures are either extraocular skin incision or indirect bicoronal flap. However these methods can leave remarkable orbital scar or scalp alopecia with possible complications. Endoscopic intranasal visualization of the medial orbital wall and lamina papyracea is a technique familar to otolaryngologists. This endoscopic view allows confirmation of fracture of medial orbital wall and herniation of orbital contents. Good visualization of the fracture can facilitate the anatomic reduction of orbital contents and the proper placement of orbital implant. Two cases of medial orbital wall fracture repaired by intranasal endoscopy using silastic sheet are reported.

누룩으로부터 분리한 Rhizopus sp.이 생산하는 α-amylase의 특성에 관한 연구

김대현,김정,정소형 東國專門大學 1997 金龜論叢 Vol.4 No.1

누룩으로부터 분리한 Rhizopus sp.이 생산하는 α-amylase의 배양조건을 약간 규명하고 효소의 활성에 미치는 영향을 검토하였다. 본 효소의 생산에 미치는 최적 pH는 5.0이었으며 대수증식기 말기인 48시간부터 원활한 효소생산을 하였으며, 정지기인 배양 72시간으로 효소생성은 최대값에 도달했다. 효소활성은 각각의 금속이온에 대해 대부분 같은 성질을 나타내었으나 Ca^(++)에 의해 활성이 증가하였으며, 열에 대하여서는 매우 불안정함을 알 수 있었다.

에어로빅스 하이킥시 운동화 중저의 경도에 따른 지면반력의 변화 및 발의 안정성에 관한 연구

김태형,이기청 한국운동역학회 1996 한국운동역학회지 Vol.6 No.1

본 연구는 에어로빅스 운동 중 하이 킥 동작시 운동화 중저의 경도 변화에 따른 바른 안정성과 지면반력의 변화를 연구함으로써 적당한 운동화의 경도를 연구하는 데 있다. 피험자는 에어로빅스 운동을 하는 20대 여성 7명을 대상으로 하였으며, 운동화는 경도를 40(연질), 50(중질), 60(경질)으로 분류하였다. 지면반력과 3차원 영상분석을 통해 운동학적, 운동역학적 변인들의 측정치를 비교 분석한 결과는 다음과 같다. 첫재, 중저의 경도는 제 1 이지시 아킬레스 건각과 후족각에는 영향을 미치나 그 밖의 각도 변인에는 영향을 미치지 않았다. 그리고 경도가 작을수록 회내 운동이 크게 나타나서 후족의 안정성에는 부정적인 영향을 미쳤다. 둘재, 중저의 경도는 최대 충격력, 최대 수직 지면반력, 최대 수직 지면반력 도달 시간, 충격량, 착지 속도에는 크게 영향을 미치지 않는 것으로 나타났는데, 이러한 변인들은 단지 동작의 변화에 따라서 크게 영향을 받는 것으로 사료된다. 즉, 본 연구 결과 중저의 경도가 증가함에 따라서 발이 안정되는 경향을 나타내지만 지면반력에는 큰 영향을 미치지 않는 것으로 나타났다. This study was performed to investigate the influence of midsole hardness of aerobic shoes on motion and attenuation during high kick in order to find out the optimal midsole hardness of aerobic shoes suitable for young females. The subjects on this study were 7 young females who had experienced in aerobics. Three types of aerobic shoes with the midsole hardness of 40, 50, 60 durometers were selected. The lower leg motion during the high kick were measured using a force platform and two 16mm high speed camera. The findings of the study were as follows : 1. The midsole hardness influenced on the initial achilles tendon and rear foot pronation angles, but did not influence the the others angles. As the midsole hardness decreased, the pronation was increased. It brought the nagative effect on the rearfoot stability. 2. The midsole hardness did not influnce on maximal vertical ground reaction force and time to maximal vertical ground reaction force, impluse, take off velocity.

다양한 절삭이송속도로 가공한 A1 7075-T6 소재의 쇼트피닝 전후 피로수명에 관한 연구

김형태,이재헌,신기훈,노승남,서성원 서울産業大學校 2005 논문집 Vol.54 No.1

Aluminum alloy 7075-T6 is ideally used for highly stressed parts such as aircraft components because of its excellent strength to weight ratio. This paper presents a study on the effect of feedrate changes on the fatigue life of A1 7075-T6 specimens before and after shotpeening. For this purpose, five groups of specimens, each of which consists of eight specimens, were first machined at five different feedrates (0.05, 0.10, 0.15, 0.20 0.25mm/rev). Half of eight specimens in each group were then peened and the others remained un-peened. Finally, the fatigue life of each specimen was measured by using 4-point rotatry bending machine. In this paper, comparison of fatigue life among ten sets of specimens is presented. One observation is that the fatigue life of unpeened specimens are inversely proportional to the feedrates. On the other hand, the fatigue life of peened specimens are similarly improved regardless of feedrates except 0.05. Based on the results, it is concluded that shotpeening may improve the fatigue life of Aluminium alloy regardless of feedrates. Therefore, machining productivity may also be increased by choosing higher feedrates for structural conponents that need to be strain-hardened by shotpeening after machining

후방 비출혈 환자에서 비내시경하 전기소작술의 치료효과

김재영,이민우,김진국,한창준,남태욱,임채형 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background and Objectives : Epistaxis is a common disease from which approximately 10% of the normal population have suffered in their life. Most bleeding sites of epistaxis are located anteriorly and easily controlled. However posterior epistaxis presents significantly great problems. A number of different treatment modalities are used to control the posterior epistaxis. Although not widely practiced, the nasal endoscopic electrocautery has also been effective. The purpose of this article is to report on the efficacy of nasal endoscopic electrocautery as an alternative and adjuvant to the standard approach for control of posterior epistaxis. Materials and Methods: We conducted retrospective chart review about 19 cases of posterior epistaxis treated from January 1998 to December 1999. Group I patients were managed by nasal packing only and group II patients were managed by nasal packing and endoscopic electrocautery. Results: Hospital days were 5.9 days in the group I and 3.6 days in the group II. The duration of nasal packing was 4.1 days in the group I and 1.8 days in the group II. The results were significant statistically Conclusion: Nasal endoscopic electrocautery was an effective treatment modality for control of posterior epistaxis.

요통환자에 대한 임상적 고찰 : 한·양방 협진병원 내원 환자를 중심으로

김형태,류규수 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

With 160 lumbago patients (85 inpatients and 75 outpatients) who received both Oriental and Western medical treatment from December, 1994 to April, 1995 at the acupuncture section and rehabilitation section of the H Hurb Hospital which is located in Seoul, a clinical study on the realities of lumbago was carried out. Findings from such a study are as follows: 1. It appeared that regarding the distribution of sex, 80 lumbago patients(50%) were male while the same number of lumbago patients were female, thereby presenting a distributional rate of male and female, 1:1 ; regarding the distribution of age groups, from the age group which consists a large number of lumbago patients, they were the age group of 30s 44 lumbago patients(which is 27.5% of total lumbago patients), age group of 60s or more than that, age group of 50s, and age group of 20s ; regarding the distribution of job, from the group which consists a large number of lumbago patients, they were the group of housewives, group of the unemployed(or the aged), group of clerical workers, group of professional job, etc. 2. It appeared that the causes of the attack of lumbago are unknown etiology 56 lumbago patients(35.0%), heavy lifting 39 patients(24.4%), longtime standing 24 patients(15%), sprain 20 patients(12.5%), and accidents and contusion 11 patients(6.9%) in the order from the most case. 3. Regarding the relapse rate among the subjects, it appeared that 106 lumbago patients(66.2%) had more than relapse, and 54 patients(33.8%) were newpatients; and among the patients having more than relapse, the case of 3rd recurrence outnumbered the case of 2nd recurrence. Regarding the distribution other relapse rate according to age groups, it appeared that the most case was in the group of 60s and more than that with 28 patients(26.2%), then the next case in the group of 30s, then the case in the group of 20s, and then the case in the group of 50s. Regarding the distribution of the relapse rate according to job, it appeared that from the most case, there were 28 lumbago patients of housewives(28.0%), 27 patients(24.7%) of theunemployed(an aged population), and 19 patients(17.8%) of clerical workers. 4. Regarding the distribution of the causes of relapse, it appeared that the most case was due to unknown etiology with 43 patients(40.2%), then the next case due to heavy lifting, then due to longtime standing, then due to sprain, and then due to accidents and contusion. Regarding the distribution of the causes of relapse accoriding to age groups, it appeared that the most case was due to unknown etiology which was seen in all the age groups ; in the age group of 30s, due to heavy lifting, then due to longtime standing, and then due to sprain; and in the age group of 60s and more than that, due to heavy lifting, then due to longtime standing, and then due to contusion. Regarding the causes of relapse according to job, it appeared that the most case was due to unknown etiology or no special cause of attack ; in the group of the unemployed(an aged population), due to heavy lifting, and then due to longtime standing in the order from the most case ; in the group of service workers, due to heavy lifting, and then due to contusion ; and in the group of clerical workers, due to heavy lifting, then due to sprain, and then due to longtime standing in the order from the most case. 5. Regarding the results of the combined treatment of Oriental medicine and Western medicine, it appeared that 86 patients(53.8%) were in a superior state, 45 patients(28.1%) in a good, satisfactory state, 15 patients(9.4%) in the evenly improved state, 8 patients(5.1%) in a lightly improved state, and 6 patients(3.8%) in a poorly improved or inferior state, showing a valid rate of 96.2%. 6. Regarding the required period of medical treatment according to the case history of lumbago, it appeared that the acutest patients(82 patients : 51.3%) required 17.5days, the semi-acute(29 patients ; 18.1%) 20.9 days, the acute(10 patients ; 12.5%) 28.1 days, and the chronic(29 patients; 18.1%) 30.5 days(p=0.0874). Regarding the required period medical treatment according to the degree of the pain, 40 patients(25.2%) having an pain in a degree of an even ache required 18.2 days, 87 patients(54.6%) having a severe pain 22.6 days, 26 patients(16.4%) having a very severe pain 27.9 days, and 7 patients(4.6%) having a light pain 29.4 days(p=0.5857). 7. Regarding the period of medical treatment according to the diagnosed names of lumbago, it appeared that in Western medicine, 57 patients(35.7%) of Accute back pain required 10.1 days, 20 patients(12.4%) of Chronic back pain 24.3% days, 57 patients(37.0%) of HNP 26 days, 19 patients(11.9%) of degenerative spondylosis 26.5 days, 4 patients(2.5%) of Spondyolisthesis 33.3 days, 1 patients(0.6%) of Spinal stenosis 25.5 days(p=0.0108) ; in Oriental medicine, 29 patients(18.2%) of Shensu-zwasum lumbago 31.7% days, 46 patients(28.8%) of Shensu lumbago 25.7 days, 27 patients(16.9%) of Zwasum-yihyul lumbago 20.6 days, 55 patients(34.4%) of Zwasum lumbago 15.5 days, 2 patients(1.3%) of Yihyul lumbago 21 days, and 1 patients(0.6%) of Shi lumbago 2 days(p=0.2762). 8. Regarding the period of medical treatment according to the diagnosed names of lumbago in case of new patients and old patients(or relapsed patients), it appeared that new patients required a period of medical treatment of 18.4 days in general or average for curing lumbago while old patients required a period of 24.1 days in general or average ; this indicates that new patients were cured earlier than old patients. Regarding the period of medical treatment according to the diagnosed names of lumbago, it appeared in Oriental lumbago, when the diagnosed names was Zwasum lumbago and Yihyul lumbago, the required period of medical treatment was short ; in Western medicine, when the diagnosed name was Acute back pain, the required period of medical treatment was short ; in Western medicine, when Shensu lumbago and Shensu lumbago develop into Chronic back pain and HNP, medical treatment of them required more days ; regarding the period of medical treatment in case of new patients and old patients, new patients required a shorter period than old patients ; in particular, in case of Shensu lumbago in Oriental medicine and Chronic back pain in Western medicine, it was understandable that the required period of medical treatment necessitates more days.

과민성 방광의 개요 및 약물치료

김태형 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.3