상악동 중격 : 발생빈도, 형태 및 해부학적 중요성

장현석,임재석,권종진 고려대학교 임프란트 연구소 2000 임프란트연구지 Vol.2 No.1

It is essential to identify and localize the maxillary sinus septa in maxillary sinus lift procedure to prevent tearing of sinus mucosa. The variations and frequency of bony septa in the maxillary sinuses were studied prospectively by means of computed tomography. PATIENTS AND METHODS: The presence and morphology of the septa in the maxillary sinuses were studied in 80 non-selected adults. RESULTS:CT examinations of 160 maxillary sinuses were done. The septo were observed in patients.

가토 두개부 골결손부 우골 유도 골이식재의 이식시 농축 혈소판 혈장(Platelet-Rich Plasma:PRP)의 효과에 대한 실험적 연구

장현석,권종진 고려대학교 임프란트연구소 2001 임프란트연구지 Vol.3 No.1

There are so many cases which need grafts of bone defect as the reconstruction of post-tumor resection surgery site or trauma site, surgical management of alveolar cleft and oronasal fistula, bone grafts associated with osseointegrated implants and maxillary sinus lifting procedure. Among the method of bone defect reconstruction, that which uses the fresh autogenous bone has disadvantages that it gives also another trauma on the donor site and volume is reduced after the operation and it has limit of quantity. Another method using the commercial allogenic bone and composite bone like the Hydroxyapatite and Tricalcium phosphate has disadvantages that it takes poor tissue responses and its material works only as the passive scaffold. To gain the functional and much alveolar bone, Research is being carried recently that developing and purifying the various growth factor, applying the results of research to clinical situation. The materials promoting the bone formation are Bone Morphogenetic Protein(BMP), Platelet-Derived Growth Factor(PDGF), Transforming Gruwth Factor-beta(TGF-β). It is reported that Platelet-Rich Plasma(PRP) has PDGF, TGF-β and the abilily of promoting the bone formation. In this study, I compared the defect that have been healed naturally without any bone grafts as the control site, the other defect have been augmented only with bovine bone grafts, with another defect have been augmented with bovine bone grafts and Platelet-Rich Plasma simultaneously. I wanted to see whether much better results of bone formation on using the PRP have been gained, through the method of histologic evaluation. The results was gained as follows on the light microscopic examination. 1. The defect have been augmented with bovine bone grafts and PRP simultaneously showed the higher bone density and much bone formation than that have been augmented only with bovine bone grafts, especially on the eighth week's histologic examination. 2. Comparing the histologic specimen of the defects by the time elapse, Bone grafts with PRP simultaneously had the fastest bone growth rate among the three defects above. 3. The defect that have been heated naturally without any bone grafts had much fibrous tissue and less new bone formation. It seems that using the bone graft and PRP simultaneously on the bone defect gains the better bone healing as the above results.

골격성 제3급 부정교합환자의 하악지 시상분할 골절단술후 하안면 폭경 및 고경의 변화에 대한 두부계측 방사선학적 연구

장현석,임재석,권종진,이부규,손형민 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Purpose : The purpose of this study was to analyze the lower third facial changes in frontal view after mandibular setback surgery. Materials and Methods : In this study, fifteen subjects(6 males and 9 females) with class III dental and skeletal malocclusions who were treated with BSSRO(Bilateral Sagittal Split Ramus Ostetomy) were used. Frontal cephalometric radiographs were taken preoperatively and more than 6 months postoperatively, and hard tissue(H2-Hl) and soft tissue changes (S2-S1) were measured on vertical and horizontal reference lines. In 15 cases, changes which developed more than 6 months after surgery were studied. Results : The results were as follows. 1.In the facial height, hard tissue decreased(2.46±2.76mm) with statistical significance(P<0.01), and soft tissue also decreased(1.64±3.66mm). As a result, the facial height generally becomes shorter after sagittal split ramus osteotomy. 2.In the mandibular width, hard tissue decreased(2.08±3.59mm) with statistical sgnificance(P<0.05), but soft tissue increased (2.14±5.73mm) without statistically significant difference (P>0.05) postoperatively. 3.In the facial index, hard tissue decreased(0.23±2.21%), but soft tissue increased(2.41±3.46%) with statistical significance. Conclusion : One of the main purpose of orthognathic surgery is to achieve facial esthetics and harmony. In order to fullfill this purpose, it is important to carry out a precise presurgical treatment planning by estimating the changes of frontal profile after surgery.

전치부 개교합을 가진 골격성 제 Ⅲ급 부정교합 환자에 있어서 하악지 시상분할 골절단술후 술후 안정성에 관한 평가

임재석,권종진,장현석,손형민,남영원,최철민 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

The purpose of this study is to assess the postoperative stability and the tendency of relapse after both sagittal split ramus osteotomy in skeletal class III with anterior open bite. This retrospective study was based on the examination of 15 patients, 6 males and 9 females, with a mean age 23.1 years. The patients were divided into two groups based on the amount of preoperative overbite(group I:<1mm, group II:≥1mm). Serial lateral cephalometric radiographs were taken within 2 weeks preoperatively, within 1 week postoperatively and at a follow up period that ranged from 7 to 24 months postoperatively. All cephalometric radiographs were traced and digitized using the Quick ceph image Pro for analysis. And then, horizontal and vertical changes of reference points(B point, Pogonion, L1) were assessed by the linear measurements in millimeters on both axes. The results were as follows : 1 Mean horizontal relapses were 0.67±0.93mm (11%) at B point (P<.05) and 0.81±1.01mm (13.2 %) at Pogonion (P<.01). 2, Mean vertical relapses were 0.63±1.62mm (33.3%) at B point and 0.53±1.95mm (31.4%) at Pogonion (P>.05) 3. The mean angular change of occlusal plane to SN was 0.24±1.19 (P>.05) and that of mandibular plane to SN was 1.03±1.85 (P<.05). 4. There was correlation between the extent of preoperative overbite and the postsurgical relapse at B point and Pogonion. 5. There was no correlation between the amount of surgically produced horizontal movement and the postoperative horizontal relapse at B point.

임프란트 식립을 위한 상악동 거상술의 임상적 연구

임재석,권종진,장현석,이성재,이부규 大韓顎顔面成形再建外科學會 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.4

A variety of materials and procedures such as sinus floor elevation, sinus-lift graft, inlay bone graft using Le Fort I osteotomy, and onlay graft have been used to create adequate bone volume in the maxillary sinus for placement of endosseous implants in the posterior atrophic maxilla. Because of the frequent lack of bone in the posterior maxilla, sinus lift procedure has become a commonly practiced treatment modality. The 138 endosseous implants of 36 patients with sinus augmentation procedures performed in Korea University Hospital from January 1991 to December 1998 were summarized and analysed. The result of this study were as follows : 1. Age ranged from 39 to 57, with a mean of 50.7. 2. The mean survival rate for 138 implants with maxillary sinus lift procedure was 80.4%. 3. There was no corelationship between the fixture length, width and the survival rate. 4. The result showed that the healing period for 8-12 months was necessary if the residual alveolar bone height was less than 5mm. 5. Autogenous iliac corticocancellous block graft showed the most favorable survival rate(95%).

피브로넥틴, I형 콜라겐과 비트로넥틴이 조골세포의 이동에 미치는 영향에 대한 연구

장현석 ( Hyon Seok Jang ),임재석 ( Jae Suk Rim ),이의석 ( Eui Seok Lee ),윤정주 ( Jung Ju Yoon ) 한국조직공학과 재생의학회 2004 조직공학과 재생의학 Vol.1 No.2

Osteoblast migration as well as adhesion is important aspect of bone formation. While the significance of extracellular matrix protein cell interactions are generally appreciated, the specific relationship osteoblast interactions with adhesive extracellular matrix proteins to cell motility is not well defined. We investigated effects of adhesive extracellular proteins on the motility of ROS 17/2.8 cells. Recombinant fibronectin domain 4 (+RGD) and type I collagen promoted cell motility in a dose-dependent manner. Recombinant fibronectin domain 4 - dependent motility was inhibited by anti-1 integrin antibody and GRGDSK peptide. Type I collagen - dependent motility was inhibited anti-2 integrin antibody, demonstrating that the migration supported by these proteins is specifically regulated by their receptors. Surprisingly, vitronectin, a major adhesive protein among serum components, repressed motility. This study demonstrates that diverse mechanisms of osteoblast migration on extracellular matrices exist.

악안면 골절의 임상적 연구

장현석(Hyon-Seok Jang),남일우(Il-Woo Nam) 대한치과의사협회 1987 대한치과의사협회지 Vol.25 No.10

자동차 송풍장치용 Slotless Outer Rotor BLDC 모터 설계 및 제작에 관한 연구

이현장(Hyon-Jang Lee),정희석(Hee-Seok Jeong),조선호(Sun-Ho Cho) 한국전자통신학회 2023 한국전자통신학회 논문지 Vol.18 No.5

본 연구에서는 자동차 송풍장치용 slotless Outer Rotor BLDC 모터를 설계하고 제작하여 기존의 모터들의 단점을 개선하였다. 제안된 모터는 Brush를 제거하여 회전 시 DC 모터의 기계적 마찰에 의한 소음을 해결하고, 구조적으로 Slotless Air-Gap 권선을 사용하여 BLDC 모터 슬롯에 의해 발생되는 코깅 토크를 개선하였다. 그리고 외부 회전자에 Magnet을 부착시키고 내부 회전자와 동시에 회전하기 때문에 자속의 변화가 생기지 않아 구조적으로 철손을 원천적으로 줄여 높은 효율을 가진다. In this paper, a slotless outer rotor BLDC motor for a vehicle blower was designed and manufactured to improve the disadvantages of general motors. The proposed motor solves the noise caused by mechanical friction of DC motor during rotation by removing the brush, Also, slotless air-gap windings are used to improve cogging torque by BLDC motor slots. Then, the motor has a structure in which a magnet is attached to the external rotor and rotates simultaneously with the internal rotor, there is no change in magnetic flux. Therefore, it has high efficiency by fundamentally reducing iron loss.

Placenta Derived Mesenchymal Stem Cells in Combination with Polycaprolactone-20% Tricalcium Phosphate Scaffolds for the Treatment of Critical-Sized Defects of the Mandible

( Eui Seok Lee ),( Byoung Moo Seo ),( Jae Suk Rim ),( Hyon Seok Jang ),( Jong Jin Kwon ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.3

Objectives: Polycaprolactone-20% tricalcium phosphate (PCL-TCP) polymers allow for cellular adherence and differentiation and are adequate scaffolds for bone regeneration in tissue engineering strategies. The placenta contains multipotent stem cells. This study evaluated the utility of placenta derived mesenchymal stem cells (PDMSCs) seeded onto PCL-TCP scaffolds for bone tissue engineering. Materials and Methods: PDMSCs were isolated from placenta. PCL-TCP scaffolds with PDMSCs were implanted in full-thickness mandibular bone defects (2×2 cm) in minipigs. In the first experimental group, defects were treated with amnion-derived MSCs placed onto the scaffold, whereas in the second experimental group, defects were treated with deciduas-derived MSCs placed onto the scaffold. As a control, a third defect was treated with the scaffold only. Histological and radiographic examinations were performed twelve weeks post-implantation. Results: Soft radiographic measurements showed that experimental groups had twice the bone density of control group. Experimental groups had a statistically significant increased bone regeneration potential compared to control group in mandibular bone defects in minipigs. Micro CT showed that experimental groups had higher levels of percent of regenerated volume fraction, regenerated bone volumes and regenerated bone surface than control group. The histologic examination revealed the presence of regenerated bone at the central area of defect. Conclusion: PDMSCs seeded into the PCL-TCP scaffolds enhance bone regeneration in mandibular defects. Therefore PCL-TCP scaffold with placenta derived mesenchymal stem cels can increase bone regeneration.

A Study On The Osteogenic Differentiation Of Adipose-Derived Adult Stem Cell

( Eui Seok Lee ),( Hyon Seok Jang ),( Jong Jin Kwon ),( Jae Suk Rim ) 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.2S