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( Hyojae Kang ),( Bumhee Yang ),( Bin Hwangbo ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Tyrosine kinase inhibitor (TKI) could be a good treatment option for lung cancer patients, especially who have EGFR mutation. However, drug induced pneumonitis is rare but serious adverse effects of TKI. In this study, we reviewed the incidence, clinical characteristics, and risk factors of TKI-induced pneumonitis. Methods: A retrospective study was performed including patients who were treated with a TKI (Gefitinib or Erlotinib) in the non-small cell lung cancer at National Cancer Center between January 1, 2011 and December 31, 2015. We reviewed the clinical data including initial laboratory data, pulmonary function test, computed tomography images. And we researched the incidence, characteristics, methods of treatment, and prognosis of the drug-induced pneumonitis. Results: In total, 1,849 patients were included (1103 for Gefitinib only, 547 for Erlotinib only, 199 for both Gefitinib and Erlotinib). Drug-induced pneumonitis were identified in 32 patients (1.73%). Among them, twenty-two patients (68.8%) were treated in the admission state, and one patient was admitted to intensive care unit. Most of them were treated with steroid (n=24, 75.0%), and the mean duration of steroid treatment was 14.0 days. When we compared the drug-induced pneumonitis group (32 patients) with the non-pneumonitis group (1817 patients), male patients showed higher risk for the pneumonitis than female patients (75.0% vs. 52.0%, p<0.01). The smoking history was the risk factor of drug induced pneumonitis (78.1% vs 48.7%, p<0.01). Underline idiopathic pulmonary fibrosis was related with the risk factor of TKI-induced pneumonitis (6.2% vs. 0.8%, p=0.0014). Other pulmonary diseases were not related the risk factor of drug induced pneumonitis, including chronic obstructive pulmonary disease, bronchiectasis, tuberculosis or status of pulmonary function test. Conclusions: Drug-induced pneumonitis of TKI was related with the male sex, smoking history, and underline idiopathic pulmonary fibrosis in our study.
Kang, Do-Yu,Cheon, Kyeong-Seong,Oh, Jun,Oh, Hyoja,Kim, Song Lim,Kim, Nyunhee,Lee, Eungyeong,Choi, Inchan,Baek, Jeongho,Kim, Kyung-Hwan,Chung, Nam-Jin,Ji, Hyeonso MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.10
<P>Bakanae disease (BD), caused by the fungal pathogen Fusarium fujikuroi, has become a serious threat in rice-cultivating regions worldwide. In the present study, quantitative trait locus (QTL) mapping was performed using F2 and F3 plants derived after crossing a BD-resistant and a BD-susceptible Korean japonica rice variety, ‘Samgwang’ and ‘Junam’, respectively. Resequencing of ‘Junam’ and ‘Samgwang’ genomes revealed 151,916 DNA polymorphisms between the two varieties. After genotyping 188 F2 plants, we constructed a genetic map comprising 184 markers, including 175 kompetitive allele-specific PCR markers, eight cleaved amplified polymorphic sequence (CAPS) markers, and a derived CAPS (dCAPS) marker. The degree of BD susceptibility of each F2 plant was evaluated on the basis of the mortality rate measured with corresponding F3 progeny seedlings by in vitro screening. Consequently, qFfR9, a major QTL, was discovered at 30.1 centimorgan (cM) on chromosome 9 with a logarithm of the odds score of 60.3. For the QTL interval, 95% probability lay within a 7.24-7.56 Mbp interval. In this interval, we found that eight genes exhibited non-synonymous single nucleotide polymorphisms (SNPs) by comparing the ‘Junam’ and ‘Samgwang’ genome sequence data, and are possibly candidate genes for qFfR9; therefore, qFfR9 could be utilized as a valuable resource for breeding BD-resistant rice varieties.</P>
S-614 A case of intracavitary pulmonary aspergillosis treated with instillation of voriconaz ole
( Hyein Lee ),( Bin Hwangbo ),( Hyojae Kang ),( Joohae Kim ),( Young Ju Choi ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Medical Treatment of symptomatic intracavitary pulmonary aspergillosis is difficult. Oral or intravenous anti-fungal agents have limited roles. Bronchial artery embolization or surgery is considered for intractable hemoptysis. Intracavitary instillation of amphotericin B through the per cutaneous catheter has been attempted for pulmonary aspergillosis with hemoptysis, showing favorable short-term outcome. We experienced a case of a 69-year-old man with chronic infection of aspergillosis in a huge right upper lobe cavity which was developed after endobronchial brachy-therapy. The patient complained chronic cough and cheat pain. Treatment with systemic voriconalzole and bronchoscopic intracavitary instillation of amphotericin B was failed. Fungal colonies were disappeared after treatment with instillation of voriconazole through fiberoptic bronchoscopy. This is the first case report of intacavitary aspergillosis treated with bronchospcic instillation of voriconazole.
MutMap 분석에 의한 벼 왜성 돌연변이 계통의 변이 유전자 탐색
오준(Jun Oh),천경성(Kyeong-Seong Cheon),강도유(Do-Yu Kang),김송림(Song Lim Kim),이은경(Eungyeong Lee),김년희(Nyunhee Kim),오효자(Hyoja Oh),최인찬(Inchan Choi),백정호(Jeongho Baek),윤인선(In Sun Yoon),김경환(Kyung-Hwan Kim),정남진(Nam-J 한국육종학회 2020 한국육종학회지 Vol.52 No.1
A dwarf mutant rice line was selected from an Ac/Ds insertion mutant population and named dwf1. The phenotype of F1 and F2 plants derived from a cross between dwf1 and Dongjin indicated that a single recessive gene is responsible for the mutant phenotype, and we named this gene dwf1. Resequencing of the dwf1 line and Dongjin (wild type) revealed 42,386 homozygous single nucleotide polymorphisms (SNPs) between dwf1 line and Dongjin. MutMap analysis was performed by sequencing a DNA pool prepared from 100 mutant type plants in the dwf1/Dongjin F2 population, and it was found that the dwf1 gene was located in the 23 ~ 30 Mbp region on chromosome 4. In this region, we found a non-synonymous SNP in the Os04g0469800 gene, which was reported as D11 gene encoding a cytochrome P450 family protein involved in the biosynthesis of brassinosteroids (BRs). This SNP was regarded as the causative SNP for the dwf1 phenotype, and the dwf1 gene is a novel allele of D11. We performed mapping of the dwf1 gene with five SNP markers on chromosome 4 with 190 dwf1/Dongjin F2 plants. The phenotype of F2 plants was completely co-segregated with genotypes of the J10402 marker, which was developed based on the non-synonymous SNP in the D11 gene. These results will contribute to the study of the molecular biological functions of the D11 gene and BRs.
하이브리드 지중열교환기 적용 지열 히트펌프 시스템의 난방 성능
손병후(Byonghu Sohn),김광수(Kwng-Soo Kim),강성재(Sungjae Kang),임효재(Hyojae Lim) 대한설비공학회 2020 대한설비공학회 학술발표대회논문집 Vol.2020 No.6
This paper presents the measurement and analysis results of the heating performance of a ground-source heat pump(GSHP) system using vertical ground heat exchanger(VGHE) and surface water heat exchanger(SWHE). In order to measure the heating performance of the system, we installed monitoring equipment including sensors for measuring temperature and power consumption, and then measured operation parameters. From measurement results, we analyzed the effect of combination ratios of the HGHE on the performance of the system. The average heating coefficient of performance(COPh) of the heat pump was 3.86, while the entire system was 2.78 over the measurement period. In steady state, COPh was slightly decreased with an decrease of entering source temperature. In addition, the application of HGHE was beneficial to the system performance; however, further research are needed to optimize the design data.
( Kyeong-seong Cheon ),( Jeongho Baek ),( Young-il Cho ),( Young-min Jeong ),( Youn-young Lee ),( Jun Oh ),( Yong Jae Won ),( Do-yu Kang ),( Hyoja Oh ),( Song Lim Kim ),( Inchan Choi ),( In Sun Yoon ) 한국육종학회 2018 Plant Breeding and Biotechnology Vol.6 No.4
Genome resequencing by next-generation sequencing technology can reveal numerous single nucleotide polymorphisms (SNPs) within a closely-related cultivar group, which would enable the development of sufficient SNP markers for mapping and the identification of useful genes present in the cultivar group. We analyzed genome sequence data from 13 Korean japonica rice varieties and discovered 740,566 SNPs. The SNPs were distributed at 100-kbp intervals throughout the rice genome, although the SNP density was uneven among the chromosomes. Of the 740,566 SNPs, 1,014 SNP sites were selected on the basis of polymorphism information content (PIC) value higher than 0.4 per 200-kbp interval, and 506 of these SNPs were converted to Kompetitive Allele-Specific PCR (KASP) markers. The 506 KASP markers were tested for genotyping with the 13 sequenced Korean japonica rice varieties, and polymorphisms were detected in 400 KASP markers (79.1%) which would be suitable for genetic analysis and molecular breeding. Additionally, a genetic map comprising 205 KASP markers was successfully constructed with 188 F2 progenies derived from a cross between the varieties, Junam and Nampyeong. In a phylogenetic analysis with 81 KASP markers, 13 Korean japonica varieties showed close genetic relationships and were divided into three groups. More KASP markers are being developed and these markers will be utilized in gene mapping, quantitative trait locus (QTL) analysis, marker-assisted selection and other strategies relevant to crop improvement.