하악골에 발생한 다발성 중심성 골종 : 증례보고 REPORT OF A CASE

전효상,이문희,정해송,이동근,김성곤,조병욱 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

Osteomas are benign tumor composed of mature compact or cancellous bone. Generally, they are classified as peripheral(periosteal) osteoma and central(endosteal) osteoma by origin. Osteomas are essentially restricted to the craniofacial skeleton and are rarely diagnosed in other bones. Most jaw osteomas are detected in young adults and are generally asymptomatic, solitary lesion. The authors present a case of a endosteal osteoma of the mandible. The lesion was located beneath both the mandibular first premolars, about 2.5㎝×1.5㎝ size. Surgical excision of the lesion was performed and we obtained good result after operation.

비소세포폐암에서 Microsatellite Instability

전효성,김정란,손지웅,박선하,박태인,김창호,김인산,정태훈,박재용 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1

연구베경:MMR 유전자의 불활성화에 의해 야기되는 뮤전적 불안정성은 발암기전의 한 부류로 인정되고 있다.저자들은 비소세포폐암의 발암과정에서의 MSI의 역할을 규명하기 위해 비소세포폐암에서 MSI의 빈도 및 MSI 유무에 따른 임상상의 차이를 조사하였다. 대상 및 방법:근치적 절제술을 받은 비소세포폐암 20예를 대상으로 하였다.동결된 폐암조직과 환자의 림프구에서 DNA를 추출한 후 3P와 9p의 15개의 marker들을 대상으로 PCR을 시행하고 7% polyacrylamide gel에서 전기영동한 후 silver 염색을 시행하였다. 암조직과 림프구 DNA의 PCR product의 band를 비교하여 MSI와 LOH를 판정하였다. 결과:1)대상환자들은 남자 19예,여자 1예였으며 모두 흡연자였고 평균 흠연력은 47 갑년이었다. 폐암의 조직형은 편평상피암 15예, 선암 4예,대세포암 1예였고, 술 후 병리학적 병기는 Ⅰ기 6예,Ⅱ기 5예, ⅢA기 7예,ⅢB기 2예였다. 2)20예 가운데 8예(40%)에서 MSI가 관찰되었으며 3예는 한 개의 marker에서,5예는 2개 이상의 marker에서 MSI가 관찰되었다. 3)LOH는 10예(50%)에서 있었으며,LOH유무에 따른 병가 및 흡연력의 차이가 없었다. 4)분석한 marker의 10% 이상에서 MSI가 관찰된 MSI-L종양은 5예였으며, 대부분의 marker에서 MSI양성인 MSI-H종양은 없었다.MSS종양과 MSI-L종양은 흡연력, 병기, 폐암 조직형 및 LOH 빈도의 유의한 차이가 없었다. 결론:비소세포폐암에서 MSI는 비교적 흔히 관찰되지만 MMR 유전자의 불활성화에 의한 MMP pathway 는 비소세포폐암의 주요 발생기전은 아닐 것으로 생각된다.향 후 비소세포폐암의 발암과정에 있어서 MMP pathway의 역할을 규명하기 위해서는 보다 많은 예를 대상으로 한 연구가 필요할 것으로 생각되며, MSI 발생기전에 관한 추가적인 연구가 필요할 것으로 생각된다. Purpose: Microsatellite instability(MSI) is frequently used as an indicator of microsatellite mutator phenotype (MMP) tumors.MSI has been observed in a percentage of non-small cell lung cancer(NSCLC).However, its role in tumorigenesis of NSCLC remains unknown.The frequency and partten of MSI in NSCLC were evaluted and clinical parameters of MSI-positive tumors with those of MSS(microsatellite stable) tumors were compared. Materials and Methods: Twenty surgically resected NSCLCs were analyzed for 15 microsatellite markers located at chromosomes 3p and 9p.The peripheral blood lymphocytes of patients were used as the source of the normal DNA. Results:1) of 20 cases, 8(40%) demonstrated MSI. 2) Instability was observed more frequently in tri- and tetra-nucleotide repeats that in dinucleotide repeats. In all cases, instability appeared as a shift of individual allelic bands. 3) LOH was observed in 10(50%) of 20 tumors analyzed. 4) Of 20 cases, MSI-H tumor(showing MSI in the majority of markers) was absent. There were 5 MSI-L tumors( showing MSI in a greater than 10% of markers). 5) No significant difference was observed between MSI-L tumors and MSI negative tumors in terms of clinicopathologic features such as pack-year history of smoking, histologic subtype, and (delete) stage of disease.There was also no significant difference in the incidence of LOH in relation to the status of MSI. Conclusion: These data strongly suggest that MSI plays different roles in lung and colon cancer.MMP pathway appears to be far less important in the tumorigenesis of NSCLC, caused mainly by cigarette smoke, with little familial tendency.(tuberculosis and Respiratory Diseases 2000,48:24-32)

다발성 장 천공을 동반한 베체트병 - 1예 보고 -

윤효영,이상전,송영진 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.2

加味金櫃腎氣丸의 抗癌 및 抗轉移 效果에 關한 硏究

김용태,전영수,김정효,김성훈 대한한방종양학회 1999 대한한방종양학회지 Vol.5 No.1

To evaluate the antitumor activity and antimetastatic effats of Kamigumgusingihwan(KGSH) studies have ken dom. The results were obtained as follows: 1. KGSH extras exhibited a weak cytotoxicity against A549, SK-OV-3, B16-F10, and SK-MEL-2 cell lines. But exhibited potent cytotoxicity against P388 cell line in a dose-dpendent manner. 2. The concentration inhibiting adhesion of A549 to complex extracellular maMx up to below 30% of control was recognized at 10^-3g/ml of KGSH 3. KGSH extrats showed a wed inhibitoty effect on DNA topo- isomerase I from calf thyus. 4. The T/C% wa 137% in KGSH treated group in S-180 bearing ICR mice. 5. In pulmonary colonization assay. a number of colonies in the lungs were decreased sigruncanny in KGSH treated group as compared with control group. 6. In hematological changes in Bl6-BL6 injected C57BL/6, numbers of WBC were decreased insignificantly in KGSH treated groups, and also those of platelet were inoeased insignificantly in KGSH treated groups as compared with control. 7. In CAM asay, KGSH extracts inhibited angiogenesis at 15ug/egg concentration significantly as compared with control. Taken together these results, it is strongly demonstrated that KGSH significantly suppressed tumor metastasis by blpcking cell adheion to exuaalula matrix. Therefore. KGSH is expected to be clinically a potem antimetastatic drug for the prevention and treatment of cancer.

대학생을 위한 예비 부모 교육 프로그램 개발을 위한 연구

윤기영,전효숙,박상임,이미숙,이석란,박수옥 서원대학교 학생생활연구소 1998 학생생활연구 Vol.16 No.-

The purpose of this study are to examine reference materials, existing lecture analysis, investigate how student response about new lecture model and to project the basic direction of pre-parent education program. The result of this study are as follows ; <Lecture Model : Parent and Child> Sequence Theme 1 Introduction, Positive Self-Concept 2 Love and Sex 3 Friends versus Lovers 4 Marriage 5 Parenting and Parent's Role 6 Pregnancy and Embriology 7 Brith 8 Middle Term Exam 9 Parent's Role for Infant and Toddler 10 Parent's Role for Child 11 Parent's Role for Youth 12 Society and Environment for Child Care 13 Communication for Parent-Child 14 Problem solving method for Child Care 15 Parent in Future 16 Final Exam

여성에 있어서 연령 및 생리주기가 대장통과시간에 영향을 미치는가?

송영진,이상전,윤효영 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.1

20대에서 60대까지의 병력상 장운동 장애가 없는 여성 43명(50세미만으로서 생기주기가 규칙적이고 검사기간동안 나포기에 있는 자 13명, 황체기에 있는자 15명, 50세이상으로서 폐경기이후인 자 15명)을 대상으로 방사선 비투과표지를 수회 투여하는 방법을 사용하여 대장 통과시간을 측정하여 다음과 같은 결과를 얻었다. 1) 우측결장 11.2 ±2.2시간, 좌측결장 9.5 ±1.1시간, 직장 및 에스상결장 10.7 ±1.9시간, 전 대장 31.3 ±2.8시간이었다. 2) 50세미만 군은 우측결장 10.9 ±1.2시간, 좌측결장 9.9 ±1.3시간, 직장에스상결장 및 직장 9.9 ±2.3시간, 전 대장 30.7 ±3.0시간이었고, 50세이상군은 우측결장 11.5 ±1.9이상, 좌측결장 8.8 ±0.8시간, 직장 및 에스상결장 12.1 ±2.0시간, 전 대장 32.4 ±2.4 시간으로 양군간에 유의한 차이가 있었다(p<0.05). 3) 난포기 여성군은 우측결장 11.1 ±7시간, 좌측결장 8.6 ±1.2시간, 직장 및 에스상결장 10.4 ±1.3시간, 전 대장 30.1 ±2.4 시간이었으며, 황체기 여성군은 우측결장 10.8 ±1.2시간, 좌측결장 11.0 ±2.1시간, 직장 및 에스상결장 9.5 ±0.8시간, 전 대장 31.3 ±4.2 시간으로 좌측결장에서는 황체기가 난포기보다 통과시간이 유의하게 길었으나(p<0.05), 전체 대장 통과시간에는 유의한 차이가 없어(p>0.05) 생리주기상의 시기에 따른 차이가 없었다(p>0.05). 이상의 결과로부터 노인화에따라 대장 통과시간이 길어짐을 알 수 있었으나 생리주기에 따른 대장통과시간의 차이는 발견할 수 없었다. 따라서, 여성에 있어서 노인화에 따른 변비는 대장통과시간의 지연과 관련이 있을지 모르나, 생기주기에 따른 변비증상의 발현은 대장통과시간의 지연과는 관련이 없음을 시사한다. 아울러 이는 황체기가 변비 증상의 심한 정도와 관련이 있을지 모르지만 그 변화 양상은 장 평활근에 대한 progesterone의 영향과는 연관이 없음을 시사하고 있다. To ellucidate the effect of age and the phase of a menstrual cycle in women on the segmental or/and total colonic transit time, mean colonic transit time was measured in 43 women(13 in the follicular phase, 15 in the luteal phase, and 15 of the postmenopause) between 3rd decade and 7 the decade. All had complained of no functional gastrointestinal symptoms, and premenopausal women have regular menstrual cycles. Multiple bolus techniques of radioopaque markers were used by taking twenty markers for three consecutive days, and then two abdominal films on the day 4th. and 7th. The results were as follows : 1) Mean transit time was 11.2 ±2.2 hours in right colon, 9.5 ±1.1 hours in left colon, 10.7 ±1.9 hours in rectun and sigmoid colon, and 31.3 ±2.8 hours in total colon. 2) Mean transit time under age 50 was 10.9 ±1.2 hours in right colon, 9.9 ±1.3 hours in left colon, 9.9 ±2.3 hours in rectum and sigmoid colon, and 30.7 ±3.0 hours in total colon, while over age 50 they were 11.5 ±1.9 hours in right colon, 8.8 ±0.8 hours in left colon, and 12.1 ±2.0 hours in rectum and sigmoid colon, and 32.4 ±2.4 hours in total colon, which showed statistically differences in rectum and sigmoid colon, and total colon(p<0.05). 3) Mean transit time of women in the follicular phase were right colon 11.1 ±7 hours, left colon 8.6 ±1.2 hours, rectum and sigmoid colon 10.4 ±1.3 hours, and total colon 30.1 ±2.4 hours, in the luteal phase were right colon 10.8 ±1.2 hours, left colon 11.0 ±2.1 hours, rectum and sigmoid colon 9.5 ±0.8 hours, and total colon 31.3 ±4.2 hours. Although transit hour in the left colon was longer in the luteal phase than in the follicular phase, no significant difference was found in the total colon transit time(p>0.05). These results showed mean colon transit time prolongs as women become older, but is not affected by the specific phase in a menstrual cycle.

북한이탈주민의 외상 후 스트레스 장애와 자연살해세포 활성

김병창,정성훈,임효덕,최종혁,전정희,전양환 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : The objective of this study was to evaluate an association between posttraumatic stress disorder (PTSD) and altered immunity m North Korean defectors who were more likely to develop medical conditions and other stress-related psychiatric disorders. Methods : Twenty-four North Korean defectors with PTSD and twenty-two controls without PTSD were recruited from the resettlement and training center for North Korean defectors in South Korea. Peripheral T lymphocyte subsets, natural killer(NK) cells, NK cell activity and plasma hormones (ACTH and cortisol) were obtained from all subjects. We also applied the Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) for all subjects. Results : We found NK cell activity was relatively lower than number of NK cells in North Korean defectors with PTSD. Subjects with PTSD had higher HAM-D and HAM-A scores than controls. However, there were no statistical differences in ACTH. cortisol, CD3, CD4, CD8, CD4/CD8 ratio, CD19 and CD56 between the two groups. Conclusion : These findings suggest North Korean defectors with PTSD show higher levels of depression, anxiety and impaired or weak immune function in NK cells.

염산에 의한 부식성 위염에 동반된 고도 이형성증 1예

김한성,박성혜,전영빈,장석효,김용일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

A 80 year-old man ingested hydrochloric acid as suicidal purpose and as a result developed an epigastric fullness and pain. Marked stricture of esophagogastric junction and gastric outlet were found by endoscopic examination after 20 days of admission. A total gastrectomy and Roux-en-Y esophagojejunostomy was performed. Grossly, resected stomach revealed redness and erosion especially over antrum and pylorus. On cross section, a flat elvated lesion measuring 0.7×0.5 cm was incidentally found on high body along lesser curvature. On microscopic examination, the mass consisted of atypical epithelial glands having increased cellularity and round hyperchromatic nuclei without invasive foci. The lesion was diagnosed with ‘epithelial dysplasia, high grade’. Corrosive gastritis and submucosal epithelial heterotopia were found in surrounding mucosa also.

Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향

김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.

Cisapride가 금식기 담낭의 수축운동에 어떤 영향을 미치는가?

송영진,장이찬,윤효영,이상전 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1

Cisapride의 식사후 담낭의 수축운동에 대한 영향을 규명하고자 20-30대의 건강인 12명(남자 6명, 여자 6명)을 대상으로 placebo, cisapride 10㎎ 혹은 20㎎을 경구복용한 후 담낭체적의 변화를 초음파로 측정하여 다음과 같은 결과를 얻었다. Placebo를 복용한 군에서는 검사기간중 완만한 체적의 변동이 있었으나, cisapride를 복용한 후에는 담낭체적이 지속적으로 현저하게 증가되었다. 이러한 담낭체적의 증가는 placebo를 복용한 군과 비교해 볼 때, cisapride 10㎎을 복용한 군에서는 60분후부터, 20㎎을 복용한 군에서는 50분후부터 통계학적 유의성이 있었으며(p<0.05), 이러한 경향은 검사종료시까지 지속되었다. 그리고 최대체적은 cisapride 10㎎을 복용한 군에서는 120분후에 최초체적의 145%에, cisapride 20㎎을 복용한 군에서는 90분후에 최초체적의 162%에 도달하였다(Fig. 2). 한편 체적곡선 아래의 면적은 cisapride 10㎎을 복용한 군은 31325 ±2518, 20㎎을 복용한 군은 33355 ±4726로, placebo를 복용한 군(23510 ±2864)보다 유의하게 컸다(p<0.05) 이상의 결과에서 cisapride의 경구섭취는 금식기 담낭의 수축운동을 억제하는 이완효과가 있음을 알 수있었다. 그리고 이러한 담낭수축억제효과는 장기간 cisapride를 복용하는 환자에서 담석형성이 촉진되는 효과가 있을 수 있고, 반대로 담석존재시 선통 발작을 억제하거나 예방하는 효과가 있을 수도 있다는 것을 시사한다. Cisapride(C23H29CIFN304) is one of the well-known prokinetic agents. It operates upon whole gastrointestinal tract, from lower esophageal sphincter to anal sphincter, and holds the most promise for patients with colonic motility disorders. It is known to function as an indirect cholinergic stimulant through increased release of acetylcholine in the intramural plexuses. Unlike metoclopramide, it does not have the antidopaminergic effects on the central nervous system. But its effect on the biliary system is not clearly elucidated. This study was performed in 12 healthy volunteers, and focused on the change of gallbladder volume after cisapride ingestion during fasting period. With the interval of 2-4days, placebo, 10㎎ or 20㎎ of cisapride were given. Cisapride inhibited the contraction of gallbladder compared with placebo. The results suggest that cisapride can induces the possible cholelithiasis, but, on the other hand, it can be used as the possible spasmolytic agent in the gallstone disease.