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( Hye Young Jwa ),( Yoo Kyung Cho ),( Eun Kwang Choi ),( Heung Up Kim ),( Hyun Joo Song ),( Soo Young Na ),( Sun Jin Boo ),( Seung Uk Jeong ),( Bong Soo Kim ),( Byoung Wook Lee ),( Byung Cheol Song ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.1
Recent studies suggest that liver cirrhosis is reversible after administering oral nucleos(t)ide analogue therapy to patients with hepatitis B virus (HBV) infection. However, few studies have addressed whether esophageal varices can regress after such therapy. We report a case of complete regression of esophageal varices during entecavir therapy in patients with HBV-related liver cirrhosis, suggesting that complications of liver cirrhosis such as esophageal varices can regress after the long-term suppression of HBV replication. (Clin Mol Hepatol 2016;22:183-187)
( Hye Young Jwa ),( Jonghoo Lee ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: Although prior hospitalization has been considered as a risk factor for infection with PDR pathogens in patients with CAP, the evidence is limited, We aimed to elucidate the clinical impact of PH on these patients. Methods: This retrospective observational cohort study with prospectively collected data was conducted at Jeju National University Hospital between January 2012 and December 2014. Propensity scores were constructed, and the clinical outcomes were compared. We also conducted subgroup analyses. Results: A total of 704 patients were identified. Patients with PHAP had more comorbidities than those with CAP. The median CURB-65 and PSI scores were higher in patients with PHAP than in those with CAP. After matching according to propensity scores, the baseline characteristics of the PHAP group were similar to those of the CAP group. The isolation rate of PDR pathogens as well as the 30-day and total in-hospital mortality did not differ between the PHAP and propensity score-matched CAP patients. PHAP patients with prior antibiotic use or duration of PH > 10 days showed significantly higher isolation rates of PDR pathogens. Multivariate logistic regression analysis demonstrated that prior antibiotic use was associated with the isolation rate of PDR pathogens. Conclusion: PH itself might not be related with higher isolation rates of PDR pathogens or mortality in patients with CO-pneumonia. It seems reasonable that broad spectrum antibiotic therapy for PDR pathogens should be selectively applie to PHAP patients with prior antibiotic use.
Kim, Jwa-Young,Yang, Byoung-Eun,Ahn, Jin-Hee,Park, Sang O,Shim, Hye-Won The Korean Academy of Prosthodonitics 2014 The Journal of Advanced Prosthodontics Vol.6 No.6
PURPOSE. Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-$Gide^{(R)}$) using a rat calvarial defect model. MATERIALS AND METHODS. Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72). The study groups were divided into a control group (no membrane) and two experimental groups (SF membrane and Bio-$Gide^{(R)}$). Each group of 24 samples was subdivided at 2, 4, and 8 weeks after implantation. New bone formation was evaluated using microcomputerized tomography and histological examination. RESULTS. Bone regeneration was observed in the SF and Bio-$Gide^{(R)}$-treated groups to a greater extent than in the control group (mean volume of new bone was $5.49{\pm}1.48mm^3$ at 8 weeks). There were different patterns of bone regeneration between the SF membrane and the Bio-$Gide^{(R)}$ samples. However, the absolute volume of new bone in the SF membrane-treated group was not significantly different from that in the collagen membrane-treated group at 8 weeks ($8.75{\pm}0.80$ vs. $8.47{\pm}0.75mm^3$, respectively, P=.592). CONCLUSION. SF membranes successfully enhanced comparable volumes of bone regeneration in calvarial bone defects compared with collagen membranes. Considering the lower cost and lesser risk of infectious transmission from animal tissue, SF membranes are a viable alternative to collagen membranes for GBR.