중등 컴퓨터과학교육을 위한 객체지향형 EPL '두리틀'의 적용 및 평가

권대용,길혜민,염용철,유승욱,進兼宗,靖久野,이원규 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.6

제 7차 컴퓨터교과 교육과정은 소프트웨어 활용 부분에 치중되어 컴퓨터과학에 관한 원리교육이 이루어지지 못하고 있다. 한편, ACM K-12 컴퓨터과학 교육과정 모델에 관한 보고서에서는 현재의 컴퓨터교육이 그릇된 방향이며 컴퓨터과학 중심의 컴퓨터교육을 위해서 프로그래밍언어 교육을 통한 원리교육의 중요성을 강조하고 있다. 본 논문에서는 프로그래밍 체험학습을 위한 객체지향 기반의 새로운 교육용프로그래밍언어인 두리틀(Dolittle)을 소개한다. 두리틀은 간결한 구문과 한국어와의 대응성, 인크리멘탈 방식의 프로그래밍, 수치, 문자열, 배열과 같은 알고리즘과 구조화, 텍스트 위주의 프로그래밍 등의 설계방침을 적용한 언어이다. 중학생을 대상으로 실제 수업에 적용해 보고 학습효과를 분석한 결과, 객체지향기반이지만 클래스나 상속 등의 개념을 모르고도 활용 가능한 교육용프로그래밍언어라는 것을 확인할 수 있었다. 또한 객체와 메소드 활용을 통하여 프로그래밍 결과를 쉽게 확인할 수 있고 오류 수정이 용이하므로, 학생들의 높은 흥미도를 유지하면서 학업성취도를 향상시키고 차후 학습으로의 연계가 수월하였다. Current computer education is difficult to educate basic concepts and principals of the computer science because the 7th curriculum of computer education is focused on the application of software. According to the ACM K-12 report about the computer science education model, current computer education is taking the wrong way and we should put the highly priority on the education of the fundamentals through programming languages for a better computer education oriented to the computer science. This paper introduces a new object-oriented educational programming language "Dolittle'". The design principals of Dolittle are simple syntax of Korean, incremental programming, text based programming, aliasing of function, and object-oriented programming. Being applied to middle school classes, we can confirm that Dolittle is easy to learn, and gives rise to high interest and keeps interest through a course,and also is of great practical use in class for programming novice.

Tree Ring Growth of Clones in a Seed Orchard of A. nephrolepis during Drought Periods

Hye-Jin Lee,Sang-Jin Yoon,Seonjeong Kim,Sun-Cheon Hong,Dayoung Lee,Tae-Lim Yeo,Yoonji Hahn,Gye-Hong Cho,Yang-Gil Kim,Kwang Hyun Nam,Hyunjoong Sung,En-Bi Choi,Jun-Hui Park,Jeong-Wook Seo,Kyu-Suk Kang 한국육종학회 2023 한국육종학회 공동학술발표집 Vol.2023 No.-

[P3-10] Preparation of Accelerated Salt-fermented Anchovy Sauce Added with Shrimp Byproducts

Hye Suk Kim,Soo Kyeong Yang,Chan Ho Park,Byung Wook Han,Kyung Tae Kang,Min Soo Heu,Jin-Soo Kim,Youn Eon Sye,Seung- Gil Ji 한국식품영양과학회 2005 한국식품영양과학회 학술대회발표집 Vol.2005 No.10

An Outbreak of Food Borne Illness Due to Methomyl Pesticide Intoxication in Korea

Gil, Hyo-Wook,Jeong, Mi-Hye,Park, Jung Soo,Choi, Hwan-Won,Kim, So-Young,Hong, Sae-Yong The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.11

<P>On February 21, 2013, 6 elderly people collapsed abruptly after eating bean sprout bibimbab (boiled rice mixed with bean sprouts and seasoned with soybean sauce) at a countryside restaurant in the Chungbuk Province, Korea. Minutes after eating the meal, all of the patients lapsed into a state of stupor. Respiratory arrest developed in 2 patients; and one of two patients died of cardiac arrest. The autopsy identified methomyl and methanol in the deceased patient's gastric contents and in the remaining soybeanbean sauce seasoning. Five of the 6 patients ingested one spoonful of the soybeanbean sauce seasoning and survived, while one patient who died of cardiac arrest, ingested approximately two spoons. Symptoms of toxicity presented quickly in the subjects and progressed rapidly, including chest tightness, an unusual sensation in the pit of the stomach, dizziness, ataxia, and finally, collapse. Three patients who drank ethanol with the meal experienced only mild toxic symptoms. Our analysis of the clinical observations in these cases suggests that ingestion of methomyl pesticide and the additive toxicity of methanol may have been responsible for the intoxication.</P>

S-86 Case of Primary Aortoenteric Fistula to Proximal Rectum

( Seo Hye Kang ),( Nam Hoon Kim ),( Dong Hyun Lee ),( Dae Gil Kang ),( Woo Hyun Paik ),( Jeong Wook Kim ),( Won Ki Bae ),( Kyung Ah Kim ),( June Sung Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Introduction: Aortoenteric fistula is a rare cause of GI bleeding and fatal due to massive bleeding and diagnostic difficulties. It is defined as a communication between the aorta and adjacent portion of gastrointestinal tract. Primary aortoenteric fistula (PAEF) is typically caused by erosion of segment of aortic aneurysm.?Case: A 79-year-old male was admitted to the Emergency department due to massive hematochezia. He presented hypotension and a pulse rate was 105 beats/min. The laboratory findings showed hemoglobin 7.8 g/dL. Initial upper endoscopy was done but there was no bleeding focus. Urgent sigmoidscopy showed stigma of recent bleeding at proximal rectum and eccentric pulsating mass with ulceration and exposed vessel. The endoscopic findings suggest a PAEF. Computed tomography images showed aneurysms in both internal iliac artery and proximal rectum was compressed by left internal iliac artery aneurysm. Direct repair of the vascular was performed and patient was discharged with no complications on the 21st postoperative day. Conclusions: The majority of AEF (87%) occurs between the aorta and the third or fourth portion of the duodenum. Jejunum is involved in 7%, ileum in 4%, and colon in only 2% of the cases. There is no case report of PAEF involving rectum in Korea. It is significant in that we present an extremely rare case of a primary fistula from an aortic aneurysm to rectum and made prompt diagnosis and treatment for this lethal disease.

Assessment of Genetic Diversity of Horse Breeds Using Microsatellite Makers

Ji-Hye Jung(정지혜),Mi-Rang Lee(이미랑),Tae-Yong Ha(하태용),Seon-Ku Kim(김선구),Teak-Soon Shin(신택순),Han-Seok Kang(강한선),Hong-Gu Lee(이홍구),Gil-Jae Cho(조길재),Kyung-Do Park(박경도),Byung-Wook Cho(조병욱) 한국생명과학회 2009 생명과학회지 Vol.19 No.2

본 연구는 마품종 간의 유전적 배경과 다양성을 분석하기 위해 제주마, 경주마, 더러브렛, 몽고마, 쿼터호스, 일본마를 기초 축으로 생물체 집단 간의 유전적 배경 및 관련성을 연구하는데 도움 되는 microsatellite marker를 사용하여 13종의 좌위에 대한 개체별 유전자형을 분석하여 대립 유전자별 빈도에 있어 품종별 차이를 보이는 microsatellite loci들을 나타냈다. 전체 개체들의 유전적 다양성을 나타내는 유전자 좌위별 품종별 기대 이형질성은 0.669-0.869를 나타냈고, 전체 집단 간의 유전자 분화정도는 0.061-0.219를 나타냈다. 이러한 대립 유전자 빈도를 근거로 하여 DISPAN 프로그램을 이용하여 집단 간 표준 유전적 거리를 도식하여 유전자 좌위별 유전적 거리는 0.137-0.414를 나타내어 마품종간의 유전적 다양성과 관련성을 고찰할 수 있게 되었다. 따라서 초위성체 유전자 표지를 이용하여 집단 내의의 혈통분석 및 분자 진화학을 연구하는데 도움이 될 것으로 사료된다. To assist in selection schemes we estimate the genetic diversity of the horse breeds. Genetic diversity at 13 microsatellite loci was compared in six horse breeds : Jeju Native Horse, American Quarter, Jeju Racing Horse, Mongolian Horse, Japanese Horse and Thoroughbred. All of the equine microsatellite used in this study were amplified and were polymorphic. The expected total heterozygosity over all the populations varied between 0.669 and 0.869 and the expected heterozygosity within population range from 0.569 to 0.219 in this study. The low coefficient of gene differentiation value showed that only 0.118 of the diversity was between horses breeds. The constructed dendrogram from the genetic distance matrix showed little differentiation between horse breeds using DISPAN program. The genetic distance using 13 microsatellites ranged between 0.137 and 0.414 for the six horse breeds. These results confirm the potential use of equine microsatellite loci as a tool for genetic studies in horse populations. The genetic diversity of the six horse breeds to each other closed to their geographical distribution. Suggesting that the loci would be suitable for horse breeds parentage testing. Therefore, Microsatellite marker seems to be very useful for clarifying the evolutionary relationships of closely related populations.

Leg Crossing-Induced Asymmetrical Trunk Muscle Activity During Seated Computer Work

( Yeon Gil Chung ),( Yong Wook Kim ),( Jong Hyuck Woen ),( Chung Hwi Yi ),( Hye Seon Jeon ),( Oh Yun Kwon ) 한국전문물리치료학회 2008 한국전문물리치료학회지 Vol.15 No.4

새우가공부산물을 이용한 속성 멸치액젓의 제조

김혜숙(Hye Suk Kim),양수경(Soo Kyeong Yang),박찬호(Chan Ho Park),한병욱(Byung Wook Han),강경태(Kyung Tae Kang),지승길(Seung-Gil Ji),서윤언(Youn Eon Sye),허민수(Min Soo Heu),김진수(Jin-Soo Kim) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.8

새우 가공부산물(두부, 갑각 및 꼬리)을 이용한 멸치액젓의 발효기간 단축 및 기호성 개선에 의한 고품질의 속성 멸치액젓을 제조할 목적으로 새우 가공부산물을 마쇄하고, 이를 멸치 마쇄물에 0%, 10%, 20% 및 30%를 각각 첨가한 다음 숙성 중 이들의 이화학적 특성, 효소학적 특성 및 수율 등을 검토하였으며, 아울러 이를 토대로 최적 숙성기간 및 첨가량의 구명을 시도하였다. 새우 가공부산물의 첨가량에 관계없이 숙성 중 수분함량 및 pH의 경우 감소하는 경향을 나타내었고, 조단백질 함량, 휘발성염기질소 함량, 갈변도 및 수율의 경우 증가하는 경향을 나타내었으며, 염도의 경우 거의 변화가 없었다. 아미노질소 및 아미노질소/총질소는 숙성 중 새우 가공부산물 0% 및 10% 첨가 제품의 경우 270일째까지 급격히 증가하는 경향을 나타내었으나, 새우 가공부산물 20% 및 30% 첨가 제품의 경우 180일째까지 급격히 증가한 후 거의 변화가 없었다. 액젓 중의 endoprotease와 exoprotease 활성 및 gel filtration의 결과, 숙성기간이 경과함에 따라 멸치액젓은 저분자화 되었으며, 이러한 경향은 새우 가공부산물의 첨가량이 증가할수록 현저하였다. 새우 가공부산물 첨가 멸치액젓의 최적 숙성기는 무첨가 및 10% 첨가 제품의 경우 270일, 20% 및 30% 첨가 제품의 경우 180일로 판단되어, 새우 가공부산물의 경우 멸치액젓의 제조 시 발효촉진제로 사용 가능하리라 판단되었다. The purpose of this study was to prepare accelerated salt-fermented anchovy sauce using a shrimp processing byproducts (head, shell and tail) as a fermenting accelerator, and to investigate its physicochemical and enzymatic properties. Four types of sauces were prepared with 0, 10, 20, and 30% (w/w) addition of shrimp byproduct and fermented at 24±2℃ for 360 days. During fermentation, all four type sauces decreased moisture content (67.5~68.0% to 64.0~64.8%) and pH (5.52~7.10 to 5.03~6.58), but showed increase in their crude protein (7.0~8.2 to 10.8%) and volatile basic nitrogen contents (40~75 to 180~200 ㎎/100 g of sauce). The ratio of amino nitrogen to total nitrogen contents of control (0%) and sauce with 10% shrimp byproducts (10% sauce) were maximized at 270 days, whereas 20% and 30% added sauces were at 180 days. Endoprotease and exoprotease activities of anchovy sauces added with 20% and 30% of shrimp byproducts tend to be higher than those of control (0%) and 10% addition. Proteolytic activities of sauces at pH 9 were about 2 times higher than those at pH 6. Amidolytic activities for LeuPNA decreased remarkably during fermentation, and control (0%) almost lost their activity at 180 days, while additional sauces were relatively stable. These suggest that alkaline protease of anchovy and shrimp byproducts as a endoprotease mainly contributed to the fermentation of salt-fermented sauces. The protein molecular weight distribution of sauces indicated 2 groups of peaks (peak 1, >70,000 da and peak 2, 3,000~29,000 da). As the fermentation proceeded, peak 1 tended to decrease in all of sauces, but peak 2 increased rapidly from 30 to 270 days. Optimum fermentation periods of control and 10% sauces were 270 days and those of 20% and 30% sauce were 180 days. The results suggest that shrimp byproduct can be used as accelerator of salt-fermented sauce.

초위성체 DNA를 이용한 제주마 집단의 품종특성 및 개체식별 체계설정

조병욱(Byung Wook Cho),정지혜(Ji Hye Jung),김상욱(Sang Wook Kim),김희수(Heui Soo Kim),이학교(Hak Kyo Lee),조길재(Gil Jae Cho),송기덕(Ki Duk Song) 한국생명과학회 2007 생명과학회지 Vol.17 No.10

본 연구는 서로 다른 상염색체에 위치하고 있는 초위성체유전 표지를 활용하여 제주마 집단의 타 품종과의 차별적 유전특성분석과 제주마 집단에서 활용할 수 있는 효율적인 개체 식별 시스템 설정을 위해 수행되었다. 공시재료로서는 5품종에서 총 191두가 사용되었으며 13종의 좌위에 대한 개체별 유전자형을 분석하였다. 이들 13종에서 출현된 총 대립유전자수는 제주마의 경우 155종이 나타났다. 한국 제주마집단에서 나타난 평균 이형접합도는 0.317-0.902였으며 marker 다형성 정보량은 0.498-0.799로 나타났다. 제주마 집단에서 나타난 대립 유전자 발현 특성은 다른 외래 품종 집단과 매우 상이한 결과를 나타냈다. ATH4 좌위의 경우 제주마 집단에서는 5종의 대립 유전자가 고른 분포를 나타낸 반면 QUA종의 경우와 THO종집단에서 특정 좌위의 극단적 발현 빈도를 나타냈다. 품종특이성을 나타내는 분자표지의 대립유전자 발현양상이 확인되었으며 이러한 품종특이성 발현 분자표지는 집단 내 개체에 대한 품종식별 유전자표지로 활용이 가능한 것으로 나타났다. 9종의 초위성체 유전 표지를 활용할 경우 누적 개체 식별력은 99.9%를 나타냈으며 두마리의 서로 다른 개체가 서로 같은 유전자형을 가질 짝확률은 0.60 × 10<SUP>-10</SUP>으로 추정되었다. 따라서 9종의 선정된 유전표지는 제주마 품종 집단에서 적정 신뢰도를 제공할 수 있는 개체 식별 시스템을 설정할 수 있을 것으로 생각된다. This study was conducted to establish the individual identification system and to estimate the genetic characteristic of Jeju native horse (JNH) using 13 microsatellite markers located on different horse autosomes. The markers were genotyped on 191 animals from five horse breeds including Jeju native horse (JNH). In total, 138 alleles were detected from the genotypes of 13 microsatellite markers. The average heterozygosities ranged from 0.317 to 0.902 and the polymorphic information content (PIC) ranged from 0.498 to 0.799 in JNH. We found that there were significant differences in allele frequencies in JNH when compared with other horse breeds. In ATH4 marker, there were specific allele frequence pattern that some of allele only found in JNH, Mongolian horse (MONG) and Jeju racing horse (JRH). The calculated cumulative power of discrimination (CPD) was 99.9% when nine microsatellite loci were used for analysis in the individual identification system. Also, the matching probability that two unrelated animals would show the same genotypes, was estimated to be 0.60×10<SUP>-10</SUP>. Therefore, in the nine markers used in this study can be used for individual identification in the Jeju native horse population.

Effect of Number and Location of Amine Groups on the Thermodynamic Parameters on the Acridine Derivatives to DNA

Kwon, Ji Hye,Park, Hee-Jin,Chitrapriya, Nataraj,Han, Sung Wook,Lee, Gil Jun,Lee, Dong Jin,Cho, Tae-Sub Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.3

The thermodynamic parameters for the intercalative interaction of structurally related well known intercalators, 9-aminoacridine (9AA) and proflavine (PF) were determined by means of fluorescence quenching study. The fluorescence intensity of 9AA decreased upon intercalation to DNA, poly[$d(A-T)_2$] and poly[$d(G-C)_2$]. A van't Hoff plot was constructed from the temperature-dependence of slope of the ratio of the fluorophore in the absence and presence of a quencher molecule with respect to the quencher concentration, which is known as a Stern-Volmer plot. Consequently, the thermodynamic parameters, enthalpy and entropy change, for complex formation was calculated from the slope and y-intercept of the van't Hoff plot. The detailed thermodynamic profile has been elucidated the exothermic nature of complex formation. The complex formation of 9AA with DNA, poly[$d(A-T)_2$] and poly[$d(G-C)_2$] was energetically favorable with a similar negative Gibb's free energy. On the other hand, the entropy change appeared to be unfavorable for 9AA-poly[$d(G-C)_2$] complex formation, which was in contrast to that observed with native DNA and poly[$d(A-T)_2$] cases. The equilibrium constant for the intercalation of PF to poly[$d(G-C)_2$] was larger than that to DNA, and was the largest among sets tested despite the most unfavorable entropy change, which was compensated for by the largest favorable enthalpy. The favorable hydrogen bond contribution to the formation of the complexes was revealed from the analyzed thermodynamic data.