조혈모세포이식술이 골수기질세포의 기원 및 조골세포로의 증식 및 분화에 미치는 효과

강무일,조성원,오은숙,백기현,이원영,오기원,김혜수,한제호,윤건호,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

Clostridium difficile 장염에 의한 속발성 유전분증에서 발현된 독성 장염

조형원,정혜경,강현주,이윤표,강혜원,심기남,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Amyloidosis is characterized by extracellular deposition of protein fibrils in one or multiple organs. AA amyloidosis is secondarily occurred to be related with chronic infections or inflammatory diseases. We report a 67-year-old man suffered from secondary AA amyloidosis related with chronic Clostridium difficile colitis after repeated total hip replacement surgery. Infection control is the most important treatment of AA amyloidosis secondary to chronic infection. However, the patient’s C. difficile colitis was not controlled well, eventually toxic megacolon with sepsis was developed. Consequently, he had to take total colectomy, but he expired with multi-organ failures. We suggested that early surgical procedure might be one option for intractable C. difficile colitis complicated with secondary amyloidosis.

우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

지속성 외래 복막투석환자에서 발생한 장간막경색증 1예

강동구,이준상,윤재호,장원철,조영일,송종호,전혜정 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

The mesenteric infarction, as a abdominal disease which show acute abdominal pain and almost need to emergency operation, has very high mortality. This mesenteric infarction has been reported very rarely. Also specific clinical manifestations are not clear, therefore initial diagnosis can be missed easily so that patients usually miss their opportunities for adequate treatment. Especially CAPD patients have high mortality because of their rareness and having similar symptoms like CAPD peritonitis. The authors report that the mesenteric infarction was miss-diagnosed to the CAF'D peritonitis with unspecific symptoms.

일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성

주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-

Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.

도장부스가 2개인 자동차 조립공장의 생산순서계획 작성

박혜규,최원준,강혜영 울산대학교 1998 경영학연구논문집 Vol.5 No.2

The main line of an automotive assembly plant normally consists of a body line, a painting line, and an assembly line. For determining the production sequence, leveling of heavy options is the major concern for body line and assembly line whereas production of bodies with the same color consecutively is more important in case of the painting line. In this paper, we propose an algorithm for generating the production sequence plan for an automotive assembly plant having the dual painting booths. The proposed algorithm turns out very effective in terms of the global performance measure of the assembly plant.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

Whole-genome resequencing analysis of 20 Micro-pigs

Da‑Hye Son,Nam‑Hyun Hwang,Won‑Hyong Chung,Ha‑Seung Seong,Hyungbum Lim,Eun‑Seok Cho,Jung‑Woo Choi,Kyung‑Soo Kang,Yong‑Min Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.3

Background Miniature pigs have been increasingly used as mammalian model animals for biomedical research because of their similarity to human beings in terms of their metabolic features and proportional organ sizes. However, despite their importance, there is a severe lack of genome-wide studies on miniature pigs. Objective In this study, we performed whole-genome sequencing analysis of 20 Micro-pigs obtained from Medi Kinetics to elucidate their genomic characteristics. Results Approximately 595 gigabase pairs (Gb) of sequence reads were generated to be mapped to the swine reference genome assembly (Sus scrofa 10.2); on average, the sequence reads covered 99.15% of the reference genome at an average of 9.6-fold coverage. We detected a total of 19,518,548 SNPs, of which 8.7% were found to be novel. With further annotation of all of the SNPs, we retrieved 144,507 nonsynonymous SNPs (nsSNPs); of these, 5968 were found in all 20 individuals used in this study. SIFT prediction for these SNPs identified that 812 nsSNPs in 402 genes were deleterious. Among these 402 genes, we identified some genes that could potentially affect traits of interest in Micro-pigs, such as RHEB and FRAS1. Furthermore, we performed runs of homozygosity analysis to locate potential selection signatures in the genome, detecting several loci that might be involved in phenotypic characteristics in Micro-pigs, such as MSTN, GDF5, and GDF11. Conclusion In this study, we identified numerous nsSNPs that could be used as candidate genetic markers with involvement in traits of interest. Furthermore, we detected putative selection footprints that might be associated with recent selection applied to miniature pigs.

학가산 삼림식생의 식물사회학적 분류와 입지환경분석

김창호,강혜원,정홍락,이호준 建國大學校基礎科學硏究所 1993 理學論集 Vol.18 No.-

영남 동북부 내륙에 위치한 학가산(870m)의 삼림식생을 식물사회학적으로 조사하고, 입지요인에 따른 식물군락의 분포특성을 고찰하였다. 조사지역의 삼림식생은 신갈나무-맑은대쑥 군집으로 밝혀졌으며, 3아군집, 3변군집으로 분류되었다. 즉, A: 뱀고사리 아군집(A-1. 굴참나무 변군집, A-2. 물푸레나무 변군집, A-3.전형 변군집), B:소나무 아군집, C:전형 아군집이다. 종합상재도표에 의한 70 %이상의 고상재도종은 신갈나무(97.5 %), 생강나무(95.0%), 둥굴레(72.5%), 털진달래(70.0%) 쇠풀푸레(70.0%), 싸리(70.0%)등이다. 식물군락의 분포특성은 입지요인에 따라 계곡 부근 및 적습한 사면의 물푸레나무림, 토양습도 및 유기물 함량이 다소 양호한 호적조건의 참나무-당단풍림, 습도와 고도가 중간적인 북사면의 참나무림, 토양조건이 건조하고 비교적 척박한 남.남서 사면의 소나무. 쇠물푸레림, 저지대의 소나무림 등의 5개 생태군으로 밝혀졌다. 종다양도, 우점도 및 종풍부도는 각각 1.047, 0.146, 10.237로 나타났다. The forest vegetation of Mt. Hakka(870m),situated in the inland part of northeastern Yeongnam district, the Korean Peninsula, was investigated phytosociologically. The ecological relationships of the vegetation units are described and discussed. Forest vegetation of the study area was indentified into Artemisio-Quercetum mongolicae KimJ.-W. 1990. And the lower units were classified by the method of Z-M school, i.e. Athyrium yokoscense subass. nov(Quercus variabilis variant, Fraxinus rhynchophylla variant, Typical variant), Pinus densiflora subass. nov.,and Typicum subass. nov..According to the synthesis table, species of the high constance degree(more than 70%) were Q. mongolica(97.5%), L. obtusiloba(95.0%), C. humilis(82.5%), P. odoratum var. pluriflorum(72.5%), R. mucronulatum var. ciliatum(70.0%), F.sieboldiana(70.0%), L. bicolor(70.0%)etc. By two dimensional analysis of temperature(elevation)and moisture(slope aspect) gradients, the forest vegetation were grouped into five ecological types: Ash forest at mesic parts near cove, oak-maple forest at the fertile sites, oak forest at submesic-middle parts of the north slope aspect, pine-ash forest at xeric-infertile soils of the south slope aspect, and pine forest distributed in lowlands. Diversity index, dominance index and species richness were shown as 1.047, 0.146, 10.239, respectively.

경기대생의 양성 평등 의식에 관한 연구

김영희,강혜원 경기대학교 2009 시민인문학 Vol.16 No.-

본 연구는 대학생의 양성평등의식 수준을 확인하는 기초연구를 수행하여 앞으로 대학생의 양성평등의식 향상에 도움이 되는 방안을 모색하려는 목적으로 진행되었다. 사용변인은 사회문화, 직업활동, 가정생활, 고육과 양육, 성(섹슈얼리티)의 5개 하위영역으로 구성된 양성평등 의식검사점수였다. 대상은 수원지역의 경기대학교에 재학하는 1-4학년의 남녀학생들이었다. 연구결과 첫째, 남학생에 비해 여학생의 양성평등의식 수준이 높았는데, 이는 5개 하위영역 모두에서 동일했다. 따라서 남학생들의 양성평등의식을 향상시키기 위한 방안을 강구할 필요가 있다. 둘째, 연령별 차이는 일부 영역에서 경향성은 있었으나 유의한 차이가 없었다. 셋째, 전공별로는 직업활동, 교육과 양육, 성(섹슈얼리티) 하위영역과 전체 점수에서 유의한 차이가 있었는데, 자연계열에 비해 인문계열 학생들의 양성평등의식 수준이 더 높았다. 따라서 자연계열 학생들의 양성평등의식 수준이 낮은 이유를 규명하고 이들의 양성평등의식을 향상시키는 방안을 모색할 필요가 있다. 앞으로 대학생들의 양성평등의식에 영향을 미치는 요인들을 구체적으로 확인하는 후속연구가 요청된다.