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전소분,박혜연,김선아,정금선,이영원,박성준,김덕환,송근호 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
A 10 years old, intact male, Maltese dog with clinical signs of labored respiration, exercise intolerance and increasing of coughing was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Physical examination revealed tachycardia, panting and mild cyanosis. This case was diagnosed as mitral valve insufficiency by clinical signs, ascultation, blood chemistry, radiography and electrocardiography. This dog was treated with ACE inhibitor (enalapril), diuretics (furosemide) and bronchodilator (aminophylline) for 14 days. After treatment, clnical signs were disappeared and also this dog was needed to be continuous monitoring and sodium restricted diet.
흰쥐에 Xylene 반복 투여가 Xylene의 대사에 미치는 영향
전태원,이혜자,윤종국,이상일,조현국 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1
실험동물에 xylene의 반복 투여가 이물질의 대사에 어떠한 영향을 미치는지를 알아보기 위하여 흰쥐에 m-xylene과 olive oil의 동량혼합액을 체중 100g당 0.25ml씩 2일 간격으로 1, 4, 8, 12 및 16회 복강으로 투여한 다음 마지막 투여 24시간 후에 처치하여 다음과 같은 결과를 얻었다. 요 중 m-methylhippuric acid 함량은 m-xylene 4회 투여군의 경우 1회 투여군에 비하여 약 56%의 유의한 증가를 보였으며 이후 12회 투여까지 유사한 결과를 나타내었으나 m-xylene 16회 투여시에는 xylene 1회 투여군 치와 유사한 치로 감소되었다. 그리고 간조직의 microsomal aniline hydroxylase와 alcohol dehydrogenase 활성은 m-xylene 12회 투여시 까지는 대체적으로 점진적인 증가를 보였으나 이후 16회 투여시에는 12회 투여군에 비하여 유의한 감소를 보였다. 또한 aldehyde dehydrogenase 활성은 m-xylene 투여 회수에 비례해서 전 실험기간 동안 감소되었으며 특히 16회 투여군에서 본 효소활성의 현저한 감소를 보였다. 한편 본 실험조건에서 투여기간에 따른 진자현미경적 미세구조의 변화는 초기에 활면소포체의 증식이 보이다가 16회 투여군에서는 활면소포체가 감소되고 조면소포체가 증가되었다. 이상 실험결과는 흰쥐에 있어서 xylene 투여 회수에 따라서 요 중 m-methylhippuric acid의 농도 변동이 초래되며 이는 효소단백 유도에 따른 xylene 대사효소 활성 변동에 기인된 결과로 생각된다. To evaluate the effect of repeated treatment of xylene on its metabolism, m-xylene (0.25ml of 50% in olive oil/100 g body weight) has been intraperitoneally given to the rats 1, 4, 8, 12 and 16 times every other day. m-Xylene was once more administered to the animals after 24 hrs since last injection of it. And then the animals were sacrificed after 24 hrs. Four times xylene treated rats showed the significantly elevated urinary m-methylhippuric acid, compared to those treated with the singe dose of m-xylene with the continued similiar high levels of urinary m-methylhippuric acid up to the animals pretreated 12 times and then those treated 16 times defined the significantly decreased urinary m-methylhippuric acid compared to those treated 12 times. On the other hand, hepatic aniline hydroxylase and alcohol dehydrogenase activities demonstrated a gradual increase from the first group to the 12 times xylene-treated animals, but those treated 16 times showed the significantly decreased value compared with the 12 times treated-group. And aldehyde dehydrogenase activities in rats treated with m-xylene 8, 12 or 16 times were significantly decreased compared to those pretreated one or four times. In the early stage of xylene administration, proliferation of SERs were seen whereas SERs were decreased and RERs were clearly increased in xylene-treated rats 16 times. These results indicate that the frequency of xylene injection may influence upon the changes in xylene metabolite, m-methylhippuric acid and it may be due to induction of xylene metabolizing enzymes.
폴리에스테르 纖維에 대한 스티렌, 아크릴산 단량체 그라프트 重合의 動力學的 考察
全東源,吳賢理,兪惠子 梨花女子大學校 韓國生活科學硏究院 1986 韓國生活科學硏究院 論叢 Vol.38 No.-
단량체농도, 개시제농도, 그라프트반응시간, 반응온도등의 그라프트중합 조건을 변화시켜 가면서 poly (ethylene terephthalate) 필름에 styrene과 acrylid acid(AA)를 각각 그라프트중합시켰다. styrene단량체의 중합에서는 0.5×10^-2M/L~20×10^-2M/L의 농도범위에서는 그라프트중합속도가 styrene의 농도에 비례하지만 그 이상의 농도에서는 그라프트중합속도 R_p는 R_p=styrene^(0.4~0.45)로 표시된다. AA의 경우는 상당한 지연시간이 존재하지만 일단중합이 개시되면 중합속도는 styrene에 비해서 크다. styrene과 AA 전부에서 일정한 개시제농도 범위까지는 그라프트중합속도가 상승되지만 그 이상의 농도에서는 그라프트중합속도가 저하된다. Graft polymerization of acrylic acid (AA) and styrene on poly (ethylene terephthalate) <PET> film using benzoylperoxide <BPO> as initiator wasinvestigated under different conditions including monomer concentration, initiator concentration, graft polymerization temperature and time. With styrene, the rate of graft polymerization increases linearly as the concentration of styrene increase in the range of 5×10^-2M/L~20×10^-2M/L. The rate, however, is proportional to the 0.4~0.5 power of the styrene concentration above 20×10^-2M /L. With AA, there is a retardation period before the polymerization starts. Once the reaction is initiated, however, the rate of polymerization becomes faster than that with styrene. In both cases, the rates increase as the concentrations increase until certain points and the, they decrease thereafter.
전정희,박혜원 창원대학교 생활과학연구소 1998 생활과학연구 Vol.- No.2
The purpose of this study is to examine post modern fashion, especially focussed the harmony of tradition and conteporary in domestic and abroad collections in 1990's. Using analyses and examination with the fashion literature, trend informations, visual materials and internet fashion sites related to Post Modernism and Post Modern fashion. The results are as follow: Collection of outside the country are presented for harmony of style, harmony of material, utilization of ornament motive. Trend design of inside the country are presented to search for new fashion from inspiration of the past. Through the post modern fashion in represented of domestic and outside of the country 1990's collections, new creative fashion designs can be confirmed that they are produced from the harmony of tradition and modern.
전동원,김종준,신혜선 服飾文化學會 2003 服飾文化硏究 Vol.11 No.3
Cotton fabric and nylon fabric were chosen as base fabric speciments for dyeing using Japanese pagoda tree colorants through chitosan treatment. With the chitosan treatment, the dye-uptake of the treated fabric increased. This treatment is also expected to be effective in terms of environment-friendliness. The effect of the dyeing methods, mordanting or non-mordanting, and chitosan treatment on the dye-uptake and air permeability of the treated fabrics was investigated. In case of cotton fabric, Al mordanted dyeing resulted in higher dye-uptake through the chitosan treatment. Therefore, the chitosan treatment is effective in this case. Japanese pagoda tree seems to have direct affinity for nylon fibre without the mordanting treatment. In case of cotton fabric, it seems that the cellulose molecules, colorants, and the chitosan make a complex, thereby the air permeability. In case of nylon fabric, due to the fact the Japanese pagoda tree colorant molecules form direct physical bonding with the nylon molecules, it seems that there is not much of air permeability reduction.
이혜자,이상희,전태원,이상일,윤종국 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.3
실험동물에 있어서 연령 차이에 따라서 xylene 독성이 어떠한 차이가 있는지를 검토하는 일환으로 5주령 및 12주령 흰쥐에 50% m-xylene을 체중 100 g 당 0.25 ml씩 1회 투여한 다음 24시간 후에 처치하여 다음과 같은 결과를 얻었다. Xylene 투여로 인한 요 중 methylhippuric acid 함량은 5주령군이 12주령군에 비해 현저하게 높게 나타났다. 그리고 간조직 중 cytochroms P-450 함량은 대조군에 있어서 5주령군이 12주령군 보다 약 50% 정도 낮게 나타났으나 xylene 투여로 인한 cytochrome P-450 함량 증가율은 12주령군 보다 5주령군에서 높게 나타났다. 간 alcohol dehydrogenase 활성치도 대조군에 있어서는 5주령군이 12주령 보다 약 35% 정도 낮게 나타났으나 xylene 투여로 인한 본 효소의 활성 증가율은 5주령군에서 오히려 높게 나타났다. 그러나 간 aldehyde dehydrogenase 활성치는 대조군 및 xylene 투여군 모두 5주령과 12주령간에 유의한 차이를 나타내지 않았다. 한편 xylene 투여시 체중 당 간무게, 간조직 malondialdehyde 함량 및 혈청 ALT 활성 변동을 통하여 간손상 정도를 상호 비교 관찰하였을 때, 12주령군이 5주령 실험동물 보다 간손상이 다소 심하게 나타남을 알 수가 있었다. 이상 실험결과는 연령에 따라 xylene에 의한 간손상의 차이는 이물질의 생체내 대사율이 달리 나타나기 때문일 것으로 생각된다. To evaluate an effect of aging on the xylene toxicity, 50% m-xylene in olive oil (0.25 ml/100 g body wt.) was administered to 5 week and 12 week-old rats one times intraperitoneally and sacrificed at 24 hrs afterwards. The increasing rate of urinary H-methylhippuric acid concentration was higher in 12 week-old rats than 5 week-old rats by the treatment of m-xylene. On the liver function findings, i.e., liver weight/body weight (%), serum levels of ALT activity and hepatic malondialdehyde content, 12 week-old rats showed more severe liver injury than 5 weeks those in xylene-treated rats. And the hepatic cytochrome P-450 contents was higher in 12 weeks rats than those of in 5 week-old rats, but the increasing rate of that was lower in 12 week-old rats. Hepatic alcohol dehydrogenase activity was also higher in 12 week-old rats than in 5 week-old rats whereas the increasing rate of that was higher in 5 week-old than those in 12 week-old rats by the xylene treatment. Furthermore, the hepatic aldehyde dehydrogenase activities were no differences between the 5 and 12 week-old rats both in the control and xylene-treated group, In conclusion, age may influences upon the hepatotoxicity with xylene and it may be responsible for xylene metabolism in rats.
함희원,성무경,전혜정,선관우 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-
In this study, gall stones from 45 patients were analyzed in vitro. Gall stones from 23 patients were cholesterol stones and the others were non-cholesterol. Correlation with each radiologic physical properties(the number of stones, shape, calcification pattern, Hounsfield units measured by computed tomography) and chemical composition(cholesterol or non-cholesterol) were analyzed. The results revealed that the numbers and size were not related to the chemical composition, but there were significant correlation with faceted stones(p=0.002) or stones with no calcification (p=0.010) and cholesterol composition, and with irregular stones(p=0.000) or stones with dense calcification(p=0.015) and non-cholesterol composition. In study of Hounsfield units, it was difficult to fix the boundary, but the difference between cholesterol composition(138.43±281.81) and non-cholesterol composition(404.32±306.06)was significant(p=0.0109).
일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성
주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-
Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.
김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
강동구,이준상,윤재호,장원철,조영일,송종호,전혜정 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-
The mesenteric infarction, as a abdominal disease which show acute abdominal pain and almost need to emergency operation, has very high mortality. This mesenteric infarction has been reported very rarely. Also specific clinical manifestations are not clear, therefore initial diagnosis can be missed easily so that patients usually miss their opportunities for adequate treatment. Especially CAPD patients have high mortality because of their rareness and having similar symptoms like CAPD peritonitis. The authors report that the mesenteric infarction was miss-diagnosed to the CAF'D peritonitis with unspecific symptoms.