오리부산물과 한약재를 이용한 추출액의 영양성분 및 중금속 노출에 대한 피해 완화 효과 : (Ⅱ) 중금속 노출에 대한 오리추출액의 피해 완화 효과 (Ⅱ) Damage Mitigation Effects on Heavy-metals Exposure of Peking-Duck By-Product Extracts

한종현,이우진,조성균,이미정,정미란,전정우,김운영,박성혜 동아시아식생활학회 2003 동아시아식생활학회지 Vol.13 No.4

This study was performed to investigate the effects of peking-duck extracts added with medicinal herbs(DJ) on the intoxication of heavy metals (Hg, Pb, Cd, As) in rats. Sprague-Dawley rats weighing 150±15g, were randomly assigned to 5 groups: basal diet only in normal control group(NCG); basal diet and heavy metals without DJ injection in heavy metal control group(HMC); basal diet, heavy metals and DJ(3㎎/㎖) injection in heavy metal low duck juice group(HMLD), basal diet, heavy metals and DJ(30㎎/㎖) injection in heavy metal middle duck juice group(HMMlD); basal diet, heavy metal and DJ(300㎎/㎖) injection in heavy metal high duck juice group(HMHD). Hg and As was injected by 50ppm and Cd and Pb by 25ppm for 17days. Also DJ oral feeding was conducted for 28days. The result of this study were as follows: Food intake and body weight gain in heavy metal administered groups were lower than those of NCG. Liver, kidney and testis weights were not significantly different among 5 groups. GOT, GPT and BUN activities were significantly reduced in DJ treated groups as compared to HMC. DJ showed the suppressing effect on the accumulation of Hg, Pb and Cd in serum, liver and kidney. Fecal Hg and Cd excretions increased with DJ feeding. The results suggested that DJ may have some protective effects on Hg, Cd and Pb intoxication by reducing the accumulation m tissues and increasing excretion. This study also showed the effective way of using duck-extract and its application to the oriental medicine.

인삼잎과 줄기 혼합 추출액의 첨가급식이 흰쥐의 성장, 영양효과 및 혈청 지질에 미치는 영향

한종현,신언환,박성혜 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.5

This study was conducted to investigate the application possibility of leaf and stem extract(LSE) extracted from the mixture of leaf and stem of ginseng radix(Panax ginseng C.A. Meyer). This study measured the intake levels and efficiency ratio, growth rate, absorption ratio of carbohydrate, lipid and protein of rat by feeding with LSE during 6 weeks. We analyse the hematological and serum metabolic variables, serum lipid concentrations. Total diet and protein intake levels were low, but efficiency ratios were significantly high in LSE administered groups than the control group. Weight gain, liver and kidney weight of LSE groups were significantly higher than the control group. Blood RBC, Hct, Hb, total protein and albumin concentrations were reasonable levels in LSE administered groups compared to the basal diet group. Also serum total cholesterol, LDL-cholesterol, triglyceride contents of LSE groups were low, but HDL-cholesterol level was higher than the basal diet group. These results imply that leaf and stem of ginseng radix could be used as possible food resources, functional food material and feed stuff.

한약재를 첨가한 오소리 발효액이 폐경기 증후군과 Estradiol 농도 및 골대사에 미치는 영향

한종현,김윤홍,이윤희,박성혜 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3

The purpose of this study was to investigated the possibility of Meles meles as an edible functional resource. To asses the effects Meles meles fermented liquid(ML) with medicinal plants in postmenopausal women, the menopause symptoms, hematological and serum chemical variables and bone health indices were examined. Twenty five postmenopausal women participated in the study. As a result, in postmenopausal women, ML supplements were effective in reducing the incidence of menopause symptoms, such as insomnia(44.0%), sensitivity(40.0%), headache(34.0%), hot flush and decreased vaginal lubrication(20.0%) after 12 weeks. Also serum estradiol and calcitonin and calcium levels were 23.27 pg/mL, 14.88 pg/mL and 8.86 ㎎/dL before the ML intake. Levels were significantly increased of estradiol and calcitonin and calcium after ML intake during 12 weeks to 30.36 pg/mL, 21.61 pg/mL and 10.01 ㎎/dL. Osteocalcin and bone alkaline phosphatase activity were 14.36 ng/mL, 21.55 U/L before the ML intake, but according to ML intake, the levels were significantly decreased. In conclusion, ML Play benefical roles in the prevention of bone loss and menopause symptoms. Howere current data are not sufficient to determine the effective doses for benefical effect as well as harmful effect and support dietary recommendation level for ML. Therefore, our results should be viewed with caution. But Meles meles fermented liquid with medicinal plants can be used as possible food resources and functional food materials, more studies are needed to identify the proper mechanism of ML.

자궁외 난관임신에 동반된 난관의 병리조직학적 소견 및 혈청 β-HCG 수치와 난관 근층 침범과의 상관관계

박혜진,김호정,구혜수,성순희,한운섭 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.7

고등학교 학생들의 환경 교육 실태와 교육 효과 분석

한성현,장봉기,이혜진 순천향대학교 기초과학연구소 2001 순천향자연과학연구 논문집 Vol.7 No.1

In this study, it is aimed to clarify the effects of the environment education among the high school students. The study is accomplished by the survey which includes a total of 558 sampled from the six high school having the environmental curriculum and without curriculum. The survey took for 10 days from the date of 3th July 2000 to 13th July 2000 and the results were as follows; 1.The results by multiple regression analysis were as follows; Score of educated environmental subjects, mother's interest of environment, awarness of severity of the environmental pollution, environmental information source (Television) were statistically significant effected to factors on environmental knowledge score (R2=0.090). 2.The factor affecting awarness of severity of environmental pollution were necessity of environmental conservations and the environmental education, scholastic grade (R2=0.101). 3.The affecting factors on the environmental practice were mother's interest of environment and necessity of environmental conservation, family type, environmental information source (parents), score of the educated environmental subjects, and environmental knowledge level (R2=0.183). From the results of this study, we are to propose as follow; Because the purpose of environment education is the practice, it is important to induce changing the recognition and behavior. Therefore educational policy have to build up experience place, to bring up professional teacher of environment and safety health education. It need to develope a reference of each subject and to utilize various media. Especially it need to choice of environment education with safety and health education.

Lipopolysaccharide, Dexamethasone 및 23,24-Dihydrocucurbitacin D가 마우스 뇌조직의 프리라디칼 발생과 제거에 미치는 영향

한기정,강종권,윤혜영,백광진,이희성,권년수 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.4

한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계

여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.

대전시 유통 과실류의 농약 잔류 실태 및 위해성 평가

한국탁,박혜진,이규승,김일중,김규섭,조성민 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

대전시 노은 도매 시장에 서 채취한 과실류와 6종의 농약잔류량을 조사한 후 이에 대한 위해성 평가를 실시하였다. 전체 120건 분석시료 중 70.8%가 농약 성분이 검출되었고 그중 1.67%가 잔류허용기준치을 초과하여 검출되었다. 검출 비율이 높은 시료는 사과, 복숭아, 포도 등이었다. 검출된 성분에서 살충제는 유기인계, 합성 pyrethroid계, 유기염소계가 비슷한 비율로 검출되었고, 살균제에서는 특히 procymidone(dicarboximide계)과 chlorothalonil(유기염소계)의 검출비율이 높았다. 검출빈도가 높은 성분은 chlorothalonil, chlorpyrifos, fenvalerate, procymidone, deltamethrin, EPN의 순이었다. 위해성을 평가하기 위해서 각 농작물에 대한 농약의 추정섭취량과 ADI를 비교한 결과, 추정섭취량의 비율이 1.221%이하로 나타나 그 영향이 매우 낮은 것으로 판단되었다. 이것은 농약 잔류 허용기준치를 초과한 농작물인 복숭아에서 chlorothalonil, EPN에 대해서도 동일한 결과를 나타내었다. Pesticide residues in some fruits collected at Noeun wholesale market, Daejeon were surveyed and assessed its risk. In 120 samples, the detection rate of pesticide was 70.8% and the rate exceed MRL was 1.67%. Highly detection rate of commodities was apple, peach and grape. Organophosphorus, organochlorine and pyrethroid insecticide were found with similar rate relatively, but most of fungicides were procymidone(dicarboximides) and chlorothalonil(organochlorine). The order of detected pesticide were chlorothalonil, chlorpyrifos, fenvalerate, procymidone, deltamethrin and EPN. In order to assess risk, estimated intake amount of each pesticide was compared to ADI. Although some peach were exceed MRL, the total amount and uptake pesticides was less than 1.22% comparing to ADI.

우리나라 일부 여고생과 여대생의 건강 위험 행태 분석

한성현,최민자,이선희,이명선,이혜진 한국모자보건학회 2000 한국모자보건학회지 Vol.4 No.1

21세기 공공도서관 발전방향 및 모델개발연구

한상완,서혜란,곽철완 한국문헌정보학회 1997 한국문헌정보학회지 Vol.31 No.2

본 연구의 목적은 21세기를 대비한 공공도서관의 발전방향과 모형을 제공하는데 있다. 21세기 공공도서관을 위한 기본 개념은 공평한 접근성과 다양한 이용자 요구를 만족시킬 수 있어야 한다. 이를 위해 공공도서관은 봉사대상과 주제분야를 중심으로 체제가 이루어져야 하며 다른 도서관과 정보를 공유할 수 있어야 한다. 또한 직원은 교육, 연구, 실무경험을 기준으로 하여 자격증을 부여하고, 한 분야에 장기적으로 근무시켜 전문가를 양성하는 배치기준이 필요하다. 도서관 모형은 인구를 중심으로하여 대도시형, 중소도시형, 그리고 농촌 및 소규모형으로 구분하는 것이 바람직하다 The purpose of this study is to provide the development direction and model for the 21 century public library. The 21 century public library should have the accessibility for everyone and provide the satisfaction for all kind of information needs. For these, public libraries would be organized by type of users and topics and share the resources with others. Staff should be hired by the certification based upon education, research, and experience. For the models of public libraries, there were divided to three types: metro, medium, and small rural type of libraries