요골동맥을 통한 관상동맥촬영 중 진단된 편위된 우측쇄골하동맥 1예

한승희,김수영,박혜경,박종성 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1

The left aortic arch with an aberrant right subclavian artery, or arteria lusoria, is the most common aortic arch anomaly, occurring in 0.5-2.5% of individuals. In such cases, the angular course of the arteria lusoria to the ascending aorta imposes difficulty in passing a guide wire to the ascending aorta during right transradial catheterization. Here, the case of a 53-year-old woman with intermittent chest tightness and coughing is reported. Aberrant right subclavian artery(arteria lusoria) was diagnosed via aortogram during right trans- radial coronary angiography. Compression of the esophagus and trachea by the aberrant right subclavian artery was demonstrated by chest computed tomography(CT).

대전시 유통 과실류의 농약 잔류 실태 및 위해성 평가

한국탁,박혜진,이규승,김일중,김규섭,조성민 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

대전시 노은 도매 시장에 서 채취한 과실류와 6종의 농약잔류량을 조사한 후 이에 대한 위해성 평가를 실시하였다. 전체 120건 분석시료 중 70.8%가 농약 성분이 검출되었고 그중 1.67%가 잔류허용기준치을 초과하여 검출되었다. 검출 비율이 높은 시료는 사과, 복숭아, 포도 등이었다. 검출된 성분에서 살충제는 유기인계, 합성 pyrethroid계, 유기염소계가 비슷한 비율로 검출되었고, 살균제에서는 특히 procymidone(dicarboximide계)과 chlorothalonil(유기염소계)의 검출비율이 높았다. 검출빈도가 높은 성분은 chlorothalonil, chlorpyrifos, fenvalerate, procymidone, deltamethrin, EPN의 순이었다. 위해성을 평가하기 위해서 각 농작물에 대한 농약의 추정섭취량과 ADI를 비교한 결과, 추정섭취량의 비율이 1.221%이하로 나타나 그 영향이 매우 낮은 것으로 판단되었다. 이것은 농약 잔류 허용기준치를 초과한 농작물인 복숭아에서 chlorothalonil, EPN에 대해서도 동일한 결과를 나타내었다. Pesticide residues in some fruits collected at Noeun wholesale market, Daejeon were surveyed and assessed its risk. In 120 samples, the detection rate of pesticide was 70.8% and the rate exceed MRL was 1.67%. Highly detection rate of commodities was apple, peach and grape. Organophosphorus, organochlorine and pyrethroid insecticide were found with similar rate relatively, but most of fungicides were procymidone(dicarboximides) and chlorothalonil(organochlorine). The order of detected pesticide were chlorothalonil, chlorpyrifos, fenvalerate, procymidone, deltamethrin and EPN. In order to assess risk, estimated intake amount of each pesticide was compared to ADI. Although some peach were exceed MRL, the total amount and uptake pesticides was less than 1.22% comparing to ADI.

레이저 웨이퍼 다이싱 장비의 가공 특성 평가

한민섭,김성수,민병권,이승우,이진하,이혜진 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

As the semiconductor wafer is required to be thinner for better compactness and higher integrity of the electronic products, mechanical dicing saw technique using the diamond blade is facing serious problems such as low cutting speed, tool wear, side wall crack and back side chipping. Recently, UV laser dicing process has emerged as an alternative methods to the blade dicing especially for the very thin wafers below 100㎛. In this study 355 nm UV laser dicing system has been developed in order to improve the productivity and reliability of ultra thin wafer dicing process. For the quality improvement of the developed dicing system various laser parameters are investigated such as power, speed and frequency of the laser beam. Moreover various measurement techniques are employed to evaluate the dicing quality using optical microscope, SEM and focused ion beam.

디지털 기술의 건강보험 보장방법에 대한 고찰: 5개 국가 중심

엄혜은,김지혜,한승진,최연미,최윤정 건강보험심사평가원 2022 HIRA RESEARCH Vol.2 No.1

STR 유전자의 개인식별력 측정을 위한 통계량

이혜승,이재원,한길로,황적준 大韓法醫學會 1998 대한법의학회지 Vol.22 No.2

When we intend to do the personal identification using DNA profiles, it will obviously be better to use as much information as possible. The power of identification is increased by using the genetic marker system such as VNTRs or STRs. Although STRs do not have many alleles per locus as VNTRs, these can be compensated by a large number of loci that are potentially usable. However, it will be more efficient to use a morphic loci. Therefore, prior to choose the genetic marker system of STRs for identification, it is essential to consider the statistical parameters of each STR locus, such as obs-H(observed heterozygosity), exp-H(expected heterozygosity), pM(probability of match), DI(discrimination index), PD(power of discrimination), MEC(mean exclusion chance), MEP(mean exclusion paternity), PIC(polymorphic information content) et al. In this article, we described the exact meaning of statistical parameters for the purpose of identification.

Master Gardener 프로그램 특성에 관한 연구 : Virginia Cooperative Extension을 중심으로 with Special Reference to the Virginia Cooperative Extension

곽혜란,한승원,이종석,김신기 한국화훼연구회 2001 화훼연구 Vol.9 No.1

The Master Gardener(MG) program is one of representative outreach program of cooperative extension at land grant Universities in U.S.A. The purpose of MG programs are primarily focused on educating community and people who want to join gardening project. MGs are valuable resources as volunteer-educators teaching environmental horticulture, increasing life quality through horticulture, community landscaping, school gardening, nutrition problems and horticultural therapy for the common-wealth or benefit of their community. MG educational programs and volunteer internships are needed to get and maintain MG title and they follow the policies and philosophies of cooperative extension. MG programs present lots of benefits by enlarge boundaries of horticulture and offer the practical educational services. To extend and activate further the value of horticulture, the MG programs should be introduced in Korea soon. MGs are regarded as new managers or primary leaders for educating horticulture, landscaping for community because of their knowledge and eagerness to help the people's advancement.

분석결과 검증 및 신뢰성 확보를 위한 실험실간 협력 실험

박혜진,고광용,한국탁,김일중,이용재,김성헌,이규승 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.2

The residual study of pesticide has been used in various areas, such as food safety, environmental protection, establishment of tolerance, and explaining the pathway and reaction mode of pesticides, and its importance was expected to increase further more. The aspect of food safety, the pesticide residue survey have been practiced at many organizations, but there were no verification of analytical results at present. In this experiment, we focused on instrumental stability, including response of each instrument and the recovery ratio of each organization's method. As samples for this experiment, we prepared cucumber and sesame, and chose 4 pesticides (bifenthrin, chlorpyrifos, diazinon, and ethoprophos), which were mostly detected from pesticide residue survey and widely used for each crop. The standard deviation of peak areas in the chromatogram of each pesticide were under 1.212 %, so it showed that most instruments were stable. The relationship of recovery ratio of each organization were over 0.996 for every pesticide and each organization. Finally, the analytical results for pesticide residue from each participated organization were not statically significant and we could put confidence in the result from each organization.

새로운 반복단위에 의한 GABARB1 유전좌의 염기서열다형성과 한국인에서 대립 유전자의 빈도

이혜린,이혜승,송은섭,한길로,황적준 大韓法醫學會 1998 대한법의학회지 Vol.22 No.2

To determine allele frequency of GABARB1 Jcus in Korean, first, we sequenced each allele, which was amplified with primers that published before. We found mismatching between allele number and size of each allele when 'GATA' repeats are counted. The sequence revealed new 'GATA' repeat. So we had made new allele designation with total number of in 176 Korean people. The heterozygosity this locus was 0.716 and mean exclusion chance (MEC) and power of discrimination (PD) were 0.433 and 0.845, respectively. In this study, we emphasized necessity of sequencing of 2-3 alleles, which have same size before setting up allelic ladder.

장기 이식 환자에서 Voriconazole 과 Cyclosporine 또는 Tacrolimus의 상호작용

한혜원,김재연,송영천,김승은,유성길 한국병원약사회 2009 병원약사회지 Vol.26 No.1

Abstract: In organ transplant patients, the opportunity of fungi infections such as invasive aspergillosis increase by use of immunosuppresant drugs and voriconazole is recommended as primary treatment drug. When voriconazole is administered with cyclosporine(CsA) or tacrolimus(FK506), caution about increment of blood CsA or FK506 concentrations that caused by the change of CYP3A4 activity is required but few domestic cases of interaction were reported yet, The purpose of this study was to assess the effect of voriconazole on the blood CsA or FK506 concentrations in transplant recipients and the factors of recipients that have an effect on the results. 25 transplant recipients who were administered voriconazole with CsA or FK506 from January 1 of 2006 to August 17 of 2008 in Asan Medical Center were objects (12 patients on CsA coadministration arm - 9 males, 3 females; 41~62years;2 liver, 2 kidney, 3 bone marrow, 5 heart transplant recipients, and 13 on FK506 coadministration arm - 7 males, 6 females;26~65years; 10 liver, 2 kidney, 1 heart transplant recipients). Blood CsA or FK506 concentrations before and after coadministration of voriconazole, and maximum concentration in one month from the first day of coadministration were monitored retrospectively. In most cases CsA or FK506 were administered as recommended doses regardless of coadministration of voriconazole, and blood concentration increased from 239.42±126. 77ng/ml to maximum 411.92±225. 76ng/ml in CsA coadministration arm(p=0.003), and from 7.72±2.79ng/ml to maximum 19.16±9.35ng/ml in FK506 coadministration arm(p=0.003). Gender, age, and the kind of transplant organ did not affect to the change of blood concentration in both two arms. In consequences, administration of voriconazole could affect on the blood CsA or FK506 concentration, and in cases of administra tion of voriconazole in transplant recipients treated with CsA or FK506, close monitoring and dose adjustment is needed.

생강이 혈압과 뇌혈류량에 미치는 영향 및 이를 이용한 건강음료의 개발

박성혜,백승화,한종현 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.2

As an attempt to develop new functional health beverage by using medicinal herb, green ginger(Zingiber officinale Roscoe), we investigated the effect of Zingiber officinale on blood pressure and regional cerebral blood flow (rCBF) of rats with Zingiber officinale extracts. Zingiber officinale extract increase rCBF significantly. The drink produced consisted of Zingiber officinale extract 1.825%, maltitol syrup 17.0%, citric aicd 0.06%, ascorbic acid 0.02%, stevioside 0.001%, ginger flavor 0.11% and water. Brix, pH and acidity of product were 13.7, 4.4 and 0.09, respectively. This drink had good score by the sensory evaluation. The above results showed that development of such functional beverage using Zingiber officinale can used as a functional material improving blood circulation in beverage industry.