Infrared multiple photon dissociation spectroscopy and density functional theory (DFT) studies of protonated permethylated β-cyclodextrin–water non-covalent complexes

Lee, Sung-Sik,Park, Soojin,Kim, Ju-Young,Kim, Hye-Rim,Lee, Sungyul,Oh, Han Bin The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.18

<P>We present infrared multiple photon dissociation (IRMPD) spectroscopy and quantum chemical calculation results for the protonated permethylated β-cyclodextrin (CD)–water non-covalent complex, the simplest β-CD non-covalent complex, in the gas-phase. The IRMPD spectrum in the region 2700–3750 cm<SUP>−1</SUP> consisted of three strong peaks at 3096, 3315, and 3490 cm<SUP>−1</SUP>. These spectral features in the experimental IRMPD spectrum were compared with a large set of infrared absorption spectra predicted using density functional theory (DFT) calculations for the protonated β-CD–water complex. Complex III (see Fig. 4c), in which the water molecule (at the primary rim) and the proton (at the secondary rim) were separated, was found to suitably reflect the main spectral characteristics found in the experimental IRMPD spectrum. The absence of the homodromic hydrogen bond ring, due to replacement of hydroxyl groups with methoxy groups in permethylated β-CD, rendered the primary rim open compared with the unmodified β-CD ‘one-gate-closed’ lowest energy conformer. This study demonstrates that IRMPD studies combined with DFT theoretical calculations can be a good method for studying molecular interactions of large host–guest pairs.</P> <P>Graphic Abstract</P><P>Water was found to interact with permethylated β-CD through multiple hydrogen bondings with methoxy groups of the rim. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cp54841d'> </P>

IT 프로젝트관리 특화 교과목 개발을 중심으로 한 IT 경영대학원 교육과정 개발 연구

박혜림,홍후조 한국교육방법학회 2012 교육방법연구 Vol.24 No.2

본 연구의 목적은 사이버대학교 대학원에서 대학원의 교육목적 및 교육목표에 부합하는 IT 경영대학원(IT 프로젝트관리 특화) 과정을 설치와 관련한 교육과정을 개발하는 데 있다. 이러한 연구 목적을 달성하기 위하여, 관련 분야 졸업생과 재학생을 대상으로 광범한 교육수요조사 결과를 활용하였으며, 첫째, 대학원의 교육목적 및 교육목표, 특성화 방향 등을 확인하고, 이에 부합하는 ‘IT 프로젝트관리(PM)’ 분야 전문 인력의 역할을 확인하여 그들에게 필요한 핵심역량을 도출하였다. 둘째, 도출한 핵심역량을 갖추는데 적합하고 ‘IT PM’ 분야의 특성화된 교육과정(안)을 개발하였다. 셋째, 두 차례의 전문가 의견 조사(N=20)를 활용하여 개발한 IT MBA(IT PM 특화) 교육과정(안)의 타당성을 검증하고, 교육과정을 확정하였다. 넷째, 교육과정 운영에 중요한 교과목의 지위와 비중, 개설 및 이수시기, 졸업요건(현장체험 및 보고서 작성) 등을 전문가 의견조사를 거쳐 확정하였다. 본 연구에 참여한 전문가들은 IT 관련 현장의 IT 엔지니어 및 중간 관리자를 주요 교육수요자로 하여, 이들이 IT PM 전문가(PM Manager/PMO Manager, CIO 등)로서의 역할을 잘 수행할 수 있도록 도움을 줄 수 있는 교육과정 내용 구성을 강조하였다. 연구 결과, IT MBA(IT PM 특화) 교육과정 모형은 Ⅱ-type Model로 제안되었다. 즉, IT PM 전문가 양성 교육과정은 실무자들의 현장 경험을 기초로 하여, ‘IT 경영’과 ‘Project 경영’을 두 기둥으로 하고, 이를 통해 길러지는 핵심역량을 갖춘 중견 관리자의 실천 역량의 고도화를 지향하는 형상으로 구안하여 제안되었다. This study aims to develop a curriculum specialized in IT PM managers for a cyber graduate school. Frameworks and procedures for curriculum development are followings: First, preliminary survey was executed to college students and graduates as latent clients. Based on results of survey, high needs of graduate school course was confirmed. Second, several times of expert meetings and literature review brought forth the drafts of key competencies and lists of courses. Third, IT PM-related specialists survey were implemented in order to reconfirm key competencies of IT PM manager, areas of courses, lists and names of courses, status and weight of courses, and time schedule of course offerings. Through these procedures 21 key competencies of IT PM managers under the two curriculum areas of IT management and Project management, and 16 course lists under the two curriculum areas had been finalized. Finally frameworks and design model(called II-type) of Information Technology MBA curriculum were presented.

NIHSS 활용을 통한 뇌졸중 환자 간호의 질향상 전략

박경현,송경애,공혜성,나화주,유수경,박소영,김상희,최혜림,배희준,한문구,양미화 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 뇌졸중 환자를 돌보는 간호현장에서는 급성기 뇌졸중 환자의 증상악화에 대한 조기사정과 적절한 대처가 매우 중요한 문제이다. 그러나 임상현장에서는 이를 객관화하고 수치화하여 모든 의료진이 의사소통할 수 있는 유용한 도구를 사용하고 있지는 못하는 실정이다. 이러한 문제를 해결하기위해 NIHSS(National Institute of Health Stroke Scale)를 신경과 진료의사를 중심으로활용하고 있지만 아직 간호현장에서는보편적으로사용하지 않고있다. 이에 뇌졸중환자간호에 NIHSS를 활용하여 뇌졸중 증상악화의 조기사정과 빠른 대처로 궁극적으로는 뇌졸중환자 간호의 질을보다 향상시키기 위하여 본활동이 시도되었다. 목적: 첫째, 간호사의 NIHSS 측정 신뢰도의 현수준을 점검하고 이를향상시키기 위한 프로그램을 개발·적용한다. 둘째, 간호사가급성기 뇌졸중환자에게 NIHSS 측정을 통하여 뇌졸중악화를 얼마나 예측할 수 있는지 분석하고 이를 향상시킬수있는 방법을 모색한다. 셋째, 궁극적으로 급성기 뇌졸중 환자의 증상악화의 조기 발견과치료를위한의료진의 올바른 대처지침을 마련하여 이를 적용한다. 의료기관: 경기도에 소재한 대학병원의 뇌졸중 집중치료실 질 향상 활동: 첫째, 간호사의 NIHSS 측정 신뢰도 향상을 위해 「NIHSS 간호사 교육 프로그램」을 마련하였다.

내부 응력이 .06 taper Profile의 피로 파절에 미치는 영향

정혜림,김진우,조경모,박세희 大韓齒科保存學會 2012 Restorative Dentistry & Endodontics Vol.37 No.2

Objectives: The purpose of this study was to evaluatie the reation between intentionally induced internal stress and cyclic fatigue failure of .06 taper ProFile. Materials and Methods: Length 25 mm, .06 taper ProFile (Dentsply Maillefer), and size 20, 25, 30, 35, and 40 were used in this study. to give the internal stress, the rotary NiTi files were put into the .02 taper, Endo-Training Bloc (Dentsply Maillefer) until auto-stop by torque controlled motor. Rotary NiTi files were grouped by the number of induced internal stress and randomly distributed among one control group and three experimental groups (n = 10, Stress 0 [control], Stress 1, Stress 2 and Stress 3). For cyclic fatigue measurement, time for separation of the rotary NiTi files was recorded. the fractured surfaces were observed by field emission scanning electron microscope (FE-SEM, SU-70, Hitachi). The tiem for separation was statistically analyzed using two-way ANOVA and post-hoc Scheffe test at 95% level. Results: In .06 taper ProFile size 20, 25, 30, 35, and 40, there were statistically significant difference on time for separation between control group and the other groups (p < 0.05). Conclustion: In the limitation of this study, cyclic fatigue failure of .06 taper ProFile is influenced by internal stress accumulated in the files. (Restor Dent Endod 2012;37(2):79-83)

코로나19 대응을 위해 한시적으로 허용된 전화상담·처방에 대한 병원급 의료공급자 인식과 만족도에 관한 연구

유혜림,김수민,박춘선,김지애 건강보험심사평가원 2021 HIRA RESEARCH Vol.1 No.1

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대학 교양교육과정의 평가 준거 개발 연구

박혜림 한국교육과정학회 2007 교육과정연구 Vol.25 No.3

다기관 전향적 임상연구를 위한 웹 데이터베이스 시스템

김혜림,최신영,유은미,박지숙 서울여자대학교 2010 정보기술논문지 Vol.8 No.-

Because many centers jointly select the subject, multi-center clinical study can promptly recruit various patient groups into the research, thus being advantageous in terms of generalization. However, prospective clinical study has difficulties in implementation, because it takes a lot of efforts to trace a large scale of subjects. The purpose of this study is to develop a web database system suitable for multi-center prospective clinical study. This study has presented three basic strategies-accurate data input, easy data tracing, and real-time data verification-to supplement the demerits of prospective clinical study. The developed system has been applied in the clinical study proceeded by the study group for Respiratory failure which is affiliated to The Korean Academy of Tuberculosis and Respiratory Diseases's Association for Research on Respiratory Failure and has been verified of its performance.

대학생의 수면양상과 수면장애요인에 관한 연구

김유진,박미경,박이랑,이보람,이혜림,전선미,양난영,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38

The results of this Study are as follows:33.6% of all participants have insomnia; 22.5% of those who have insomnia are DIS(difficulty in initiating sleep), 17.3% are DMS(difficulty returning to sleep once awakened) and 7.0% awakened too early. 3 4.8% experience sleepiness during daytime. Type 1, experiencing insomnia and sleepi ness during daytime together, is 12.0%, Type 2, with insomnia only, is 21.6%, Type 3, with sleepiness during daytime only, is 22.8% and 43.5% experience no sleeping disturbances. After studying only those with 3 types of sleeping disturbances, it is found that the most common cause of such disturbance is stress 88.4%, anxiety 56.0%, no apparent reason 33.8%, anxiety/fear/terror 29.3%, hurry 23.6%, alcohol/caffeine 16.9%, bedroom tem perature 11.1%, urination during nighttime and persons living together 10.7%, noise from inside 8.9%, illumination 8.0%, and pain/itch 5.8%. The one group revealed significant differences in residential environment(p=0.003). Sex, age, education level, medicine, monthly earning revealed no meaningful differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), whether taking enough sleep(p=0.029), whether taking regular sleep(p=0.005) showed significant differences depending on whether or not having insomnia, and mean duration of sleep time, time to sleep, time of rising, whether taking naps did not reveal significant differences. Of sleep behavior, time to sleep(p=0.000), whether taking naps(p=0.000), indicated significant differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), and whether taking enough sleep(p=0.000), time of going to bed (p=0.002), whether or not taking nap(p=0.000), whether or not taking regular sleep(p=0.010) indicated significant differences among the sleeping disturbance types.

선천성 피부 형성부전증 1례 보고

황성진,박혜림,김희석,김동철,김정헌 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.2

Aplasia cutis congenita is a disorder of heterogeneous group characterized by isolate or multiple, localized or widespread areas of skin defect at birth. Since the first report by Cordon in 1767, it has been relatively rarely reported disorder abroad as well as domestically . It has several clinical subtypes classified by the location and pattern of skin absence, the presence of associated malformations and the mode of inheritance with unknown cause. We had a newborn male infant with this disorder clinically diagnosed, who showed wide full thickness skin defects on right knee and medial surface of ankle from birth, that covered with thin yellowish membrane and showed focal ulcerative area. On his familial history, there were four aplasia cutis congenita patients in the patient's mother in his maternal family side through four generations. Patient mother showed wide spread atrophic scarred looking appearance on her right lower leg. Chromosomal analysis revealed as normal male karyotype. The biopsy of lesions showed ulcerated surface and underlying chronic inflammation with total absence of epidermis. He had no associated congenital anomaly. The lesions healed rapidly for four weeks by conservative treatment as moist wound dressing and systemic antibiotic administrations. As a relatively uncommon skin anomaly, one case of aplasia cutis congenita is reported with review of references.

황사 기간 동안에 어린이, 성인, 노인에서의 자각증상과 예방행동에 대한 조사연구

이보은,하은희,박혜숙,권지숙,신경림 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.1

Purpose: Recently there are scientific evidences for the health effects of Asian dust-storms. Particularly in 2002, the daily average of PM_(10) exceeded 600 and 700 ㎍/㎥ in March and April respectively. We examined the effects of Asian dust-storms on perceived symptoms and preventive behaviors among children, adults, and elders. Method: The subjects of this study were 425 children, 444 adults and 60 elders. A questionnaire survey was carried out on the children and the adults by teachers and on the elders by interviewers to obtain information on demographic variables, perceived symptoms and preventive behaviors, previous respiratory disease, environmental tobacco smoke, and proximity between the house and the road during Asian dust-storms. We analyzed using descriptive statistics, X_(2) test and multiple logistic regression models. After adjustment for potential confounders, we estimated the odds ratios and 95% confidence intervals of the children and the elders for perceived symptoms and preventive behaviors. Result: The elders had a significantly higher prevalence of respiratory symptoms than the other groups. The children had a significantly higher prevalence than the adults in getting URI (1.51), coughing (1.68), rhinorrhea (1.46), fever (2.39) and medication for allergy or asthma (1.90). The children had better behaviors than the elders in closing windows (3.57), taking less outdoor recreational activity (2.59) and staying home (2.60).