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김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
급성 조증에서 기분안정제와 리스페리돈의 병합 투여 효과 : 다기관 개방연구
김광수,배치운,윤진상,김영훈,이양현,지익성,이철,송혜경,최성구,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2
Ohjective : The primary purpose of this study was a replication of the effectiveness and tolerability of rispehdone in the treatment of patients with acute mania in very larger cohon in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods : A total of 909 patients with DSM-TV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson-Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extra-pyramidal symptom (EPS). Results : This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change=-23.5±11.8, p<0.0001 ; mean change=-2.7±1.5, p<0.0001, respectively) from the baseline to the endpoint (week 6). Number of patients with 50% reduction or more in the YMRS and CGI-s scores was 693 (77.8%) and 630 (70.7%) at endpoint, respec-tively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. Conclusion : The present larger open study demonstrates that hsperidone add-on therapy is effective and tolerable in treat-ment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.
( Hye-jin Ku ),( You-tae Kim ),( Ju-hoon Lee ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.5
Although the genus Leuconostoc, generally found in various fermented foods, has often been suggested to be a novel probiotic for food fermentation and health promotion, the strains in this genus showed low acid tolerance and low osmotic stress resistance activities, which are required for survival during food fermentation events. Recently, a novel species of Weissella, W. jogaejeotgali FOL01<sup>T</sup> (= KCCM 43128 = JCM 30580), was isolated from Korean fermented clams. To determine the genomic features of this new species, its genome was completely sequenced and analyzed. The genome consists of a circular chromosome of 2,114,163 bp of DNA with a G+C content of 38.8%, and the plasmid pFOL01 consists of 35,382 bp of DNA with a G+C content of 39.1%. The genome analysis showed its potential for use in food fermentation and osmotic stress resistance abilities for processing in food industries. In addition, this strain was predicted to have acid tolerance and adhesion to the mucosal layer for survival and colonization in the gut. Subsequent experiments substantiated these abilities, suggesting that W. jogaejeotgali may have probiotic potential and a high survival rate during food fermentation. Therefore, it may be suitable as a novel probiotic strain for various applications in food industries.
( Hye-jin Ku ),( You-tae Kim ),( Ju-hoon Lee ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.7
To understand the formation of initial gut microbiota, three initial fecal samples were collected from two groups of two breast milk-fed (BM1) and seven formula milk-fed (FM1) infants, and the compositional changes in gut microbiota were determined using metagenomics. Compositional change analysis during week one showed that Bifidobacterium increased from the first to the third fecal samples in the BM1 group (1.3% to 35.1%), while Klebsiella and Serratia were detected in the third fecal sample of the FM1 group (4.4% and 34.2%, respectively), suggesting the beneficial effect of breast milk intake. To further understand the compositional changes during progression from infancy to childhood (i.e., from three weeks to five years of age), additional fecal samples were collected from four groups of two breast milk-fed infants (BM2), one formula milk-fed toddler (FM2), three weaning food-fed toddlers (WF), and three solid food-fed children (SF). Subsequent compositional change analysis and principal coordinates analysis (PCoA) revealed that the composition of the gut microbiota changed from an infant-like composition to an adult-like one in conjunction with dietary changes. Interestingly, overall gut microbiota composition analyses during the period of progression from infancy to childhood suggested increasing complexity of gut microbiota as well as emergence of a new species of bacteria capable of digesting complex carbohydrates in WF and SF groups, substantiating that diet type is a key factor in determining the composition of gut microbiota. Consequently, this study may be useful as a guide to understanding the development of initial gut microbiota based on diet.
Ku, Hye Jin,Kim, Hye Young,Kim, Hyeong Hoe,Park, Hee Ju,Cheong, Jae Hun WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.1
<P>To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon cooperative activation.</P>
Investigation of persistent infection with bovine viral diarrhea in Korean native cattle
Hye-Young Jeoung(Hye-Young Jeoung),Eun-Yong Lee(Eun-Yong Lee),Se-Jin Park(Se-Jin Park),Hyung-Woo Kang(Hyung-Woo Kang),Ji-Young Park(Ji-Young Park),Kyoung-Ki Lee(Kyoung-Ki Lee),Bok-Kyung Ku(Bok-Kyung K 한국예방수의학회 2022 한국예방수의학회 학술대회자료집 Vol.2022 No.-
( Hye Jin Ku ),( Ju Hoon Lee ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.6
Metagenomic analysis of the human intestinal microbiota has extended our understanding of the role of these bacteria in improving human intestinal health; however, a number of reports have shown that current total fecal DNA extraction methods and 16S rRNA universal primer sets could affect the species coverage and resolution of these analyses. Here, we improved the extraction method for total DNA from human fecal samples by optimization of the lysis buffer, boiling time (10 min), and bead-beating time (0 min). In addition, we developed a new longrange 16S rRNA universal PCR primer set targeting the V6 to V9 regions with a 580 bp DNA product length. This new 16S rRNA primer set was evaluated by comparison with two previously developed 16S rRNA universal primer sets and showed high species coverage and resolution. The optimized total fecal DNA extraction method and newly designed long-range 16S rRNA universal primer set will be useful for the highly accurate metagenomic analysis of adult and infant intestinal microbiota with minimization of any bias.
구혜진(Hye-jin Ku),박희숙(Hee-sook Park) 영곡사회심리발달학회 2022 사회심리발달연구 Vol.3 No.2
본 연구의 목적은 지속가능발전목표(SDGs)의 13번째 목표인 기후행동에 대한 개념도 분석으로 유아교사의 지식체계를 고찰하는 데 있다. 연구에 필요한 자료는 경기 지역 어린이집 교사 24명을 대상으로 기후행동 지식체계에 대한 개념도를 설문 조사하여 수집하였다. 개념도에 나타난 내용지식과 지식수준을 분석한 결과, 유아교사는 총 36개의 상위개념을 사용하였다. ‘생활 속 실천’, ‘환경문제’, ‘개념 인식’, ‘에너지 절약’, ‘교육 실천’, ‘개념 행동’, ‘대체 에너지’의 총 7개 대표용어를 도출하였다. 유아교사의 기후행동에 대한 지식수준을 알아본 결과 ‘에너지 절약’이 가장 높은 빈도를 나타냈다. 이는 실제 교육활동 시 ‘환경문제’, ‘개념 인식’ 보다는 ‘에너지 절약’에 많이 편중되어 있다는 것을 의미한다. 본 연구의 결과를 통해 기후행동에 대한 유아교사의 지식내용과 수준이 조직적이지 않고 분절된 형태로 되어있다고 볼 수 있다. 개념도 분석을 통해 기후행동에 대한 복합적인 지식을 위계적이고 다층적으로 구조화할 수 있는 교사교육의 필요성을 확인하였다. The purpose of this study is to examine through concept map analysis the knowledge system of early childhood teachers about ‘Climate Action’, the 13th of the UN’s Sustainable Development Goals (SDGs). Data were collected by surveying 24 preschool teachers in Gyeonggi Province about their climate action knowledge systems. Analysis of the collected data showed that early childhood teachers used a total of 36 superordinate concepts, with 'adaptation in daily life', 'environmental problems,' 'recognition of concepts,' 'energy conservation,' 'education practice,' 'concept behavior' and 'alternative energy' identified as 7 key terms. ‘Energy conservation’ was the most frequently utilized term, implying that educators put more emphasis on ‘energy conservation’ rather than on ‘environmental problems’ or ‘concept recognition.’ Based on the results of this study, the level of comprehension around climate action seems to be disorganized and disconnected amongst early childhood educators, requiring a method of education that structures complex climate action concepts in a measured and layered manner for teachers.
소면적 재배작물 중 살균제 Mefentrifluconazole의 잔류 특성
정혜진 ( Hye-jin Jeong ),박소현 ( So-hyun Park ),심재룡 ( Jae-ryong Shim ),김종규 ( Jong-kyu Kim ),김광래 ( Gwang-rae Kim ),장유진 ( You-jin Jang ),임은지 ( Eun-ji Lim ),우상원 ( Sang-won Woo ),박종우 ( Jong-woo Park ),이근식 ( Ku 한국환경농학회 2021 한국환경농학회 학술대회집 Vol.2021 No.-
엽채소류, 기능성 작물에 대한 소비자의 관심으로 다양한 소면적 작물이 재배되고 있고, 기후변화와 새로운 작물의 재배로 병해충 발생 종류가 지속적으로 증가에 따라 소면적 작물 중심으로 농약등록 요구가 증가되고 있으나, 농약업계는 경제성을 이유로 소면적 작물용 농약의 등록을 기피하고 있어 잔류허용기준이 설정된 농약의 수가 제한적이다. 한편, 2019년부터 우리나라에서는 농약허용물질목록고시제(Positive List System, PLS)를 전면시행하여 잔류허용기준 미설정 농약에 대한 잔류허용기준을 0.01 mg/kg으로 일괄 적용함으로서 미등록 농약 사용으로 인한 부적합 농산물의 생산 가능성이 커지고 있다. 이에 본 연구는 소면적 재배작물인 엇갈이배추, 시금치, 미나리, 쪽파에 대해 비교적 최근에 개발된 이소프로피놀 트리아졸계 살균제인 Mefentrifluconazole의 잔류성을 구명하여 농약품목등록 자료 및 잔류농약의 안전성 평가를 위한 기초자료로 활용하고자 하였다. Mefentrifluconazole은 식물의 물관부를 통해 서서히 흡수되어 살균효과를 오랫동안 지속하며 다른 약제에 대해 저항성을 가진 균에 대해서도 높은 활성을 가지고 있다. 본 연구를 수행하기 위해 Mefentrifluconazole 10% 액상수화제를 소면적 엽경채류인 엇갈이배추, 시금치, 미나리, 쪽파에 대해 2,000배 희석액을 7일 간격으로 3회 살포하여 각 작물에서의 Mefentrifluconazole 잔류특성을 연구하였다. 시험에 사용된 4가지 소면적 작물에 대한 Mefentrifluconazole의 정량한계는 모두 0.01 mg/kg이었으며, 회수율시험은 LOQ, 10LOQ 및 최고잔류농도 수준의 3농도에서 각각 5반복으로 수행하였다. 각 작물에 대한 Mefentrifluconazole의 회수율은 엇갈이배추 78.8∼92.6%, 시금치 72.1∼91.4%, 미나리 83.0∼94.9%, 쪽파 91.2∼104.8%의 회수율 범위를 나타내었다. Mefentrifluconazole의 잔류량은 엇갈이배추 0.34∼2.80 mg/kg, 시금치 0.22∼7.13 mg/kg, 미나리 0.22∼4.99 mg/kg 그리고 쪽파 0.04∼1.22 mg/kg으로 나타났다. 각 작물에서 농약의 잔류량은 약제살포 후 시간이 경과함에 따라 경시적으로 감소하는 경향을 나타내었다. 이들 4가지 작물에 대한 Mefentrifluconazole의 생물학적 반감기를 조사한 결과 엇갈이배추 5.0일, 시금치 2.9일, 미나리 3.4일 그리고 쪽파의 경우는 3.2일로 나타났다. 우리나라에서 시험약제인 Mefentrifluconazole의 각 작물에 대한 안전사용기준 및 잔류허용기준은 아직까지 미설정되어 있어, 본 잔류시험의 결과를 토대로 Mefentrifluconazol 10% 액상수화제의 안전사용기준은 각 작물에 대해 각각 수확 7일전, 3회로 제안하며, 이에 따라 잔류허용기준은 엇갈이배추, 시금치 및 미나리에 대해서는 7 mg/kg, 쪽파는 1 mg/kg으로 추천하고자 한다.