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Case Reports : A Case of Assisted Reproductive Therapy-induced Erythema Nodosum
( Hye Chan Jeon ),( Mi Ra Choi ),( Seung Hwan Paik ),( Sun Jae Na ),( Jong Hee Lee ),( So Yun Cho ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3
Erythema nodosum is a common variant of panniculitis. It is characterized by tender erythematous nodule and plaque on the anterior aspect of the leg. The etiology is not fully understood. It may be associated with a variety of disorders, including infection, medication, autoimmune disorders, pregnancy, and malignancy. A 33-year-old Korean woman presented with 1 week history of painful erythematous plaques on both knees. She was 7 weeks pregnant with assisted reproductive therapy, and had been maintained on daily intramuscular progesterone injection for 4 weeks. Histological examination of the lesions revealed septal panniculitis without vasculitis. Two days after discontinuing progesterone injection, the symptoms and lesions started to resolve. Herein we present a case of erythema nodosum caused by progesterone injection for endometrial preparation.
( Hye Chan Jeon ),( Mi Ra Choi ),( Seung Hwan Paik ),( Chang Ho Ahn ),( Hyun Sun Park ),( Kwang Hyun Cho ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3
Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara(R)) has been reported. We present 4 cases of KA treated with topical imiquimod, applied 3 to 4 times a week. Obvious improvement was observed after 4 to 6 weeks of application and the lesions were almost cleared leaving scars after 9 to 11 weeks. These results show that topical imiquimod can be an effective option for the conservative management of KA as previously reported. We also suggest that lesions treated with imiquimod cream should be considered for biopsy to judge histopathological remission after 5 to 8 weeks of application to shorten the duration of the treatment.
( Hye Chan Jeon ),( Seung Hwan Paik ),( Hyun Je Kim ),( Seon Pil Jin ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Sebaceous glands do not have selective chromophores for lasers compared to the other skin structures. So the application of lasers to the sebaceous disorders has been challenging. Recently, however, development of photodynamic therapy (PDT) shines a light on the treatment of sebaceous disease. In addition, indocyanine green (ICG) differs a little from other photosensitizers in two ways. It releases less reactive oxygen radicals, but it is a strong chromophore to the red light (wavelength 700 to 850 nm). We targeted sebaceous glands by application of ICG to the skin. It is differentiated from the previous ones in that we use different photosensitizers and lasers. The PDT was conducted using long pulsed alexandrite laser (755nm) with ICG in three different sebaceous gland diseases (sebaceous hyperplasia, acne vulgaris and skin pore) with different treatment protocols. For the treatment of acne or skin-pore, the preparation before treatment is necessary. This is because the preparation and application time regulates the absorption depth of ICG. As the patients with skin-pore usually accompany rosacea, anti-inflammatory treatments were carried out together. For treating sebaceous hyperplasia with a large volume of the lesions occupying the lower part of the dermis, we used long pulsed alexandrite laser after intralesional injection of ICG. This new method could be widely used with less downtime and cosmetically satisfactory results.
전혜찬 ( Jeon Hye Chan ) 한국스페인어문학회 2003 스페인어문학 Vol.0 No.29
El arte ha muerto se ha convertido en un tema central del arte de nuestro tiempo. En este arti´culo trato de indagar porque´ el arte moderno ha muerto y cua´l es el significado de su muerte. Para empezar, explico el concepto revolucionario del arte moderno que se convirtio´ en una bu´squeda de una realidad absoluta como si fuera una pseudo-religio´n desde el final del siglo XVIII en el mundo occidental. Y he averiguado porque´ Hegel proclamo´ la muerte del arte por primera vez desde hace casi dos cientos an~os. Hemos visto que la muerte del arte en la e´poca de Hegel se refirio´ a la muerte del arte tradicional que fue sustituido por el arte roma´ntico-es el prinpicio del arte moderno- que fue una ruptura con la trascendencia de la religio´n de la sociedad. Despue´s indagamos porque´ el arte moderno ha llegado al fin y su significado. Primero, la pe´rdida de lo sublime que fue el principio fundamental del arte moderno nos hizo reflexionar la muerte del arte moderno. Esto quiere decir que el arte moderno ha abandonado el viaje hero´ico de bu´squeda de una isla uto´pica. En consecuencia el arte moderno perdio´ su aurora y empezo´ a confundirse con los objetos ready-mades de Duchamp. Segundo, el Vanguardismo, la fase u´ltima del arte moderno ha sido sentenciado como muerto porque su principio de la ruptura con la tradicio´n perdio´ la fuerza cri´tica y creadora. La rebelio´n convertida en procedimiento, la cri´tica en reto´rica, la transgresio´n en ceremonia. Las rupturas y sus impactos que hace la sociedad posmoderna con las alta-tecnologias y el derrumbe de las valores fundamentales como familia, sexo y Estado, transforman el arte moderno en algo trivial sin novedad. Es decir en nuestra sociedad posmoderna la rebelio´n de los artistas contra las tradiciones autoritarias para conseguir ma´s libertad para arte y vida ya perdio´ su fundamento porque ya gozamos de esa libertad ilimitada que nos amenaza por su fuerza ciega.
( Chan-young Ock ),( Shin-hye Yoo ),( Bhumsuk Keam ),( Miso Kim ),( Tae Min Kim ),( Yoon Kyung Jeon ),( Dong-wan Kim ),( Doo Hyun Chung ),( Dae Seog Heo ) 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.5
Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factors affecting PFS of crizotinib and develop a prognostic model for advanced ALK-positive NSCLC. Methods: Clinicopathologic features of patients enrolled in PROFILE 1001, 1005, 1007, and 1014 (training cohort) were reviewed. We conducted multivariate Cox analysis for PFS and overall survival (OS) in the training cohort (n = 159) and generated a proportional hazards model based on significant clinicopathologic factors, and then validated the model in an independent validation cohort (n = 40). Results: In the training cohort, the objective response rate was 81.5%. Median PFS and OS from the start of crizotinib were 12.4 and 31.3 months, respectively. Multivariate Cox analysis showed poor performance status, number of metastatic organs (≥ 3), and no response to crizotinib independently associated shorter PFS. Based on a score derived from these three factors, median PFS and OS of patients with one or two factors were significantly shorter compared to those without these factors (median PFS, 22.4 months vs. 10.5 months vs. 6.5 months; median OS, not reached vs. 29.1 months vs. 11.8 months, respectively; p < 0.001 for each group). This model also had validated in an independent validation cohort. Conclusions: Performance status, number of metastatic organs, and response to crizotinib affected PFS of crizotinib in ALK-positive NSCLC. Based on these factors, we developed a simple and useful prediction model for PFS.
Jeon, Chan-Oh,Kang, Soo-Won,Park, Seung-Beom,Lim, Kyung-Taek,Hwang, Kwang-Woo,Min, Hye-Young The Korean Society of Ginseng 2011 Journal of Ginseng Research Vol.35 No.4
Myeloid-derived suppressor cells (MDSCs) actively suppress immune cells and have been considered as an impediment to successful cancer immunotherapy. Many approaches have been made to overcome such immunosuppressive factors and to exert effective anti-tumor effects, but the possibility of using medicinal plants for this purpose has been overlooked. Korean red ginseng (KRG) is widely known to possess a variety of pharmacological properties, including immunoboosting and anti-tumor activities. However, little has been done to assess the anti-tumor activity of KRG on MDSCs. Therefore, we examined the effects of KRG on MDSCs in tumor-bearing mice and evaluated immunostimulatory and anti-tumor activities of KRG through MDSC modulation. The data show that intraperitoneal administration of KRG compromises MDSC function and induces T cell proliferation and the secretion of IL-2 and IFN-${\gamma}$, while it does not exhibit direct cytotoxicity on tumor cells and reduced MDSC accumulation. MDSCs isolated from KRG-treated mice also express significantly lower levels of inducible nitric oxide synthase and IL-10 accompanied by a decrease in nitric oxide production compared with control. Taken together, the present study demonstrates that KRG enhances T cell function by inhibiting the immunosuppressive activity of MDSCs and suggests that although KRG alone does not exhibit direct anti-tumor effects, the use of KRG together with conventional chemo- or immunotherapy may provide better outcomes to cancer patients through MDSC modulation.