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- 검색키워드
- 저자 : ( Hoyoung Kim ) (검색결과 387 건)
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Kim Hoyoung,Lim Taehyun,Ha Go Eun,Lee Jee-Young,Kim Jun-Woo,Chang Nienping,Kim Si Hyun,Kim Ki Hun,Lee Jaeick,Cho Yongju,Kim Byeong Wook,Abrahamsson Alva,Kim Sung Hwan,Kim Hyo-Ji,Park Sehan,Lee Sang Ja 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF1R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G protein-coupled receptor (GPCR) structures to develop drugs. X-ray free-electron lasers (XFELs), which prevent radiation damage and provide access to high-resolution compositions, have helped accelerate GPCR structural studies. We elucidated the crystal structure of CRF1R complexed with a BMK-I-152 antagonist at 2.75 Å using fixed-target serial femtosecond crystallography. The results revealed that two unique hydrogen bonds are present in the hydrogen bond network, the stalk region forms an alpha helix and the hydrophobic network contains an antagonist binding site. We then developed two antagonists—BMK-C203 and BMK-C205—and determined the CRF1R/BMK-C203 and CRF1R/BMK-C205 complex structures at 2.6 and 2.2 Å, respectively. BMK-C205 exerted significant antidepressant effects in mice and, thus, may be utilized to effectively identify structure-based drugs against CRF1R.
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Kim, Cham,Kim, Chang Eun,Baek, Ju Young,Kim, Dong Hwan,Kim, Jong Tae,Ahn, Ji Hyeon,Lopez, David Humberto,Kim, Taewook,Kim, Hoyoung American Chemical Society 2016 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.55 No.19
<P>Various chemical reaction processes have been adopted to synthesize Bi2Te3 thermoelectric nanomaterials for achieving remarkably low thermal conductivities, but chemical contaminations were usually pointed out as flaws, severely deteriorating electrical conductivities. We devised a novel water-based chemical reaction process for a Bi2Te2.7Se0.3 nanocompound in which the possibility for chemical contaminations was reduced. We successfully synthesized a small and highly distributed Bi2Te2.7Se0.3 nanocompound with high purity and adequately packed it via a spark plasma sintering process to produce a nanobulk structure. The resulting nanobulk specimen exhibited a physical density as high as the theoretical one with highly distributed nanograins; thus,. we were able to obtain remarkably high electrical,conductivity while maintaining thermal: conductivity as lbw as possible. The synergistic effect was greatly induced between the transport properties;. thus, the highest reported figure of merit value was achieved for n-type Bi2Te3 in the bulk phase.</P>
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Kim Hoyoung,Kim Jihoon,Choe Yeon Hyeon,Kim Sung Mok 대한의학회 2023 Journal of Korean medical science Vol.38 No.45
Background: There is a strong correlation between risk factors for coronary artery disease (CAD) and aortic aneurysm (AA). We aimed to investigate the prevalence and prognostic impact of CAD and AA in patients who underwent coronary aorta computed tomography (CACT) protocol, which allowed simultaneous evaluation of coronary artery and aorta. Methods: Between 2010 and 2021, 1,553 patients who underwent CACT were enrolled from a tertiary center. The presence and location of AA and the presence of CAD were identified from CT. The primary outcome was a composite of cardiovascular death, acute coronary syndrome requiring urgent revascularization, and stroke at 3 years after the index CT scan. Results: Out of 1,553 enrolled patients, 179 (11.5%) had AA. The prevalence of CAD was significantly higher in patients with AA than those without (47.5% vs. 18.3%, P < 0.001). Among patients with AA, the prevalence of comorbid CAD was higher in those with abdominal AA than thoracic AA (57.3% vs. 37.8%, P = 0.014), respectively. In multivariable analysis, the presence of CAD was an independent predictor of primary outcome at 3 years (hazard ratio [HR], 2.58; 95% CI, 1.47–4.51; P = 0.001), while AA was not (HR, 1.00; 95% CI, 0.48–2.07; P = 0.993). Conclusion: In this cohort of patients undergoing simultaneous evaluation of coronary artery and aorta using CACT protocol, patients with AA had an increased risk of comorbid CAD compared to those without AA. CAD was independently associated with adverse clinical outcomes at 3 years.
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Kim, Cham,Kim, Chang Eun,Baek, Ju Young,Kim, Dong Hwan,Kim, Jong Tae,Ahn, Ji Hyeon,Lopez, David Humberto,Kim, Hoyoung Elsevier 2016 Scripta materialia Vol.119 No.-
<P><B>Abstract</B></P> <P>Chemical reaction processes for thermoelectric nanomaterials have received a lot of attention because of subsequent small and uniform nanostructures, causing a remarkable reduction in thermal conductivity; however, they typically showed low electrical properties possibly due to contaminations by chemicals resulting in low ZT. We devised a new chemical process for synthesizing an n-type Bi<SUB>2</SUB>Te<SUB>2.7</SUB>Se<SUB>0.3</SUB> nanocompound without the chemicals causing potential contaminations. The product exhibited a predominant electrical conductivity while retaining the advantage of chemical reaction routes; thus, synergistic effect of the thermoelectric transport properties was greatly induced, resulting in the highest ZT among n-type Bi<SUB>2</SUB>Te<SUB>3</SUB> materials in bulk phase.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Kim, Hoyoung,Hwang, Eunkyoung,Park, Hyanjoo,Lee, Byung-Seok,Jang, Jong Hyun,Kim, Hyoung-Juhn,Ahn, Sang Hyun,Kim, Soo-Kil Elsevier BV 2017 Applied Catalysis B Vol.206 No.-
<P><B>Abstract</B></P> <P>Electrodeposited Cu<I> <SUB>x</SUB> </I>Mo<SUB>100− <I>x</I> </SUB> catalysts were prepared on a Ti substrate for the hydrogen evolution reaction (HER) in acidic medium. By varying the electrolyte composition for electrodeposition, the atomic concentration of the Cu<I> <SUB>x</SUB> </I>Mo<SUB>100− <I>x</I> </SUB> electrocatalysts could be controlled, and the Mo content ranged between 0.8 and 6.9%. In the first cyclic voltammetry scan in a 0.5M H<SUB>2</SUB>SO<SUB>4</SUB> electrolyte, the recorded HER current densities of the Cu<I> <SUB>x</SUB> </I>Mo<SUB>100− <I>x</I> </SUB> electrocatalysts at −0.50V<SUB>RHE</SUB> increased on increasing the Mo content to 3.8%; then, a further increase in Mo to 6.9% led to a saturation in the HER activity. The maximum value of the normalized current density with respect to the electrochemical surface area and the loading mass was found for the Cu<SUB>99.2</SUB>Mo<SUB>0.8</SUB> electrocatalyst. Characterization of the prepared catalysts revealed that the enhancement of catalytic activity originates from changes in the grain size and electronic structure. To operate a single cell of the proton exchange membrane water electrolyzer (PEMWE), we electrodeposited CuMo catalyst on carbon paper, and this was used as the cathode, while IrO<SUB>2</SUB> electrodeposited on carbon paper was used as the anode. The cell performance was normalized with respect to the metal mass loading and was found to be 3.4A/mg<SUB>metal</SUB> at 1.9V, a 2.2–10.8 times better catalyst cost-activity relationship compared to that of currently reported PEMWEs using Pt-based cathodes. Consequently, the results presented here show that non-noble metal cathodes can be used for PEMWE operation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cu<SUB>x</SUB>Mo<SUB>100−x</SUB> catalysts are prepared for hydrogen evolution reaction in acidic medium. </LI> <LI> Small amount of Mo enhances catalytic activity of Cu<SUB>x</SUB>Mo<SUB>100−x</SUB> catalysts. </LI> <LI> Water electrolyzer with non-precious catalyst demonstrates reasonable performance. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Kim, Cham,Baek, Ju Young,Kim, Dong Hwan,Kim, Jong Tae,Lopez, David Humberto,Kim, Taewook,Kim, Hoyoung Elsevier 2017 Journal of Alloys and Compounds Vol.722 No.-
<P><B>Abstract</B></P> <P>We studied a polycrystalline p-type WSe<SUB>2</SUB> semiconductor for thermoelectric applications. The polycrystalline WSe<SUB>2</SUB> nanocompound was prepared via a thermal reaction process of tungsten and selenium elements and it was sintered to produce a bulk structure using spark plasma sintering equipment. The resulting bulk specimen showed different morphological aspects, in which we observed irregularly-shaped grains along the direction perpendicular to the sintering pressing direction (i.e., along transversal direction) while finding thin layers along the parallel direction (i.e., along longitudinal direction). The specimen recorded a significantly low longitudinal thermal conductivity possibly because longitudinal phonon transport should be hindered due to the thin layers. Electron transport along the longitudinal direction might not be greatly interrupted by the morphological characteristics because the specimen recorded high carrier mobility along the direction resulting in lower electrical resistivity than that of a single crystalline equivalent. The specimen also showed moderate carrier concentration, which led to a plausible Seebeck coefficient. Since the specimen exhibited the significantly low thermal conductivity with the electrical properties, it recorded a higher figure of merit than the equivalent, which is the highest thermoelectric performance for p-type WSe<SUB>2</SUB> in bulk phase ever developed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new thermal reaction process was devised for a polycrystalline WSe<SUB>2</SUB> nanocompound. </LI> <LI> The nanocompound showed morphological anisotropy led to decoupling of conductivities. </LI> <LI> The highest thermoelectric performance was done for bulk phase WSe<SUB>2</SUB> ever reported. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Method for evaluating interfacial resistances of thermoelectric devices using I-V measurement
Kim, Dong Hwan,Kim, Cham,Kim, Jong Tae,Yoon, Duck Ki,Kim, Hoyoung Elsevier 2018 MEASUREMENT -LONDON- Vol.129 No.-
<P><B>Abstract</B></P> <P>Research on the methodology for predicting and analyzing the performance of a thermoelectric device (TED) can offer various possibilities for enhancing its energy conversion characteristics. In this work, the methodology to determine the electrical contact resistance and the interfacial thermal resistance of a TED was studied. Based on one-dimensional heat transfer equations of power generation mode that includes electrical contact resistance and interfacial thermal resistance, we derived explicit expressions for the open circuit voltage and the short circuit current as the limiting cases of the external electrical load. The measurements of the open circuit voltage and the short-circuit current of TED were carried out for various thermal interface materials (TIMs) between the TED and heat reservoirs under varying compressive forces. The electrical contact resistance and the interfacial thermal resistance of a TED were determined by matching the measured values of the open circuit voltage and the short circuit current of a TED to the results of the analytic model. The electrical contact resistivity of the TED tested was approximately 3 × 10<SUP>−9</SUP> Ωm<SUP>2</SUP>, irrespective of the compressive force, the hot-side temperature, and the TIMs. The interfacial thermal resistance varied sensitively with the TIMs and decreased with the compressive forces.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An evaluation method of the interfacial resistance of a TEG device is proposed. </LI> <LI> Analytic expressions for the V<SUB>OC</SUB> and I<SUB>SC</SUB> have been derived. </LI> <LI> The electrical contact resistance of a thermoelectric device calculated. </LI> <LI> The evaluation method can be used as an index to improve the soldering process. </LI> </UL> </P>
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Kim, Cham,Baek, Ju Young,Kim, Dong Hwan,Kim, Jong Tae,Lopez, David Humberto,Kim, Taewook,Kim, Hoyoung THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.60 No.-
<P><B>Abstract</B></P> <P>A polycrystalline WSe<SUB>2</SUB> nanocompound was produced via a brief thermal reaction between the atomic elements. It should grow along the in-plane direction with covalent bonds rather than along the through-plane direction with van der Waals forces, leading to both crystallographic and morphological anisotropies. Not only the anisotropies should structurally induce strong phonon scattering but they alleviate possible electron scattering at the van der Waals forces; thus, we greatly reduced thermal conductivity while minimizing electrical conductivity loss. The decoupled conductivities resulted in enhancement in figure of merit, by approximately 70% at 350°C, thus affording a promising material for mid-temperature thermoelectric operations.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Kim, Hoyoung,Park, Hyanjoo,Kim, Dong-Kwon,Choi, Insoo,Kim, Soo-Kil Elsevier 2019 Journal of alloys and compounds Vol.785 No.-
<P><B>Abstract</B></P> <P>Ni-P catalysts with various compositions were fabricated by pulse electrodeposition in pursuit of highly efficient and durable hydrogen evolution via proton exchange membrane water electrolysis. Pulse electrodeposition enabled the preparation of a Ni-P catalyst with a high portion of P, thereby conferring acid-resistant properties to the catalyst. Specifically, precise control of the deposition potential made it possible to leach Ni from bulk Ni-P and thus to vary the composition. With greater P incorporation, the catalyst became amorphous. The activity of the as-prepared Ni-P catalysts for the hydrogen evolution reaction (HER) in acidic medium was evaluated by cyclic voltammetry, confirming the strong dependence of the activity on the composition. The Ni-P catalyst with a bulk composition of Ni<SUB>78</SUB>P<SUB>22</SUB> exhibited the best HER activity with an overpotential of 105 mV at −10 mA cm<SUP>−2</SUP>. The current density of the single cell with the electrodeposited Ni<SUB>78</SUB>P<SUB>22</SUB> cathode and electrodeposited IrO<SUB>2</SUB> anode was 1.31 A cm<SUP>−2</SUP> at 2.0 V<SUB>cell</SUB>. Compared to reported values for other non-Pt or Pt cathodes for electrolysis, the electrolyzer with the Ni<SUB>78</SUB>P<SUB>22</SUB> cathode strongly outperforms the non-Pt cathodes, and the performance is more than a half of that of the Pt cathode.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ni-P catalysts with high P contents were fabricated by pulse electrodeposition. </LI> <LI> As-prepared Ni-P catalysts were tested for H<SUB>2</SUB> evolution via half-cell experiment. </LI> <LI> Ni<SUB>78</SUB>P<SUB>22</SUB> catalyst showed excellent catalytic activity and durability for acidic HER. </LI> <LI> Electrolyzer with Ni<SUB>78</SUB>P<SUB>22</SUB> cathode clearly outperforms others with non-Pt catalysts. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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