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Shaking Table Test of Water Supply Pipes Installed in a Full-Scale Masonry Structure
Houli Wu,Endong Guo,Dezhang Sun,Chenxi Mao,Haoyu Zhang,Zhibin Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.2
The seismic performance of indoor water supply pipes plays a significant role during earthquakes, and the failure of pipes causes severe economic losses and other disasters. This paper presents shaking table test research on water supply pipes installed in a full-scale masonry structure. Three different material pipes and three different material fillers were combined to evaluate the difference in seismic performance. In this study, normalized floor response spectra and pipe acceleration amplification factors obtained from experimental data were compared with code provisions. Spectrum analysis was used to evaluate the pipeline seismic response, and the results showed that the combination of pipes and fillers with similar material properties vibrated partially at multiple frequencies. In contrast, the combination of pipes and fillers with very different material properties only vibrated near the predominant structural period.
( Wenyong Ding ),( Houli Zhang ),( Yuefei Xu ),( Li Ma ),( Wenli Zhang ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.8
Mycobacterium tuberculosis, a causative pathogen of tuberculosis (TB), still threatens human health worldwide. To find a novel drug to eradicate this pathogen, we tested taurine-5- bromosalicylaldehyde Schiff base (TBSSB) as an innovative anti-mycobacterial drug using Mycobacterium smegmatis as a surrogate model for M. tuberculosis. We investigated the antimicrobial activity of TBSSB against M. smegmatis by plotting growth curves, examined the effect of TBSSB on biofilm formation, observed morphological changes by scanning electron microscopy and transmission electron microscopy, and detected differentially expressed proteins using two-dimensional gel electrophoresis coupled with mass spectrometry. TBSSB inhibited mycobacterial growth and biofilm formation, altered cell ultrastructure and intracellular content, and inhibited cell division. Furthermore, M. smegmatis adapted itself to TBSSB inhibition by regulating the metabolic pathways and enzymatic activities of the identified proteins. NDMA-dependent methanol dehydrogenase, NAD(P)H nitroreductase, and amidohydrolase AmiB1 appear to be pivotal factors to regulate the M. smegmatis survival under TBSSB. Our dataset reinforced the idea that Schiff base-taurine compounds have the potential to be developed as novel anti-mycobacterial drugs.
( Ru Qiang Yuan ),( Yun Peng Diao ),( Wen Li Zhang ),( Yuan Lin ),( Shan Shan Huang ),( Houli Zhang ),( Li Ma ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.8
Staphylococcus aureus is a major human pathogen, implicated in both community and hospital acquired infections. The therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult because of multidrug resistance and strong biofilmforming properties. Schiff bases have attracted attention as promising antibacterial agents. In this study, we investigated the in vitro activity of taurine-5-bromosalicylaldehyde Schiff base (TBSSB) against MRSA. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) were determined using a microtiter broth dilution method. TBSSB effectively inhibited planktonic MRSA, with an MIC of 32 μg/ml. The time-kill curve confirmed that TBSSB exhibited bactericidal activity against MRSA. TBSSB was also found to significantly inhibit MRSA biofilm formation at 24 h, especially at 1×MIC and sub-MIC levels. Furthermore, scanning electron microscopy and transmission electron microscopy showed remarkable morphological and ultrastructural changes on the MRSA cell surface, due to exposure to TBSSB. This study indicated that TBSSB may be an effective bactericidal agent against MRSA.