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남자 고등학교 세팍타크로 경기의 공격기술에 관한 분석 연구
김영호,고문석,제임스전,이영익,차정훈,현종건,김범수,임종만,이석인 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6
This research aims at analysis of attack technique in sepaktakraw games. For this purpose, 3 high school coaches observed and recorded each game Five times in videos of high school male players' thirty games in 2003. The conclusion from the analysis of the recorded data are as follows. 1. Scissors spike was the most popular (favorite) attack technique. Rolling spike, tapping spike and heading spike was popular in order. 2. Heading spike showed the highest success rate (73.5%) in attack technique. And tapping spike (69.5%), scissors spike (57.8%) and rolling spike (67.11) showed a lower success rate in order. In failure rate, heading spike (5.5%), tapping spike (36.5%), scissors spike (32.2%) and rolling spike (32.9%) had a higher percentage in order. 3. When receive was stable, the success rate in attach technique was 47.1%, the failure rate was 20.1%. On the other hand, when receive was unstable, the success rate in attach technique was 16.5%, the failure rate was 14.3%.
Hoon-Suk Cha,안중경,Jaejoon Lee,안광성,Eun-Mi Koh,Eun-Kyung Bae 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.6
Inadequate apoptosis contributes to synovial hyperplasia in rheumatoid arthritis (RA). Recent study shows that low expression of Puma might be partially responsible for the decreased apoptosis of fibroblast-like synoviocytes (FLS). Slug, a highly conserved zinc finger transcriptional repressor, is known to antagonize apoptosis of hematopoietic progenitor cells by repressing Puma transactivation. In this study,we examined the expression and function of Slug in RA FLS. Slug mRNA expression was measured in the synovial tissue (ST) and FLS obtained from RA and osteoarthritis patients. Slug and Puma mRNA expression in FLS by apoptotic stimuli were measured by real-time PCR analysis. FLS were transfected with control siRNA or Slug siRNA. Apoptosis was quantified by trypan blue exclusion, DNA fragmentation and caspase-3assay. RA ST expressed higher level of Slug mRNA compared with osteoarthritis ST. Slug was significantly induced by hydrogen peroxide (H2O2) but not by exogenous p53 in RA FLS. Puma induction by H2O2stimulation was significantly higher in Slug siRNA-transfected FLS compared with control siRNA-transfected FLS. After H2O2 stimulation, viable cell number was significantly lower in Slug siRNA-transfected FLS compared with control siRNA-transfected FLS. Apoptosis enhancing effect of Slug siRNA was further confirmed by ELISA that detects cytoplasmic histone-associated DNA fragments and caspase-3 assay. These data demonstrate that Slug is overexpressed in RA ST and that suppression of Slug gene facilitates apoptosis of FLS by increasing Puma transactivation. Slug may therefore represent a potential therapeutic target in RA.
Cha, Hoon-Suk,Bae, Eun-Kyung,Ahn, Joong-Kyong,Lee, Jae-Joon,Ahn, Kwang-Sung,Koh, Eun-Mi Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.6
Inadequate apoptosis contributes to synovial hyperplasia in rheumatoid arthritis (RA). Recent study shows that low expression of Puma might be partially responsible for the decreased apoptosis of fibroblast-like synoviocytes (FLS). Slug, a highly conserved zinc finger transcriptional repressor, is known to antagonize apoptosis of hematopoietic progenitor cells by repressing Puma transactivation. In this study, we examined the expression and function of Slug in RA FLS. Slug mRNA expression was measured in the synovial tissue (ST) and FLS obtained from RA and osteoarthritis patients. Slug and Puma mRNA expression in FLS by apoptotic stimuli were measured by real-time PCR analysis. FLS were transfected with control siRNA or Slug siRNA. Apoptosis was quantified by trypan blue exclusion, DNA fragmentation and caspase-3 assay. RA ST expressed higher level of Slug mRNA compared with osteoarthritis ST. Slug was significantly induced by hydrogen peroxide ($H_2O_2$) but not by exogenous p53 in RA FLS. Puma induction by $H_2O_2$ stimulation was significantly higher in Slug siRNA-transfected FLS compared with control siRNA-transfected FLS. After $H_2O_2$ stimulation, viable cell number was significantly lower in Slug siRNA-transfected FLS compared with control siRNA-transfected FLS. Apoptosis enhancing effect of Slug siRNA was further confirmed by ELISA that detects cytoplasmic histone-associated DNA fragments and caspase-3 assay. These data demonstrate that Slug is overexpressed in RA ST and that suppression of Slug gene facilitates apoptosis of FLS by increasing Puma transactivation. Slug may therefore represent a potential therapeutic target in RA.
Synthesis and Photoisomerization Properties of Polynorbornenes with Azobenzene Chromophores
Kang, Suk-Hoon,Shin, Hee-Deuk,Oh, Cha-Hwan,Choi, Dong-Hoon,Park, Ki-Hong Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.7
We successfully synthesized the addition-type polynorbonenes (PNB) exhibiting photochromic properties and excellent thermal stability. Three norbornene-based monomers with different azobenzene moiety (R=NO2, H,OCH3) were synthesized by transesterification method. The corresponding PNB copolymers were synthesized by transition metal-catalyzed addition polymerization method, and characterized by GPC, UV-Vis spectroscopy, NMR, and thermal analysis. For comparison of the photochromic properties depending on the rigidity of polymer backbone, we prepared the polymethylmethacrylate (PMMA) copolymer with the corresponding azobenzene moiety. We investigated the photoisomerization behavior by means of optical muitichannel analyzer with Xe lamp as well as real-time UV-Vis spectroscopy with high-pressure mercury lamp. Among three PNB copolymers, a polymer with azobenzene (R=H) was the most adaptable for observation of photoisomerization behavior. It was found that the rate of photoisomerization and relaxation depended on the structure of azobenzene chromophore, rather than that of polymer backbone.
류마티스 관절염 환자에서 혈장 호모시스테인, 혈청 비타민 B12, 엽산 농도에 관한 연구
차훈석 ( Hoon Suk Cha ),전찬홍 ( Chan Hong Jeon ),고재현 ( Jay Hyun Koh ),이창근 ( Chang Keun Lee ),김진석 ( Jin Seok Kim ),김종원 ( Jong Won Kim ),강성욱 ( Seong Wook Kang ),송영욱 ( Yeong Wook Song ),고은미 ( Eun Mi Koh ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.3
Objective: Cardiovascular disease is the most frequent cause of death in rheumatoid arthritis(RA) patients and hyperhomocysteinemia is an independent risk factor for cardiovascular disease. We evaluated the status of homocysteine, vitamin B12 and folate in RA patients and the influence of the drugs used in RA on homocysteine and vitamin levels Methods: Fifty-six RA patients and 22 controls were studied. Plasma total homocysteine was measured by HPLC method and serum folate and vitamin B12 were measured by chemiluminescence immunoassay. In RA patients, age, sex, disease duration, medications and laboratory findings were analyzed. Results: Serum vitamin B12 level was significantly lower in RA patients compared to controls(p=0.033). No significant difference in serum folate level was found between RA patients and controls but plasma total homocysteine level was significantly higher in RA patients. There was no difference in plasma total homocysteine level between patients taking MTX with folate and controls, but plasma total homocysteine level was significantly higher in patients not taking MTX compared with controls(p=0.028). In RA patients taking only hydroxyl-chloroquine(HCQ) as a DMARD, there was significantly lower serum folate level(p=0.033) and higher plasma total homocysteine level(p=0.043) compared with controls. There was a significant negative correlation between plasma total homocysteine level and serum folate level in RA patients(r=-0.319, p=0.017). Conclusion: Plasma total homocysteine level was increased in RA patients but not in patients taking MTX and folate. These findings suggested that folate supplementation may be effective to prevent hyperhomocysteinemia in RA patients.
차훈석 ( Hoon Suk Cha ),전찬홍 ( Chan Hong Jeon ),최화정 ( Hwa Jung Choi ),안광성 ( Kwang Sung Ahn ),송영욱 ( Yeong Wook Song ),고은미 ( Eun Mi Koh ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.2
Objective: The rheumatoid synovium is a hypoxic environment and hypoxia has been implicated to have a role in the pathogenesis of rheumatoid arthritis (RA). In this work, we tried to investigate the effect of hypoxia on the expression of matrix metalloproteinase (MMP)-1, -3 and tissue inhibitor of metalloproteinase (TIMP)-1 in rheumatoid and osteoarthritis (OA) fibroblast-like synoviocytes (FLS). Methods: FLS obtained from RA and OA patients were cultured under normoxic or hypoxic condition for 48 hours. Western blot analyses for MMP-1, -3 and TIMP-1 were performed. TIMP-1 mRNA levels were measured by Northern blot analysis. Results: Hypoxia increased MMP-1 expression in rheumatoid FLS compared with normoxia. TIMP-1 expression was decreased by hypoxia in rheumatoid FLS in both protein and mRNA levels. On the other hand, hypoxia did not significantly affect MMP-1, -3 and TIMP-1 expressions in OA FLS. Conclusion: These results suggest that microenvironment such as hypoxia may directly contribute to joint destruction in RA by increasing the ratio of MMP-1 to TIMP-1 production in FLS.
차민석(Min Suk Cha),이대훈(Dae Hoon Lee),김관태(Kwan-Tae Kim),이재옥(Jae-Ok Lee),송영훈(Young-Hoon Song),김석준(Seock Joon Kim) 한국연소학회 2007 KOSCOSYMPOSIUM논문집 Vol.- No.-
Plasma assisted combustion is an old subject for the combustion society, but recently, the subject is refocused partly because techniques for non-thermal plasmas are progressed significantly, and partly because there are lots of applications which need to be overcome by a new reaction technology. In the present study, we have developed plasma assisted burner (plasma burner), which can be used as a heating source in a diesel particulate filter system. The burner can bum 20 - 60 ㏄/min of diesel fuel with 50 lpm of fresh air in an exhaust pipe of 2.0 liter diesel engine. Using 20 ㏄/min of diesel fuel, an exhaust temperature for 2.0 liter disel engine can be raised up to around 600 ℃ for the range of engine speeds is idle 3,000 rpm. The characteristics of the plasma burner are reported, and the possible operating mechanism of it will be discussed based on the effects of an electric field and a plasma on flames.
차민석(Min Suk Cha),이대훈(Dae Hoon Lee),김관태(Kwan-Tae Kim),이재옥(Jae-Ok Lee),송영훈(Young-Hoon Song),김석준(Seok Joon Kim) 한국연소학회 2007 한국연소학회지 Vol.12 No.4
Plasma assisted combustion is an old subject for the combustion society, but recently, the subject is refocused partly because techniques for non-thermal plasmas are progressed significantly, and partly because there are lots of applications which need to be overcome by a new reaction technology. In the present study, we have developed plasma assisted burner (plasma burner), which can be used as a heating source in a diesel particulate filter system. The burner can burn 20-60 cc/min of diesel fuel with 50 lpm of fresh air in an exhaust pipe of 2.0 liter diesel engine. Using 20 cc/min of diesel fuel, an exhaust temperature for 2.0 liter diesel engine can be raised up to around 600℃ for a wide range of engine speed (idle - 3,000 rpm). The characteristics of the plasma burner are reported, and the possible operating mechanism of it will be discussed based on the effects of an electric field and a plasma on flames.