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경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염
홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.
Ferric Reductase Activity of the ArsH Protein from Acidithiobacillus ferrooxidans
( Mo Hong Yu ),( Qian Chen ),( Juan Du ),( Lin Tang ),( Fang Qin ),( Bo Miao ),( Xue Ling Wu ),( Jia Zeng ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.5
The arsH gene is one of the arsenic resistance system in bacteria and eukaryotes. The ArsH protein was annotated as a NADPH-dependent flavin mononucleotide (FMN) reductase with unknown biological function. Here we report for the first time that the ArsH protein showed high ferric reductase activity. Glu104 was an essential residue for maintaining the stability of the FMN cofactor. The ArsH protein may perform an important role for cytosolic ferric iron assimilation in vivo.
Yu-lou Tian,Fang Liu,Hong-jing Sun,Pin Lv,Yu-ming Cao,Mo Yu,Yang Yue 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.5
Objective: To assess the labial and lingual alveolar bone thickness in adults with maxillary central incisors of different inclination by cone-beam computed tomography (CBCT). Methods: Ninety maxillary central incisors from 45 patients were divided into three groups based on the maxillary central incisors to palatal plane angle; lingual-inclined, normal, and labial-inclined. Reformatted CBCT images were used to measure the labial and lingual alveolar bone thickness (ABT) at intervals corresponding to every 1/10 of the root length. The sum of labial ABT and lingual ABT at the level of the root apex was used to calculate the total ABT (TABT). The number of teeth exhibiting alveolar fenestration and dehiscence in each group was also tallied. One-way analysis of variance and Tukey’s honestly significant difference test were applied for statistical analysis. Results: The labial ABT and TABT values at the root apex in the lingual-inclined group were significantly lower than in the other groups (p < 0.05). Lingual and labial ABT values were very low at the cervical level in the lingual-inclined and normal groups. There was a higher prevalence of alveolar fenestration in the lingual-inclined group. Conclusions: Lingual-inclined maxillary central incisors have less bone support at the level of the root apex and a greater frequency of alveolar bone defects than normal maxillary central incisors. The bone plate at the marginal level is also very thin.
A Mutation in <i>PMP2</i> Causes Dominant Demyelinating Charcot-Marie-Tooth Neuropathy
Hong, Young Bin,Joo, Jaesoon,Hyun, Young Se,Kwak, Geon,Choi, Yu-Ri,Yeo, Ha Kyung,Jwa, Dong Hwan,Kim, Eun Ja,Mo, Won Min,Nam, Soo Hyun,Kim, Sung Min,Yoo, Jeong Hyun,Koo, Heasoo,Park, Hwan Tae,Chung, Ki Public Library of Science 2016 PLoS genetics Vol.12 No.2
<▼1><P>Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of peripheral neuropathies with diverse genetic causes. In this study, we identified p.I43N mutation in <I>PMP2</I> from a family exhibiting autosomal dominant demyelinating CMT neuropathy by whole exome sequencing and characterized the clinical features. The age at onset was the first to second decades and muscle atrophy started in the distal portion of the leg. Predominant fatty replacement in the anterior and lateral compartment was similar to that in CMT1A caused by <I>PMP22</I> duplication. Sural nerve biopsy showed onion bulbs and degenerating fibers with various myelin abnormalities. The relevance of <I>PMP2</I> mutation as a genetic cause of dominant CMT1 was assessed using transgenic mouse models. Transgenic mice expressing wild type or mutant (p.I43N) <I>PMP2</I> exhibited abnormal motor function. Electrophysiological data revealed that both mice had reduced motor nerve conduction velocities (MNCV). Electron microscopy revealed that demyelinating fibers and internodal lengths were shortened in both transgenic mice. These data imply that overexpression of wild type as well as mutant <I>PMP2</I> also causes the CMT1 phenotype, which has been documented in the <I>PMP22</I>. This report might expand the genetic and clinical features of CMT and a further mechanism study will enhance our understanding of <I>PMP2</I>-associated peripheral neuropathy.</P></▼1><▼2><P><B>Author Summary</B></P><P>Isolation of causative mutation is still challenging in genetic diseases with a variety of genetic causes. We discovered a mutation in a novel gene from a family exhibiting a peripheral neuropathy by virtue of next-generation sequencing. Although the family shows characteristic clinical features of hereditary motor and sensory neuropathy, we could not find a mutation from well-known genes. To demonstrate the clinical relevance of the novel gene, we generated transgenic mice, which carry the patients’ mutation within their chromosome. The transgenic mice exhibited the same phenotype as the patients including peripheral neuropathic symptoms and reduced locomotor function. We also observed the affected peripheral nervous system through electron microscopy. It seems that the expression of the mutant protein impairs the myelin of peripheral nervous system. These data might expand the genetic, clinical, and pathophysiological features of the peripheral neuropathy and a further investigation will enhance our understanding of disease in the peripheral nervous system.</P></▼2>
Hong, Young B.,Park, Jin‐,Mo,Yu, Jin S.,Yoo, Da H.,Nam, Da E.,Park, Hyung J.,Lee, Ji‐,Su,Hwang, Sun H.,Chung, Ki W.,Choi, Byung‐,Ok Wiley Periodicals, Inc. 2017 Journal of the peripheral nervous system Vol.22 No.3
<P><B>Abstract</B></P><P>Mutations in the gap junction protein beta 1 gene (<I>GJB1</I>) cause X‐linked Charcot‐Marie‐Tooth disease type 1 (CMTX1). CMTX1 is representative of the intermediate type of CMT, having both demyelinating and axonal neuropathic features. We analyzed the clinical and genetic characterization of 128 patients with CMTX1 from 63 unrelated families. Genetic analysis revealed a total of 43 mutations including 6 novel mutations. Ten mutations were found from two or more unrelated families. p.V95M was most frequently observed. The frequency of CMTX1 was 9.6% of total Korean CMT family and was 14.8% when calculated within genetically identified cases. Among 67 male and 61 female patients, 22 females were asymptomatic. A high‐arched foot, ataxia, and tremor were observed in 87%, 41%, and 35% of the patients, respectively. In the male patients, functional disability scale, CMT neuropathy score, and compound muscle action potential of the median/ulnar nerves were more severely affected than in the female patients. This study provides a comprehensive summary of the clinical features and spectrum of GJB1 gene mutations in Korean CMTX1 patients.</P>
Deuterium Clusters Fusion Induced by the Intense Femtosecond Laser Pulse
Hong-Jie, Liu,Zhi-Jian, Zheng,Yu-Qiu, Gu,Bao-Han, Zhang,Yong-Joo, Rhee,Sung-Mo, Nam,Jae-Min, Han,Yong-Woo, Rhee,Kwon-Hae, Yea,Jia-Bin, Chen,Hong-Bin, Wang,Chun-Ye, Jiao,Ying-Ling, He,Tian-Shu, Wen,Xia ALLERTON PRESS INC 2007 CHINESE PHYSICS LETTERS Vol.24 No.2
<P>Neutrons (2.45 MeV) from deuterium cluster fusion induced by the intense femtosecond (30 fs) laser pulse are experimentally demonstrated. The average neutron yield 10<SUP>3</SUP> per shot is obtained. It is found that the yield slightly increases with the increasing laser spot size. No neutron can be observed when the laser intensity I < 4.3×10<SUP>15</SUP> W/cm<SUP>2</SUP>.</P>
Yu, Byeong Ho,Seo, Byeong-Mo,Hong, Sung Hyup,Yeon, Sanghun,Lee, Kwang Ho Elsevier 2018 Energy and buildings Vol.176 No.-
<P><B>Abstract</B></P> <P>The non-insulated underfloor supply plenum and the heat gain of the cool supply air into supply plenum results in significant magnitude of thermal decay defined as the supply air temperature rise. Eventually, these changes have influence on the room air stratification, causing negative effects throughout whole system. Therefore, for the optimization of UFAD system, it is important to understand these fundamentals and relevant effects on the overall system operation. In this study, comparative analysis was conducted during cooling period using validated EnergyPlus model, after employing different operational configurations related to room air stratification and thermal decay. The thermal behavior and cooling energy performance were analyzed by observing the convective heat transfer, thermal decay, airflow, stratification among different operational configurations. As a result, it was observed that the existence of non-insulated supply plenum have influences on the thermal behavior in occupied zone, and the corresponding heat transfer has load reduction effect of the space by about 40%. However, there were still significant amounts of cooling energy consumption in the form of thermal decay despite the reduced cooling load, indicating that unintended and additional energy consumption was occurred in supply plenum. In addition, return air temperature rise by the room air stratification increased the cooling coil load. Eventually, these effects canceled each other out. As a result, compared to CBAD system, standard UFAD system consumed more electric energy by approximately 30%, and for fully-insulated UFAD system, 6% energy saving could be achieved.</P>
Hong, Junshik,Kim, Seok Jin,Ahn, Jae-Sook,Song, Moo Kon,Kim, Yu Ri,Lee, Ho Sup,Yhim, Ho-Young,Yoon, Dok Hyun,Kim, Min Kyoung,Oh, Sung Yong,Park, Yong,Mun, Yeung-Chul,Do, Young Rok,Ryoo, Hun-Mo,Lee, Je Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.2
<P><B>Purpose</B></P><P>This study was conducted to evaluate outcomes in adult patients with Burkitt lymphoma (BL) or Burkitt-like lymphoma treated with an rituximab plus hyper-CVAD (R-hyper-CVAD) regimen by focusing on tolerability and actual delivered relative dose intensity (RDI).</P><P><B>Materials and Methods</B></P><P>Patients ≥ 20 years of age and pathologically diagnosed with BL or Burkitt-like lymphoma were treated with at least one cycle of R-hyper-CVAD as the first-line treatment in this study. Eligible patients’ case report forms were requested from their physicians to obtain clinical and laboratory data for this retrospective study.</P><P><B>Results</B></P><P>Forty-three patients (median age, 51 years) from 14 medical centers in Korea were analyzed, none of which were infected with human immunodeficiency virus. The majority of patients had advanced diseases, and 24 patients achieved a complete response (75.0%). After a median follow-up period of 20.0 months, 2-year event-free and overall survival rates were 70.9% and 81.4%, respectively. Eleven patients (25.6%) were unable to complete the R-hyper-CVAD regimen, including six patients due to early death. The RDIs of adriamycin, vincristine, methotrexate, and cytarabine were between 60% and 65%, which means less than 25% of patients received greater than 80% of the planned dose of each drug. Poor performance status was related to the lower RDIs of doxorubicin and methotrexate.</P><P><B>Conclusion</B></P><P>R-hyper-CVAD showed excellent treatment outcomes in patients who were suitable for dose-intense chemotherapy. However, management of patients who are intolerant to a dose-intense regimen remains problematic due to the frequent occurrence of treatmentrelated complications.</P>