야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

KAL기 추락에 의한 대량재해의 개인식별

강신몽,이원태,고영창,최상규,김윤희,이홍석,서재관,윤중진,이혜경,최득린,김종열,윤창육,변명식,이장홍 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2

Individual identification is an important part in medicolegal field especially in mass disaster. At July, 27, 1989, KAL KE-803 was crashed on landing at Tripoli International Airport, Liba. The plane was caught in fire and sixty eight Koreans were sacrified. The majority of victims were severely charred and injured. The authors examed all dead bodies and successfully identified all the cases through visual, anthropological, odontological, radiological and pathological methods including fingerprint and blood typing.

각종 골대체물질들의 골형성능에 관한 비교연구

설정현,최원희,김정철,홍정수,서동보 大韓成形外科學會 1992 Archives of Plastic Surgery Vol.19 No.4

We studied the bone forming capacity of the various bone substitute materials for the confirmation of bone regeneration with each case i.e Hydroxyapatite(SURGIBON), kiel obne, B.O.P. and bone dust. The bone dust was used for control. In 18 New Zealand white rabbits, four partial thickness bone defects were created on the outer table of parietal bone, which were measured 1.5mm in depth x 8mm in diameter. Bone substitute materials were filled in each bone defect. The animals were sacrified at 2, 4, 6, 8 weeks after taking a plain skull film, and then both macroscopic and microscopic examinations were done. The results were as follows : 1. Hydroxyapatite : good bone regeneration with moderately increased eosinophil. 2. KIEL BONE : no bone regeneration and markedly increased eosinophil. 3. B.O.P. : no evidence of bone growth during postoperative 8 weeks. 4. BONE DUST : persistent osteoblast existed during experimental period, more likely as own bone. We summarized that the hydroxyapatite is a biocompatible matrix implantable as a bone graft substitute and more bone regeneration than other bone substitutes during the experimental period.

Al-Si合金의 閃光法에 의한 熱擴散係數測定에 關한 硏究

許甫寧,裵源泰,徐弘三,李寬洙,朴種一 慶尙大學校 1984 論文集 Vol.23 No.2

本 硏究를 通하여 얻은 結果는 다음과 같다. 1. Al-Si 合金에서 Si量이 增加할수록 熱擴散係數는 감소하나, 共晶組成(Al-12%Si) 部近에서는 亞共晶, 過共晶組成에 비하여 약간 增加하였다. 비열과 비중등의 조건이 一定하다면 熱擴散係數는 pure Al 이 8.47, 亞共晶(6%)組成이 3.24, 共晶組成(12%)이 3.99, 過共晶組成(18%Si)이 3.01(×10-5m2/sec)이다. 2. Cu, P, Na로 개량처리 하였을 때 共晶組成이내에서는 Cu의 경우에 열확산계수가 가장 적었으나, 과공정조성에서는 Cu의 경우가 가장 높았다. After pure Al, Al-6% Si(hypoeutectic composition), Al-12% Si(eutectic comp.) and Al-18% Si(hypereutectic comp.) among Al-Si alloys were treated refinement with addition of Cu(0.5%), P(0.5%) or Na(0.5%), their thermal diffusivities were measured by flash method. And then their microstructures and thermal diffusivities were investigated. The results obtained are as follows. 1. According as sillicon contents in Al-Si alloys increase, the thermal diffusivities decreases, but it increases slightly at eutectic composition(Al-12% Si alloy), if its density and heat capacity are constant, the thermal diffusivities are 8.47(pure Al), 3.24(6% Si), 3.99(12% Si) and 3.01(18% Si) (X10-5m/sec) respectively. 2. When the refinement treated with Cu, P, and Na, the effects of thermal diffusivities of alloys with Cu treated is the lowest under eutectic composition, but its effects is the best at hypereutectc composition.

유방에서 기원된 전이성 췌장암종 1예 : A case report

김윤신,이미숙,장원재,임성철,기근홍,전호종,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Pancreas is known for the unfavorable soil to the metastatic carcinoma, and pancreatic metastasis is achieved after systemic dissemination was developed. The primary tumors of metastatic pancreatic carcinoma are breast, lung, Iymphoma, malignant melanoma, leukemia, stomach. and colon. The breast carcinoma is the commonest tumor to metastasize to pancreas and both tumors are related to estrogen receptor for tumor growth. In the present case, tumor cells had small round nucleus and showed indian file infltrating pattern and lack of cohesion, which are seen in infiltrative breast carcinoma. The patient was underwent radical mastectomy due to infiltrative ductal carcinoma three years ago. And also the tumor cells showed nuclear reactivity to immunostaining for estrogen receptor In combination of the histopathologic. immunohistochemical, and her past history, we concluded that breast carcinoma was metastasized to pancreas, and we report a case of metastatic pancreatic carcinoma from breast with review of literatures.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Effect of Cycloheximide on Proenkephalin a mRNA Levels and the Secretion of [Met5]-enkephalin Induced by Nicotine and 12-0-Tetradecanoylphorbol-13-acetate in Bovine Adrenal Its Medullary Chromaffin Cells

Suh, Hong won,Kim, Yung Hi Korean Society of Molecular Biology 1995 Molecules and cells Vol.5 No.1

Antinociceptive Mechanisms of Dipsacus Saponin C Administered Intracerebroventricularly in the Mouse

Suh, Hong-Won,Song, Dong-Keun,Son, Kun-Ho,Wie, Myung-Bok,Lee, Keun-Ho,Jung, Keun-Young,Do, Jea-Chul,Kim, Yung-Hi 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

1. Dipsacus saponin C (DSC) adminlstered intracerebroventricularly (ICV) showed an antinociceptive effect in a dose-dependent (from 3.75 to 30μg) manner as measured by the tailflick assay. The antinociception induced by DSC at the dose of 30μg was maintained at least 1 h. 2. Sulfated cholecystokinin (CCK, from 0.1 to 0.5ng); muscimol (a GABA_(A) receptor agonist, from 50 to 200ng); MK-801 [(±)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohepten-5, 10-imine maleate, from 0.1 to 1μg], a noncompetitive N-methyl-??=aspartic acid (NMDA) receptor antagonist; or CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, from 0.1 to 0.5μg), a non-NMDA receptor antagonist, injected ICV significantly reduced the inhibition of the tail-flick response induced by DSC (30μg) administered ICV. However, naloxone (an opioid receptor antagonist, 2μg) or baclofen (a GABA_(B) receptor antagonint, 10ng) did not affect the inhibition of the tail-flick response induced by DSC. 3. The intrathecl (IT) injection of yohimbine (an α₂-adrenergic receptor antagonist, from 5 to 20μg) and methysergide (a serotonin receptor antagonist, from 5 to 20μg) but not naloxone (from 2 to 8μg), significantly attenuated inhibition of the tail-flick response induced by DSC (30μg) administered ICV. 4. Our results suggest that DSC has an antinociceptive effect when it is administered supraspinally and GABA_(A), NMDA and non-NMDA receptors, but not opioid and GABA_(B) receptors located at the supraspinal level, may be involved in DSC-induced antinociception. Furthermore, DSC administered supraspinally may produce antinociception by stimulating descending α₂-adrenergic and serotonin pathways but not the opioidergic pathway. Copyright ⓒ 1996 Elsevier Science lnc. GEN PHARMAC 27;7:1167-1172, 1996.

Defeat and Triumph in The Readie and Easie Way: The Intentional Irony of the Title in the Second Edition

( Hong Won Suh ) 한국밀턴과 근세영문학회(구 한국밀턴학회) 2008 중세근세영문학 Vol.18 No.2

By the time Milton published the second edition of The Readie and Easie Way, it was now too late to change the course of England`s history, and his proposed political model was already beyond the reach of his people. Milton`s decision go ahead with the publication of the second edition, therefore, deserves some scrutiny. In this essay, I propose that this decision was prompted by the very defeat of his cause. I also propose that the title of treatise now contains an intentional irony that was not discernible in the first edition. In fact there are two opposing types of the ready and easy way suggested by the second edition: the one, if it had been carefully considered and swiftly acted upon, would have saved the country from thralldom; the opposite, the way back to thralldom chosen by the people of England, would lead to certain destruction. Milton stresses time and again the opportunity given by God, which the English people had disgracefully ignored. Such opportunity is not to come again. So clearly on display before the people of England, the reformation had been so tantalizingly close to fruition. Now, according to Milton, the true ready and easy way is no longer ready and easy. Only its opposite shadow remains, a path leading to "a precipice of destruction" that "the deluge of this epidemic madness would hurrie us through the general defection of a misguided and abus`d multitude" (YP7: 463). Milton`s stance at the end of the treatise is that of a prophet who finds triumph in the face of defeat. While his cause is utterly lost, his prophecies (he had, after all, warned England of the dire consequences of disobedience as early as the beginning of his prose career) remain true and tested.

REGULATION OF OPIOID PEPTIDE GENE EXPRESSION : ROLE OF PROTOONCOGENES

Hong Won Suh,Je Seong Won,Dong Keun Song,Yung Hi Kim 생화학분자생물학회 1996 생화학분자생물학회 춘계학술발표논문집 Vol.- No.-