Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

악성흑색점흑색종 19예에 대한 임상 및 병리 조직학적 연구

홍원진 ( Won Jin Hong ),장홍선 ( Hong Sun Jang ),이상희 ( Sang Hee Lee ),이상은 ( Sang Eun Lee ),정기양 ( Kee Yang Chung ),노미령 ( Mi Ryung Roh ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10

Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4∼15% of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003∼2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickness (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage III; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide excision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-α therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mebutate. Two patients had BRAF V600E mutation; 1, NRAS G12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients. (Korean J Dermatol 2016;54(10):769∼775)

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

청색증 선천성심장질환의 임상연구 : 활로 4징 증의 개심술

홍장수,한병선 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Twenty-four cases of tetralogy of Fallot corrected totally using extracorporeal circulation in this department are presented during the period from April 1983 to August 1985. Of 24 cases, there were 20 cases of type Ⅱ ventricular septal defect and 4 cases of type Ⅰ defect. Types of right ventricular outflow tract obstruction were a case of pulmonic valvular stenosis, 2 cases of infundibular stenosis, and 21 cases of combined type. There were associated anomaly such as 3 caces of pulmonary arsenal hypoplasia, 3 cases of atrial septal defect, a case of left superior vena cava, and 2 cases of right side aortic arch. Transannular patch for right ventricular outflow tract reconstruction was necessary in 9 cases. Operative death was 5 cases and late death was a case, but other remaining cases followed up over 2 months carried out normal life,

생약추출물에 의한 화상치료효과

문선인, 홍장수 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

연구목적: 본 연구는 당귀, 작약, 시호 등 다양한 약초 성분을 혼합하여 제조한 생약추출물이 화상치 료제로서의 가능성이 있는지 확인하기 위한 전임상 예비실험으로 2도 화상을 입힌 랫드의 피부에 수차 례 살포하고 시간경과에 따른 피부조직의 치유 정도를 자연치유군과 비교해 평가하고자 하였다. 대상 및 방법: 4주령의 랫드를 5마리씩 양군에 배정하여 2도 화상을 유도한 후 한군은 자연치과정을, 나머지 한 군은 생약추출물을 살포한 후 3일간 치유과정을 육안으로 관찰하고 면역조직염색을 통한 조 직변화를 비교 평가하였다. 결과: 화상 3일 후의 창상부위는 육안 상으로 관찰했을 때 생약처리군의 경우가 자연치유군에 비해 상 대적으로 매우 빠르게 호전되는 것으로 나타났으며 병리조직학적 비교에서도 생약처리군의 경우가 다 소 경미한 것으로 나타났으나 화상 중앙부위에 대한 조직학적 차이는 관찰되지 않았다. 결론: 본 연구에서 비록 조직학적 측면에서의 효과를 검증하지는 못하였으나 생약추출물의 화상치유 효과에 대한 충분한 가능성을 확인할 수 있었다. 보다 구체적이고 장기적인 연구를 통하여 생약추출물 의 화상치유 효과를 검증할 필요성이 있다.

골프지도자의 지도유형이 지도효율성에 미치는 영향

김장환,홍준선,박진기 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This study aims to determine the impact of the Leadership style of a golf instructor on the Effectiveness of gold instruction and to help instructors put productive instruction methods into practice. To accomplish the goals of the study, golfers who held membership in private golf ranges in Daegu were sampled, The Systematic Stratified Cluster Random Sampling was adopted to choose 300 members, 50 each from six golf ranges, A questionnaire was distributed to the sampled golfers at each golf range after they were given a brief explanation about the purpose and contents of the survey as well as about what they should keep in mind in answering the questions, The golfers were asked to answer those questions using the self-administration method, Of the 300 responses returned, 279 valid answers (93%) were used for the study after excluding some incomplete or inadequate ones. With the SPSS 11.0 package program, general characteristics of the golfers were analyzed using Frequency Analysis, Multiple Regression Analysis was employed to learn the impact of the leadership style of a golf instructor on the effectiveness of gold instruction, The results of the research conducted with the research methods and data analysis described above are as follows: Firstly, the leadership style of the golf instructors proved to have a significant impact on golfers' perceived satisfaction with the provided instruction, Specifically, among various instructional attitudes, Training & instructive Behavior had the most influence. instructor's Positive Feedback Behavior, Democratic Behavior, and Social Support Behavior also had some significant impact. Secondly, the leadership style of the golf instructors turned out to have a significant impact on golfers' perceived performance improvement, dice again, Training & instructive Behavior were the most important factors, while Positive Feedback Behavior and Social Support Behavior also had significant influence. Thirdly, the leadership style of the golf instructors had significant effect on the overall improvement of the golfers' average scores, Training & instructive Behavior contributed to enhancing golfers' performance most, while Social Support Behavior of an instructor also played a significant role. Keeping in mind the above research results, this study concludes that Training & instructive Behavior is the most effective and desirable leadership style of an instructor in terms of boosting golfers' perceived satisfaction, promoting their perceived performance improvement, and increasing their golf scores, in addition, this study suggests that the Autocratic Behavior of a golf instructor has no significant impact on enhancing the effectiveness of golf instruction thus instructors should refrain from behaving in an authoritarian way.

항암화학요법 치료시 환자에서 발생하는 오심 및 구토에서의 정맥주사용 및 경구용 Tropisetron의 제 4상 연구

배진선,김장용,장일성,윤완희,노승무,홍기훈 최신의학사 1997 最新醫學 Vol.40 No.7

마이크로 유체 채널 내 응용을 위한 3차원 구조의 FET형 센서 제작

류홍근,김동선,정용택,박혜정,신장규,박진성,임근배 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

史料紹介 : 『御尋朝鮮覺書』(小田四郞兵衛著) 異本 『朝鮮風俗記』

하우봉,홍성덕,장순순,小幡倫裕 전북대사학회 1997 전북사학 Vol.19ㆍ20 No.-

두개외 경동맥 협착증에 대한 스텐트 삽입술의 추적 결과

윤영섭,홍범기,최동훈,김선호,김동익,김승민,장양수,심원흠 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11