위발성 위장관 악성림프종 환자에서 항암치료의 효과

김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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이형동질에 의한 중세 교회건축과 성가의 리듬에 관한 연구

이홍규,동정근 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

This study intends to understand the relation of architecture and music in the Middle Age. Art, in any age, is the expression of the characteristic attitudes of the people of that age toward important aspects of life. In an age when the Church is the principle social institution, the task confronting artists is that of expressing religious sentiments in harmony with the particular doctrine of dominant religious group. Architecture and music are affected. by the dominant group. For the purpose, analyzed is isomorphism of Gestalt theory. The objects of this study are rhythms of European Cathedrals and Chants. It is a generally accepted that the rhythm of columned arrangement in cathedral is based on music in the Middle Age. The analysis shows that the rhythm of columned arrangement, as opposed to common knowledge, effects on the rhythm of chants and the change of rhythmic flow in architecture has an inclination to coincide with that in music, though somewhat different from genre. Art is the communicator of an idea and culture and society and is based on experience. The influence of one art on another is important in determining the artistic trends of a particular art.

結合原價配分(Joint Cost Allocation)의 統合模型에 관한 硏究 : 財務報告 目的과 意思決定 目的의 統合을 위하여 For Financial Reporting and Decision Making

李讚洙,崔洪圭 강릉대학교 영동산업문제연구소 1985 産經論叢 Vol.3 No.-

Joint Products refer to more than one product produced from a single set of inputs (such as raw material and labor factors) in a predetermined ratio. Typical of the joint product industries are petroleum refining, meat packing, dairies and chemicals. Each of these takes a single set of inputs and produces several outputs in somewhat fixed proportions. The major need for any joint cost allocation is an appeal to inventory valuation for financial reporting, requlatory, or income tax requirements. In decisions such as how much of a product to produce, most joint cost allocations will lead to more trouble than benefit. Therefore, the purpose of this study is to obtain joint costs that are consistent with a decision model of the firm and permit some apparent decentralization of decision making. The best joint cost allocation methods are that they compatible with respect to decision making, or behavior congruent. George Hadley discusses the application of linear programming to the joint product problem, but as will be illustrated in case 3, the model that he presented will need to be modified under certain conditions. Several papers use marginal analysis of the firm's profit function to specify particular allocations. Manes and Smith used Kuhn-Tucker conditions to identify those joint. Products which are by-products and to which none of the raw material joint costs should be allocated. Jensen expanded this notion by including costs of further processing or disposal of by-products. This paper analyzes the traditional joint cost allocations such as (1) physical unit method (2) relative sales value method (3) net realizable value method (4) sales to production ratio method for inventory valuation and income determination. But this method of joint cost allocations are irrelevant to decision making. Therefore, This study presents joint cost allocation methods that are consistent with a decision model of the firm. If enough information exists about the cost and demand functions for the joint products, it is possible to obtain simultaneously the optimal price - output decision and a joint cost allocation that is consistent with this decision. In order to obtain this desirable situation, we must be willing to abandon traditional joint cost allocation methods and use nonlinear programming techniques. The joint cost allocation derived from the nonlinear programming model is consistent with the underlying output decision of the firm and can be used as a basis for decentralized and incremental decisions.

산처리에 의한 정수슬러지 감량화

이병문,권재현,안규홍,이석헌,권대영 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

The acidic treatment of waterworks sludge released organic materials as well as inorganics such as Al, Fe and Mn. Through solubilization as mentioned above, the content of suspended solids reduced by 18% at final pH 3.5. It also increased thickening efficiency and dewaterability of sludge. However overdosing of H_2SO_4 made dewaterability deteriorated. It showed that the optimal condition of acidic treatment be as follows; 5.5㎖ dose of H_2SO_4(97%)/1 sludge, final pH 3.5 and 15minutes of reaction time. Under these conditions, reduction efficiencies of sludge through thickening and dewatering were 57% and 92.2% respectively and then 7.8% of raw sludge released as cake compared to 10.5% without acidic pre-treatment. Therefore, mass of dewatered cake decreased by 26% through acidic treatment. Water content of dewatered cake was reduced from 71% to 62% due to this treatment. The changes of sludge properties including particle size, zeta-potential and bound water by acidic treatment appear to be important keys in assesment of the improvement of sludge dewaterability.

유리섬유강화 복합절연재료의 열화특성에 관한 연구

이규철,유근민,김경석,박홍태 울산대학교 1996 공학연구논문집 Vol.27 No.2

본 연구에서는 주위 환경 열화에 따른 복합절연재료의 절연특성과 수명을 향상시키기 위해 고온에서 흡습량을 변화시켰을 때와 탈습량을 변화시켰을 때 흡십시료와 탈습시료의 전기적 특성 및 기계적 특성을 조사하였다. 유리섬유 각층의 흡습상수는 각각 1층에서 0.0117, 2층에서 0.0123, 3층에서 0.0152를 나타냈다. 전기적 특성 및 기계적 특성은 복합재료의 흡습에 따라 크게 떨어졌다. 70℃에서 습기가 완전히 건조되어도 흡습전의 전기적 및 기계적 특성을 얻기가 어려운 것으로 나타났다. 수분에 의해 발생한 복합절연재료내에 존재하는 많은 결함들은 에폭시 메트릭스와 필라사이에 존재하였다. The electrical and mechanical properties of moisture absorbed and moisture desorbed specimens were investigated to improve the insulating characteristics and the reliability of composite materials against environment aging. Moisture absorption constants with the layers of glass fiber showed 0.0117 in 1 layer, 0,0123 in 2 layer and 0.0152 in 3 layer, respectively. Although moisture was removed at 70℃, it was impossible to obtain the initial electrical and mechanical properties. Many defects induced by moisture were observed at the interface between epoxy matrix and filler in composite materials.

W/O 마이크로에멀젼의 크기와 구조 분석 및 이를 이용한 Ag 나노막대의 제조

이진규,임경희,김홍운 한국공업화학회 2004 응용화학 Vol.8 No.1

This study investigated on sizes and structures of water-in-oil microemulsions composed of AOT/cyclohexane/aqueous solutions by small-angle neutron scattering method. From SANS spectra it is observed that spherical form whose size is 4-10㎚ and cylindrical form whose length is 25-30㎚ are formed at four different microemulsion regions. The silver nanopaticles (sherical and rod0like) are prepared at ME4 and ME10 which ratio three components as 7.35/91.81/0.84 and 37.63/57.20/5.17, respectively.