새마을 所得增大의 主要作物들에 대한 蛋白質, 油分含量 및 脂肪酸 分析

李洪宰,李鐘一 순천대학 새마을연구소 1986 새마을硏究論文集 Vol.2 No.-

Recently, researches on oil crops in Korea were breeding on edible oil crops such as rapeseed sesaeme, peanut, perilla. Numerous varieties were reieased as a result of ective breeding works on edible oil crops, that is 7 rape varieties including Yudal, Mokpo-11, Yongdang, Nozeogchae, Naechan, Yeongsanyuchae and Cheongpungyuchae(hybrid), 5 varieties sesame including Suweon-5, 9, 21, Kwangsanggae and Danbaekggae, 5 peanut varieties including Seoduntangkong, Yeonghotangkong, Oltankong, Shinpungtangking and Seadltang-kong, 3 perilla varieties including Daegu, Suweon 8 and 10, respectively. This varieties showed a good oil quality with high oleic and linoleic acids content, but perilla oil seemed to be unsuitable for a edible use, since about 53 percent of its fatty acids was in the form of unsaturated linolen-ic acid.

복합 관동맥병변에서의 Rotational Atherectomy : 초기결과

김진우,박성욱,홍명기,이상곤,이일수,이철환,최기준,강덕현,송재관,김재중,박승정 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

[P8-29] Korean Cibotium barometz as a Potent Inhibitor against an iNOS Expression via an Inhibition of NF-kB in LPS-Induced RAW 264.7 Macrophage Cells

Seul Lee,Chang Hyun Jin,Young Man Lee,Hyo Jung Lee,Ji Young Oh,Yong Dae Park,Myung Woo Byun,Hong Sun Yook,II Yun Jeong 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10

순환식 반응기에서 UV-TiO₂를 이용한 반응성염료의 제거에 관한 연구

조일형(II Hyoung Cho),김현용(Hyun Yong Kim),이용규(Yong Gyoo Lee),박경렬(Kyung Yeul Park),이홍근(Hong Keun Lee) 한국환경보건학회 2000 한국환경보건학회지 Vol.26 No.1

Photocatalytic degradation of reactive dye, Red 120, has been carried out on TiO₂ particles as photocatalyst under UV irradiation. In this experiment, comparison on the removal of reactive dye by photolysis photocatalyst adsorption and photocatalysis as well as the effect of experimental parameters such as the number of column employed, circulation flow rate, intensity of the light, pH and TiO₂ dosage affecting the reaction efficiency of photocatalytic degradation of reactive dye in circular type reactor was examined. The results of this study were as follows. 1. With both UV light illumination and TiO₂ present, reactive dye was more effectively eliminated than with either UV or TiO₂ alone. It was found that application of TiO₂ photocatalysis to reactive dye was possible. 2. As the number of column employed increased, the removal efficiency of reactive dye was increased. 3. A s the circulation flow rate of solution increased, the removal efficiency of reactive dye was increased. However, over 1 !/min of the circulation flow rate, the efficiency was limited. 4 . Photocatalytic degradation of reactive dye increased linearly with increasing UV light intensity. However, over 15 mW/㎠ of UV light intensity, the efficiency reached a plateau. 5. The photocatalytic degradation rate was greater in acid media of pH 5.2 than in neutral and alkaline media. 5. Photocatalytic removal efficiency of reactive dye increased with increasing TiO₂ dosage. However, over 1.0 g/L of TiO₂ dosage, the efficiency reached a plateau.

Antinociceptive Effects of Intrathecal Metabotropic Glutamate Receptor Compounds and Morphine in Rats

Choi, Jeong II,Lee, Hyung Kon,Chung, Sung Tae,Kim, Chang Mo,Bae, Hong Beom,Kim, Seok Jai,Yoon, Myung Ha,Chung, Sung Su,Jeong, Chang Young The Korean Pain Society 2005 The Korean Journal of Pain Vol.18 No.1

Background: Spinal metabotropic glutamate receptors (mGluRs) and opioid receptors are involved in the modulation of nociception. Although opioid receptors agonists are active for pain, the effects of the compounds for the mGluRs have not been definitely investigated at the spinal level. We examined the effects of the intrathecal mGluR compounds and morphine in the nociceptive test, and then we further clarified the role of the spinal mGluRs. In addition, the nature of the pharmacological interaction after the coadministration of mGluRs compounds with morphine was determined. Methods: Catheters were inserted into the intrathecal space of male SD rats. For the induction of pain, $50{\mu}l$ of 5% formalin solution or a thermal stimulus was applied to the hindpaw. An isobolographic analysis was used for the evaluation of the drug interaction. Results: Neither group I mGluR compounds nor group III mGluR compounds produced any antinociceptive effect in the formalin test. The group II mGluR agonist (APDC) had little effect on the formalin-induced nociception. The group II mGluR antagonist (LY 341495) caused a dose-dependent suppression of the phase 2 flinching response on the formalin test, but it did not reduce the phase 1 response of the formalin test nor did it increase the withdrawal latency of the thermal stimulus. Isobolographic analysis revealed a synergistic interaction after the intrathecal delivery of a LY 341495-morphine mixture. Conclusions: These results suggest that group II mGluRs are involved in the facilitated processing at the spinal level, and the combination of LY 341495 with morphine may be useful to manage the facilitated pain state.

[P8-34] Radioprotective role of Nelumbo nucifera against a radiation一induced oxidative stress in rats

Hyo Jung Lee,Yong Dae Park,Young Man Lee,Chang Hyun Jin,Seul Lee,Dae Seong Choi,Myung Woo Byun,II Yun Jeong,Hong Sun Yook 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10

폴립절제 후 추적대장내시경검사 가이드라인

홍성노 ( Sung Noh Hong ),양동훈 ( Dong Hoon Yang ),김영호 ( Young Ho Kim ),홍성필 ( Sung Pil Hong ),신성재 ( Sung Jae Shin ),김성은 ( Seong Eun Kim ),이보인 ( Bo In Lee ),이석호 ( Suck Ho Lee ),박동일 ( Dong Ii Park ),김현수 ( Hyu 대한소화기학회 2012 대한소화기학회지 Vol.59 No.2

1. 기준대장내시경검사에서 샘종이 3개 이상 발견된 환자는 추적대장내시경검사에서 진행신생물이 발견될 위험이 증가한다. 2. 기준대장내시경검사에서 10 mm 이상 크기의 샘종이 발견된 환자는 추적대장내시경검사에서 진행신생물이 발견될 위험이 증가한다. 3. 기준대장내시경검사에서 관융모 또는 융모샘종이 발견된 환자는 관샘종이 발견된 환자에 비해 추적대장내시경검사에서 진행신생물이 발견될 위험이 증가한다. 4. 기준대장내시경검사에서 제거한 샘종이 고도이형성을 동반한 경우, 저도이형성을 동반한 경우에 비해 추적대장내시 경검사에서 진행신생물이 발견될 위험이 증가한다. 5. 기준대장내시경검사에서 10 mm 이상의 톱니모양폴립이 발견된 환자는 추적대장내시경검사에서 진행신생물의 발생위험이 증가한다. 6. 추적검사에서 진행신생물 발생의 고위험군은 기준대장 내시경검사에서 샘종의 개수가 3개 이상, 가장 큰 샘종의 크기가 10 mm 이상, 관융모 또는 융모샘종, 고도이형성을 동반한 샘종, 또는 크기 10 mm 이상의 톱니모양폴립 중 한 가지 이상의 소견이 진단된 경우이다. 7. 일정한 자격을 갖춘 대장내시경의사가 양호한 대장정결 상태에서 양질의 기준대장내시경검사를 시행하였음을 전제로, 기준대장내시경검사 소견이 폴립절제 후 진행신생물의 발생 고위험군에 해당되지 않는 경우 추적대장내시경검사를 폴립절제 후 5년에 시행할 것을 권고한다. 그러나, 상기의 전제 조건이 만족되지 않거나 기준대장내시경검사 이전의 대장내 시경검사에서 고위험군에 해당하는 소견을 보였던 경우에는 기준대장내시경 소견이 고위험군에 해당되지 않더라도 추적 검사 기간을 단축할 것을 권고한다. 8. 일정한 자격을 갖춘 대장내시경의사가 양호한 대장정결 상태에서 양질의 기준대장내시경검사를 시행하였음을 전제로, 기준대장내시경검사 소견이 폴립절제 후 진행신생물의 발 생 고위험군에 해당하는 경우는 추적대장내시경검사를 폴립 절제 후 3년에 시행할 것을 권고한다. 그러나, 상기의 전제조건이 만족되지 않거나 기준대장내시경검사 소견, 샘종의 절제상태, 환자의 전신 상태, 가족력 및 과거력 등을 고려하여 추적검사 기간을 단축할 수 있다. Post-polypectomy surveillance has become a major indication for colonoscopy as a result of increased use of screening colonoscopy in Korea. However, because the medical resource is limited, and the first screening colonoscopy produces the greatest effect on reducing the incidence and mortality of colorectal cancer, there is a need to increase the efficiency of postpolypectomy surveillance. In the present report, a careful analytic approach was used to address all available evidences to delineate the predictors for advanced neoplasia at surveillance colonoscopy. Based on the results of review of the evidences, we elucidated the high risk findings of the index colonoscopy as follows: 1) 3 or more adenomas, 2) any adenoma larger than 10 mm, 3) any tubulovillous or villous adenoma, 4) any adenoma with high-grade dysplasia, and 5) any serrated polyps larger than 10 mm. In patients without any high-risk findings at the index colonoscopy, surveillance colonoscopy should be performed five years after index colonoscopy. In patients with one or more high risk findings, surveillance colonoscopy should be performed three years after polypectomy. However, the surveillance interval can be shortened considering the quality of the index colonoscopy, the completeness of polyp removal, the patient`s general condition, and family and medical history. This practical guideline cannot totally take the place of clinical judgments made by practitioners and should be revised and supplemented in the future as new evidence becomes available.

다량 뿌리혹 형성 콩 계통 개발 및 관련인자 분석

김용욱,이홍석,박의호,이석하,하보근,이주석,윤광일 한국콩연구회 1999 韓國콩硏究會誌 Vol.16 No.2

콩과작물에 있어서 뿌리혹의 질소고정능력 향상은 화학비료의 저투입에 의한 농업환경 오염 경감 및 생산비 감소등 재배적인 면에서 유리하다. 최근 본 연구진은 신팔달콩 2호에서 EMS (ethylmethane sulfonate)를 처리하여 다량 뿌리혹이 형성되는 돌연변이체를 개발하였다. 다량 뿌리혹 형성 (hypernodulation) 콩 계통과 원품종과의 접목실험 결과에 의하면, 기존에 호주, 미국, 일본 등지에 개발된 변이체와 유사한 뿌리혹 형성기작을 가지고 있는 것으로 추측되며, 이는 원품종의 지상부에서 생성되는 뿌리혹 형성 억제물질이 다량 뿌리혹 형성 계통에는 존재하지 않는 것으로 생각되었다. 한편 다량 뿌리혹 형성 콩 계통은 질소고정 능력이 높으나, 지상부 생육이 적어서 개체당 수량은 원품종에 비하여 낮았다. 따라서, 다량 뿌리혹 형성 계통의 농업적 이용은 낮은 수준의 질소를 시비하여 생산비를 경감하고, 동시에 밀식율 유도하여 원품종과 대등한 단위면적당 수량을 확보하는 차원에서 가능할 것으로 생각되어진다. 한편, 다량 뿌리혹 형성 관련 유전인자를 구명하기 위하여 SSR 마아커를 이용한 다량 뿌리혹 계통과 원품종과의 DNA 변이를 조사한 결과, 대부분의 마아커에 대한 변이가 인정되지 않았다. 따라서, 다량 뿌리혹 콩 계통은 단순 유전인자 혹은 한 개의 DNA base pair의 변화로 유기된 돌연변이에 의하여 유래 된 것으로 생각된다.

대장폴립절제술 가이드라인

이석호 ( Suck Ho Lee ),신성재 ( Sung Jae Shin ),박동일 ( Dong Ii Park ),김성은 ( Seong Eun Kim ),홍성필 ( Sung Pil Hong ),홍성노 ( Sung Noh Hong ),양동훈 ( Dong Hoon Yang ),이보인 ( Bo In Lee ),김영호 ( Young Ho Kim ),김현수 ( Hyu 대한소화기학회 2012 대한소화기학회지 Vol.59 No.2

1. 대장폴립절제술 전 혈전색전증 발생 고위험군에서는 아스피린 복용을 계속해야 하고, 혈전색전증 발생 저위험군에서는 환자 및 폴립의 특성에 따라 중단 여부를 결정해야 하며, 혈전 발생위험이 없는 군에서는 가능하면 아스피린을 중단하는 것이 권고된다. 2. 미소폴립의 제거에서는 완전 제거율, 안정성, 회수조직의 조직학적 적정성 여부를 고려할 때 고온 생검법은 권고되지 않는다. 3. 폴립절제술 시점막하 주사는 조기 출혈 예방에 도움이 되지만 지연 출혈 예방효과는 분명치 않다. 4. 크기가 큰(>1 cm) 목 있는 폴립의 절제에서 절제 전예방적 시술(루프 혹은 클립 유치)은 조기 출혈의 예방에 도움이 되지만 지연 출혈의 예방효과는 분명치 않다. 5. 폴립 절제 후 생성된 인공궤양에 대한 예방적 시술(아르곤플라스마 응고술 혹은 클립 유치술)은 지연 출혈 예방에 도움이 되지 않는다. 6. 폴립절제술 후 조직검사에서 점막하 침범이 있으면서 완전절제(절제면 음성)된 선암으로 판정된 경우 림프관 혹은 정맥 침범이 있거나, 분화도가 나쁜 경우, 침범 깊이가 깊을 경우에는 림프절 전이의 위험이 증가하므로 추가적인 수술적 절제를 고려해야 한다. There are indirect evidences to suggest that 80% of colorectal cancers (CRC) develop from adenomatous polyps and that, on average, it takes 10 years for a small polyp to transform into invasive CRC. In multiple cohort studies, colonoscopic polypectomy has been shown to significantly reduce the expected incidence of CRC by 76% to 90%. Colonoscopic polypectomy is performed frequently in primary, secondary and tertiary and medical centers in Korea. However, there are no evidence-based, procedural guidelines for the appropriate performance of this procedure, including the technical aspects. For the guideline presented here, Pubmed, Medline, and Cochrane Library literature searches were performed. When little or no data from well-designed prospective trials were available, an emphasis was placed on the results from large series and reports from recognized experts. Thus, these guidelines for colonoscopic polypectomy are based on a critical review of the available data as well as expert consensus. Further controlled clinical studies are needed to clarify aspects of this statement, and revision may be necessary as new data become available. This guideline is intended to be an educational device to provide information that may assist endoscopists in providing care to patients. This guideline is not a rule and should not be construed as a legal standard of care or as encouraging, advocating, requiring, or discouraging any particular treatment. Clinical decisions for any particular case involve a complex analysis of the patient`s condition and the available courses of action.

한국인의 후두암 발생에서 음주, Aldehyde Dehydrogenase 2(ALDH2)와 N-Acetyltransferase 2(NAT2) 유전자 다형성의 역할

권순욱(Soon Uk Kwon),심윤상(Yoon Sang Shim),이용식(Yong Sik Lee),홍성출(Seong Chool Hong),김광일(Kwang Il Kim),홍영준(Young Joon Hong),홍석일(Seok II Hong),김현주(Hyun Joo Kim),김헌(Heon Kim),이국행(Guk Haeng Lee) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2

Objectives: Alcohol intake has been reported to be a risk factor of laryngeal cancer. Since the aldehyde dehydrogenase 2 (ALDH2) genotype is a major determinant of personal alcohol drinking habit, there is a possibility that ALDH2 genotype would be a risk factor for laryngeal cancer. N-Acetyltransferase 2 (NAT2) is a detoxifying enzyme and its polymorphism has been reported to be related to the risk of many environmental cancers. However, studies on the associations between these two genotypes and laryngeal cancer risk are scarce. We have assessed the effects of alcohol intake and the genotype of ALDH2 and NAT2 on the risk of laryngeal cancer in Koreans. Materials and Methods: Eighty-four pathologically proven laryngeal cancer patients and 168 age matched controls were included as the study subjects. Information about alcohol intake and smoking habit was collected using a self administered questionnaire. ALDH2 and NAT2 genotypes were analyzed using PCR-RFLP methods. Results: Alcohol intake was significant as a risk factor for laryngeal cancer (OR : 2.58, 95% CI : 1.24, 5.36), especially for supraglottic laryngeal cancer (OR : 3.24, 95% CI : 1.02, 10.31). Personal drinking habit was closely related with personal smoking habit, which was a potent risk factor of laryngeal cancer. In a stratified analysis according to the level of cumulative smoking amount, drinking was significant neither in light smokers (equal or less than 30 pack-years) nor in heavy smoker (over 30 pack-years). The ALDH2 genotype was significantly associated with the risk of laryngeal cancer in a univariate analysis. The statistical significance, however, disappeared after adjusting alcohol intake using a multiple conditional logistic model. The NAT2 genotype was not significant as a risk factor for laryngeal cancer. Conclusion: Alcohol drinking and ALDH2 genotype would have indirect effects on laryngeal cancer by their correlations with cigarette smoking or with alcohol drinking. It is less likely that the NAT2 genotype would be a potent risk factor of laryngeal cancer.