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Hong Euy Lim,Il-Young Oh,Fred J Kueffer,Kelly Anna van Bragt,Young Keun On 대한심장학회 2022 Korean Circulation Journal Vol.52 No.10
Background and Objectives: Cryoballoon catheter ablation for the treatment of patients with symptomatic atrial fibrillation (AF) has been adopted globally, but there are limited multicenter reports of 12-month outcomes in the Korean patient population. This analysis evaluated the clinical performance and safety of cryoballoon ablation (CBA) according to standard-of-care practices in Korea. Methods: This evaluation of Korean patients with AF was conducted within the larger Cryo Global Registry, which is a prospective, multicenter, post-market registry. Freedom from a ≥30-second recurrence of atrial arrhythmias (after a 90-day blanking period until 12 months) and procedural safety were examined in subjects treated with CBA at 3 Korean centers. Results: Overall, 299 patients with AF (60±11 years old, 24.7% female, 50.5% paroxysmal AF) underwent CBA using the Arctic Front Advance cryoballoon. Of those, 298 were followed-up for at least 12 months. Mean procedure-, left atrial dwell- and fluoroscopy time was 76±21 minutes, 56±23 minutes, and 27±23 minutes, respectively. Freedom from AF recurrence at 12 months was 83.9% (95% confidence interval [CI], 76.9–88.9%) in the paroxysmal and 61.6% (95% CI, 53.1–69.0%) in the persistent AF cohort. Rhythm monitoring was performed on average 4.7±1.4 times during the follow-up period. Serious device- or procedure-related adverse events occurred in 2 patients (0.7%). The 12-month Kaplan-Meier estimate of freedom from repeat ablation and cardiovascular-related hospitalization was 93.8% (95% CI, 90.4–96.1%) and 89.7% (95% CI, 85.6–92.7%), respectively. Conclusions: CBA is an efficient, effective, and safe procedure for the treatment of AF patients when used according to real-world practices in Korea.
Clinical Value of Serum Uric Acid in Patients with Suspected Coronary Artery Disease
( Hong Euy Lim ),( Seong Hwan Kim ),( Eung Ju Kim ),( Jin Won Kim ),( Seung Woon Rha ),( Hong Seog Seo ),( Chang Gyu Park ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.1
Background/Aims: Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. Methods: The study group comprised 687 consecutive patients with suspected CAD who had undergone coronary angiography. CAD was defined as stenosis≥50% of the luminal diameter. CAD severity was expressed as 1-, 2-, or 3-vessel disease. Metabolic syndrome (MS) was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and aortofemoral pulse wave velocity (PWV) was obtained by arterial catheterization invasively. Results: In total, 395 patients had CAD. SUA was higher in patients with CAD as compared to those without CAD (5.5 ±1.0 vs. 5.2 ±1.0 mg/dL, p=0.004). In addition, SUA was significantly associated with the severity of CAD (p=0.002). However, after adjusting for significant confounding factors including age, diabetes, smoking, cholesterol, MS, and PWV, SUA was not an independent risk factor for CAD (p=0.151). Based on a subgroup analysis, SUA was more closely associated with CAD in women than in men, and in the highest quartile (≥ 6.4 mg/dL) than in the first quartile (< 4.8 mg/dL); however, these results were not significant (p=0.062, p=0.075, respectively). In a multivariate regression analysis, the most important determinant of SUA was MS (i.e., insulin resistance syndrome), which is strongly associated with CAD. Conclusions: In patients with suspected CAD, SUA was not an independent risk factor for CAD and may be merely a marker of insulin resistance. (Korean J Intern Med 2010;25:21-26)
( Hong Euy Lim ),( Hwan Seok Yong ),( Sung Hee Shin ),( Jeong Cheon Ahn ),( Hong Seog Seo ),( Dong Joo Oh ),( Young Moo Ro ),( Chang Gyu Park ) 대한내과학회 2004 The Korean Journal of Internal Medicine Vol.19 No.4
Backgroud : Recent studies have demonstrated that the size and shape of the hyperenhanced areas on contrast-enhanced magnetic resonance imaging (ceMRI) were nearly identical to areas of irreversible injury, as defined by histochemical staining. We compare
Lim, Hong Euy,Lee, Moon-Soo,Ko, Young-Hoon,Park, Young-Min,Joe, Sook-Haeng,Kim, Yong-Ku,Han, Changsu,Lee, Hwa-Young,Pedersen, Susanne S,Denollet, Johan The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.1
<P>This study aimed to develop a Korean version of the Type D Personality Scale-14 (DS14) and evaluate the psychiatric symptomatology of Korean cardiac patients with Type D personality. Healthy control (n = 954), patients with a coronary heart disease (n = 111) and patients with hypertension and no heart disease (n = 292) were recruited. All three groups completed DS14, the Eysenck Personality Questionnaire (EPQ), the state subscale of Spielberger State and Trait Anxiety Inventory (STAI-S), the Center for Epidemiologic Studies Short Depression Scale (CESD), and the General Health Questionnaire (GHQ). The Korean DS14 was internally consistent and stable over time. 27% of the subjects were classified as Type D. Type D individuals had significantly higher mean scores on the STAI-S, CESD, and GHQ compared to non-Type D subjects in each group. The Korean DS14 was a valid and reliable tool for identifying Type D personality. The general population and cardiovascular patients with Type D personality showed higher rate of depression, anxiety and psychological distress regarding their health. Therefore, identifying Type D personality is important in clinical research and practice in chronic medical disorders, especially cardiovascular disease, in Korea.</P>
Case Reports : Mercury inhalation poisoning and acute lung injury
Hong Euy Lim,Jae Jeong Shim,Sang Yub Lee,Sin Hyung Lee,Jae Yun Jo,Kwang Ho In,Han Gyum Kim,Se Hwa Yoo,Kyung Ho Kang 대한내과학회 1998 The Korean Journal of Internal Medicine Vol.13 No.2
Acute mercury inhalation poisoning is a rare cause of acute lung injury. It is usually fatal because of progressive pulmonary failure. We experienced a patient with acute respiratory distress syndrome (ARDS) after illicit use of mercury vapor for hemorrhoi
( Hong Euy Lim ),( Jin Oh Na ),( Sung Il Im ),( Cheol Ung Choi ),( Seong Hwan Kim ),( Jin Won Kim ),( Eung Ju Kim ),( Seong Woo Han ),( Seung Woon Rha ),( Chang Gyu Park ),( Hong Seog Seo ),( Dong Joo 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6
Background/Aims: There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structural and functional remodeling. Methods: The study population consisted of 104 consecutive patients who underwent catheter ablation (CA) for AF (paroxysmal atrial fibrillation [PAF], 82; persistent atrial fibrillation [PeAF], 22). IAS thickness and left atrium volume (LAV) using TTE, and LA voltage (LAVOL) using 3-dimensional electroanatomical mapping system were assessed during sinus rhythm. Results: IAS thickness was significantly correlated with maximal LAV (LAVmax) (r = 0.288, p = 0.003), mean LAVOL (r = -0.537, p < 0.001), total left atrium emptying fraction (LAEFtotal; r = -0.213, p = 0.030), and active LAEF (LAEFactive; r = -0.249, p = 0.014). IAS thickness was greater in the high-risk group (≥ 2) compared to other groups according to CHA2DS2-VASc score (p = 0.019). During a follow-up of 19.6 months, 23 subjects (22.1%; PAF, 17; PeAF, 6) had recurrence of arrhythmia. Univariate analysis showed that LAVmax, minimal LAV, mean LAVOL, LVEFtotal, LVEFactive, and IAS thickness were associated with recurrence of arrhythmia. However, on multivariate analysis, only mean LAVOL and LAEFactive were independent risk factors for recurrence. Conclusions: Although IAS thickness showed significant correlations with parameters for LA structural and functional remodeling, this parameter alone could not independently predict recurrence of arrhythmia after CA for AF.
Electrocardiographic Manifestations of Cardiac Metastasis in Lung Cancer
LIM, HONG EUY,PAK, HUI-NAM,JUNG, HYE CHEOL,KIM, JIN SEOK,SHIM, WAN JOO,KIM, YOUNG-HOON Wiley-Blackwell Publishing, Inc 2006 PACE. Pacing and Clinical Electrophysiology Vol. No.
<P>We describe a case of primary lung cancer with myocardial metastasis, documented with electrocardiogram (ECG) mimicking myocardial ischemia and manifesting VT. Metastatic tumor to the myocardium proper is uncommon and difficult to diagnose because of nonspecific signs and symptoms. We observed such ECG changes in this case were initially misinterpreted as acute coronary syndrome. The diagnosis of cardiac metastasis was confirmed by contrast-enhanced magnetic resonance imaging and computed tomography.</P>