18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

요골동맥을 이용한 관동맥 조영술의 유용성

윤정한,이승환,이한요,김장영,김일회,최윤종,이형준,이명옥,김승년,황성오,홍인수,최경훈 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.10

The Effectiveness and Safety of Direct-Acting Antivirals for HCV Infection during Clinical Practice

( Hoe Soo Jang ),( Sung Kyun Na ),( Eun Kwang Choi ),( Byung-cheol Song ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: This study assessed the real-world experience for efficacy and safety of direct-acting antivirals (DAAs) for patients with HCV infection. Methods: This retrospective study analyzed 127 patients with HCV infection (genotype 1b, n=77; genotype 1a, n=1; mixed with genotype 1a/1b n=1; genotype 2, n=48) who were treated with DAAs. In patients with genotype 1b without NS5A RAV (n=64), daclatasvir and asunaprevir (DCV+ASV) therapy was introduced. In patients with genotype Ib harbouring NS5A RAV (n=13), a patient infected with genotype 1a, a patient with mixed genotype 1a/1b (n=1) and a patients with genotype 1b whose NS5A RAV were not available, were treated with sofosbuvir and ledipasvir (SOF+LDV). Genotype 2 patients (n=48) were treated with sofosbuvir and rivabirin (SOF +RBV). Results: Of the 127 patients (male, n=63 [49.6%]; mean age, 62.9 years; liver cirrhosis 47 [37%]), 66 patients (52.0%) were interferon- experienced. In genotype I patients, SVR12 was achieved in 59 (92.2%) in DCV+ASV group. Among 5 patients without SVR12, virologic breakthrough occurred in a patient and virologic relapse occurred in 4 patients (6.3%). In SOF+LDV group, SVR12 occurred in all patients. In SOF +RBV group, SVR12 was achieved in 46 patients (95.8%). In genotype 1 patients treated with DCV+ASV, 2 patients early stopped the treatment because of economic problem (n=1) and virolgic breakthrough (n=1). In genotype 2 patients, 3 patients (SVR12, n=1, no SVR12, n=2), all were over 70 year old, stopped the medication due to gastrointestinal troubles (n=2) or pruritus (n=1). During or after DAA treatment, hepatocellular carcinoma developed in 2 patients (1 in DCV+ASV group and 1 in SOF +RBV group) whose ages were over 75 years. Conclusions: DAAs provide high rate of SVR12 and safety in patients with HCV infection. However, in some older patients, especially ribavirin containing regimen is not tolerable and HCC can develop during or after DAAs treatment.

Poster Session : PS 1287 ; Pulmonology : Clinical Characteristics of Pleural Effusion of Scrub Typhus Patient : An 8-Year Single Center Experience in South Korea

( Hoe Soo Jang ),( Hyung Ho Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The aim of this study is to investigate the characteristics of pleural effusion and to identify the factors associated with the occurrence of pleural effusion of adult scrub typhus patients which are currently unclear. Methods: We conducted a retrospective analysis of the medical records of the confirmed adult scrub typhus patients between January 2004 and December 2011 at Chosun University Hospital in South Korea. 445 confirmed adult scrub typhus patients were divided into two groups for comparison: the patients group without pleural effusion (n=352) and with effusion (n=93). And data of 18 patients with examined pleural effusion were summarized. Results: Multivariate analysis demonstrated that following four factors were signifi-cantly associated with the occurrence of pleural effusion of scrub typhus as independent risk factors: older age (odd ratio[OR] = 1.03, p = 0.037); male sex (OR = 1.92, p = 0.020); presence of underlying heart failure (OR = 2.63, p = 0.039, CI = 1.05-6.56); lower albumin (OR = 0.11, p = <0.001). Most of the effusions were bilateral location (88%) and small in size (91%). The mean pleural fiuid WBC count was 1619.7/mm3, and the differential count showed a predominance of mononuclear cell in 11 patients. Effusion of 11 patients (61.1%) was classified as exudates by Light`s criteria. The mean pleural fiuid total protein was 2.30 ± 0.58 g/dL, and the mean pleural fiuid LDH was 275.8 ± 101.6 U/L. The mean pleural fiuid pH was 7.43 ± 0.82. The mean ADA was 32.5 ± 20.9 U/L, and ADA was above 35 U/L in 8 patients (44.4%). Conclusions: This study provides first data regarding the factors associated with the occurrence of pleural effusion and the characteristics of pleural effusion of adult scrub typhus.

증례 : 감염 ; 수리남 여행 후 발생한 치쿤구니야

장회수 ( Hoe-soo Jang ),정종훈 ( Jong-hun Chung ),김조아 ( Joa Kim ),한선애 ( Sun Ae Han ),윤나라 ( Na-ra Yun ),김동민 ( Dong-min Kim ) 대한내과학회 2016 대한내과학회지 Vol.90 No.3

치쿤구니야는 치쿤구니야바이러스에 의해 발생하는 감염증으로 모기에 의해 사람에게 전염되며 임상적으로 2-7일간지속되는 발열, 관절통, 두통, 반점구진상 발진 등을 일으킨다. 본 증례의 경우 수리남에 다녀온 여행력이 있는 환자에서 증상 발생 15일째 시행한 효소결합면역흡착법(ELISA) 그리고 간접면역형광항체법상 음성이었으나 23일째 재시행한 항체검사상 치쿤구니야가 진단되었다. 이에 IgM 항체가 형성되는 시기가 증상 발생 후 5일 이후부터 형성되므로 임상적으로 치쿤구니야가 의심되는 경우 반드시 추적 검사가 필요할 것으로 사료된다. Chikungunya infection is caused by an arbovirus transmitted by the Aedes mosquito. A 19-year-old man who had traveled to the Republic of Surinam to perform volunteer work complained of a fever, arthralgia, articular stiffness, and a skin rash on both the arm and trunk. Chikungunya fever was diagnosed using a Chikungunya virus specific IgM antibody in an enzyme-linked immunosorbent assay (ELISA) using blood samples obtained during follow-up visits. In this report, we describe a case of imported Chikungunya fever that presented with arthralgia and a skin rash, with islands of normal skin, that occurred following travel to Surinam, South America. (Korean J Med 2016;90:262-265)

Flexural Behavior of High-Strength Concrete Beams Confined with Stirrups in Pure Bending Zone

Jang, Il-Young,Park, Hoon-Gyu,Kim, Yong-Gon,Kim, Sung-Soo,Kim, Jong-Hoe Korea Concrete Institute 2009 International Journal of Concrete Structures and M Vol.3 No.1

The purpose of this study is to establish flexural behavior of high-strength concrete beams confined in the pure bending zone with stirrups. The experiment was carried out on full-scale high-strength reinforced concrete beams, of which the compressive strengths were 40 MPa and 70 MPa. The beams were confined with rectangular closed stirrups. Test results are reviewed in terms of flexural capacity and ductility. The effect of web reinforcement ratio, longitudinal reinforcement ratio and shear span to beam depth ratio on ductility are investigated. The analytic method is based on finite element method using fiber-section model, which is known to define the behavior of reinforced concrete structures well up to the ultimate state and is proven to be valid by the verification with the experimental results above. It is found that confinement of concrete compressive regions with closed stirrups does not affect the flexural strength but results in a significantly increased ductility. Moreover, the ductility tends to increase as the quantity of stirrups increases by reducing the spacing of stirrups.

On the Ductility of High-Strength Concrete Beams

Jang, Il-Young,Park, Hoon-Gyu,Kim, Sung-Soo,Kim, Jong-Hoe,Kim, Yong-Gon Korea Concrete Institute 2008 International Journal of Concrete Structures and M Vol.2 No.2

Ductility is important in the design of reinforced concrete structures. In seismic design of reinforced concrete members, it is necessary to allow for relatively large ductility so that the seismic energy is absorbed to avoid shear failure or significant degradation of strength even after yielding of reinforcing steels in the concrete member occurs. Therefore, prediction of the ductility should be as accurate as possible. The principal aim of this paper is to present the basic data for the ductility evaluation of reinforced high-strength concrete beams. Accordingly, 23 flexural tests were conducted on full-scale structural concrete beam specimens having concrete compressive strength of 40, 60, and 70MPa. The test results were then reviewed in terms of flexural capacity and ductility. The effect of concrete compressive strength, web reinforcement ratio, tension steel ratio, and shear span to beam depth ratio on ductility were investigated experimentally.

Synthesis and Electro-Optical Properties of Fluorene-Based Copolymer for Organic Photovoltaic Device Application

Kim, Jang Soo,Song, Myungkwan,Park, Jin Su,Yoon, Mikyoung,Yoon, Hoe Won,Kim, Ae Jin,Lee, Jae Wook,Gal, Yeong-Soon,Jin, Sung-Ho Informa UK (TaylorFrancis) 2011 MOLECULAR CRYSTALS AND LIQUID CRYSTALS - Vol.538 No.1

소아기 Cerebral Rete Mirabile 병소에 대한 Encephalo-duro-arterio-synangiosis : 치험 2 예 Report of Two Operative Cases

황장회,이재수,강준기,백민우,김달수,하영수,송진언 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.1

Cerebral rete mirabile is a unusual form of chronic cerebrovascular occlusive disease characterized usually by bilateral stenosis of distal internal carotid arteries and their vicinity, by a hazy network of collateral circulation at the base of brain called moyamoya vessels and clinically by recurring hemispheric ischemic attack in children. We have reported here 2 cases of cerebral rete mirabile in children and performed newly developed operative procedure which we think is an ideal surgical method for treatment of this disease in children and is compared with other surgical treatment.

전두엽의 해면상 혈관종

황장희,이재수,하영수,최창락,송진언 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.4

Cerebral cavernous hemangioma is very rare disease in the cerebral vascular malformations. We experienced a case of this vascular malformations at the left frontal lobe near the cortex which had symptoms and signs of abrupt generalized tonicclonic seizure. This malformation is encountered more commonly in adult in the third to fifth decade, and is found most frequently in the white matter of the cerebral hemisphere. The value of computerized tomography (C-T) in the detection of such malformations is stressed. Good result was obtained by the microsurgical approach to these malformations.