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급성 족관절 염좌에 대한 봉약침 효과-무작위대조시험, 이중맹검
송호섭,Song, Ho-Seub 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.2
Objective : The aim of the study was to investigate the therapeutic effect of BVA in the treatment of patients with acute ankle sprain. Design : A prospective randomized double-blind study of BVA was conducted. Setting : The study was done in the Kyungwon University Seoul Hospital from August 1st, 2004 to June 15th, 2005. Patients : 30 patients diagnosed with acute ankle sprain, especially 2nd degree on the Ankle grade pain chart(AGPC) participated in the study, who were divided into two groups (A and B) randomly by a coordinator flipping a coin. Group A and B were relevant to control and BVA group respectively, of which a coordinator never informed any other participant involved. Eventually 13 of 17 in group A and 11 of 13 in Group B finished all the process of the clinical trial. Intervention : In both group A and B, The Procedure of acupuncture treatment was made similar by appearance that four acupoints such as 坵墟(GB40), 中封(LR4), 商丘(SP5), 解谿(ST41) of the injured side were selected and Normal saline aqua-acupuncture(control, as a placebo) or BVA was done and then acupuncture at 坵墟(GB40), 中封(LR4), 商丘(SP5), 解谿(ST41), 足三里(ST36), 陽陵泉(G34) of the affected side was given again. the needles were retained for 20 minutes under the infrared rays. The treatment was given daily for a week. Outcome Measures : Ankle-Hindfoot Scale (AHS) and Visual Analogue Scale(VAS) were followed by three treatments. Statistical Analysis : Analysis regarding variations in AHS and VAS is carried out by applying Mann-Whitney test and Wilcoxon signed rank test sign test with level of significance at 5%. Results : At the end of the treatment, there was significant statistical differences between the two groups in VAS and AHS as well, while at the 3rd day only a VAS showed statistical significance. In each group, both VAS and AHS showed statistical significance along with duration of treatment. Conclusions : BVA was thought to be effective alternatives for relieving symptoms of acute ankle sprain, although further study was needed on the large scale.
Growth and Dielectric Properties of Pb5Ge3O11 Films on Pt/Ti/SiO2/Si
Dae-Hwang Yoo,Ho Seub Lee,Chang Hee Chung,Jin-Soo Kim,Sang Su Kim,Tae-Kwon Song 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.47 No.2
Pb5Ge3O11 (PGO) films were grown on Pt/Ti/SiO2/Si substrate at 550 C by a pulsed laser deposition (PLD) method by using a pulsed KrF excimer laser. It was proved that the films were grown well with c-axis preferred orientation by XRD experiments. In the case of PGO film with a thickness of 0.3 μm, the maximum capacitance which may be related to the phase transition was shown at 110 C, which is lower than for PGO ceramic. Capacitance measurement of films at room temperature shows dielectric dispersion in the low-frequency region and the dispersion becomes stronger in the case of thinner film, which means that the surface characteristics contribute to low-frequency dielectric dispersion.
Analysis of Trend of Studies on Microneedle Treatment System (MTS)
Chun Hea Sun,Song Ho-Seub 대한약침학회 2021 Journal of pharmacopuncture Vol.24 No.4
Objectives: The purpose of this study was to analyze the microneedle therapy system (MTS) and its research methods for the past 10 years in Korea. Methods: Data on microneedle therapy system were collected using NDSL, KISS, RISS, and OASIS electronic databases from January 2010 to August 2021. “microneedle,” “derma stamp,” “microneedle therapy system” were used as the keywords. The present study, however, excluded data that were 1) unrelated to the microneedle therapy system, 2) from review/meta/protocol studies, and 3) from overseas studies. Data selected through the primary screening process, animal studies, case reports, and clinical data were included in the analysis. However, information data not related to the microneedle therapy system were excluded from the study. Results: Among the MTS-related papers published from January 2010 to August 2021, 7 animal research, 2 clinical trials, and 10 case studies were published. Based on the research topics, there were 8 papers on skin improvement and skin diseases, 7 papers on hair growth and hair loss, 3 papers on stability, and 1 paper on peripheral facial paralysis. Conclusion: Most of the studies related to MTS focused on skin, hair, and stability. The effect of MTS on hair growth and skin improvement has been confirmed, and it has been proven to have significant effects on the treatment of acne, acne scars, and hair loss in clinical practice. No serious side effects were observed during the MTS treatment, and the safety assessment confirmed that it was safe for use.
Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
Hye Ji Park,Yong Kyung Lee,Ho Seub Song,Goon Joung Kim,Dong Ju Son,Jae Woong Lee,Jin Tae Hong 한국독성학회 2006 Toxicological Research Vol.22 No.1
It was previously found that melittin inhibited NF-κB activity by reacting with signal molecules of NF-κB which is critical contributor in cancer cell growth by induction of apoptotic cell death. We here investigated whether melittin inhibits cell growth of human prostate cancer cells through induction of apoptotic cell death, and the possible signal pathways. Melittin (0~1 ㎍/㎖) inhibited prostate cancer cell growth in a dose dependent manner. Conversely related to the growth inhibitory effect, melittin increased the induction of apoptotic cell death in a dose dependent manner. Melittin also inhibited DNA binding activity of NF-κB, an anti-apoptotic transcriptional factor. Consistent with the induction of apoptotic cell death and inhibition of NF-κB, melittin increased the expression of pro-apoptotic proteins caspase-3, and Bax but down-regulated anti-apoptotic protein Bcl-2. These findings suggest that melittin could inhibit prostate cancer cell growth, and this effect may be related with the induction of apoptotic cell death via inactivation of NF-κB.
Study of Latest Trend on Acupuncture for Obesity Treatment
Chun Hea Sun,Kim Dong-Hwan,Song Ho-Seub 대한약침학회 2021 Journal of pharmacopuncture Vol.24 No.4
Objectives: The aim of this review was to appraise Korean studies published between 2010 and 2021 which examined the role of acupuncture in the treatment of obesity. Methods: We performed a search of the NDSL, KISS, RISS, OASIS, PubMed, EMBASE electronic databases for relevant animal researches, case reports, and clinical trials, using the following search terms: ‘obesity’, ‘acupuncture’, ‘electroacupuncture’, and ‘pharmacopuncture’. We excluded previous reviews and meta-analyses, studies not related to obesity or acupuncture treatment, as well as studies conducted in countries other than Korea. We also excluded studies where relevant information on acupuncture treatment in obesity could not be obtained. Results: Most studies were conducted in animals, followed by case reports and clinical trials. In animal researches and case reports, pharmacopuncture was the most used intervention. In case studies, electroacupuncture, thread-embedding therapy, manual acupuncture, acupotomy, and auricular acupuncture were also used. In animal researches, pharmacopuncture treatment was associated with improvement in obesity indices. In the case of local obesity, specific acupuncture techniques such as thread-embedding therapy and pharmacopuncture were associated with significant improvements in local obesity, even when diet and exercise were not controlled for. Conclusion: Acupuncture treatment showed significant benefit in the treatment of obesity, with a local effect evident for certain approaches, such thread-embedding therapy and acupotomy.
Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
Park Hye-Ji,Lee Yong-Kyung,Song Ho-Seub,Kim Goon-Joung,Son Dong-Ju,Lee Jae-Woong,Hong Jin-Tae Korean Society of ToxicologyKorea Environmental Mu 2006 Toxicological Research Vol.22 No.1
It was previously found that melittin inhibited $NF-{\kappa}B$ activity by reacting with signal molecules of $NF-{\kappa}B$ which is critical contributor in cancer cell growth by induction of apoptotic cell death. We here investigated whether melittin inhibits cell growth of human prostate cancer cells through induction of apoptotic cell death, and the possible signal pathways. Melittin ($0{\sim}1\;{\mu}g/ml$) inhibited prostate cancer cell growth in a dose dependent manner. Conversely related to the growth inhibitory effect, melittin increased the induction of apoptotic cell death in a dose dependent manner. Melittin also inhibited DNA binding activity of $NF-{\kappa}B$, an anti-apoptotic transcriptional factor. Consistent with the induction of apoptotic cell death and inhibition of $NF-{\kappa}B$, melittin increased the expression of pro-apoptotic proteins caspase-3, and Bax but down-regulated anti-apoptotic protein Bcl-2. These findings suggest that melittin could inhibit prostate cancer cell growth, and this effect may be related with the induction of apoptotic cell death via inactivation of $NF-{\kappa}B$.
가성낭을 동반한 만성 췌장염 환자에서 발생한 비장경색 및 비장파열 1 예
조용구(Yong Gu Cho),임영찬(Young Chan Lim),한병호(Beoung Ho Han),김충기(Chung Kee Kim),임홍섭(Hong Seub Lim),심영웅(Young Woong Sim),송갑영(Gap Young Song) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, portal hypertension, splenic torsion, septicemia and drugs, etc. Splenic infarction accompained by chronic pancreatitis is most likely due to splenic vein thrombosis, surrounding tissue fibrosis accompanied with splenic vessel occlusion, and intrasplenic penetration of pancreatic pseudocyst. Recently, we experienced a case of splenic infarction and rupture in a 46-year-old male who had been diagnosed as chronic pancreatitis with pseudocyst. (Korean J Gastroenterol 2001;38:457-460)