위암에서 근치적 절제술 후 전이 림프절 수가 예후에 미치는 영향

임호영,최진혁,김현수,남동기,김효철 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

Gastric cancer is the most common cause of cancer death in Korea, and the most important prognostic factor for patients with gastric cancer is the extent of TNM stage. Among TNM staging system, lymph node involvement (N) has been recognized as one of the significant prognostic indicators after curative resection. Recently, nodal stage of new AJCC TNM staging system has changed its emphasis on the location of metastatic lymph nodes to the number of metastatic lymph nodes. Thus, we attempted to analyze the survival difference based on the number of metastatic lymph nodes after curative resection of gastric cancer. Two hundred and forty two patients of curatively resected gastric cancer were retrospectively studied to identify the number of metastatic lymph nodes to influence prognosis. The following results were obtained. The results showed that there was a significant difference in the survival rate between the patients with 0-2 metastatic lymph nodes and those with ≥3 metastatic lymph nodes in adjuvant chemotherapy (FA) group (DFS; 36.7% vs. 23.4%, OS; 38.3% vs. 26.0%). In adjuvant chemoimmunotherapy (FA+poly-AU) group, there was a significant difference in the overall survival between the patients with 0∼2 metastatic lymph nodes and those with ≥ 3 metastatic lymph nodes(70.1% vs. 47.4%). The present report demonstrates the prognostic importance of the number of metastatic lymph nodes in gastric cancer after curative resection and a necessity of further evaluation of current nodal stage.

상아질 결합제의 종류와 처리방법에 따른 전단결합강도와 상아질-레진 결합계면 미세구조에 관한 연구

임창하,이용렬,정영화,송호준,박영준 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.1

The purpose of this study was to evaluate the dentin bonding agents (DBA) with the variations of the bonding system generations (4^th, 5^th and 6^th) and application methods by comparing the shear bond strengths (SBS) which were determined 24 h after application and dentin-adhesive interface microstructure. It was also aimed to suggest the theoretical clues for the adequate use of each bonding systems. The parameters were 1) generation of bonding systems (one product of 4^th, eight products of 5^th, and three products of 6^th generation), 2) moisture condition of the dentin surface after acid conditioning (moist group vs. dry group), 3) solvent type of the primers (three acetone-based, one acetone/ethanol-based, two water/ethanol-based, four water-based, one ethanol-based, one water/acetone-based), and 4) type of etchants (seven with phosphoric acid, three with self-etching primer, and one with 10-3 etchant). The results were as follows; One-bottle adhesives had comparable shear bond strengths compared to multiple component bonding agents, and some showed even higher results. Single Bond had the highest SBS value (20.6 ㎫) in the moist subgroup. For 4th and 5th generation DBAs, except for Mac Bond Ⅱ, all bonding systems showed lower SBS when dentin became desiccated after the conditioning-rinsing step, and generally shorter resin tags were produced in dry condition. Acetone-based adhesives generally showed better penetrability into dentinal tubules, and tended to be more sensitive to the degree of dentin dampness compared to those of the ethanol- or water-based adhesives. With Mac Bond Ⅱ which uses a self-etching primer, even though the hybrid layer was thin with a thickness of 1∼2 μ m, SBS was comparatively high. In the case of 6^th generation DBAs, Prompt L-Pop showed significantly lower SBS to dentin (7.4 ㎫) compared to those of AQ bond (13.3 ㎫) and One-Up Bond F (13.1 ㎫)(p<0.05). The hybrid layer was thin with a thickness of about 1μ m. In the case of AQ bond and One-Up Bond F, dentinal tubules were relatively well sealed. In the case of Prompt L-Pop, on the other hand, some of the dentinal tubules were not completely sealed, and fractured resin tags and separation between the hybrid layer and composite resin were observed. In the case of AQ bond, about 15μ m-thick resin layer was formed and many of the adhesive resin tags could not penetrate deep into the dentinal tubules. In the case of One-Up Bond F, many resin tags which are more than 50μ m-long were formed, but short penetration was also seen in some tubules. It is concluded that even though resin tag formation contributes in some extent for the bond strength, sufficient penetration of the adhesive resin to the exposed collagen meshwork and complete curing there in, and having sufficient strength to withstand the stress caused by the polymerization shrinkage during the light curing is essential for the success of the bonding procedure.

요통환자에 있어서 MRI 소견상 추간판 팽윤의 임상적 의의

선호영,조성일,이정웅,임상덕,정상돈,윤영석 최신의학사 1993 最新醫學 Vol.36 No.12

크롬(Ⅵ)의 체내 흡수와 소실속도에 관한 연구

김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.

레슬링선수들의 체중감량에 따른 섭취열량과 신체조성의 변화

백영호,염종우,염원상,김세종,서혜림 부산대학교 체육과학연구소 2000 體育科學硏究所 論文集 Vol.16 No.-

This study was to find out calorie intake and body composition changes in accordance with weight loss of wrestlers. The wrestlers were divided three groups : no weight loss groups, 5∼7% weight loss group and over 7% weight loss group. And they were observed three : before weight loss, at measuring weight and before games. The following are the conclusion of this study: 1.The changes of calorie intake 1) Before weight loss, the percentage of the daily intake to the daily energy expenditure was 57.7% for the no weight loss group, 47.2% for the 5%∼7% weight loss group and 53.7% for the over 7% weight loss group. 2) The calorie intake of each group per meal: the no weight loss group intake 1,118kcal before weight loss, 760.9kcal before weight measurement and 1026.8kcal from after weight measurement to before games, and the 5∼7% weight loss group intake 955.4kcal before weight loss, 483.1kcal before weigh measurement and 880.4kcal from after weight measurement to before games, and the over 7% weight intake 959.3kcal before weight loss, 339.4kcal before weight measurement and 872.7kcal from after weight measurement to before games. 3) The ratios of calorie intake(protein : fat : glucose) : the no weight loss group showed 16.7∼35.1% : 20.8∼23.8% : 44.1∼60%, the 5∼7% weight loss group showed 15.5∼26.6% : 22.2∼23.7% : 50.6∼62.3% and the over 7% weight loss group showed 15.0∼30.2% : 19.6∼27,6% : 50.7∼59 4%. 2.The changes in body composition 1) After weight loss, weight and BMI changes in accordance with weight loss among groups showed meaningful differences in all circumstances : weight, before games versus at measuring weight and before weight loss versus before games.(p≤.001) 2) In the changes of total body water, protein, mineral, fat mass and %fat in accordance with weight loss among groups, when we compared those of before games with those of at measuring weight, we found that the over 7% weight loss group showed a meaningful increase over the no weight loss group.(p≤0.5) 3) In the changes within groups, though we found no meaningful difference, total body water, protein and mineral of before games were less than those of before weight loss, and fat mass and %fat of before games were higher than those of before weight loss. According to the results of this study, the wrestlers lost their weights intensively in three days before games by eating less and when lean body mass was restored, the level was lower than before weight loss. Therefore, these results intake the weakness of exercise capacity, long-term weight loss plan is more helpful than short-term weight loss, and for the enhancement of exercise capacity systematic plan and training of the weigh loss should be done.

운동시 성장호르몬 대사에 관한 고찰

백영호,염종우,서혜림 부산대학교 체육과학연구소 2000 體育科學硏究所 論文集 Vol.16 No.-

Through the literature study of the effects on the growth hormone metabolic of exercises, we had a conclusion as follows: 1.During exercises, growth hormone secretion has a variable of exercise Intensity and time, secretion threshold of growth hormone by exercises has a constant latency period of 15∼20 minutes after beginning exercise, and growth hormone secretion reacher to maximum after 30 minutes of the maximum exercises. 2.There are more or less differences of time, but amount of secretion of the growth hormone is shown to be similar according to the gender. 3.Injection of the growth hormone to the elders is shown to be most effective in the case of accompanied with exercises. 4.Because exercises causes the natural secretion of the growth hormone and the metabolic, the constant exercises are needed regardless of ages.

집단에 따른 노인들의 자가건강관리행태, 일상생활수행능력, 신체적 자기효능감에 관한 연구

김세종,이의철,염원상,서혜림,백영호 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

This study was carried out to identify the status of self-care, activity of daily living and physical self-efficacy among aged people in Pusan and thus to provide basic data for maintaining health, making affirmative-self among elders. The subjects of this study were 761 elders 65years and over in Pusan. The means of measurement used were the status self-care scale, activity of daily living scale and physical self-efficacy scale. The data was used by One-way Anova, Duncan's Multiple Range and Pearson's Correlation Coefficient as statistical method. The level of significance of all hypotheses tested was p<.05 and the results were as follows; 1) Aged people who participated in elderly academy classes was higher than other groups in the status of self-care statistically significant. 2) Aged people who participated in elderly academy classes and elderly houses ·respect for age association and group were higher than other groups in activity of daily living statistically significant. 3) Aged people who participated in elderly academy classes, elderly house ·respect for age association and just stay at home group were higher than other group in physical self-efficacy statistically significant. 4) Aged people's status of self-care, activity of daily living and physical self-efficacy was statistically significant correlation with each other.

환경호르몬에 관한 연구동향과 안전대처 방안

염원상,이의철,서혜림,김세종,백영호 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

From a theoretical research on recent investigations of endocrine disruptors, the results of this study were as follow; 1. Endocrine Disruptors means an exogenous chemical substance that causes adverse health effects in an intact organism, or its progeny, consequent to changes in endocrine function. 2. It is required that the cooperative study and research is propelled among administrative organs, scientific research companies and the common people companies for fundamental protecting about endocrine disruptors. 3. It is necessary that the network data-base and international cooperation works should be intensified. 4. Development of techniques which can distinguish and classify the endocrine disruptors, more testing and continuous monitoring are required.

Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

동종 골수이식 후 만성 이식편대숙주질환과 동반되어 신증후군으로 발현된 IgA 신병증 1예

정철권,김현수,박준성,정성현,조도연,최진혁,남동기,임호영,김명성,신규태,임현이,김효철 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

동종 골수이식 후 발생하는 신기능부전은 원인이 다양하여 감별에 어려움이 있다. 만성 GVHD는 흉선의 기능저하에 따른 면역관용의 실패로 발생되는 자가면역현상에 의해 발생되는 것으로 알려져 있으며 드물게 신장을 침범하여 신증후군을 일으키기도 한다. CaA의 용량을 줄이거나 투약중지 후 발생한 만성 GVHD에 동반된 신증후군의 경우 조기에 신조직검사를 시행하여 감별진단하고 CsA의 용량을 증량하거나 재투약하여 좋은 치료 결과를 보일 것으로 기대된다. 저자들은 문헌고찰을 통해 동종 골수이식 후 발생된 신증후군이 유사한 임상양상을 보이며 발생기전에 만성 GVHD와 자가면역현상이 연관되어 있음을 확인하였으며 동종 골수이식 후 신증후군의 임상양상을 보이는 환자에서 병리조직학적으로 lgA 신병증을 진단하고 이러한 lgA 신병증이 발생기전에 만성 GVHD와 자가 면역현상이 연관되어 있을 가능성을 최초로 확인하였으며 CsA를 이용하여 성공적으로 치료한 경험을 하였기에 보고하는 바이다. Renal insufficiency is occasionally encountered in allogeneic bone marrow transplantation and its cause is difficult to ascertain. Chronic graft-versus-host disease (GVHD) related to thymic dysfunction is immune-mediated and involves autoreactivity of T-lymphocytes derived from donor marrow to recipient's major histocompatibility complex(MHC) minor antigens. The clinical mainifestations of chronic GVHD are similar to those of autoimmune disease but kidney involvement is rare. Few cases of nephrotic syndrome with membranous nephropathy or minimal change nephrotic syndrome have been reported to be associated with chronic GVHD in allogeneic bone marrow transplant recipient especially after cyclosporine A(CsA) withdrawal, and these cases have responded well to CsA. Therefore, it is prudent to differentiate the cause of post-transplant renal insufficiency using renal biopsy and to start CsA in a case of nephrotic syndrome associated with chronic GVHD as early as possible. We report a case who had a massive proteinuria during the post-allogeneic marrow transplantation period. The cause of nephrotic syndrome was diagnosed as IgA nephropathy by renal biopsy. The patient was successfully treated with reintroduction of CsA.