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Kim, Ho Gak,Han, Jimin,Kim, Myung-Hwan,Cho, Kyu Hyun,Shin, Im Hee,Kim, Gwang Ha,Kim, Jae Seon,Kim, Jin Bong,Kim, Tae Nyeun,Kim, Tae Hyeon,Kim, Tae Hyo,Kim, Jae Woo,Ryu, Ji Kon,Moon, Young Soo,Moon, Jo WJG Press 2009 World journal of gastroenterology Vol.15 No.1
<P>To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.</P>
상부위장관질환 환자에서 H . pylori 감염에 의한 위점막의 조직학적 변화와 혈청 Gastrin 및 혈청 IgG항체가의 상관관계
손호상(Ho Sang Shon),최정윤(Jung Yoon Choe),김지희(Chi Hui Kim),김태석(Tae Sug Kim),김채기(Chae Gi Kim),김이근(Ih Geun Kim),안기성(Ki Sung Ahn),김호각(Ho Gak Kim),오훈규(Hoon Kyu Oh),김용진(Yong Jin Kim),배정동(Jung Dong Bae) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3
N/A Background/Aims: This study was performed to investigate the relationship between Helicobacter pylori infection and degree of gastric mucosal inflammation, IgG antibody titer against H. pylori, and fasting serum gastrin level. Methods: Patients were divided into 2 groups(H. pylori positive and negative) by identification of H. pylori in biopsied specimens with special staining. In H. pylori positive group, the density of gastric K. pylori colonization was further graded semiquantitatively from 1 to 3. The severity of gastritis in each group was scored according to the Sydney system from 0 to 3. Serum IgG antibody titer against H. pylori was detected by second-generation antigen based enzyme immunoassay(Cobas Core Anti-Helicobacter pylori EIA). Fasting serum gastrin level was measured by standard radioimmunoassay technique. Results: The severity of gastritis in H. pylori positive group was significantly higher than H. pylori negative group in mononuclear cell infiltration(pC0.001), activity of PMNL(pC0.001), and glandular atrophy(pC0.01). In H. pylori positive group, the density of H. pylori colonization was significantly correlated with mononuclear cell infiltration(r=0.67, p0.001), activity of PMNL(r=0.70, p0.001), and grandular atrophy (r=0.38, pC0.001). Neither density of H. pylori colonization nor severity of gastritis was correlated with fasting gastrin level and IgG antibody titer against H. pylori. Conclusions: H. pylori infection results in localized inflammatory reaction in gastric mucosa with relation to density of H. pylori colonization, but serum H. pylori IgG antibody titer does not reflect the severity of gastritis. Fasting serum gastrin level also has no relation with the density of H. pylori colonization and severity of gastritis. These findings suggest that the factor which cause inflammation in gastric mucosa may be different from that cause gastrin secretion or formation of IgG antibody. (Korean J Gastroenterol 1996; 28:311 - 319)
비스테로이드성 진통소염제 유발 위십이지장병증에 대한 Helicobact er py lori 감염의 영향
김재훈,김창수,최병렬,오동호,이창형,박재복,배정동,오훈규,김호각,도준형,현대성 대한소화기학회 1999 대한소화기학회지 Vol.33 No.4
Background/Aims: To determine the effect of H. pylori infection on gastroduodenopathy induced by nonsteroidal anti-inflammatory drugs (NSAIDs), we investigated endoscopic morphology and histolo gic findings of gastroduodenopathy in symptomatic patients taking NSAIDs in relation to H. pylor infection. Methods: One hundred and eight symptomatic patients who were taking NSAIDs or took NSAIDs more than 4 days within recent 2 weeks were performed gastroduodenoscopy. For H. pylori infected group and uninfected group, we compared endoscopic mucosal damages according to modi fied Lanza scale, histologic findings and severity of bleeding. Results: Fifty-four patients (50%) were infected with H. pylori. The endoscopic score and the pH of gastric juice of both groups were no different, but the bleeding evidence on ulcer was more prevalent in H. pylori-infected group Chemical gastritis was dominant in H. pylori-uninfected group (p$lt;0.001) and chronic inflammation and activity of polymorphonuclear leukocytes in gastric mucosa were more frequent in H. pylori-infected group (p$lt;0.001). Conclusions: H. pylori infection is not associated with aggravation of gastroduodenopathy in patients taking NSAIDs. Among the gastrodudenopathy, chemical gastritis is mainly caused by NSAIDs and inflammatory cell infiltration is mainly caused by H. pylori infection.
Cryopreservation of putative pre-pubertal bovine spermatogonial stem cells by slow freezing
Kim, Ki-Jung,Lee, Yong-An,Kim, Bang-Jin,Kim, Yong-Hee,Kim, Byung-Gak,Kang, Hyun-Gu,Jung, Sang-Eun,Choi, Sun-Ho,Schmidt, Jonathan A.,Ryu, Buom-Yong Elsevier 2015 Cryobiology Vol.70 No.2
<P><B>Abstract</B></P> <P>Development of techniques for the preservation of mammalian spermatogonial stem cells (SSCs) is a critical step in commercial application of SSC based technologies, including species preservation, amplification of agriculturally valuable germ lines, and human fertility preservations. The objective of this study was to develop an efficient cryopreservation protocol for preservation of bovine SSCs using a slow freezing technique. To maximize the efficiency of SSC cryopreservation, the effects of various methods (tissue vs. cell freezing) and cryoprotective agents (trehalose, sucrose, and polyethylene glycol [PEG]) were tested. Following thawing, cells were enriched for undifferentiated spermatogonia by differential plating and evaluated for recovery rate, proliferation capacity, and apoptosis. Additionally, putative stem cell activity was assessed using SSC xenotransplantation. The recovery rate, and proliferation capacity of undifferentiated spermatogonia were significantly greater for germ cells frozen using tissue freezing methods compared to cell freezing methods. Cryopreservation in the presence of 200mM trehalose resulted in significantly greater recovery rate, proliferation capacity, and apoptosis of germ cells compared to control. Furthermore, cryopreservation using the tissue freezing method in the presence of 200mM trehalose resulted in the production of colonies of donor-derived germ cells after xenotransplantation into recipient mouse testes, indicating putative stem cell function. Collectively, these data indicate that cryopreservation using tissue freezing methods in the presence of 200mM trehalose is an efficient cryopreservation protocol for bovine SSCs.</P>
Calcium sensitization involved in dexmedetomidine-induced contraction of isolated rat aorta
Kim, Jae-Gak,Sung, Hui-Jin,Ok, Seong-Ho,Kwon, Seong-Chun,Cheon, Kwang Seong,Kim, Hye Jung,Chang, Ki Churl,Shin, Il-Woo,Lee, Heon-Keun,Chung, Young-Kyun,Sohn, Ju-Tae Canadian Science Publishing 2011 Canadian journal of physiology and pharmacology Vol.89 No.9
<P> Dexmedetomidine, a full agonist of the α2B-adrenoceptor that is mainly involved in vascular smooth muscle contraction, is primarily used for analgesia and sedation in intensive care units. High-dose dexmedetomidine produces hypertension in children and adults. The goal of this in vitro study was to investigate the role of the calcium (Ca<SUP>2+</SUP>) sensitization mechanism involving Rho-kinase, protein kinase C (PKC), and phosphoinositide 3-kinase (PI3-K) in mediating contraction of isolated rat aortic smooth muscle in response to dexmedetomidine. The effect of dexmedetomidine on the intracellular Ca<SUP>2+</SUP> level ([Ca<SUP>2+</SUP>]i) and tension was measured simultaneously. Dexmedetomidine concentration-response curves were generated in the presence or absence of the following antagonists: rauwolscine, Y 27632, LY 294002, GF 109203X, and verapamil. Dexmedetomidine-induced phosphorylation of PKC and membrane translocation of Rho-kinase were detected with Western blotting. Rauwolscine, Y 27632, GF 109203X, LY 294002, and verapamil attenuated dexmedetomidine-induced contraction. The slope of the [Ca<SUP>2+</SUP>]i-tension curve for dexmedetomidine was higher than that for KCl. Dexmedetomidine induced phosphorylation of PKC and membrane translocation of Rho-kinase. These results suggest that dexmedetomidine-induced contraction involves a Ca<SUP>2+</SUP> sensitization mechanism mediated by Rho-kinase, PKC, and PI3-K that is secondary to α2-adrenoceptor stimulation in rat aortic smooth muscle. </P>
김재훈,김창수,최병렬,이창형,오동호,배정동,박미옥,김호각,도준형 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.5
Gastroduodenal Crohn's Disease (CD), which is uncommon in adults, involves the gastric antrum and proximal duodenum in most cases, and results in epigastric pain, weight loss, and gastric outlet obstruction, raising initial suspicion that it may be peptic ulcer disease or a malignancy. On upper endoscopy, aphthous ulcers are typical in the early stages but linear or stellate ulcers with a cobblestone appearance and luminal narrowing can be found in advanced diseases. Multiple mucosal biopsies are helpful for diagnosis despite the fact that granulomas are seen in less than one third of all cases. Gastroduodenal CD requires oral sulfasalazine therapy or systemic corticosteroid therapy in advanced cases. A case of gastroduodenal CD in a 37-year-old man admitted with epigastric pain, anorexia, vomiting and weight loss is herein reported. Malignancy was suspected as a result of the patient's clinical manifestations and endoscopic findings. An endoscopic biopsy revealed an active inflammation in the mucosa and lamina propria. The patient's condition improved with oral sulfasalazine and prednisolone therapy.
Sketch of International Digestive Endoscopy Network 2012 Meeting: Overview
Ho Gak Kim 대한소화기내시경학회 2012 Clinical Endoscopy Vol.45 No.3
International Digestive Endoscopy Network (IDEN) is an international meeting covering scientific subjects of diverse topics about upper gastrointestinal (GI) endoscopy, colonoscopy, endoscopic ultrasonography, and PB endoscopy. IDEN is organized by Korean Society of Gastrointestinal Endoscopy and the Korean Gastrointestinal Endoscopy Research Foundation, and took its first step in 2011 in Seoul, Korea. IDEN inaugurated a new era of diagnostic and therapeutic GI endoscopy. IDEN 2012 was designed to offer participants from all over the world with opportunities to share up-to-date knowledge about basic and clinical aspects of GI endoscopy and to engage in in-depth discussion with worldwide well-known experts. During the 2 days of meeting, there were 62 invited lectures, 28 case-based discussions, 20 video lectures, and 6 breakfast with the experts. There were a total of 598 participants registered from 12 countries, including Asian countries, Europe, and USA as well as Korea.