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RISS 인기검색어
- 검색키워드
- 저자 : ( Hiroki Nakashima ) (검색결과 4 건)
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Age-Related Changes in Walking Motion of Japanese Females
Irma Nur AFIAH,Hiroki NAKASHIMA,Satoshi MURAKI 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5
The purpose of this study was to investigate the effects of aging on gait parameters at two different speed conditions in Japanese females. This study involved 42 healthy Japanese females who were divided into three groups: (1) 14 younger females, mean age 22.3 ± 1.6 years, (2) 14 older females (65 to 75 years old), mean age 70.7 ± 1.8 years, and (3) 14 very old females (≥ 76 years old), mean age 78.2 ± 3.5 years. Various parameters were measured: basic gait parameters (speed of walking, right step length, left step length, step length, difference between right and left step lengths, ratio of step length to height, ratio of step length to lower-limb length, and cadence) and gait cycle parameters (time of swing phase, time of stance phase, time of one gait cycle, percentage of swing phase, and percentage of stance phase). The walking speeds in groups 1, 2, and 3 were 72 ± 5.4, 71.4 ± 7.3, and 69.7 ± 6.7 at the self-selected speed, and 91.3 ± 7.4, 86.2 ± 8.3, and 85.1 ± 9.1 m/min at the fast speed, respectively. In two-way repeated-measure ANOVA, all the parameters showed statistically significant effects of speed conditions (p<0.05), except the difference between right and left step lengths. Statistically significant effects of groups were found in right step length, left step length, step length, and difference between right and left step lengths (p<0.05). In addition, significant interactions between speed conditions and groups were found in the time of swing phase, time of stance phase, and time of one gait cycle (p<0.05). Under the self-selected speed condition among the three groups, posthoc pairwise Bonferroni-corrected comparison showed significant differences in right step length, left step length, step length, and difference between right and left step lengths (p<0.05). Under the fast speed condition, however, significant differences were only found in right step length, left step length, and step length (p<0.05).
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Age-Related Changes in Walking Motion of Japanese Females: Basic Analysis of Gait Motion
( Irma Nur Afiah ),( Hiroki Nakashima ),( Satoshi Muraki ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
The purpose of this study was to investigate the effects of aging on gait parameters at two different speed conditions in Japanese females. This study involved 42 healthy Japanese females who were divided into three groups: (1) 14 younger females, mean age 22.3 ± 1.6 years, (2) 14 older females (65 to 75 years old), mean age 70.7 ± 1.8 years, and (3) 14 very old females (≥ 76 years old), mean age 78.2 ± 3.5 years. Various parameters were measured: basic gait parameters (speed of walking, right step length, left step length, step length, difference between right and left step lengths, ratio of step length to height, ratio of step length to lower-limb length, and cadence) and gait cycle parameters (time of swing phase, time of stance phase, time of one gait cycle, percentage of swing phase, and percentage of stance phase). The walking speeds in groups 1, 2, and 3 were 72 ± 5.4, 71.4 ± 7.3, and 69.7 ± 6.7 at the self-selected speed, and 91.3 ± 7.4, 86.2 ± 8.3, and 85.1 ± 9.1 m/min at the fast speed, respectively.
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Kosaku Nanki,Shinta Mizuno,Katsuyoshi Matsuoka,Keiko Ono,Shinya Sugimoto,Hiroki Kiyohara,Mari Arai,Moeko Nakashima,Kozue Takeshita,Keiichiro Saigusa,Mitsutoshi Senoh,Tadashi Fukuda,Makoto Naganuma,Har 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrentClostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis(UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient’s diarrhea and eradicated C. difficilebacteriologically without any severe complications. Molecular biological analysis of the patient’s fecal microbiota showedthat FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinalsymptoms of CDI and could prevent further recurrences of CDI.
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( Shinta Mizuno ),( Kosaku Nanki ),( Katsuyoshi Matsuoka ),( Keiichiro Saigusa ),( Keiko Ono ),( Mari Arai ),( Shinya Sugimoto ),( Hiroki Kiyohara ),( Moeko Nakashima ),( Kozue Takeshita ),( Makoto Na 대한장연구학회 2017 Intestinal Research Vol.15 No.1
Background/Aims: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC) is proposed as a potential approach to resolving their dysbiosis; however, its safety and efficacy have not been confirmed. This single-arm, open-label, non-randomized study aimed to evaluate the safety and efficacy of FMT for Japanese patients with UC as the first registered clinical trial in Japan. Methods: We enrolled 10 patients with active UC despite medical therapy. The donors were the patients` relatives and were carefully screened for infectious diseases. Fecal material was administered via colonoscopy, and the primary endpoint was the presence or absence of serious adverse events related to FMT. The secondary endpoint was a change in partial Mayo score at 12 weeks post-FMT. Scores ≤2 were considered a clinical response. Fecal samples were collected to follow changes in gut microbiota, while extracted complementary DNA were analyzed by a next-generation sequencer. We obtained written informed consent from all patients and donors. This study was approved by our Institutional Review Board and is registered in the University hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN 000012814). Results: Five patients with moderate disease and five with severe disease were enrolled. No severe adverse effects were observed. One patient achieved clinical response; however, none of the patients` microbiota diversity recovered to the donor levels. Conclusions: The use of single FMT for UC was safe; however, we failed to show its clinical efficacy and potential to change the intestinal microbiota. (Intest Res 2017;15:68-74)
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