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        Original Article : Effect of Helicobacter pylori Eradication on the Development of Refl ux Esophagitis and Gastroesophageal Refl ux Symptoms: A Nationwide Multi-Center Prospective Study

        ( Na Young Kim ),( Sang Woo Lee ),( Jin Il Kim ),( Gwang Ho Baik ),( Sung Jung Kim ),( Geom Seog Seo ),( Hyo Jeong Oh ),( Sang Wook Kim ),( Heyjin Jeong ),( Su Jin Hong ),( Ki Nam Shim ),( Jeong Eun S 대한간학회 2011 Gut and Liver Vol.5 No.4

        Background/Aims: A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of refl ux esophagitis (RE) and gastroesophageal refl ux disease (GERD) symptoms in the Korean population. Methods: In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms. Results: RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylorinegative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age ≥60 years (odds ratio [OR], 7.11; 95% confi dence interval [CI], 1.92 to 26.41), alcohol consumption (OR, 4.43; 95% CI, 1.03 to 19.19) and F/ U cholesterol levels ≥200 mg/dL (OR, 5.03; 95% CI, 1.32 to 19.17) were significant risk factors for the development of RE. There was no signifi cant difference in the development of GERD symptoms or weight according to H. pylori status during the 2-year F/U. Conclusions: Eradication of H. pylori did not affect the development of refl ux esophagitis or GERD symptoms among patients in outpatient gastroenterology clinics in South Korea. (Gut Liver 2011;5:437-446)

      • Measurement of Skin Hydration Using IoT Devices

        ( Sekyoo Jeong ),( Jongmi Lim ),( Heyjin Song ),( Changhee Han ),( Hyunjung Kim ) 한국피부장벽학회 2016 한국피부장벽학회지 Vol.18 No.1

        Non-invasive measurement of skin functions, such as epidermal permeability barrier function, skin hydration and skin surface pH, generally requires specialized apparatus and controlled environmental conditions (i.e., temperature and relative humidity). While these data can provide invaluable information about the skin functions, they can only represent skin functions under specific experimental conditions. In order to analyze the changes of skin functions according to the practical environmental changes, such as by seasonal change or air pollution status, large number of data sets over a long-term measurement period are required. Considering the price and measurement protocols, classical measurement apparatuses are not practically applicable for these kinds of studies. Recent advances in IoT (internet of things) technology and sensor technology have made it possible for developing various kinds of wearable devices, which can track and record enormous number of data sets from human behaviors. Recently, we developed a portable device that measures the skin hydration and stores the data using IoT technology. Hypothetically, it can provide enough data sets which make it available to analyze the overall tendency of skin functions. While there are clear limits of these approaches, such as uncontrolled measurement conditions and non-standardized measurement protocols, big data analysis may overcome these limitations. In this talk, results of preliminary study will be discussed and further study plans with the device will suggested.

      • Measurement of Skin Hydration Using IoT Devices

        ( Jongmi Lim ),( Heyjin Song ),( Changhee Han ),정세규 ( Sekyoo Jeong ) 한국피부장벽학회 2016 한국피부장벽학회지 Vol.18 No.1

        Non-invasive measurement of skin functions, such as epidermal permeability barrier function, skin hydration and skin surface pH, generally requires specialized apparatus and controlled environmental conditions (i.e., temperature and relative humidity). While these data can provide invaluable information about the skin functions, they can only represent skin functions under specific experimental conditions. In order to analyze the changes of skin functions according to the practical environmental changes, such as by seasonal change or air pollution status, large number of data sets over a long-term measurement period are required. Considering the price and measurement protocols, classical measurement apparatuses are not practically applicable for these kinds of studies. Recent advances in IoT (internet of things) technology and sensor technology have made it possible for developing various kinds of wearable devices, which can track and record enormous number of data sets from human behaviors. Recently, we developed a portable device that measures the skin hydration and stores the data using IoT technology. Hypothetically, it can provide enough data sets which make it available to analyze the overall tendency of skin functions. While there are clear limits of these approaches, such as uncontrolled measurement conditions and non-standardized measurement protocols, big data analysis may overcome these limitations. In this talk, results of preliminary study will be discussed and further study plans with the device will suggested.

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