골반 종괴의 악성도 선별검사를 위한 난소형태지수의 유용성

노흥태 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

A morphology index based on morphologic characteristics of ovarian tumors was developed. Specific categories included tumor volume, wall structure, and septal structure. A point scale (0-4) was developed within each category with the total points per evaluation varing from 0-12. Transvaginal sonograms on 50 patients undergoing exploratory laparotomy for ovarian masses were evaluated using this index. The results obtained were summarized as followings : 1. The mean morphology index of malignant ovarian tumors was 9.01 ± 1.63 which was statistically higher than 3.07 ± 1.78 of benign ovarian lesions. 2. When the cutoff point of mean morphology index score was decided as above 5, sensitivity, speciticity, positive and negative predictive value for malignant ovarian tumor were 1.000, 0.829, 0.563, 1.000, respectively. 3. The most reliable morphological characteristic in distinguishing ovarian cancers from benign lesions was wall structure. In conclusion, it is suggested that the routine application of a morphology index by transvaginal sonogram in ovarian tumor may be helpful to clinician for distinguishing benign ovarian lesion from malignant ovarian tumor.

Papanicolaou Smear에서 채취기구에 따른 자궁경부 세포진의 비교검토

노흥태 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

As a population screening test, the Papanicolaou smear has been shown to be effective in reducing the incidence of invasive carcinoma of the cervix. However, one of the problems with screening is the occurence of false negative results with the smear test. Analysis of the reasons behind false negative reports has identified two broad areas where errors are likely to be made : in the laboratory and in the sampling procedure. In order to find out the importance of sampler in cervical cytology to detect early cervical neoplasia, we performed this study on 396 patients by using cervex-brush(105 women), cytobrush(95 women), spatula(96 women), and cotton swab(100 women). Attributes tabulated included the following: background (hemorrhage, cell destruction, mucus) and cell component(squamous & columnar cells, clot, sheet, single) in percent per slide The following results were obtained: 1. In the background, hemorrhage was least in samples using the cotton swab and cell destruction was significantly smaller in samples using cervex-brush and cytohrush than in cotton swab(p 0.05). Mucus was not significant between 4 devices. 2. In the cell component, the incidence for the presence of squamous cells was significantly higher in samples using the cervex brush and spatula than in cotton swab(p 0.05). The incidence for the presence of columnar cells was highest in samples using the cervex-brush, next was cytobrush. 3. In the cell distribution, clot was not significant between 4 devices. Sheet was not significant only between cervex-brush and spatula. Single cell was noted in highest rate in samples using the cervex-brush. But cotton sawb and cytobrush(p=0.2587), cotton swab and spatula (p=0.4326) were not significant. 4. In the analysis of the results over class III Pap smear, cervex brush was higher detection than the cotton swab(p 0.05). From the above results, cervex-brush, as like cytobrush, was important sampler in mass screening of early cervical neoplasia with Pap smear. And the use of cotton swab was not good.

경계성 난소 종양의 임상적 고찰

노흥태,이종범 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Approximately 10 20% of epithelial ovarian tumors are tumor of borderline malignancy or carcinoma of low malignancy potential. Epithelial stratification, cellular atypia, mitotic activity, and absence of ovarian stromal invasion set the histologic criteria for diagnosis. The aim of this study was to analyse the group of patients with borderline ovarian tumors. The analysis included 39 patients, operated for ovarian tumor of borderline malignancy in the Gynecological Department of Chungnam National University Hospital from May 1992 to April 1999. The study takes into account comparison of: age of patients, obstetrical past, clinical signs and symptoms, clinical stage(according to FIGO), type of surgery, tumor pathology, post- surgical treatment. Furthermore, long-term follow-up was assessed. The incidence of borderline malignant ovarian tumor was 28.3%. The mean age was 39.2 years (range, 15 to 79). The most common chief complaint was palpable mass(41.0%). 94.8% of tumors were recognised in stage I (FIGO). 74.4% of the tumors were histological mucinous, 25.6% were serous. All patients were treated by surgery and 17.9% received cisplatin-containing chemotherapy.

人蔘이 Vinblastine을 投與한 家兎의 肝機能에 미치는 影響

盧興泰 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2

Vinblastine, an oncolytic agent isolated from the plant Catharantus roseus G. Don(Vinca rosea Linn.) of the family Apocynaceae, is now used commonly in clinical cancer therapy. But it has some adverse effects, which include depression of bone marrow, impairments of renal and hepatic function as well as congenital malformation of the fetus. In this investigation, the mixture of ginseng extract-vinblastine was administered intravenously to rabbits to compare the effects on the liver function with those of liver function injected vinblastine alone. Experiments were done in three groups : one day group where vinblastine (0.3mg/kg) and ginseng extract(80mg/kg) were given in a single dose, 5 days group where vinblastine (0.05mg/kg with daily increase of 0.05mg/kg) and ginseng extract (10mg/kg with daily increase of 10mg/kg) were given for 5 days, and 15 days group in that the way of 5 days group were repeated with 5 days resting interval. The results were summarized as follows : 1. Plasma concentrations of albumin and globulin after administration of vinblastine alone showed much lower value than those of control, and the values of albumin and globulin after administeration of ginseng extract-vinblastine showed higher value, nearly to control. 2. Plasma levels of GOT and GPT after administration of vinblastine alone were significantly elevated compare to those of control, but the value after administration of ginseng extract as well showed lower ones which were nearly as control. 3. Plasma concentrations of B. S. P. retended after administration of vinblastine alone showed much higher value than those of control, but the value was not significantly different when ginseng extract was added. 4. Plasma bilirubin level showed higher value with the administration of vinblastine alone, but as ginseng extract was added, the value was not significantly different from that of control. 5. Plasma concentration of cholesterol after administration of vinblastine alone showed much higher value than that of control, but as ginseng extract was given together with vinblastine, it showed as nearly low as control.

대전시내 여학생의 초경에 관한 연구

노흥태 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

Menarche is an important life event in girls biologically and the onset of the menarche differs with the individual and is affected by such variables as climate, genetics, socio-economic status, ethnicity, geographical location and general physical condition. In an effort to evaluate the experience rate of menarche, the age of menarche, the relation between menarche and height, the knowledge concerning menarche and emotional responses for menarche, the author conducted surveys for 1490 girls, who are primary, middle, high school girls, college and business women. The results obtained from the surveys are as follows. 1. Experience rate of menarche was 12.6% in primary school, 66.8% in the middle school, 99.0% in the high school, 98.9% in the college girls, 100% in the business women. 2. The mean age at menarche was 13.9±1.4 years. The earliest age of menmche was 9 and the latest age 18. 3. According to age group, menarche occurs sooner by degrees. 4. The shorter girls had earlier menarche and the taller girls had later. 5. Knowledge concerning menarche was obtained mostly from school teacher and friends or sisters. 6. 84.5% of total number experienced fear and anxiety at the occurrance of menarche.

초음파를 이용한 태아체중 예측

노흥태 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Sonographic measurements of biparietal diameter(BPD), head circumference(HC), abdominal circumference(AC), femur length(FL), were made in 56 cases of pregnant women who deliveried within 72 hours of measurement, using real-time systems with 3.5㎒ transducers. Estimation of fetal weight was calculated by application of equation proposed by Shepard et al and Hadlock et al. Actual birth weights were compared with predicted value The results were as followings 1. Correlation between estimated and actual fetal wight was very significant.(P<0.0001) 2. The mean of absolute difference for estimated and actual weight was smallest for equation 2 (BPD, AC, FL) with 170gm and largest for equation 4 (AC, HC, FL) with 208gm. 3. Using each equation, the calculated estimated fetal weight fallen within ten percentile range compared to actual birth weight was highest at equation 3(BPD, AC, HC, FL) for 92.9%. 4. Analysing mean residual between estimated and actual fetal weight by according to weight distribution, 3500-3999gm group showed underestimation. 5. In near term pregnant women, when BPD measurement is inaccruate and sometimes cannot be obtained easily. In this cases, with use of AC and FL to calculated estimated fetal weight which are acceptable and reliable.

불임환자에 있어서 Chlamydia trachomatis 감염에 관한 고찰

노흥태 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Clinical study of Chlamydia trachomatis detection using direct immunofluorescence on infertility was performed on the 54 infertile women and 30 normal control women who visited the department of Obstetrics and Gynecology of Chungnam National University Hospital during the period of 9 months from January to September, 1985. The following results were obtained. 1. Positive rate of Chlamydia trachomatis in normal control women was 13.3%. 2. Positive rate of Chlamydia trachomatis in infertile women was 46.3%, which was significantly higher than normal control women (p<0.05). 3. The prevalence of Chlamydia trachomatis was increased with young age. The most commonly affected age was 20∼24 years. 4. The tubal factor was increased than non tubal factor in etiological analysis for Chlamydia trachomatis.

폐경기 여성의 정신건강에 관한 연구

노흥태 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

A study on psychiatric status on menopausal women was measured by General Health Questionnaire by Goldberge and Hiller on 90 women(control : 40, menopausal women : 50). Questionnaires filled up by patient herself after medical personal interview during the period of February, 1986 to September, 1986. This study was tried to know whether emotional status of menopausal women is somatic symptom. or anxiety & insomnia or social dysfunction or severe depression and General Health Questionnaire is valuable tool for Ob & Gyn patients. The results obtained were as follows : 1. The scores in menopausal women obtained significantly higher in somatic, anxiety and insomnia and severe depressive scales than control group. 2. The scores between spontaneous & sugical menopausal women were noted significant differences. But, in subgroup, the score of somatic symptom and anxiety & insomnia appears to be higher than that of social dysfunction and severe depression 3. The scores between duration of menopause were higher in short period than longer poriod.

폐경기 증후군 환자에서 Cyclofenil의 유용성

노흥태,이창환 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The postmenopausal period is associated with a significant increase in the incidence of agerelated conditions. It is becoming increasingly clear, however, that some of these conditions, specifically osteoporosis and cardiovascular disease, are related to estrogen deficiency as well as to age. For this reason, gynecologic care of postmenopausal women should adress the issue of hormonal replacement therapy. However, estrogen therapy is often responsible for genital or extragenital side effects. Among non-steroid agents, cyclofenil is known to be useful due to action at the level of the hypophyseal and hypothalamic centers. These action is in reducing the secretion of FSH and restoring normal endorphin, dopamine, and norephinephrine activities, thus favorably affecting the entire post-menopausal neurovegetative symptomatology. The purpose of this study was to investigate the clinical efficacy and safety for cyclofenil administered orally at 200mg daily for 8 consecutive weeks in 30 patients with the postmenopausal symptoms. The results were as follows: 1. The distribution of clinical symptoms in the studied patients prior to treatment was: hot Flush, 100.0%; sweating, 86.7%; fatigue, 70.0%; anxiety, 66.7%; depression, 60.0%; headache, 56.7% sleep disturbance 46.7%, and vaginal burning sensation, 40.0%. 2. The efficacy rate after treatment with cyclofenil was 84.7% in the sweat, 75.0% in the vaginal burning sensation, 71.4% in the sleep disturbance and fatigue, 70.0% in the hot flush, 60. 0% in the anxiety, 41.9% in the headache, and 27.8% in the depression. 3, There was no definite evidence of side effects observed during the study. These data suggest that cyclofenil therapy is effective in reducing the incidence of postmenopausal syndrome.

膣 트리코모나스 및 칸디다症의 臨床統計的 考察

盧興泰 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Clinical study on trichomonas & Candida vaginitis was done on the 400 women who visited the Chungnam Hongseung Province Hospital, Chungnam Hongseung Kun Health Center and Chungnam Cheungyeang Kun Health Center Branch during the 6 Month, from April to September 1977, obtaining the following results: 1. In the Prevalence of Trichomonas & Candida infections on each group, pregnancy group was highest prevalence. 2. In relation to the pregnancy, the prevalence of trichornonas and candida infections was 32.8% and 41.9%, respectively. In relation to the duration of pregnancy, first trimester was highest prevalence of 52.3% in Trichomonas, but in candida, prevalence increased as the duration to the oral pill users, the prevalence of trichornonas & Candida infections was 27.4% & 38.7%, respectively. 4. In loop group, the prevalence of trichomonas & candida infections was slightly higher than that of control. 5. Mixed infections was 4.4%. In classfiying the groups, prostitutes group was highest prevalence of 7.5%. 6. The most commonly affected age group for both trichomonas and candida infections was 30∼34 years. 7. The prevalence of trichomonas & candida infections was higher in the lower education group. 8. The prevalence of trichomonas & candida infections with leukorrhea was 28.1% and 37.3%, respectively. 9. The prevalence of trichomonas & candida infections in persons with no subjective symptom was 10.4% and 13.8%, respectively. 10. In diagnostic methods, wet smear & culture was similar results in trichomonas infections, but in candida, culture was higher than wet smear.